DK2938597T3 - N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amin sulfatsalte, fremstilling deraf og anvendelse af samme - Google Patents
N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amin sulfatsalte, fremstilling deraf og anvendelse af samme Download PDFInfo
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- DK2938597T3 DK2938597T3 DK13815780.5T DK13815780T DK2938597T3 DK 2938597 T3 DK2938597 T3 DK 2938597T3 DK 13815780 T DK13815780 T DK 13815780T DK 2938597 T3 DK2938597 T3 DK 2938597T3
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- propyl
- disease
- diisobutylamino
- pharmaceutically acceptable
- amine
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- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- Bioinformatics & Cheminformatics (AREA)
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Claims (12)
1. A/-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[<^imidazol-2-amin sulfatsalt og farmaceutisk acceptable solvater deraf.
2. Sulfatsaltet ifølge krav 1, der har formlen II
Formel II hvor x er 0,5 til 4, og farmaceutisk acceptable solvater deraf.
3. Sulfatsaltet ifølge krav 2 og farmaceutisk acceptable solvater deraf, kendetegnet ved at x er 1,5 til 2,5.
4. Sulfatsaltet ifølge krav 2 og farmaceutisk acceptable solvater deraf, kendetegnet ved at x er 0,5 til 1,5.
5. Sulfatsaltet ifølge krav 2 og farmaceutisk acceptable solvater deraf, kendetegnet ved at x er 2,5 til 3,5.
6. Sulfatsaltet ifølge krav 2, der har formlen III
hvor x er som defineret i krav 2, og y er 0,5 til 5.
7. Farmaceutisk sammensætning omfattende sulfatsaltet ifølge et hvilket som helst af kravene 1 til 6, eller en farmaceutisk acceptabel solvat deraf, og mindst én farmaceutisk acceptabel bærer, fortynder, excipiens og/eller adjuvans.
8. Sulfatsaltet ifølge et hvilket som helst af kravene 1 til 6, eller en farmaceutisk acceptabel solvat deraf, til anvendelse som et lægemiddel.
9. Sulfatsaltet ifølge et hvilket som helst af kravene 1 til 6, eller en farmaceutisk acceptabel solvat deraf, til anvendelse i behandling og/eller forebyggelse afen sygdom valgt blandt neurodegenerative sygdomme, amyloidopatier, tauopatier og mentale udviklingssygdomme.
10. Sulfatsaltet til anvendelse ifølge krav 9, hvor sygdommen er valgt blandt Alzheimers sygdom, Lewy body demens (DLB), amyotrofisk lateral sklerose (ALS) med frontotemporal demens, inklusionslegeme myopati med Pagets knoglesygdom og/eller frontotemporal demens (IBMPFD), frontotemporal lobar degeneration, synucleopatier, Huntingtons sygdom, Parkinsons sygdom, amyloid angiopatier, frontotemporal demens med Parkinsonisme forbundet til kromosom 17 og Downs syndrom.
11. Sulfatsaltet ifølge et hvilket som helst af kravene 1 til 6, eller en farmaceutisk acceptabel solvat deraf, til anvendelse til udskydelse af optræden hos en patient af en sygdom valgt blandt neurodegenerative sygdomme, amyloidopatier, tauopatier og mentale udviklingssygdomme.
12. Sulfatsaltet til anvendelse ifølge krav 11, hvor sygdommen er valgt blandt Alzheimers sygdom, Lewy body demens (DLB), amyotrofisk lateral sklerose (ALS) med frontotemporal demens, inklusionslegeme myopati med Pagets knoglesygdom og/eller frontotemporal demens (IBMPFD), frontotemporal lobar degeneration, synucleopatier, Huntingtons sygdom, Parkinsons sygdom, amyloid angiopatier, frontotemporal demens med Parkinsonisme forbundet til kromosom 17 og Downs syndrom.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12306690 | 2012-12-27 | ||
| PCT/EP2013/078068 WO2014102339A1 (en) | 2012-12-27 | 2013-12-27 | Sulphate salts of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine, preparation thereof and use of the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2938597T3 true DK2938597T3 (da) | 2017-01-09 |
Family
ID=47501005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13815780.5T DK2938597T3 (da) | 2012-12-27 | 2013-12-27 | N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amin sulfatsalte, fremstilling deraf og anvendelse af samme |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US9562018B2 (da) |
| EP (1) | EP2938597B1 (da) |
| JP (1) | JP6384923B2 (da) |
| KR (1) | KR102115060B1 (da) |
| CN (1) | CN105008333B (da) |
| AU (2) | AU2013369288B2 (da) |
| BR (1) | BR112015015474B1 (da) |
| CA (1) | CA2895285C (da) |
| DK (1) | DK2938597T3 (da) |
| ES (1) | ES2605494T3 (da) |
| HK (1) | HK1215582A1 (da) |
| HR (1) | HRP20161612T2 (da) |
| HU (1) | HUE030930T2 (da) |
| IL (1) | IL239450B (da) |
| LT (1) | LT2938597T (da) |
| MX (1) | MX363367B (da) |
| NZ (1) | NZ708959A (da) |
| PL (1) | PL2938597T3 (da) |
| PT (1) | PT2938597T (da) |
| RS (1) | RS55511B1 (da) |
| RU (1) | RU2655454C2 (da) |
| SI (1) | SI2938597T1 (da) |
| WO (1) | WO2014102339A1 (da) |
| ZA (1) | ZA201504521B (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2938597T (pt) | 2012-12-27 | 2016-12-09 | Université De Lille 2 Droit Et Santé | Sais sulfato de n-(3-(4-(3-(isobutilamino)propil)-piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amina, sua preparação e sua utilização |
| CN107466292B (zh) | 2015-03-16 | 2020-05-01 | 国家医疗保健研究所 | 新型1,4-双(3-氨基丙基)哌嗪衍生物及其用途 |
| TWI744300B (zh) * | 2016-03-23 | 2021-11-01 | 里爾中央醫學中心 | 改良性熱處理的血小板顆粒裂解液在製備用於治療神經系統疾病的組合物的用途 |
| IL301559A (en) | 2020-10-01 | 2023-05-01 | Alzprotect | Succinate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[D]imidazol-2-amine, their preparation and use |
| MX2023003715A (es) | 2020-10-07 | 2023-04-24 | Alzprotect | Uso de sales de sulfato de n-(3-(4-(3-(diisobutilamino)propil)pipe razin-1-il)propil)-1h-benzo[d]imidazol-2-amina y solvatos de los mismos para el tratamiento de enfermedades neuronales motoras y trastornos de la union neuromuscular. |
| KR20240128694A (ko) | 2021-12-20 | 2024-08-26 | 알즈프로텍트 | 운동 뉴런 질환 및 신경근 접합부 장애의 치료를 위한 N-(3-(4-(3-(디이소부틸아미노)프로필)피페라진-1-일)프로필)-1H-벤조[d]이미다졸-2-아민 숙시네이트 염 및 이의 용매화물의 사용 |
| WO2023180537A1 (en) | 2022-03-25 | 2023-09-28 | Alzprotect | Use of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine salts and solvates thereof for the treatment of sensory neuron diseases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2674856B1 (fr) * | 1991-04-05 | 1993-07-30 | Esteve Labor Dr | Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments. |
| CA2263367A1 (fr) * | 1997-06-12 | 1998-12-17 | Transgene S.A. | Nouveaux complexes lipidiques pour le transfert d'au moins une substance therapeutiquement active, notamment un polynucleotide, dans une cellule cible et utilisation en therapie genique |
| WO2000018767A2 (en) | 1998-09-30 | 2000-04-06 | Neurogen Corporation | 2-piperazino alkylamino benzoazole derivatives: dopamine receptor subtype specific ligands |
| WO2002096431A1 (en) * | 2001-05-25 | 2002-12-05 | The Regents Of The University Of California | Optically active compounds clearing malformed proteins |
| US20040116441A1 (en) * | 2002-10-30 | 2004-06-17 | Pfizer Inc | Methods of using sulfonic acid derivatives |
| EP1581517B1 (en) * | 2002-12-23 | 2007-02-21 | Janssen Pharmaceutica N.V. | Substituted 1-piperidin-4-yl-4-azetidin-3-yl-piperazine derivatives and their use as neurokinin antagonists |
| US9044478B2 (en) * | 2004-11-10 | 2015-06-02 | Institut National De La Sante Et De La Recherche Medicale | Use of 1,4-bis (3-aminoalkyl) piperazine derivatives in the treatment of neurodegenerative diseases |
| PT2938597T (pt) * | 2012-12-27 | 2016-12-09 | Université De Lille 2 Droit Et Santé | Sais sulfato de n-(3-(4-(3-(isobutilamino)propil)-piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amina, sua preparação e sua utilização |
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2013
- 2013-12-27 PT PT138157805T patent/PT2938597T/pt unknown
- 2013-12-27 LT LTEP13815780.5T patent/LT2938597T/lt unknown
- 2013-12-27 PL PL13815780T patent/PL2938597T3/pl unknown
- 2013-12-27 AU AU2013369288A patent/AU2013369288B2/en active Active
- 2013-12-27 EP EP13815780.5A patent/EP2938597B1/en active Active
- 2013-12-27 KR KR1020157017192A patent/KR102115060B1/ko active IP Right Grant
- 2013-12-27 ES ES13815780.5T patent/ES2605494T3/es active Active
- 2013-12-27 RS RS20161055A patent/RS55511B1/sr unknown
- 2013-12-27 DK DK13815780.5T patent/DK2938597T3/da active
- 2013-12-27 WO PCT/EP2013/078068 patent/WO2014102339A1/en active Application Filing
- 2013-12-27 RU RU2015130671A patent/RU2655454C2/ru active
- 2013-12-27 MX MX2015008502A patent/MX363367B/es unknown
- 2013-12-27 BR BR112015015474-3A patent/BR112015015474B1/pt active IP Right Grant
- 2013-12-27 JP JP2015550088A patent/JP6384923B2/ja active Active
- 2013-12-27 NZ NZ70895913A patent/NZ708959A/en unknown
- 2013-12-27 HU HUE13815780A patent/HUE030930T2/hu unknown
- 2013-12-27 CN CN201380068524.8A patent/CN105008333B/zh active Active
- 2013-12-27 SI SI201330408A patent/SI2938597T1/sl unknown
- 2013-12-27 US US14/655,642 patent/US9562018B2/en active Active
- 2013-12-27 CA CA2895285A patent/CA2895285C/en active Active
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2015
- 2015-06-16 IL IL239450A patent/IL239450B/en active IP Right Grant
- 2015-06-23 ZA ZA2015/04521A patent/ZA201504521B/en unknown
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2016
- 2016-03-29 HK HK16103579.5A patent/HK1215582A1/zh unknown
- 2016-12-01 HR HRP20161612TT patent/HRP20161612T2/hr unknown
- 2016-12-22 US US15/388,349 patent/US10537569B2/en active Active
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2018
- 2018-03-28 AU AU2018202218A patent/AU2018202218B2/en active Active
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2019
- 2019-08-27 US US16/552,436 patent/US10772884B2/en active Active
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