EA202090728A1 - Применение нор-урсодезоксихолевой кислоты для снижения печеночного жира - Google Patents
Применение нор-урсодезоксихолевой кислоты для снижения печеночного жираInfo
- Publication number
- EA202090728A1 EA202090728A1 EA202090728A EA202090728A EA202090728A1 EA 202090728 A1 EA202090728 A1 EA 202090728A1 EA 202090728 A EA202090728 A EA 202090728A EA 202090728 A EA202090728 A EA 202090728A EA 202090728 A1 EA202090728 A1 EA 202090728A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- application
- liver fat
- ursodeoxycholic acid
- reduce liver
- reduce
- Prior art date
Links
- QYYDXDSPYPOWRO-JHMCBHKWSA-N (3r)-3-[(3r,5s,7s,8r,9s,10s,13r,14s,17r)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]butanoic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CC(O)=O)C)[C@@]2(C)CC1 QYYDXDSPYPOWRO-JHMCBHKWSA-N 0.000 title abstract 2
- 210000004185 liver Anatomy 0.000 title abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Abstract
В заявке описано применение Nor-UDCA для лечения гепатостеатоза у пациентов, у которых доля печеночного жира составляет более 10%.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17193777.4A EP3461485A1 (en) | 2017-09-28 | 2017-09-28 | Use of nor-ursodeoxycholic acid for reducing liver fat |
| PCT/EP2018/076461 WO2019063790A1 (en) | 2017-09-28 | 2018-09-28 | USE OF NOR-URSODESOXYCHOLIC ACID TO REDUCE HEXTIC GREASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202090728A1 true EA202090728A1 (ru) | 2020-07-16 |
Family
ID=60042996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202090728A EA202090728A1 (ru) | 2017-09-28 | 2018-09-28 | Применение нор-урсодезоксихолевой кислоты для снижения печеночного жира |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11850252B2 (ru) |
| EP (2) | EP3461485A1 (ru) |
| JP (1) | JP7266588B2 (ru) |
| CN (1) | CN111356459A (ru) |
| AU (1) | AU2018343995B2 (ru) |
| CA (1) | CA3076562A1 (ru) |
| EA (1) | EA202090728A1 (ru) |
| IL (1) | IL273489A (ru) |
| WO (1) | WO2019063790A1 (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114276401A (zh) * | 2021-12-27 | 2022-04-05 | 中山百灵生物技术股份有限公司 | 一种24-去甲熊去氧胆酸的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2392336T (lt) | 2005-05-12 | 2016-10-10 | Medizinische Universität Graz | 24-norudca, skirta autoimuninio hepatito gydymui |
| TR201901012T4 (tr) * | 2007-07-25 | 2019-02-21 | Univ Graz Medizinische | Arteriosklerozun tedavisinde nor-safra asitlerinin kullanımı. |
| EP2468762A1 (en) | 2010-11-30 | 2012-06-27 | Dr. Falk Pharma Gmbh | Optimized synthesis of pure, non-polymorphic, crystalline bile acids with defined particle size |
| WO2016130961A1 (en) * | 2015-02-13 | 2016-08-18 | The Regents Of The University Of California | Methods and compositions for identifying non-alcoholic fatty liver disease |
-
2017
- 2017-09-28 EP EP17193777.4A patent/EP3461485A1/en active Pending
-
2018
- 2018-09-28 WO PCT/EP2018/076461 patent/WO2019063790A1/en active Search and Examination
- 2018-09-28 EP EP18778488.9A patent/EP3687544A1/en active Pending
- 2018-09-28 EA EA202090728A patent/EA202090728A1/ru unknown
- 2018-09-28 US US16/652,044 patent/US11850252B2/en active Active
- 2018-09-28 JP JP2020517804A patent/JP7266588B2/ja active Active
- 2018-09-28 CN CN201880063797.6A patent/CN111356459A/zh active Pending
- 2018-09-28 CA CA3076562A patent/CA3076562A1/en active Pending
- 2018-09-28 AU AU2018343995A patent/AU2018343995B2/en active Active
-
2020
- 2020-03-22 IL IL273489A patent/IL273489A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3461485A1 (en) | 2019-04-03 |
| US20200246357A1 (en) | 2020-08-06 |
| WO2019063790A1 (en) | 2019-04-04 |
| IL273489A (en) | 2020-05-31 |
| CA3076562A1 (en) | 2019-04-04 |
| US11850252B2 (en) | 2023-12-26 |
| AU2018343995B2 (en) | 2024-02-01 |
| CN111356459A (zh) | 2020-06-30 |
| JP7266588B2 (ja) | 2023-04-28 |
| EP3687544A1 (en) | 2020-08-05 |
| JP2020535179A (ja) | 2020-12-03 |
| AU2018343995A1 (en) | 2020-04-09 |
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