CN105745219B - 结合β淀粉状蛋白的肽及其用于治疗和诊断阿尔茨海默痴呆症的用途 - Google Patents

结合β淀粉状蛋白的肽及其用于治疗和诊断阿尔茨海默痴呆症的用途 Download PDF

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CN105745219B
CN105745219B CN201480053169.1A CN201480053169A CN105745219B CN 105745219 B CN105745219 B CN 105745219B CN 201480053169 A CN201480053169 A CN 201480053169A CN 105745219 B CN105745219 B CN 105745219B
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beta
amyloid
peptide
oligomers
peptides
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CN105745219A (zh
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D.维尔博尔德
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Priaved Ltd
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Forschungszentrum Juelich GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Engineering & Computer Science (AREA)
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  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201480053169.1A 2013-09-26 2014-09-23 结合β淀粉状蛋白的肽及其用于治疗和诊断阿尔茨海默痴呆症的用途 Active CN105745219B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE102013016002.2A DE102013016002A1 (de) 2013-09-26 2013-09-26 Zyklische, Amyloid-Beta-bindende Peptide und deren Verwendung
DE102013016002.2 2013-09-26
DE102014003262.0 2014-03-12
DE102014003262.0A DE102014003262A1 (de) 2014-03-12 2014-03-12 Amyloid-Beta-bindende Peptide und deren Verwendung für die Therapie und die Diagnose der Alzheimerschen Demenz
PCT/DE2014/000477 WO2015043567A1 (de) 2013-09-26 2014-09-23 Amyloid-beta-bindende peptide und deren verwendung für die therapie und die diagnose der alzheimerschen demenz

Publications (2)

Publication Number Publication Date
CN105745219A CN105745219A (zh) 2016-07-06
CN105745219B true CN105745219B (zh) 2020-10-09

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US (2) US10995118B2 (enExample)
EP (2) EP3049099B1 (enExample)
JP (1) JP6660877B2 (enExample)
CN (1) CN105745219B (enExample)
DK (1) DK3049099T3 (enExample)
ES (2) ES2953883T3 (enExample)
WO (1) WO2015043567A1 (enExample)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
DE102016125645A1 (de) 2016-12-23 2018-06-28 Forschungszentrum Jülich GmbH D-enantiomere Peptide zur Therapie von chronischem und neuropathischem Schmerz
CN106866792B (zh) * 2017-02-24 2020-09-04 中山大学 一类环十肽分子及其应用
DE102017010842A1 (de) * 2017-11-23 2019-05-23 Forschungszentrum Jülich GmbH Verfahren zur Quantifizierung von Proteinaggregaten einer Proteinfehlfaltungserkrankung in einer Probe
DE102021121435A1 (de) 2021-08-18 2023-02-23 Priavoid Gmbh Aß-BINDENDE SUBSTANZEN
WO2025038979A1 (en) * 2023-08-16 2025-02-20 LVIS-Regain LP Compositions and methods for prophylaxis and/or treatment of amyloid b peptide proteinopenia in alzheimer's and other diseases

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* Cited by examiner, † Cited by third party
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WO2002081505A2 (de) * 2001-04-06 2002-10-17 imb Institut für molekulare Biotechnologie e.V. Peptid zur diagnose und therapie der alzheimer-demenz
CN1437442A (zh) * 1999-11-05 2003-08-20 阿克松尼克斯公司 适于体内应用治疗与折叠成淀粉样蛋白、淀粉样蛋白样沉积物的异常蛋白或其富含β－折叠的致病性前体有关的疾病的肽类似物和模拟物
US7384910B2 (en) * 1997-10-08 2008-06-10 Castillo Gerardo M Small peptides for the treatment of Alzheimer's disease and other beta-amyloid protein fibrillogenesis disorders

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CA2214247C (en) 1995-03-14 2004-02-10 Praecis Pharmaceuticals Incorporated Modulators of amyloid aggregation
DE69930164T2 (de) 1998-12-18 2006-11-23 The Penn State Research Foundation Intein-vermittelte cyclisierung von peptiden
AU1608801A (en) 1999-11-15 2001-05-30 Parker Hughes Institute Diamino platinum (ii) antitumor complexes
CA2530927A1 (en) * 2003-06-30 2005-01-06 Tel Aviv University Future Technology Development L.P. Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases
GB0503434D0 (en) * 2005-02-18 2005-03-30 Senexis Ltd Amyloid-binding peptides, analogues and uses thereof
DE102005049537B4 (de) 2005-10-17 2010-04-22 Forschungszentrum Karlsruhe Gmbh Verfahren zur Herstellung zyklischer Peptide und Verwendung der derart hergestellten zyklischen Peptide
DE102006015140A1 (de) 2006-03-31 2007-10-11 Philipps-Universität Marburg Heterozyklische Verbindungen mit Wirkung gegen neurodegenerative Erkrankungen
WO2007145589A1 (en) * 2006-06-15 2007-12-21 Per Arvidsson Peptides that are capable of binding to amyloid-beta peptide.
EP2139524A1 (en) 2007-03-23 2010-01-06 The Governors of the University of Alberta Multivalent heterobifunctional polymers and methods of their use
DE102008037564A1 (de) * 2008-11-19 2010-05-20 Forschungszentrum Jülich GmbH Zusammensetzung zur Herstellung von anti-Amyloid beta-Peptid-Antikörpern mit D-Peptiden
DE102010019336A1 (de) 2010-05-05 2011-11-10 Forschungszentrum Jülich GmbH Mittel zur Behandlung der Alzheimerschen Demenz
DE102010017130B4 (de) 2010-05-28 2018-11-29 Forschungszentrum Jülich GmbH Hybrid-Verbindung, deren Verwendung und Verfahren zu deren Herstellung
WO2013021353A1 (en) 2011-08-11 2013-02-14 Bar-Ilan University Surface modified proteinaceous spherical particles and uses thereof
CN104380111B (zh) 2012-04-05 2017-08-29 于利希研究中心有限公司 包含多价结合淀粉样β蛋白的D‑肽的聚合物及其应用
DE102012102998B4 (de) 2012-04-05 2013-12-05 Forschungszentrum Jülich GmbH Polymere, enthaltend multivalente Amyloid-Beta-bindende D-Peptide und deren Verwendung
JP2015518474A (ja) * 2012-04-05 2015-07-02 フォルシュングスツェントルム ユーリッヒ ゲゼルシャフト ミット ベシュレンクテル ハフツングＦｏｒｓｃｈｕｎｇｓｚｅｎｔｒｕｍ Ｊｕｅｌｉｃｈ ＧｍｂＨ 血液、血液生産物及び器官を処置する方法
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DK2991664T3 (da) * 2013-04-30 2019-12-02 Forschungszentrum Juelich Gmbh Midler til forebyggelse og behandling af følgesygdomme af HIV og andre virusinfektioner

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US7384910B2 (en) * 1997-10-08 2008-06-10 Castillo Gerardo M Small peptides for the treatment of Alzheimer's disease and other beta-amyloid protein fibrillogenesis disorders
CN1437442A (zh) * 1999-11-05 2003-08-20 阿克松尼克斯公司 适于体内应用治疗与折叠成淀粉样蛋白、淀粉样蛋白样沉积物的异常蛋白或其富含β－折叠的致病性前体有关的疾病的肽类似物和模拟物
WO2002081505A2 (de) * 2001-04-06 2002-10-17 imb Institut für molekulare Biotechnologie e.V. Peptid zur diagnose und therapie der alzheimer-demenz

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EP3049099A1 (de) 2016-08-03
CN105745219A (zh) 2016-07-06
JP2016539911A (ja) 2016-12-22
ES2953883T3 (es) 2023-11-16
EP3747454C0 (de) 2023-06-07
EP3747454A1 (de) 2020-12-09
US11274125B2 (en) 2022-03-15
EP3747454B9 (de) 2023-10-04
WO2015043567A1 (de) 2015-04-02
US20200317734A1 (en) 2020-10-08
DK3049099T3 (da) 2020-09-21
EP3747454B1 (de) 2023-06-07
JP6660877B2 (ja) 2020-03-11
US10995118B2 (en) 2021-05-04
ES2818929T3 (es) 2021-04-14
US20160297852A1 (en) 2016-10-13
US20200002379A9 (en) 2020-01-02
EP3049099B1 (de) 2020-06-17

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