DK3370828T3 - Oximforbindelse som agonister af muscarin m1- og/eller m4- receptoren - Google Patents

Oximforbindelse som agonister af muscarin m1- og/eller m4- receptoren Download PDF

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Publication number
DK3370828T3
DK3370828T3 DK16793975.0T DK16793975T DK3370828T3 DK 3370828 T3 DK3370828 T3 DK 3370828T3 DK 16793975 T DK16793975 T DK 16793975T DK 3370828 T3 DK3370828 T3 DK 3370828T3
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Prior art keywords
muscarin
agonists
receptor
oxim
compound
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DK16793975.0T
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Danish (da)
English (en)
Inventor
Giles Albert Brown
Benjamin Gerald Tehan
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Heptares Therapeutics Ltd
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK16793975.0T 2015-11-02 2016-11-02 Oximforbindelse som agonister af muscarin m1- og/eller m4- receptoren DK3370828T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1519352.7A GB201519352D0 (en) 2015-11-02 2015-11-02 Pharmaceutical compounds
PCT/GB2016/053396 WO2017077292A1 (en) 2015-11-02 2016-11-02 Oxime compounds as agonists of the muscarinic m1 and/or m4 receptor

Publications (1)

Publication Number Publication Date
DK3370828T3 true DK3370828T3 (da) 2020-07-13

Family

ID=55130557

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16793975.0T DK3370828T3 (da) 2015-11-02 2016-11-02 Oximforbindelse som agonister af muscarin m1- og/eller m4- receptoren

Country Status (10)

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US (2) US11208396B2 (OSRAM)
EP (2) EP3370828B1 (OSRAM)
JP (1) JP6799596B2 (OSRAM)
CN (1) CN108290055B (OSRAM)
AU (1) AU2016348847B2 (OSRAM)
CA (1) CA3003669C (OSRAM)
DK (1) DK3370828T3 (OSRAM)
ES (1) ES2804774T3 (OSRAM)
GB (1) GB201519352D0 (OSRAM)
WO (1) WO2017077292A1 (OSRAM)

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WO2018112842A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
WO2018112843A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
GB201709652D0 (en) * 2017-06-16 2017-08-02 Heptares Therapeutics Ltd Pharmaceutical compounds
JP7166331B2 (ja) * 2017-08-01 2022-11-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 中間体化合物及び方法
CA3079188A1 (en) * 2017-10-17 2019-04-25 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
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GB201810239D0 (en) * 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
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GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds
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Publication number Publication date
CA3003669C (en) 2024-04-09
CN108290055A (zh) 2018-07-17
HK1253036A1 (en) 2019-06-06
AU2016348847B2 (en) 2021-07-08
JP2018536653A (ja) 2018-12-13
AU2016348847A1 (en) 2018-06-07
EP3370828B1 (en) 2020-04-15
US11208396B2 (en) 2021-12-28
CN108290055B (zh) 2021-05-14
GB201519352D0 (en) 2015-12-16
US20220298133A1 (en) 2022-09-22
EP3797778A1 (en) 2021-03-31
US12291512B2 (en) 2025-05-06
US20200165220A1 (en) 2020-05-28
CA3003669A1 (en) 2017-05-11
EP3370828A1 (en) 2018-09-12
WO2017077292A1 (en) 2017-05-11
ES2804774T3 (es) 2021-02-09
JP6799596B2 (ja) 2020-12-23

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