DK2983763T3 - Drivmekanisme til en lægemiddelfremføringsanordning - Google Patents

Drivmekanisme til en lægemiddelfremføringsanordning Download PDF

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DK2983763T3
DK2983763T3 DK14716553.4T DK14716553T DK2983763T3 DK 2983763 T3 DK2983763 T3 DK 2983763T3 DK 14716553 T DK14716553 T DK 14716553T DK 2983763 T3 DK2983763 T3 DK 2983763T3
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dose
housing
drive sleeve
drive
sleeve
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DK14716553.4T
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Daniel Berning
Philippe Blank
Wolfgang Pelzer
Björn Wilden
Michael Pfoser
Stefan Bayer
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Sanofi Sa
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A61M5/3153—Dosing by single stroke limiting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose

Claims (15)

1. Drivmekanisme på en lægemiddelfremføringsanordning til dispensering af en dosis af et medikament, hvilken mekanisme omfatter: - et aflangt hus (30), der strækker sig i en aksial retning (1, 2), - en stempelstang (80) til at gå operabelt i indgreb med et stempel (16) i en patron (14) til forskydning af stemplet (16) i aksial distal retning (1), - en drivmuffe (60), der strækker sig i aksial retning (1, 2) og er roterbart understøttet i huset (30), - en dosisindstillingsdel (40) , hvor drivmuffen (60) kan frigøres operabelt fra stempelstangen (80) og gå roterbart i indgreb med dosisindstillingsdelen (40) til indstilling af dosen, der er kendetegnet ved, at - dosisindstillingsdelen (40) er roterbart understøttet på en sidevægsdel (31) af huset (30) og kan rotere i forhold til en akse (41) , der strækker sig i radial retning (r) i forhold til det aksialt aflange hus.
2. Drivmekanisme ifølge krav 1, hvor drivmuffen (60) kan kobles operabelt med stempelstangen (80) og frigøres operabelt fra dosisindstillingsdelen (40) til dispensering af dosen.
3. Drivmekanisme ifølge et hvilket som helst af ovennævnte krav, hvor drivmuffen (60) kan forskydes i aksial retning (1, 2) mellem en proksimal dosisindstillingsposition og en distal dosisinjektionsposition til selektiv og skiftevis kobling og afkobling med stempelstangen (80) og med dosisindstillingsdelen (40).
4. Drivmekanisme ifølge et hvilket som helst af ovennævnte krav, der yderligere omfatter en dosisinjektionsdel (50) i en proksimal ende af huset (30), hvor dosisinjektionsdelen (50) kan forskydes i aksial retning (1, 2) mellem en proksimal dosisindstillingsposition og en distal dosisinjektionsposition og distalt støder mod drivmuffen (60) til forskydning af drivmuffen (60) til dosisinjektionspositionen.
5. Drivmekanisme ifølge krav 4, hvor dosisinjektionsdelen (50) er roterbart fastgjort til huset (30) og omfatter en låsedel (52) til at gå i indgreb med dosisindstillingsdelen (40), når den når dosisinjektionspositionen.
6. Drivmekanisme ifølge krav 4 eller 5, hvor drivmuffen (60) kan forskydes i distal retning (1) i forhold til huset (30) mod virkningen af et fjederelement (61), der virker aksialt mellem drivmuffen (60) og huset (30).
7. Drivmekanisme ifølge et hvilket som helst af ovennævnte krav, hvor dosisindstillingsdelen (40) omfatter et tandhjul (42) til at gå i indgreb med et kronhjul (62) på drivmuffen (60), når den er i dosisindstillingspositionen.
8. Drivmekanisme ifølge et hvilket som helst af ovennævnte krav, der yderligere omfatter en understøtningsdel (110), der er solidt fastgjort til huset (30) og har en radialt udadgående sokkeldel (111) til understøtning af et hult skaft (43) på dosisindstillingsdelen (40).
9. Drivmekanisme ifølge krav 8, hvor understøtningsdelen (110) yderligere omfatter en aksialt udgående holder (112) i en proksimal ende til glidbar modtagelse af dosisinjektionsdelen (50) .
10. Drivmekanisme ifølge et hvilket som helst af ovennævnte krav 8 eller 9, hvor en sidste dosisbegrænsende del (130) er anbragt mellem sokkeldelen (111) og det hule skaft (43), hvor den sidste dosisbegrænsende del (130) er i gevindindgreb med sokkeldelen (111) og er roterbart fastgjort og glidbart forskydelig i forhold til det hule skaft (43) , eller hvor den sidste dosisbegrænsende del (130) er i gevindindgreb med det hule skaft (43) og er roterbart fastgjort og glidbart forskydelig i forhold til sokkeldelen (111) ·
11. Drivmekanisme ifølge krav 10, hvor den sidste dosisbegrænsende del (130) kan forskydes langs sokkeldelen (111) mellem et nuldosisbegrænsende stop (114) og et sidste dosisbegrænsende stop (116), der strækker sig radialt mellem modsatte endedele af sokkeldelen (111) eller det hule skaft (43) .
12. Drivmekanisme ifølge et hvilket som helst af ovennævnte krav, hvor drivmuffen (60) er roterbart og aksialt glidbart i indgreb med en dosisvisende muffe (90), der er i gevindindgreb med indersiden af huset (30), hvor den dosisvisende muffe (90) omfatter mindst ét stop (93, 94) i den ene aksiale ende til at støde mod et enkelt dosisbegrænsende stop (33, 34), der er placeret på indersiden af huset (30) .
13. Drivmekanisme ifølge et hvilket som helst af ovennævnte krav, hvor drivmuffen (60) er roterbart påvirket i forhold til huset (30) ved hjælp af en spiralfjeder (68), der strækker sig omkring drivmuffen (60).
14. Drivmekanisme ifølge et hvilket som helst af ovennævnte krav, hvor stempelstangen (80) er i gevindindgreb med en drivmøtrik (70), der er aksialt fastgjort til huset (30) og er roterbart understøttet i huset (30), hvor drivmuffen (60) er roterbart i indgreb med drivmøtrikken (70), når den er i dosisinjektionspositionen, og hvor drivmuffen (60) og drivmøtrikken (70) er afkoblet, når drivmuffen (60) er i dosisindstillingspositionen.
15. Lægemiddelfremføringsanordning til dispensering af en dosis af et medikament, som omfatter: en drivmekanisme (3) ifølge et hvilket som helst af ovennævnte krav og - en patron (14), der er mindst delvist fyldt med medikamentet og er anbragt i huset (30) af drivmekanismen (3) eller i en patronholder (12), der er fastgjort til huset (30).
DK14716553.4T 2013-04-10 2014-04-08 Drivmekanisme til en lægemiddelfremføringsanordning DK2983763T3 (da)

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EP13163084 2013-04-10
PCT/EP2014/056987 WO2014166907A2 (en) 2013-04-10 2014-04-08 Drive mechanism for a drug delivery device

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EP (1) EP2983763B1 (da)
JP (1) JP6465862B2 (da)
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CN106902421B (zh) * 2017-01-17 2020-03-31 燕山大学 一种个人化麻醉闭环控制系统
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BR112022005836A2 (pt) * 2019-09-30 2022-06-21 Amgen Inc Dispositivo de administração de fármaco
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EP2983763B1 (en) 2017-05-24
WO2014166907A3 (en) 2014-12-31
JP2016518187A (ja) 2016-06-23
JP6465862B2 (ja) 2019-02-06
US20160045668A1 (en) 2016-02-18
CN105102031B (zh) 2019-01-18
CN105102031A (zh) 2015-11-25
WO2014166907A2 (en) 2014-10-16
HK1214781A1 (zh) 2016-08-05
US10099015B2 (en) 2018-10-16

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