DK3133080T3 - PRESENT UNKNOWN CYTOSTATIC 7-DEAZAPURIN NUCLEOSIDES - Google Patents

PRESENT UNKNOWN CYTOSTATIC 7-DEAZAPURIN NUCLEOSIDES Download PDF

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Publication number
DK3133080T3
DK3133080T3 DK16174985.8T DK16174985T DK3133080T3 DK 3133080 T3 DK3133080 T3 DK 3133080T3 DK 16174985 T DK16174985 T DK 16174985T DK 3133080 T3 DK3133080 T3 DK 3133080T3
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DK
Denmark
Prior art keywords
ddd
mhz
nmr
compound
jgem
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Application number
DK16174985.8T
Other languages
Danish (da)
English (en)
Inventor
Michal Hocek
Petr Naus
Original Assignee
Inst Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic
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Application filed by Inst Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic filed Critical Inst Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic
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Publication of DK3133080T3 publication Critical patent/DK3133080T3/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14Pyrrolo-pyrimidine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • HELECTRICITY
    • H02GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02JCIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
    • H02J7/00032Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries characterised by data exchange
    • H02J7/00036Charger exchanging data with battery
    • HELECTRICITY
    • H02GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02JCIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
    • H02J7/00047Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries with provisions for charging different types of batteries

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Power Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK16174985.8T 2008-01-18 2009-01-15 PRESENT UNKNOWN CYTOSTATIC 7-DEAZAPURIN NUCLEOSIDES DK3133080T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2224708P 2008-01-18 2008-01-18
EP09702842.7A EP2231689B1 (en) 2008-01-18 2009-01-15 Novel cytostatic 7-deazapurine nucleosides

Publications (1)

Publication Number Publication Date
DK3133080T3 true DK3133080T3 (en) 2018-11-26

Family

ID=40434932

Family Applications (2)

Application Number Title Priority Date Filing Date
DK09702842.7T DK2231689T3 (en) 2008-01-18 2009-01-15 NOVEL cytostatic 7-deazapurine nucleosides
DK16174985.8T DK3133080T3 (en) 2008-01-18 2009-01-15 PRESENT UNKNOWN CYTOSTATIC 7-DEAZAPURIN NUCLEOSIDES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK09702842.7T DK2231689T3 (en) 2008-01-18 2009-01-15 NOVEL cytostatic 7-deazapurine nucleosides

Country Status (18)

Country Link
US (1) US8093226B2 (OSRAM)
EP (2) EP3133080B1 (OSRAM)
JP (2) JP5485172B2 (OSRAM)
CN (1) CN101977923B (OSRAM)
AU (1) AU2009204568B2 (OSRAM)
CA (1) CA2711384C (OSRAM)
CY (2) CY1118104T1 (OSRAM)
DK (2) DK2231689T3 (OSRAM)
ES (2) ES2693551T3 (OSRAM)
HR (2) HRP20161344T1 (OSRAM)
HU (2) HUE030767T2 (OSRAM)
LT (2) LT2231689T (OSRAM)
NZ (1) NZ586610A (OSRAM)
PL (2) PL2231689T3 (OSRAM)
PT (2) PT2231689T (OSRAM)
SI (2) SI2231689T1 (OSRAM)
TR (1) TR201815961T4 (OSRAM)
WO (1) WO2009089804A1 (OSRAM)

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RS53245B2 (sr) 2007-06-13 2022-10-31 Incyte Holdings Corp Soli inhibitora janus kinaze (r)-3-(4-(7h-pirolo(2,3-d) pirimidin-4-il)-1h-pirazol-1-il)-3-ciklopentilpropan-nitrila
CL2009001884A1 (es) * 2008-10-02 2010-05-14 Incyte Holdings Corp Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
CA2759131C (en) * 2009-04-22 2017-06-20 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 7-deazapurine nucleosides for therapeutic uses
PL2432472T3 (pl) 2009-05-22 2020-03-31 Incyte Holdings Corporation 3-[4-(7H-Pirolo[2,3-d]pirymidyn-4-ylo)-1H-pirazol-1-ilo]oktano- lub heptano-nitryle jako inhibitory JAK
TW201100429A (en) 2009-05-22 2011-01-01 Incyte Corp N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
TW201113285A (en) 2009-09-01 2011-04-16 Incyte Corp Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
MX354212B (es) 2010-03-10 2018-02-19 Incyte Corp Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1).
EA202091303A3 (ru) 2010-05-21 2021-05-31 Инсайт Холдингс Корпорейшн Композиция ингибитора jak для местного применения
EP2640392B1 (en) * 2010-11-18 2015-01-07 Kasina Laila Innova Pharmaceuticals Private Ltd. Substituted 4-(selenophen-2(or 3)-ylamino)pyrimidine compounds and methods of use thereof
CA2818542A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
WO2012068440A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
CN103797010B (zh) 2011-06-20 2016-02-24 因塞特控股公司 作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為jak抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
US9193733B2 (en) 2012-05-18 2015-11-24 Incyte Holdings Corporation Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
NZ708157A (en) 2012-11-15 2019-07-26 Incyte Holdings Corp Sustained-release dosage forms of ruxolitinib
TWI634121B (zh) 2013-03-06 2018-09-01 英塞特控股公司 用於製備jak抑制劑之方法及中間物
MX394928B (es) 2013-08-07 2025-03-24 Incyte Holdings Corp Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1).
US9498467B2 (en) 2014-05-30 2016-11-22 Incyte Corporation Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
EP3478701B1 (en) 2016-06-29 2022-08-10 Ustav organicke chemie a biochemie AV CR, v.v.i. Substituted thienopyrrolopyrimidine ribonucleosides for therapeutic use
CZ307334B6 (cs) 2016-08-02 2018-06-13 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Substituované heteropentadieno-pyrrolopyrimidinové ribonukleosidy pro terapeutické použití
AR113922A1 (es) 2017-12-08 2020-07-01 Incyte Corp Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
WO2019152374A1 (en) 2018-01-30 2019-08-08 Incyte Corporation Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one)
CZ308104B6 (cs) 2018-03-12 2020-01-08 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v. v. i. Pyridinopyrrolopyrimidinové ribonukleosidy pro terapeutické použití
HUE067471T2 (hu) 2018-03-30 2024-10-28 Incyte Corp Gennyes verejtékmirigy-gyulladás kezelése jak inhibitorok alkalmazásával
WO2020206289A1 (en) * 2019-04-05 2020-10-08 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5
MA56544A (fr) * 2019-06-18 2022-04-27 Taiho Pharmaceutical Co Ltd Nouveau compose ester d'acide phosphorique possedant un squelette pyrolo-pyrimidine ou sel pharmaceutiquement acceptable de celui-ci
EP4106763A1 (en) * 2020-02-17 2022-12-28 Katholieke Universiteit Leuven KU Leuven Research & Development Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
CN112190590A (zh) * 2020-11-06 2021-01-08 牡丹江医学院 一种治疗动脉粥样硬化的硒核苷及其药物组合物

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JP3489991B2 (ja) * 1997-07-07 2004-01-26 理化学研究所 3’−デオキシリボヌクレオチド誘導体
JP3318579B2 (ja) * 1997-07-07 2002-08-26 理化学研究所 Dnaの塩基配列決定方法
CZ9901996A3 (cs) * 1999-06-04 2001-01-17 Ústav organické chemie a biochemie AV ČR Nové 6-fenylpurinové 9-ß-D-ribonukleosidy s antineoplastickým účinkem, jejich použití k přípravě farmaceutických preparátů a farmaceutické přípravky, které je obsahují
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US20080280842A1 (en) * 2004-10-21 2008-11-13 Merck & Co., Inc. Fluorinated Pyrrolo[2,3-D]Pyrimidine Nucleosides for the Treatment of Rna-Dependent Rna Viral Infection
CN101043893A (zh) * 2004-10-21 2007-09-26 默克公司 治疗RNA-依赖性RNA病毒感染的氟化吡咯并[2,3-d]嘧啶核苷
TW200720285A (en) * 2005-04-25 2007-06-01 Genelabs Tech Inc Nucleoside compounds for treating viral infections

Also Published As

Publication number Publication date
AU2009204568B2 (en) 2013-10-03
NZ586610A (en) 2012-08-31
EP3133080B1 (en) 2018-08-01
US20090203637A1 (en) 2009-08-13
LT3133080T (lt) 2018-11-12
JP5485172B2 (ja) 2014-05-07
CY1118104T1 (el) 2017-06-28
CN101977923B (zh) 2014-10-08
EP3133080A1 (en) 2017-02-22
SI2231689T1 (sl) 2016-11-30
CA2711384C (en) 2016-07-26
PT2231689T (pt) 2016-10-07
ES2693551T3 (es) 2018-12-12
HRP20181774T1 (hr) 2018-12-28
EP2231689B1 (en) 2016-07-20
PL2231689T3 (pl) 2017-01-31
SI3133080T1 (sl) 2018-12-31
CY1121364T1 (el) 2020-05-29
JP2014058567A (ja) 2014-04-03
AU2009204568A1 (en) 2009-07-23
PT3133080T (pt) 2018-11-16
WO2009089804A1 (en) 2009-07-23
HRP20161344T1 (hr) 2016-11-18
DK2231689T3 (en) 2016-09-19
TR201815961T4 (tr) 2018-11-21
CA2711384A1 (en) 2009-07-23
US8093226B2 (en) 2012-01-10
HUE041598T2 (hu) 2019-05-28
HUE030767T2 (en) 2017-05-29
JP2011509949A (ja) 2011-03-31
EP2231689A1 (en) 2010-09-29
PL3133080T3 (pl) 2018-12-31
ES2598503T3 (es) 2017-01-27
CN101977923A (zh) 2011-02-16
LT2231689T (lt) 2016-10-25

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