DK3134386T3 - Isoindolin-1-on-derivater med kolinerg muscarin-m1-receptor-positiv allosterisk modulatoraktivitet til behandling af alzheimers sygdom - Google Patents

Isoindolin-1-on-derivater med kolinerg muscarin-m1-receptor-positiv allosterisk modulatoraktivitet til behandling af alzheimers sygdom Download PDF

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Publication number
DK3134386T3
DK3134386T3 DK15726362.5T DK15726362T DK3134386T3 DK 3134386 T3 DK3134386 T3 DK 3134386T3 DK 15726362 T DK15726362 T DK 15726362T DK 3134386 T3 DK3134386 T3 DK 3134386T3
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cholinerg
muscarin
isoindolin
alzheimer
receptor
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DK15726362.5T
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Danish (da)
English (en)
Inventor
Masami Yamada
Shinkichi Suzuki
Takahiro Sugimoto
Minoru Nakamura
Hiroki Sakamoto
Makoto Kamata
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Takeda Pharmaceuticals Co
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    • A—HUMAN NECESSITIES
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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DK15726362.5T 2014-04-23 2015-04-22 Isoindolin-1-on-derivater med kolinerg muscarin-m1-receptor-positiv allosterisk modulatoraktivitet til behandling af alzheimers sygdom DK3134386T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014089585 2014-04-23
PCT/JP2015/062912 WO2015163485A1 (en) 2014-04-23 2015-04-22 Isoindoline-1-one derivatives as cholinergic muscarinic m1 receptor positive alloesteric modulator activity for the treatment of alzheimers disease

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DK3134386T3 true DK3134386T3 (da) 2020-08-17

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DK15726362.5T DK3134386T3 (da) 2014-04-23 2015-04-22 Isoindolin-1-on-derivater med kolinerg muscarin-m1-receptor-positiv allosterisk modulatoraktivitet til behandling af alzheimers sygdom

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US (16) US9315458B2 (cg-RX-API-DMAC7.html)
EP (1) EP3134386B1 (cg-RX-API-DMAC7.html)
JP (1) JP6517239B2 (cg-RX-API-DMAC7.html)
KR (1) KR102349237B1 (cg-RX-API-DMAC7.html)
CN (1) CN106536508B (cg-RX-API-DMAC7.html)
AR (1) AR100154A1 (cg-RX-API-DMAC7.html)
AU (1) AU2015250610B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016024472B1 (cg-RX-API-DMAC7.html)
CA (1) CA2946519C (cg-RX-API-DMAC7.html)
CL (1) CL2016002661A1 (cg-RX-API-DMAC7.html)
CR (1) CR20160544A (cg-RX-API-DMAC7.html)
CY (1) CY1123569T1 (cg-RX-API-DMAC7.html)
DK (1) DK3134386T3 (cg-RX-API-DMAC7.html)
DO (1) DOP2016000286A (cg-RX-API-DMAC7.html)
EA (1) EA030373B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP16090152A (cg-RX-API-DMAC7.html)
ES (1) ES2811088T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20201171T1 (cg-RX-API-DMAC7.html)
HU (1) HUE050543T2 (cg-RX-API-DMAC7.html)
IL (1) IL248393B (cg-RX-API-DMAC7.html)
LT (1) LT3134386T (cg-RX-API-DMAC7.html)
MX (1) MX373274B (cg-RX-API-DMAC7.html)
MY (1) MY195742A (cg-RX-API-DMAC7.html)
NZ (1) NZ725921A (cg-RX-API-DMAC7.html)
PE (1) PE20161400A1 (cg-RX-API-DMAC7.html)
PH (1) PH12016502095B1 (cg-RX-API-DMAC7.html)
PL (1) PL3134386T3 (cg-RX-API-DMAC7.html)
PT (1) PT3134386T (cg-RX-API-DMAC7.html)
RS (1) RS60524B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201608785PA (cg-RX-API-DMAC7.html)
SI (1) SI3134386T1 (cg-RX-API-DMAC7.html)
TN (1) TN2016000455A1 (cg-RX-API-DMAC7.html)
TW (1) TWI664165B (cg-RX-API-DMAC7.html)
UA (1) UA122391C2 (cg-RX-API-DMAC7.html)
UY (1) UY36091A (cg-RX-API-DMAC7.html)
WO (1) WO2015163485A1 (cg-RX-API-DMAC7.html)

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