DK2934612T3 - Vævsklæbersammensætninger - Google Patents
Vævsklæbersammensætninger Download PDFInfo
- Publication number
- DK2934612T3 DK2934612T3 DK13821692.4T DK13821692T DK2934612T3 DK 2934612 T3 DK2934612 T3 DK 2934612T3 DK 13821692 T DK13821692 T DK 13821692T DK 2934612 T3 DK2934612 T3 DK 2934612T3
- Authority
- DK
- Denmark
- Prior art keywords
- combination
- lipidated
- protein
- thrombin
- clot
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/12—Polypeptides, proteins or derivatives thereof, e.g. degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/043—Mixtures of macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/12—Polypeptides, proteins or derivatives thereof, e.g. degradation products thereof
- A61L33/126—Fibrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Sealing Material Composition (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (15)
1. Kombination omfattende en lipideret vævsfaktor, thrombin, og fibrinogen.
2. Kombinationen ifølge krav 1, hvor mindst et af N-glykosyleringsstederne af vævsfaktoren er ikke-funktionelle.
3. Kombinationen ifølge et hvilket som helst af kravene 1-2, hvor vævsfaktoren er et fusionsprotein omfattende en første del, der omfatter vævsfaktorproteinet, og en anden del, der omfatter et andet peptid eller protein.
4. Kombinationen ifølge krav 3, hvor den anden del er et tag.
5. Kombinationen ifølge et hvilket som helst af kravene 1-4, hvor fusionsproteinet har en første del, der omfatter det modne humane vævsfaktorprotein hvor mindst et af N-glykosyleringsstederne er ikke-funktionelle, og en anden del, der omfatter et His-tag.
6. Kombinationen ifølge krav 5, hvor fusionsproteinet svarer til SEQ ID NO: 5.
7. Kombinationen ifølge krav 6, hvor det lipiderede TF er indsat i en mikrovesikel.
8. Kombinationen ifølge et hvilket som helst af kravene 1-14, hvor thrombin er human thrombin.
9. Kombinationen ifølge et hvilket som helst af kravene 1-15, hvor fibrinogen er human fibrinogen.
10. Vævsklæbersammensætning omfattende kombinationen ifølge et hvilket som helst af kravene 1-9, og en materialebærer.
11. Farmaceutisk sammensætning omfattende en terapeutisk effektiv mængde af kombinationen som defineret i et hvilket som helst af kravene 1-9, sammen med andre egnede farmaceutisk eller veterinært acceptable excipienser og/eller bærere.
12. Kombination ifølge et hvilket som helst af kravene 1-9 eller sammensætningen ifølge krav 10 til anvendelse som vævsklæbermiddel.
13. Kombinationen ifølge et hvilket som helst af kravene 1-9 eller sammensætningen ifølge krav 10-11 til anvendelse som et lægemiddel.
14. Kombination ifølge et hvilket som helst af kravene 1-9 eller en sammensætning ifølge et hvilket som helst af kravene 10-11 til anvendelse i behandling af blødninger.
15. Kit omfattende kombinationen som defineret i et hvilket som helst af kravene 1-9 og en applikator, der tillader den simultane anvendelse afalle komponenterne der udgør kombinationen.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12198839.8A EP2745852A1 (en) | 2012-12-21 | 2012-12-21 | Sealant compositions |
| PCT/EP2013/077674 WO2014096354A1 (en) | 2012-12-21 | 2013-12-20 | Sealant compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2934612T3 true DK2934612T3 (da) | 2017-06-26 |
Family
ID=47563088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13821692.4T DK2934612T3 (da) | 2012-12-21 | 2013-12-20 | Vævsklæbersammensætninger |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20160082145A1 (da) |
| EP (2) | EP2745852A1 (da) |
| JP (1) | JP6518591B2 (da) |
| CN (1) | CN104955493A (da) |
| AU (1) | AU2013366544B2 (da) |
| BR (1) | BR112015014926B1 (da) |
| CY (1) | CY1118938T1 (da) |
| DK (1) | DK2934612T3 (da) |
| ES (1) | ES2627053T3 (da) |
| HR (1) | HRP20170880T1 (da) |
| HU (1) | HUE034649T2 (da) |
| LT (1) | LT2934612T (da) |
| MX (1) | MX361222B (da) |
| PL (1) | PL2934612T3 (da) |
| PT (1) | PT2934612T (da) |
| SI (1) | SI2934612T1 (da) |
| WO (1) | WO2014096354A1 (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010906B (zh) * | 2018-08-16 | 2021-05-14 | 陈明远 | 一种促进术后伤口局部止血及促进术后创面上皮化的生物胶水及其工作方法 |
| US11666682B2 (en) * | 2020-08-31 | 2023-06-06 | Ethicon, Inc. | Method of stopping CSF leaks and apparatus therefor |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE241340T1 (de) * | 1994-02-17 | 2003-06-15 | New York Blood Ct Inc | Biologische bioadhäsive präparate, die fibrinkleber und liposomen enthalten, verfahren für ihre herstellung und verwendung |
| EP0885020A1 (en) * | 1996-02-20 | 1998-12-23 | Cohesion Corporation | Tissue sealant compositions and methods of use thereof |
| WO1999018931A1 (en) * | 1997-10-10 | 1999-04-22 | University Of Virginia | Use of fibrin sealant to maintain hemostasis, lymphostasis and prevent local accumulation of body fluids |
| EP1749536A1 (en) * | 2005-08-03 | 2007-02-07 | Thrombotargets Europe, S.L. | Activated factor X stimulants as new antihemorrhagic agents for topical use |
| EP1939218A1 (en) | 2006-12-29 | 2008-07-02 | Thrombotargets Europe, S.L. | Microvesicles derived from recombinant yeast having haemostatic activities and uses thereof |
| EP2145695A1 (de) | 2008-07-14 | 2010-01-20 | Sika Technology AG | Vorrichtung zur Klebstoffapplikation |
| EP2380905A1 (en) | 2010-04-19 | 2011-10-26 | Thrombotargets Europe, S.L. | Phospholipid-enriched vesicles bearing tissue factor having haemostatic activities and uses thereof |
-
2012
- 2012-12-21 EP EP12198839.8A patent/EP2745852A1/en not_active Withdrawn
-
2013
- 2013-12-20 WO PCT/EP2013/077674 patent/WO2014096354A1/en active Application Filing
- 2013-12-20 EP EP13821692.4A patent/EP2934612B1/en active Active
- 2013-12-20 AU AU2013366544A patent/AU2013366544B2/en not_active Ceased
- 2013-12-20 JP JP2015548630A patent/JP6518591B2/ja not_active Expired - Fee Related
- 2013-12-20 ES ES13821692.4T patent/ES2627053T3/es active Active
- 2013-12-20 DK DK13821692.4T patent/DK2934612T3/da active
- 2013-12-20 LT LTEP13821692.4T patent/LT2934612T/lt unknown
- 2013-12-20 PT PT138216924T patent/PT2934612T/pt unknown
- 2013-12-20 HU HUE13821692A patent/HUE034649T2/hu unknown
- 2013-12-20 BR BR112015014926A patent/BR112015014926B1/pt not_active IP Right Cessation
- 2013-12-20 SI SI201330670T patent/SI2934612T1/sl unknown
- 2013-12-20 US US14/653,862 patent/US20160082145A1/en not_active Abandoned
- 2013-12-20 CN CN201380071345.XA patent/CN104955493A/zh active Pending
- 2013-12-20 MX MX2015007625A patent/MX361222B/es active IP Right Grant
- 2013-12-20 PL PL13821692T patent/PL2934612T3/pl unknown
-
2017
- 2017-06-08 CY CY20171100597T patent/CY1118938T1/el unknown
- 2017-06-08 HR HRP20170880TT patent/HRP20170880T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2627053T3 (es) | 2017-07-26 |
| EP2745852A1 (en) | 2014-06-25 |
| PT2934612T (pt) | 2017-06-26 |
| LT2934612T (lt) | 2017-07-25 |
| CN104955493A (zh) | 2015-09-30 |
| EP2934612B1 (en) | 2017-03-15 |
| CY1118938T1 (el) | 2018-01-10 |
| JP6518591B2 (ja) | 2019-05-22 |
| AU2013366544B2 (en) | 2017-05-25 |
| BR112015014926B1 (pt) | 2020-01-28 |
| MX361222B (es) | 2018-11-30 |
| JP2016510315A (ja) | 2016-04-07 |
| EP2934612A1 (en) | 2015-10-28 |
| HUE034649T2 (hu) | 2018-02-28 |
| MX2015007625A (es) | 2015-12-15 |
| US20160082145A1 (en) | 2016-03-24 |
| SI2934612T1 (sl) | 2017-08-31 |
| AU2013366544A1 (en) | 2015-07-09 |
| HRP20170880T1 (hr) | 2017-08-25 |
| WO2014096354A1 (en) | 2014-06-26 |
| PL2934612T3 (pl) | 2017-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101884954B1 (ko) | 지혈 작용을 가진 조직인자를 함유하는 인지질이 풍부한 소포 및 그의 용도 | |
| CN103917554A (zh) | 用于改善重构后纯化的因子viii的稳定性的方法 | |
| AU2011244379A1 (en) | Phospholipid-enriched vesicles bearing tissue factor having haemostatic activities and uses thereof | |
| Connolly et al. | Mice lacking the thrombin receptor, PAR1, have normal skin wound healing. | |
| EP2948169B1 (en) | Hemostatic compositions | |
| JP2003500364A (ja) | フィブリノーゲン、トロンビン、トランスグルタミナーゼ及びプロテイナーゼインヒビターを含有する局所投与のための薬剤 | |
| NO324064B1 (no) | Farmasoytisk preparat omfattende vWF-propeptid samt fremgangsmate for fremstilling og anvendelse derav | |
| US20100197893A1 (en) | Method to produce fibrin monomer in acid media for use as tissue sealant | |
| DK2934612T3 (da) | Vævsklæbersammensætninger | |
| US20110053851A1 (en) | Haemostasis-modulating compositions and uses therefor | |
| JPH0199565A (ja) | フィブリン糊調製用キット | |
| JP2023541650A (ja) | 止血管理を改善するシステム |