DK2991671T3 - Oral dosering af glp-1-forbindelser - Google Patents
Oral dosering af glp-1-forbindelser Download PDFInfo
- Publication number
- DK2991671T3 DK2991671T3 DK14721834.1T DK14721834T DK2991671T3 DK 2991671 T3 DK2991671 T3 DK 2991671T3 DK 14721834 T DK14721834 T DK 14721834T DK 2991671 T3 DK2991671 T3 DK 2991671T3
- Authority
- DK
- Denmark
- Prior art keywords
- peptide
- composition
- glp
- ethoxy
- preceding embodiments
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
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- Emergency Medicine (AREA)
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Claims (21)
1. Fast sammensætning omfattende et GLP-l-peptid og en forstærker til anvendelse som et medikament ved oral administration, hvor: a) nævnte peptid har plasmahalveringstid hos mennesker på mindst 60 timer; b) nævnte sammensætning administreres mindst 3 gange; og c) nævnte sammensætning administreres således at forholdet mellem plasmahalveringstiden i dage hos mennesker af nævnte peptid og doseringsintervallet i dage af nævnte sammensætning er mere end 2:1.
2. Sammensætningen til anvendelse ifølge krav 1, hvor nævnte sammensætning administreres hver anden dag eller oftere.
3. Sammensætningen til anvendelse ifølge krav 2, hvor nævnte sammensætning administreres to gange dagligt, en gang dagligt, eller hver anden dag.
4. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor nævnte sammensætning er i formen af en tablet.
5. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor nævnte sammensætning administreres mindst 5 gange, såsom mindst 7 gange eller mindst 10 gange.
6. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor nævnte forstærker er et salt af A/-(8-(2-hydroxybenzoyl)amino)kaprylsyre, såsom SNAC.
7. Sammensætningen til anvendelse ifølge krav 6, hvor mængden af SNAC er 100-500 mg SNAC, eller hvor mængden af SNAC er 50-90 vægtprocent af nævnte sammensætning.
8. Sammensætningen til anvendelse ifølge krav 7, hvor mængden af SNAC er 200-400 mg eller hvor mængden af SNAC er 300 mg.
9. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor nævnte forstærker er et salt af kaprinsyre, såsom natriumkaprat.
10. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor nævnte peptid har plasmahalveringstid hos mennesker på mindst 72 timer.
11. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor nævnte peptid administreres i en mængde på 0,01-100 mg, såsom 2-60 mg, eller såsom mindst 5 mg eller mindst 10 mg.
12. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor nævnte sammensætning omfatter 1-100 mg GLP-l-peptid og 100-500 mg eller 50-90 vægtprocent SNAC.
13. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor nævnte sammensætning omfatter 1-100 mg GLP-l-peptid, 100-500 mg SNAC, mikrokrystallinsk cellulose, povidon og magnesiumstearat.
14. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor nævnte peptid er semaglutid eller /V£26{2-[2-(2-{2-[2-(2-{(S)-4-Carboxy-4-[10-(4-carboxyphenoxy)- decanoylamino]butyrylamino>ethoxy)ethoxy]acetylamino>ethoxy)ethoxy]acetyl>, /V£57-{2-[2-(2-{2-[2-(2-{(S)-4-carboxy-4-[10-(4- carboxyphenoxy)decanoylamino]butyrylamino}ethoxy)- ethoxy]acetylamino}ethoxy)ethoxy]acetyl}-[Aib8,Arg34,Lys37]GLP-l(7-37)-OH.
15. Sammensætningen til anvendelse ifølge krav 14, hvor nævnte peptid er semaglutid.
16. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor nævnte sammensætning omfatter 1-100 mg semaglutid og 100-500 mg eller 50-90 vægtprocent SNAC, eller hvor nævnte sammensætning omfatter 2-60 mg semaglutid og 200-400 mg SNAC.
17. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor nævnte sammensætning omfatter 2-40 mg semaglutid og 200-400 mg SNAC, såsom 300 mg SNAC.
18. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor nævnte sammensætning yderligere omfatter en eller flere farmaceutisk acceptable excipienser.
19. Sammensætningen til anvendelse ifølge et hvilket som helst af kravene 4-18, hvor vægten af nævnte tablet er i området på 150 mg til 1000 mg, såsom i området på 300-600 mg eller såsom 300-500 mg.
20. Sammensætningen som defineret i et hvilket som helst af de foregående krav, hvor nævnte sammensætning er til anvendelse i behandlingen eller forebyggelsen af diabetes og/eller fedme.
21. Sammensætningen til anvendelse ifølge krav 20, hvor nævnte anvendelse er behandlingen eller forebyggelsen af type 2-diabetes.
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| EP13166205 | 2013-05-02 | ||
| PCT/EP2014/058974 WO2014177683A1 (en) | 2013-05-02 | 2014-05-02 | Oral dosing of glp-1 compounds |
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| DK2991671T3 true DK2991671T3 (da) | 2018-10-08 |
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| SI (1) | SI2991671T1 (da) |
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| MX355361B (es) | 2011-04-12 | 2018-04-17 | Novo Nordisk As | Derivados de peptido 1 tipo glucagon (glp-1) doblemente acilados. |
| DK2827845T3 (da) | 2012-03-22 | 2019-04-01 | Novo Nordisk As | Sammensætninger omfattende et fremføringsmiddel og fremstilling deraf |
| RU2641198C3 (ru) | 2012-03-22 | 2021-12-10 | Ново Нордиск А/С | Композиции glp-1 пептидов и их получение |
| SI2827845T1 (sl) | 2012-03-22 | 2019-04-30 | Novo Nordisk A/S | Sestavki, ki obsegajo dostavno sredstvo in njihova priprava |
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| KR20180115814A (ko) * | 2013-05-02 | 2018-10-23 | 노보 노르디스크 에이/에스 | Glp-1 화합물의 경구 투여 |
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| US11471512B2 (en) * | 2019-03-01 | 2022-10-18 | Merck Sharp & Dohme Llc | Pharmaceutical compositions of a peptide |
| JP2023502004A (ja) | 2019-11-07 | 2023-01-20 | ノヴォ ノルディスク アー／エス | Ｇｌｐ－１作動薬、ｓｇｌｔ２阻害剤、およびｎ－（８－（２－ヒドロキシベンゾイル）アミノ）カプリル酸の塩を含む固形組成物 |
| US20230082544A1 (en) | 2020-02-18 | 2023-03-16 | Novo Nordisk A/S | Pharmaceutical formulations |
| EP4142695A1 (en) | 2020-04-29 | 2023-03-08 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist and histidine |
| KR20230029480A (ko) | 2020-07-22 | 2023-03-03 | 노보 노르디스크 에이/에스 | 경구 전달에 적합한 glp-1 및 gip 수용체에서의 공-작용제 |
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| MX355361B (es) | 2011-04-12 | 2018-04-17 | Novo Nordisk As | Derivados de peptido 1 tipo glucagon (glp-1) doblemente acilados. |
| EP2729481B1 (en) | 2011-07-08 | 2018-10-17 | Amylin Pharmaceuticals, LLC | Engineered polypeptides having enhanced duration of action with reduced immunogenicity |
| RU2641198C3 (ru) | 2012-03-22 | 2021-12-10 | Ново Нордиск А/С | Композиции glp-1 пептидов и их получение |
| SI2827845T1 (sl) | 2012-03-22 | 2019-04-30 | Novo Nordisk A/S | Sestavki, ki obsegajo dostavno sredstvo in njihova priprava |
| ES2871328T3 (es) * | 2012-06-20 | 2021-10-28 | Novo Nordisk As | Formulación de comprimido que comprende un péptido y un agente de suministro |
| KR20180115814A (ko) * | 2013-05-02 | 2018-10-23 | 노보 노르디스크 에이/에스 | Glp-1 화합물의 경구 투여 |
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2014
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- 2014-05-02 EP EP14721834.1A patent/EP2991671B1/en not_active Revoked
- 2014-05-02 EP EP18188817.3A patent/EP3485900A1/en active Pending
- 2014-05-02 SI SI201430880T patent/SI2991671T1/sl unknown
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- 2014-05-02 KR KR1020157032843A patent/KR102272671B1/ko active IP Right Grant
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