EA201790902A1 - Способ получения комплекса железа(iii) с n-ацетиласпартилированным казеином и его применение в фармацевтических композициях - Google Patents
Способ получения комплекса железа(iii) с n-ацетиласпартилированным казеином и его применение в фармацевтических композицияхInfo
- Publication number
- EA201790902A1 EA201790902A1 EA201790902A EA201790902A EA201790902A1 EA 201790902 A1 EA201790902 A1 EA 201790902A1 EA 201790902 A EA201790902 A EA 201790902A EA 201790902 A EA201790902 A EA 201790902A EA 201790902 A1 EA201790902 A1 EA 201790902A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- acetyl
- iii
- iron
- casein
- kasein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4732—Casein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
В заявке в целом описан новый способ получения комплексов железа(III) с N-ацетил-L-аспартилированным казеином. Продукт, который можно получить способом, предлагаемым в настоящем изобретении, можно безопасно использовать для населения в целом или для животных при лечении дефицита железа. Способ, предлагаемый в настоящем изобретении, включает стадии (a) реакции казеина с N-ацетил-L-аспартилхлоридом с получением N-ацетил-L-аспартилированного казеина, (b) последующей реакции N-ацетил-L-аспартилированного казеина с хлоридом железа(III) и (c) получения комплекса железа(III) с N-ацетил-L-аспартилированным казеином.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14386034.4A EP3034512B1 (en) | 2014-12-19 | 2014-12-19 | A process for producing iron (III) casein N-acetyl-aspartylated complexes and use thereof in pharmaceutical compositions |
| PCT/EP2015/074482 WO2016096203A1 (en) | 2014-12-19 | 2015-10-22 | A process for producing iron (iii) casein n-acetyl-aspartylated complexes and use thereof in pharmaceutical compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201790902A1 true EA201790902A1 (ru) | 2017-10-31 |
| EA031968B1 EA031968B1 (ru) | 2019-03-29 |
Family
ID=52354737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201790902A EA031968B1 (ru) | 2014-12-19 | 2015-10-22 | Способ получения комплекса железа(iii) с n-ацетиласпартилированным казеином и его применение в фармацевтических композициях |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US20170340747A1 (ru) |
| EP (1) | EP3034512B1 (ru) |
| AP (1) | AP2017009801A0 (ru) |
| AU (1) | AU2015365885B2 (ru) |
| BR (1) | BR112017006621B1 (ru) |
| CA (1) | CA2959226C (ru) |
| CL (1) | CL2017001611A1 (ru) |
| CO (1) | CO2017003313A2 (ru) |
| CY (1) | CY1120037T1 (ru) |
| DK (1) | DK3034512T3 (ru) |
| EA (1) | EA031968B1 (ru) |
| ES (1) | ES2655238T3 (ru) |
| GE (1) | GEP20207081B (ru) |
| HR (1) | HRP20171965T1 (ru) |
| HU (1) | HUE035302T2 (ru) |
| IL (1) | IL251449B (ru) |
| LT (1) | LT3034512T (ru) |
| MX (1) | MX2017008100A (ru) |
| MY (1) | MY185391A (ru) |
| NO (1) | NO3034512T3 (ru) |
| PE (1) | PE20180660A1 (ru) |
| PH (1) | PH12017500391A1 (ru) |
| PL (1) | PL3034512T3 (ru) |
| PT (1) | PT3034512T (ru) |
| RS (1) | RS56714B1 (ru) |
| SA (1) | SA517381261B1 (ru) |
| SG (1) | SG11201702593TA (ru) |
| SI (1) | SI3034512T1 (ru) |
| WO (1) | WO2016096203A1 (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR1009589B (el) | 2018-04-05 | 2019-09-11 | Ιουλια Κλεωνος Τσετη | Φαρμακευτικο σκευασμα για την αντιμετωπιση της αναιμιας, σε καταλληλο περιεκτη, που διατηρει στεγανα διαχωρισμενα μεταξυ τους τα δραστικα συστατικα: συμπλοκο του τρισθενους σιδηρου με ν-ακετυλο-l-ασπαρτικη καζεϊνη και πενταϋδρικο φυλλινικο ασβεστιο |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB910321A (en) | 1960-02-25 | 1962-11-14 | Olivier Paul Gaudin | Improvements in and relating to a process for preparing ferrous salts of aspartic acid and medicines containing these salts |
| IT1150213B (it) | 1982-03-02 | 1986-12-10 | Italfarmaco Spa | Derivati di ferro biodisponibile esenti da gastrolesivita',procentimento di preparazione e relative composizioni farmaceutiche |
| IT1207996B (it) | 1986-03-18 | 1989-06-01 | Magis Farmaceutici | Composti contenenti ferro biodisponibile, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono. |
| GB9621273D0 (en) | 1996-10-11 | 1996-11-27 | Cortecs Ltd | Therapeutic method |
| IT1297022B1 (it) | 1997-12-24 | 1999-08-03 | Chemi Spa | Complesso di ferro-succinilcaseina, processo per la sua preparazione e composizioni farmaceutiche che lo contengono |
| ITMO20040200A1 (it) | 2004-07-29 | 2004-10-29 | Biofer Spa | Processo per la produzione di complessi ferro succinilcaseina e ferro casein acetil aspartilato e loro utilizzato nelle relative composizioni farmaceutiche. |
-
2014
- 2014-12-19 EP EP14386034.4A patent/EP3034512B1/en active Active
- 2014-12-19 PT PT143860344T patent/PT3034512T/pt unknown
- 2014-12-19 LT LTEP14386034.4T patent/LT3034512T/lt unknown
- 2014-12-19 SI SI201430535T patent/SI3034512T1/en unknown
- 2014-12-19 HU HUE14386034A patent/HUE035302T2/en unknown
- 2014-12-19 DK DK14386034.4T patent/DK3034512T3/en active
- 2014-12-19 PL PL14386034T patent/PL3034512T3/pl unknown
- 2014-12-19 ES ES14386034.4T patent/ES2655238T3/es active Active
- 2014-12-19 RS RS20171312A patent/RS56714B1/sr unknown
- 2014-12-19 NO NO14386034A patent/NO3034512T3/no unknown
-
2015
- 2015-10-22 BR BR112017006621-1A patent/BR112017006621B1/pt active IP Right Grant
- 2015-10-22 GE GEAP201514514A patent/GEP20207081B/en unknown
- 2015-10-22 PE PE2017000363A patent/PE20180660A1/es unknown
- 2015-10-22 US US15/536,855 patent/US20170340747A1/en not_active Abandoned
- 2015-10-22 AP AP2017009801A patent/AP2017009801A0/en unknown
- 2015-10-22 AU AU2015365885A patent/AU2015365885B2/en active Active
- 2015-10-22 CA CA2959226A patent/CA2959226C/en active Active
- 2015-10-22 EA EA201790902A patent/EA031968B1/ru unknown
- 2015-10-22 WO PCT/EP2015/074482 patent/WO2016096203A1/en active Application Filing
- 2015-10-22 MY MYPI2017701462A patent/MY185391A/en unknown
- 2015-10-22 SG SG11201702593TA patent/SG11201702593TA/en unknown
- 2015-10-22 MX MX2017008100A patent/MX2017008100A/es active IP Right Grant
-
2017
- 2017-03-02 PH PH12017500391A patent/PH12017500391A1/en unknown
- 2017-03-29 IL IL251449A patent/IL251449B/en active IP Right Grant
- 2017-04-05 SA SA517381261A patent/SA517381261B1/ar unknown
- 2017-04-05 CO CONC2017/0003313A patent/CO2017003313A2/es unknown
- 2017-06-19 CL CL2017001611A patent/CL2017001611A1/es unknown
- 2017-12-19 HR HRP20171965TT patent/HRP20171965T1/hr unknown
- 2017-12-21 CY CY20171101341T patent/CY1120037T1/el unknown
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