DK318985A - Fremgangsmaade til fremstilling af 5-aryl-1,6-naphthyridin-2(1h)-on-derivater samt mellemprodukter til brug ved fremgangsmaaden - Google Patents

Fremgangsmaade til fremstilling af 5-aryl-1,6-naphthyridin-2(1h)-on-derivater samt mellemprodukter til brug ved fremgangsmaaden Download PDF

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Publication number
DK318985A
DK318985A DK318985A DK318985A DK318985A DK 318985 A DK318985 A DK 318985A DK 318985 A DK318985 A DK 318985A DK 318985 A DK318985 A DK 318985A DK 318985 A DK318985 A DK 318985A
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DK
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Prior art keywords
procedure
naphthyridine
intermediates
aryl
derivatives
Prior art date
Application number
DK318985A
Other languages
Danish (da)
English (en)
Other versions
DK318985D0 (da
Inventor
George Yohe Lesher
Baldev Singh
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of DK318985D0 publication Critical patent/DK318985D0/da
Publication of DK318985A publication Critical patent/DK318985A/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK318985A 1984-07-13 1985-07-12 Fremgangsmaade til fremstilling af 5-aryl-1,6-naphthyridin-2(1h)-on-derivater samt mellemprodukter til brug ved fremgangsmaaden DK318985A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/630,810 US4560691A (en) 1984-07-13 1984-07-13 5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation

Publications (2)

Publication Number Publication Date
DK318985D0 DK318985D0 (da) 1985-07-12
DK318985A true DK318985A (da) 1986-01-14

Family

ID=24528649

Family Applications (1)

Application Number Title Priority Date Filing Date
DK318985A DK318985A (da) 1984-07-13 1985-07-12 Fremgangsmaade til fremstilling af 5-aryl-1,6-naphthyridin-2(1h)-on-derivater samt mellemprodukter til brug ved fremgangsmaaden

Country Status (19)

Country Link
US (1) US4560691A (fr)
EP (1) EP0168037B1 (fr)
JP (1) JPS6140286A (fr)
KR (1) KR870001089B1 (fr)
AR (1) AR242388A1 (fr)
AT (1) ATE50259T1 (fr)
AU (1) AU584103B2 (fr)
DE (1) DE3575926D1 (fr)
DK (1) DK318985A (fr)
ES (1) ES8706151A1 (fr)
FI (1) FI852765L (fr)
GR (1) GR851677B (fr)
IL (1) IL75733A (fr)
MX (1) MX161361A (fr)
NO (1) NO852677L (fr)
NZ (1) NZ212647A (fr)
PH (1) PH21844A (fr)
PT (1) PT80809B (fr)
ZA (1) ZA855280B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4532247A (en) * 1983-08-08 1985-07-30 Sterling Drug Inc. 5-(Hydroxyalkyl or alkanoyloxymethyl)-1,6-naphthyridin-2(1H)-one and cardiotonic use thereof
US4567186A (en) * 1985-01-14 1986-01-28 Sterling Drug Inc. 5-Heteryl-1,6-naphthyridin-2(1H)-ones, cardiotonic use thereof and intermediates therefor
NZ214837A (en) * 1985-01-28 1988-10-28 Sterling Drug Inc 5-substituted 1,6 naphthyridin-2(1h)-ones
DE3840341A1 (de) * 1988-11-30 1990-06-07 Basf Ag Verfahren zur herstellung von 1-nitroanthrachinon-2-carbonsaeure
US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
NZ524806A (en) * 2000-10-23 2006-03-31 Smithkline Beecham Corp Tri-substituted 8H-pyrido[2,3-d]pyrimidin-7-one compounds
RU2004133811A (ru) * 2002-04-19 2005-04-20 Смитклайн Бичам Корпорейшн (US) Новые соединения
AU2004212957A1 (en) * 2003-02-14 2004-09-02 Smithkline Beecham Corporation Novel compounds
JP2008535822A (ja) * 2005-03-25 2008-09-04 グラクソ グループ リミテッド 新規化合物
UY29440A1 (es) 2005-03-25 2006-10-02 Glaxo Group Ltd Nuevos compuestos
WO2006104917A2 (fr) * 2005-03-25 2006-10-05 Glaxo Group Limited Procede de preparation de derives pyrido[2,3-d]pyrimidin-7-one et 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one
PE20061193A1 (es) * 2005-03-25 2006-12-02 Glaxo Group Ltd DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38
CN105218388B (zh) * 2015-10-26 2017-07-11 西北农林科技大学 β‑羰基烯胺类化合物及作为制备植物病原菌抗菌剂的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4412077A (en) * 1982-03-15 1983-10-25 Sterling Drug Inc. Process for preparing 5-(lower-alkanoyl)-6-(lower-alkyl)-2(1H)-pyridinone
US4415580A (en) * 1982-08-02 1983-11-15 Sterling Drug Inc. Certain 2-(1H)-pyridinones cardiotonic compositions containing same and method of using same

Also Published As

Publication number Publication date
IL75733A0 (en) 1985-11-29
PH21844A (en) 1988-03-17
FI852765A0 (fi) 1985-07-12
AR242388A1 (es) 1993-03-31
IL75733A (en) 1988-07-31
DK318985D0 (da) 1985-07-12
MX161361A (es) 1990-09-18
NO852677L (no) 1986-01-14
EP0168037B1 (fr) 1990-02-07
ATE50259T1 (de) 1990-02-15
ES8706151A1 (es) 1987-06-01
JPS6140286A (ja) 1986-02-26
EP0168037A3 (en) 1986-03-26
KR870001089B1 (ko) 1987-06-04
AU584103B2 (en) 1989-05-18
FI852765L (fi) 1986-01-14
GR851677B (fr) 1985-11-26
AU4474785A (en) 1986-01-16
PT80809B (en) 1987-01-12
KR860001109A (ko) 1986-02-22
EP0168037A2 (fr) 1986-01-15
PT80809A (en) 1985-08-01
NZ212647A (en) 1988-07-28
US4560691A (en) 1985-12-24
ES545139A0 (es) 1987-06-01
DE3575926D1 (de) 1990-03-15
ZA855280B (en) 1986-02-26

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