PH21844A - 1,6-naphthyridin-2(1h)-ones useful as cardiotonics - Google Patents

1,6-naphthyridin-2(1h)-ones useful as cardiotonics

Info

Publication number
PH21844A
PH21844A PH32510A PH32510A PH21844A PH 21844 A PH21844 A PH 21844A PH 32510 A PH32510 A PH 32510A PH 32510 A PH32510 A PH 32510A PH 21844 A PH21844 A PH 21844A
Authority
PH
Philippines
Prior art keywords
cardiotonics
naphthyridin
ones useful
ones
useful
Prior art date
Application number
PH32510A
Other languages
English (en)
Inventor
George Yohe Lesher
Baldev Singh
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of PH21844A publication Critical patent/PH21844A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PH32510A 1984-07-13 1985-07-11 1,6-naphthyridin-2(1h)-ones useful as cardiotonics PH21844A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/630,810 US4560691A (en) 1984-07-13 1984-07-13 5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation

Publications (1)

Publication Number Publication Date
PH21844A true PH21844A (en) 1988-03-17

Family

ID=24528649

Family Applications (1)

Application Number Title Priority Date Filing Date
PH32510A PH21844A (en) 1984-07-13 1985-07-11 1,6-naphthyridin-2(1h)-ones useful as cardiotonics

Country Status (19)

Country Link
US (1) US4560691A (fr)
EP (1) EP0168037B1 (fr)
JP (1) JPS6140286A (fr)
KR (1) KR870001089B1 (fr)
AR (1) AR242388A1 (fr)
AT (1) ATE50259T1 (fr)
AU (1) AU584103B2 (fr)
DE (1) DE3575926D1 (fr)
DK (1) DK318985A (fr)
ES (1) ES8706151A1 (fr)
FI (1) FI852765L (fr)
GR (1) GR851677B (fr)
IL (1) IL75733A (fr)
MX (1) MX161361A (fr)
NO (1) NO852677L (fr)
NZ (1) NZ212647A (fr)
PH (1) PH21844A (fr)
PT (1) PT80809B (fr)
ZA (1) ZA855280B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4532247A (en) * 1983-08-08 1985-07-30 Sterling Drug Inc. 5-(Hydroxyalkyl or alkanoyloxymethyl)-1,6-naphthyridin-2(1H)-one and cardiotonic use thereof
US4567186A (en) * 1985-01-14 1986-01-28 Sterling Drug Inc. 5-Heteryl-1,6-naphthyridin-2(1H)-ones, cardiotonic use thereof and intermediates therefor
NZ214837A (en) * 1985-01-28 1988-10-28 Sterling Drug Inc 5-substituted 1,6 naphthyridin-2(1h)-ones
DE3840341A1 (de) * 1988-11-30 1990-06-07 Basf Ag Verfahren zur herstellung von 1-nitroanthrachinon-2-carbonsaeure
US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
DK1333833T3 (da) 2000-10-23 2011-12-12 Glaxosmithkline Llc Ny trisubstitueret 8H-pyridol[2,3-d]pyrimidin-7-on-forbindelse til behandling af CSBP/RK/p38-kinnasemedierede sygdomme
CA2482022A1 (fr) * 2002-04-19 2003-10-30 Smithkline Beecham Corporation Nouveaux composes
US7550480B2 (en) * 2003-02-14 2009-06-23 Smithkline Beecham Corporation Compounds
MY145281A (en) 2005-03-25 2012-01-13 Glaxo Group Ltd Novel compounds
WO2006110298A2 (fr) * 2005-03-25 2006-10-19 Glaxo Group Limited Nouveaux composes
AR053450A1 (es) * 2005-03-25 2007-05-09 Glaxo Group Ltd Derivados de 3,4-dihidro-pirimido(4,5-d)pirimidin-2-(1h)-ona 1,5,7 trisustituidos como inhibidores de la quinasa p38
CA2603163A1 (fr) * 2005-03-25 2006-10-05 Glaxo Group Limited Procede de preparation de derives pyrido[2,3-d]pyrimidin-7-one et 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one
CN105218388B (zh) * 2015-10-26 2017-07-11 西北农林科技大学 β‑羰基烯胺类化合物及作为制备植物病原菌抗菌剂的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4412077A (en) * 1982-03-15 1983-10-25 Sterling Drug Inc. Process for preparing 5-(lower-alkanoyl)-6-(lower-alkyl)-2(1H)-pyridinone
US4415580A (en) * 1982-08-02 1983-11-15 Sterling Drug Inc. Certain 2-(1H)-pyridinones cardiotonic compositions containing same and method of using same

Also Published As

Publication number Publication date
US4560691A (en) 1985-12-24
EP0168037A3 (en) 1986-03-26
FI852765L (fi) 1986-01-14
JPS6140286A (ja) 1986-02-26
PT80809A (en) 1985-08-01
IL75733A (en) 1988-07-31
IL75733A0 (en) 1985-11-29
NO852677L (no) 1986-01-14
GR851677B (fr) 1985-11-26
PT80809B (en) 1987-01-12
ATE50259T1 (de) 1990-02-15
EP0168037B1 (fr) 1990-02-07
EP0168037A2 (fr) 1986-01-15
KR870001089B1 (ko) 1987-06-04
DE3575926D1 (de) 1990-03-15
KR860001109A (ko) 1986-02-22
ZA855280B (en) 1986-02-26
ES8706151A1 (es) 1987-06-01
DK318985A (da) 1986-01-14
NZ212647A (en) 1988-07-28
ES545139A0 (es) 1987-06-01
DK318985D0 (da) 1985-07-12
AU4474785A (en) 1986-01-16
FI852765A0 (fi) 1985-07-12
MX161361A (es) 1990-09-18
AU584103B2 (en) 1989-05-18
AR242388A1 (es) 1993-03-31

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