DK3134386T3 - Isoindolin-1-on-derivater med kolinerg muscarin-m1-receptor-positiv allosterisk modulatoraktivitet til behandling af alzheimers sygdom - Google Patents

Isoindolin-1-on-derivater med kolinerg muscarin-m1-receptor-positiv allosterisk modulatoraktivitet til behandling af alzheimers sygdom Download PDF

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Publication number
DK3134386T3
DK3134386T3 DK15726362.5T DK15726362T DK3134386T3 DK 3134386 T3 DK3134386 T3 DK 3134386T3 DK 15726362 T DK15726362 T DK 15726362T DK 3134386 T3 DK3134386 T3 DK 3134386T3
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cholinerg
muscarin
isoindolin
alzheimer
receptor
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DK15726362.5T
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Danish (da)
English (en)
Inventor
Masami Yamada
Shinkichi Suzuki
Takahiro Sugimoto
Minoru Nakamura
Hiroki Sakamoto
Makoto Kamata
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Takeda Pharmaceuticals Co
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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DK15726362.5T 2014-04-23 2015-04-22 Isoindolin-1-on-derivater med kolinerg muscarin-m1-receptor-positiv allosterisk modulatoraktivitet til behandling af alzheimers sygdom DK3134386T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014089585 2014-04-23
PCT/JP2015/062912 WO2015163485A1 (en) 2014-04-23 2015-04-22 Isoindoline-1-one derivatives as cholinergic muscarinic m1 receptor positive alloesteric modulator activity for the treatment of alzheimers disease

Publications (1)

Publication Number Publication Date
DK3134386T3 true DK3134386T3 (da) 2020-08-17

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ID=53276227

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DK15726362.5T DK3134386T3 (da) 2014-04-23 2015-04-22 Isoindolin-1-on-derivater med kolinerg muscarin-m1-receptor-positiv allosterisk modulatoraktivitet til behandling af alzheimers sygdom

Country Status (36)

Country Link
US (16) US9315458B2 (enExample)
EP (1) EP3134386B1 (enExample)
JP (1) JP6517239B2 (enExample)
KR (1) KR102349237B1 (enExample)
CN (1) CN106536508B (enExample)
AR (1) AR100154A1 (enExample)
AU (1) AU2015250610B2 (enExample)
BR (1) BR112016024472B1 (enExample)
CA (1) CA2946519C (enExample)
CL (1) CL2016002661A1 (enExample)
CR (1) CR20160544A (enExample)
CY (1) CY1123569T1 (enExample)
DK (1) DK3134386T3 (enExample)
DO (1) DOP2016000286A (enExample)
EA (1) EA030373B1 (enExample)
EC (1) ECSP16090152A (enExample)
ES (1) ES2811088T3 (enExample)
HR (1) HRP20201171T1 (enExample)
HU (1) HUE050543T2 (enExample)
IL (1) IL248393B (enExample)
LT (1) LT3134386T (enExample)
MX (1) MX373274B (enExample)
MY (1) MY195742A (enExample)
NZ (1) NZ725921A (enExample)
PE (1) PE20161400A1 (enExample)
PH (1) PH12016502095B1 (enExample)
PL (1) PL3134386T3 (enExample)
PT (1) PT3134386T (enExample)
RS (1) RS60524B1 (enExample)
SG (1) SG11201608785PA (enExample)
SI (1) SI3134386T1 (enExample)
TN (1) TN2016000455A1 (enExample)
TW (1) TWI664165B (enExample)
UA (1) UA122391C2 (enExample)
UY (1) UY36091A (enExample)
WO (1) WO2015163485A1 (enExample)

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