DK3049099T3 - Amyloid-beta-bindende peptider og anvendelse deraf til terapi og diagnosticering af alzheimers demens - Google Patents
Amyloid-beta-bindende peptider og anvendelse deraf til terapi og diagnosticering af alzheimers demens Download PDFInfo
- Publication number
- DK3049099T3 DK3049099T3 DK14799955.1T DK14799955T DK3049099T3 DK 3049099 T3 DK3049099 T3 DK 3049099T3 DK 14799955 T DK14799955 T DK 14799955T DK 3049099 T3 DK3049099 T3 DK 3049099T3
- Authority
- DK
- Denmark
- Prior art keywords
- dementia
- alzheimer
- diagnosis
- therapy
- binding peptides
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102013016002.2A DE102013016002A1 (de) | 2013-09-26 | 2013-09-26 | Zyklische, Amyloid-Beta-bindende Peptide und deren Verwendung |
| DE102014003262.0A DE102014003262A1 (de) | 2014-03-12 | 2014-03-12 | Amyloid-Beta-bindende Peptide und deren Verwendung für die Therapie und die Diagnose der Alzheimerschen Demenz |
| PCT/DE2014/000477 WO2015043567A1 (de) | 2013-09-26 | 2014-09-23 | Amyloid-beta-bindende peptide und deren verwendung für die therapie und die diagnose der alzheimerschen demenz |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3049099T3 true DK3049099T3 (da) | 2020-09-21 |
Family
ID=51932152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14799955.1T DK3049099T3 (da) | 2013-09-26 | 2014-09-23 | Amyloid-beta-bindende peptider og anvendelse deraf til terapi og diagnosticering af alzheimers demens |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10995118B2 (enExample) |
| EP (2) | EP3049099B1 (enExample) |
| JP (1) | JP6660877B2 (enExample) |
| CN (1) | CN105745219B (enExample) |
| DK (1) | DK3049099T3 (enExample) |
| ES (2) | ES2953883T3 (enExample) |
| WO (1) | WO2015043567A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102016125645A1 (de) | 2016-12-23 | 2018-06-28 | Forschungszentrum Jülich GmbH | D-enantiomere Peptide zur Therapie von chronischem und neuropathischem Schmerz |
| CN106866792B (zh) * | 2017-02-24 | 2020-09-04 | 中山大学 | 一类环十肽分子及其应用 |
| DE102017010842A1 (de) * | 2017-11-23 | 2019-05-23 | Forschungszentrum Jülich GmbH | Verfahren zur Quantifizierung von Proteinaggregaten einer Proteinfehlfaltungserkrankung in einer Probe |
| DE102021121435A1 (de) | 2021-08-18 | 2023-02-23 | Priavoid Gmbh | Aß-BINDENDE SUBSTANZEN |
| WO2025038979A1 (en) * | 2023-08-16 | 2025-02-20 | LVIS-Regain LP | Compositions and methods for prophylaxis and/or treatment of amyloid b peptide proteinopenia in alzheimer's and other diseases |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2214247C (en) | 1995-03-14 | 2004-02-10 | Praecis Pharmaceuticals Incorporated | Modulators of amyloid aggregation |
| US7384910B2 (en) * | 1997-10-08 | 2008-06-10 | Castillo Gerardo M | Small peptides for the treatment of Alzheimer's disease and other beta-amyloid protein fibrillogenesis disorders |
| DE69930164T2 (de) | 1998-12-18 | 2006-11-23 | The Penn State Research Foundation | Intein-vermittelte cyclisierung von peptiden |
| EA004739B1 (ru) * | 1999-11-05 | 2004-08-26 | Эксоникс, Инк. | ПЕПТИДНЫЕ АНАЛОГИ И МИМЕТИКИ, ПОДХОДЯЩИЕ ДЛЯ ПРИМЕНЕНИЯ IN VIVO ПРИ ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С АНОМАЛЬНОЙ УКЛАДКОЙ БЕЛКОВ В АМИЛОИДНЫЕ ИЛИ АМИЛОИДПОДОБНЫЕ ОТЛОЖЕНИЯ, ИЛИ ИХ ПАТОЛОГИЧЕСКИЕ ПРЕДШЕСТВЕННИКИ, ОБОГАЩЕННЫЕ b-СКЛАДКАМИ |
| AU1608801A (en) | 1999-11-15 | 2001-05-30 | Parker Hughes Institute | Diamino platinum (ii) antitumor complexes |
| DE10117281A1 (de) | 2001-04-06 | 2002-10-24 | Inst Molekulare Biotechnologie | Peptid zur Diagnose und Therapie der Alzheimer-Demenz |
| CA2530927A1 (en) * | 2003-06-30 | 2005-01-06 | Tel Aviv University Future Technology Development L.P. | Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases |
| GB0503434D0 (en) * | 2005-02-18 | 2005-03-30 | Senexis Ltd | Amyloid-binding peptides, analogues and uses thereof |
| DE102005049537B4 (de) | 2005-10-17 | 2010-04-22 | Forschungszentrum Karlsruhe Gmbh | Verfahren zur Herstellung zyklischer Peptide und Verwendung der derart hergestellten zyklischen Peptide |
| DE102006015140A1 (de) | 2006-03-31 | 2007-10-11 | Philipps-Universität Marburg | Heterozyklische Verbindungen mit Wirkung gegen neurodegenerative Erkrankungen |
| WO2007145589A1 (en) * | 2006-06-15 | 2007-12-21 | Per Arvidsson | Peptides that are capable of binding to amyloid-beta peptide. |
| EP2139524A1 (en) | 2007-03-23 | 2010-01-06 | The Governors of the University of Alberta | Multivalent heterobifunctional polymers and methods of their use |
| DE102008037564A1 (de) * | 2008-11-19 | 2010-05-20 | Forschungszentrum Jülich GmbH | Zusammensetzung zur Herstellung von anti-Amyloid beta-Peptid-Antikörpern mit D-Peptiden |
| DE102010019336A1 (de) | 2010-05-05 | 2011-11-10 | Forschungszentrum Jülich GmbH | Mittel zur Behandlung der Alzheimerschen Demenz |
| DE102010017130B4 (de) | 2010-05-28 | 2018-11-29 | Forschungszentrum Jülich GmbH | Hybrid-Verbindung, deren Verwendung und Verfahren zu deren Herstellung |
| WO2013021353A1 (en) | 2011-08-11 | 2013-02-14 | Bar-Ilan University | Surface modified proteinaceous spherical particles and uses thereof |
| CN104380111B (zh) | 2012-04-05 | 2017-08-29 | 于利希研究中心有限公司 | 包含多价结合淀粉样β蛋白的D‑肽的聚合物及其应用 |
| DE102012102998B4 (de) | 2012-04-05 | 2013-12-05 | Forschungszentrum Jülich GmbH | Polymere, enthaltend multivalente Amyloid-Beta-bindende D-Peptide und deren Verwendung |
| JP2015518474A (ja) * | 2012-04-05 | 2015-07-02 | フォルシュングスツェントルム ユーリッヒ ゲゼルシャフト ミット ベシュレンクテル ハフツングＦｏｒｓｃｈｕｎｇｓｚｅｎｔｒｕｍ Ｊｕｅｌｉｃｈ ＧｍｂＨ | 血液、血液生産物及び器官を処置する方法 |
| DE102012102999A1 (de) | 2012-04-05 | 2013-10-10 | Forschungszentrum Jülich GmbH | Verfahren zur Behandlung von Blut, Blutprodukten und Organen |
| DK2991664T3 (da) * | 2013-04-30 | 2019-12-02 | Forschungszentrum Juelich Gmbh | Midler til forebyggelse og behandling af følgesygdomme af HIV og andre virusinfektioner |
-
2014
- 2014-09-23 JP JP2016517288A patent/JP6660877B2/ja active Active
- 2014-09-23 DK DK14799955.1T patent/DK3049099T3/da active
- 2014-09-23 CN CN201480053169.1A patent/CN105745219B/zh active Active
- 2014-09-23 EP EP14799955.1A patent/EP3049099B1/de active Active
- 2014-09-23 ES ES20180219T patent/ES2953883T3/es active Active
- 2014-09-23 US US15/022,749 patent/US10995118B2/en active Active
- 2014-09-23 WO PCT/DE2014/000477 patent/WO2015043567A1/de not_active Ceased
- 2014-09-23 EP EP20180219.6A patent/EP3747454B9/de active Active
- 2014-09-23 ES ES14799955T patent/ES2818929T3/es active Active
-
2020
- 2020-06-22 US US16/908,606 patent/US11274125B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3049099A1 (de) | 2016-08-03 |
| CN105745219A (zh) | 2016-07-06 |
| JP2016539911A (ja) | 2016-12-22 |
| ES2953883T3 (es) | 2023-11-16 |
| EP3747454C0 (de) | 2023-06-07 |
| EP3747454A1 (de) | 2020-12-09 |
| US11274125B2 (en) | 2022-03-15 |
| EP3747454B9 (de) | 2023-10-04 |
| WO2015043567A1 (de) | 2015-04-02 |
| US20200317734A1 (en) | 2020-10-08 |
| EP3747454B1 (de) | 2023-06-07 |
| JP6660877B2 (ja) | 2020-03-11 |
| US10995118B2 (en) | 2021-05-04 |
| ES2818929T3 (es) | 2021-04-14 |
| US20160297852A1 (en) | 2016-10-13 |
| US20200002379A9 (en) | 2020-01-02 |
| EP3049099B1 (de) | 2020-06-17 |
| CN105745219B (zh) | 2020-10-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2968485T3 (da) | Peptidvaccine til forebyggelse og immunterapi af demens af Alzheimers-typen | |
| DK3024497T3 (da) | Fremgangsmåder og præparater til behandling af hjernesygdomme | |
| DK3134386T3 (da) | Isoindolin-1-on-derivater med kolinerg muscarin-m1-receptor-positiv allosterisk modulatoraktivitet til behandling af alzheimers sygdom | |
| DK3988168T3 (da) | Enheder og metoder til ultralydskosmetik med flere fokus | |
| DK3283106T3 (da) | Terapeutiske antistoffer og anvendelser deraf | |
| DK3221349T3 (da) | Humaniserede tau-antistoffer i Alzheimers sygdom | |
| DK2558446T5 (da) | Nye forbindelser til behandling af sygdomme associerede med amyloid- eller amyloidlignende proteiner | |
| DK3035926T3 (da) | Forbindelser og fremgangsmåder til behandling af en epilepsilidelse | |
| EP4035688C0 (en) | MRI IMAGING OF AMYLOID PLAQUE USING LIPOSOMES | |
| DK3116911T3 (da) | Anti-mcam-antistoffer og tilhørende fremgangsmåder til anvendelse | |
| DK2937422T3 (da) | Fremgangsmåde og et kit til ikke-invasiv detektering af patogene genmutationer for fosterdøvhed | |
| DK3363805T3 (da) | Fremgangsmåder til syntese af sphingomyeliner og dihydrosphingomyeliner | |
| DK3119911T3 (da) | Forbindelser til anvendelse til behandling af alzheimers sygdom hos apoe4+/+ patienter | |
| DK3044315T3 (da) | Nukleinsyrer og fremgangsmåder til behandling af pompes sygdom | |
| DK2994160T3 (da) | Behandling af alzheimers sygdom subpopulationer med poolet immunoglobulin g | |
| DK3099800T3 (da) | Ekspression og oprensning af crm197 og beslægtede proteiner | |
| EP3320521A4 (en) | ATOMIC THERAPEUTIC INDICATOR | |
| DK2964767T3 (da) | Toksingener og fremgangsmåder til anvendelse deraf | |
| DK3560937T3 (da) | Fremgangsmåder til fremstilling af 18f-mærkede psma-målrettede billeddannelsesmidler og diagnostiske fremgangsmåder dermed | |
| DK3149049T3 (da) | Il-22 til anvendelse til behandling af stofskiftesygdomme | |
| EP3522909A4 (en) | HLA RESTRICTED VGLL1 PEPTIDES AND THEIR USE | |
| DK3044229T3 (da) | Peptider til anvendelse i behandlingen af oral mucositis | |
| DK3057979T3 (da) | Proteiner med diagnostiske og terapeutiske anvendelser | |
| EP3318188A4 (en) | MAGNETIC IMAGING MACHINE | |
| DK3049099T3 (da) | Amyloid-beta-bindende peptider og anvendelse deraf til terapi og diagnosticering af alzheimers demens |