DK3034512T3 - En proces til fremstilling af jern(III)-kasein-N-acetyl-aspartylerede komplekser og anvendelse deraf i farmaceutiske sammensætninger - Google Patents
En proces til fremstilling af jern(III)-kasein-N-acetyl-aspartylerede komplekser og anvendelse deraf i farmaceutiske sammensætninger Download PDFInfo
- Publication number
- DK3034512T3 DK3034512T3 DK14386034.4T DK14386034T DK3034512T3 DK 3034512 T3 DK3034512 T3 DK 3034512T3 DK 14386034 T DK14386034 T DK 14386034T DK 3034512 T3 DK3034512 T3 DK 3034512T3
- Authority
- DK
- Denmark
- Prior art keywords
- acetyl
- casein
- iron
- aspartylated
- solution
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4732—Casein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (6)
1. Proces til fremstillingen af jern(III)-kompleks med N-acetyl-L-aspartyleret kasein, omfattende trinnene: (a) at reagere kasein med N-acetyl-L-aspartylchlorid, for at danne N-acetyl-L-aspartyleret kasein, (b) efterfølgende at reagere den N-acetyl-L-aspartylerede kasein med jern(III)chlorid; og (c) at opnå jern(III)-komplekset med N-acetyl-L-aspartyleret kasein.
2. Processen ifølge krav 1, hvor den anvendte kasein er kasein af levnedsmiddelkvalitet.
3. Processen ifølge krav 1, hvor trin (a) omfatter at tilvejebringe en opløsning af kasein, og hvor tilføjelse af N-acetyl-L-aspartylchlorid til kaseinopløsningen udføres ved en pH på mellem 6 og 9.
4. Processen ifølge krav 1, hvor N-acetyl-L-aspartylchloridet fremstilles in situ, fortrinsvis under anvendelse af klorerende reagenser valgt fra gruppen bestående af thionyl chlorid (SOCI2), phosphorpentachlorid (PCI5), phosphortrichlorid (PCb), carbontetrachlorid (CCU), oxalylchlorid (COCI)2, phosphorylchlorid (POCI3), 2-chlor-l,3-bis(methoxycarbonyl)guanidin (Palau'Chlor), cyanurchlorid og N-chlorsuccinimid.
5. Processen ifølge krav 1, hvor jern(III)-komplekset med N-acetyl-L-aspartyleret kasein opnået i trin (c) klares, før det sendes til tørring eller sprøjtetørring eller frysetørring.
6. Proces til fremstilling af en farmaceutisk sammensætning omfattende et jern(III)-kompleks med N-acetyl-L-aspartyleret kasein af levnedsmiddelkvalitet, hvilken proces omfatter processen ifølge et hvilket som helst af kravene 1-5 og at kombinere jern(III)-komplekset med N-acetyl-L-aspartyleret kasein af levnedsmiddelkvalitet med farmaceutiske excipienser, i særdeleshed valgt fra fortyndingsmidler og konserveringsmidler.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14386034.4A EP3034512B1 (en) | 2014-12-19 | 2014-12-19 | A process for producing iron (III) casein N-acetyl-aspartylated complexes and use thereof in pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3034512T3 true DK3034512T3 (da) | 2018-01-15 |
Family
ID=52354737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14386034.4T DK3034512T3 (da) | 2014-12-19 | 2014-12-19 | En proces til fremstilling af jern(III)-kasein-N-acetyl-aspartylerede komplekser og anvendelse deraf i farmaceutiske sammensætninger |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US20170340747A1 (da) |
| EP (1) | EP3034512B1 (da) |
| AP (1) | AP2017009801A0 (da) |
| AU (1) | AU2015365885B2 (da) |
| BR (1) | BR112017006621B1 (da) |
| CA (1) | CA2959226C (da) |
| CL (1) | CL2017001611A1 (da) |
| CO (1) | CO2017003313A2 (da) |
| CY (1) | CY1120037T1 (da) |
| DK (1) | DK3034512T3 (da) |
| EA (1) | EA031968B1 (da) |
| ES (1) | ES2655238T3 (da) |
| GE (1) | GEP20207081B (da) |
| HR (1) | HRP20171965T1 (da) |
| HU (1) | HUE035302T2 (da) |
| IL (1) | IL251449B (da) |
| LT (1) | LT3034512T (da) |
| MX (1) | MX2017008100A (da) |
| MY (1) | MY185391A (da) |
| NO (1) | NO3034512T3 (da) |
| PE (1) | PE20180660A1 (da) |
| PH (1) | PH12017500391A1 (da) |
| PL (1) | PL3034512T3 (da) |
| PT (1) | PT3034512T (da) |
| RS (1) | RS56714B1 (da) |
| SA (1) | SA517381261B1 (da) |
| SG (1) | SG11201702593TA (da) |
| SI (1) | SI3034512T1 (da) |
| WO (1) | WO2016096203A1 (da) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR1009589B (el) * | 2018-04-05 | 2019-09-11 | Ιουλια Κλεωνος Τσετη | Φαρμακευτικο σκευασμα για την αντιμετωπιση της αναιμιας, σε καταλληλο περιεκτη, που διατηρει στεγανα διαχωρισμενα μεταξυ τους τα δραστικα συστατικα: συμπλοκο του τρισθενους σιδηρου με ν-ακετυλο-l-ασπαρτικη καζεϊνη και πενταϋδρικο φυλλινικο ασβεστιο |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB910321A (en) | 1960-02-25 | 1962-11-14 | Olivier Paul Gaudin | Improvements in and relating to a process for preparing ferrous salts of aspartic acid and medicines containing these salts |
| IT1150213B (it) | 1982-03-02 | 1986-12-10 | Italfarmaco Spa | Derivati di ferro biodisponibile esenti da gastrolesivita',procentimento di preparazione e relative composizioni farmaceutiche |
| IT1207996B (it) | 1986-03-18 | 1989-06-01 | Magis Farmaceutici | Composti contenenti ferro biodisponibile, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono. |
| GB9621273D0 (en) | 1996-10-11 | 1996-11-27 | Cortecs Ltd | Therapeutic method |
| IT1297022B1 (it) | 1997-12-24 | 1999-08-03 | Chemi Spa | Complesso di ferro-succinilcaseina, processo per la sua preparazione e composizioni farmaceutiche che lo contengono |
| ITMO20040200A1 (it) | 2004-07-29 | 2004-10-29 | Biofer Spa | Processo per la produzione di complessi ferro succinilcaseina e ferro casein acetil aspartilato e loro utilizzato nelle relative composizioni farmaceutiche. |
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2014
- 2014-12-19 PL PL14386034T patent/PL3034512T3/pl unknown
- 2014-12-19 PT PT143860344T patent/PT3034512T/pt unknown
- 2014-12-19 SI SI201430535T patent/SI3034512T1/en unknown
- 2014-12-19 DK DK14386034.4T patent/DK3034512T3/da active
- 2014-12-19 HU HUE14386034A patent/HUE035302T2/en unknown
- 2014-12-19 ES ES14386034.4T patent/ES2655238T3/es active Active
- 2014-12-19 RS RS20171312A patent/RS56714B1/sr unknown
- 2014-12-19 LT LTEP14386034.4T patent/LT3034512T/lt unknown
- 2014-12-19 NO NO14386034A patent/NO3034512T3/no unknown
- 2014-12-19 EP EP14386034.4A patent/EP3034512B1/en active Active
-
2015
- 2015-10-22 SG SG11201702593TA patent/SG11201702593TA/en unknown
- 2015-10-22 EA EA201790902A patent/EA031968B1/ru unknown
- 2015-10-22 MY MYPI2017701462A patent/MY185391A/en unknown
- 2015-10-22 AP AP2017009801A patent/AP2017009801A0/en unknown
- 2015-10-22 BR BR112017006621-1A patent/BR112017006621B1/pt active IP Right Grant
- 2015-10-22 CA CA2959226A patent/CA2959226C/en active Active
- 2015-10-22 PE PE2017000363A patent/PE20180660A1/es unknown
- 2015-10-22 AU AU2015365885A patent/AU2015365885B2/en active Active
- 2015-10-22 GE GEAP201514514A patent/GEP20207081B/en unknown
- 2015-10-22 WO PCT/EP2015/074482 patent/WO2016096203A1/en active Application Filing
- 2015-10-22 US US15/536,855 patent/US20170340747A1/en not_active Abandoned
- 2015-10-22 MX MX2017008100A patent/MX2017008100A/es active IP Right Grant
-
2017
- 2017-03-02 PH PH12017500391A patent/PH12017500391A1/en unknown
- 2017-03-29 IL IL251449A patent/IL251449B/en active IP Right Grant
- 2017-04-05 CO CONC2017/0003313A patent/CO2017003313A2/es unknown
- 2017-04-05 SA SA517381261A patent/SA517381261B1/ar unknown
- 2017-06-19 CL CL2017001611A patent/CL2017001611A1/es unknown
- 2017-12-19 HR HRP20171965TT patent/HRP20171965T1/hr unknown
- 2017-12-21 CY CY20171101341T patent/CY1120037T1/el unknown
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