DK2931265T6 - Modificerede AXL-petider og deres anvendelse til inhibering af AXL-signalering i en antimetastatisk terapi - Google Patents

Modificerede AXL-petider og deres anvendelse til inhibering af AXL-signalering i en antimetastatisk terapi Download PDF

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Publication number
DK2931265T6
DK2931265T6 DK13862780.7T DK13862780T DK2931265T6 DK 2931265 T6 DK2931265 T6 DK 2931265T6 DK 13862780 T DK13862780 T DK 13862780T DK 2931265 T6 DK2931265 T6 DK 2931265T6
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DK
Denmark
Prior art keywords
axl
inhibition
modified
peptides
signaling
Prior art date
Application number
DK13862780.7T
Other languages
Danish (da)
English (en)
Other versions
DK2931265T3 (en
Inventor
Amato J Giaccia
Erinn Bruno Rankin
Jennifer R Cochran
Yu Miao
Susan Hershenson
Mihalis Kariolis
Douglas Jones
Katherine Fuh
Original Assignee
Univ Leland Stanford Junior
Aravive Biologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50934967&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2931265(T6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Leland Stanford Junior, Aravive Biologics Inc filed Critical Univ Leland Stanford Junior
Publication of DK2931265T3 publication Critical patent/DK2931265T3/en
Application granted granted Critical
Publication of DK2931265T6 publication Critical patent/DK2931265T6/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DK13862780.7T 2012-12-14 2013-12-12 Modificerede AXL-petider og deres anvendelse til inhibering af AXL-signalering i en antimetastatisk terapi DK2931265T6 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261737276P 2012-12-14 2012-12-14
PCT/US2013/074786 WO2014093690A1 (en) 2012-12-14 2013-12-12 Modified axl peptides and their use in inhibition of axl signaling in anti-metastatic therapy

Publications (2)

Publication Number Publication Date
DK2931265T3 DK2931265T3 (en) 2018-04-16
DK2931265T6 true DK2931265T6 (da) 2023-05-01

Family

ID=50934967

Family Applications (2)

Application Number Title Priority Date Filing Date
DK13862780.7T DK2931265T6 (da) 2012-12-14 2013-12-12 Modificerede AXL-petider og deres anvendelse til inhibering af AXL-signalering i en antimetastatisk terapi
DK17196662.5T DK3326622T3 (da) 2012-12-14 2013-12-12 Modificerede peptider og deres anvendelse ved hæmning af AXL-signalering inden for anti-metastaseterapi

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK17196662.5T DK3326622T3 (da) 2012-12-14 2013-12-12 Modificerede peptider og deres anvendelse ved hæmning af AXL-signalering inden for anti-metastaseterapi

Country Status (11)

Country Link
US (3) US9822347B2 (cg-RX-API-DMAC7.html)
EP (2) EP3326622B1 (cg-RX-API-DMAC7.html)
JP (2) JP6345690B2 (cg-RX-API-DMAC7.html)
AU (3) AU2013359179B2 (cg-RX-API-DMAC7.html)
CA (1) CA2894539C (cg-RX-API-DMAC7.html)
DK (2) DK2931265T6 (cg-RX-API-DMAC7.html)
ES (2) ES2862335T3 (cg-RX-API-DMAC7.html)
FI (1) FI2931265T6 (cg-RX-API-DMAC7.html)
NO (1) NO3049208T3 (cg-RX-API-DMAC7.html)
PT (2) PT3326622T (cg-RX-API-DMAC7.html)
WO (1) WO2014093690A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011207381B2 (en) * 2010-01-22 2016-06-09 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of AXL signaling in anti-metastatic therapy
US9074192B2 (en) * 2010-01-22 2015-07-07 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of AXL signaling in anti-metastatic therapy
WO2013090776A1 (en) 2011-12-15 2013-06-20 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of axl/gas6 signaling in the treatment of disease
PT3326622T (pt) * 2012-12-14 2021-04-07 Univ Leland Stanford Junior Péptidos axl modificados e sua utilização na inibição da sinalização de axl em terapêutica anti-metastática
CA2909669C (en) 2014-10-20 2023-12-12 Ruga Corporation Antiviral activity of gas6 inhibitor
ES2834618T3 (es) * 2014-12-18 2021-06-18 Aravive Biologics Inc Actividad antifibrótica del inhibidor de GAS6
MX2020007130A (es) * 2017-11-04 2021-02-15 Aravive Biologics Inc Métodos para el tratamiento de cánceres metastásicos utilizando receptores señuelo axl.
EP4398937A4 (en) * 2021-09-11 2025-07-09 Aravive Inc METHODS FOR TREATING LOCALLY ADVANCED OR METASTATIC PANCREATIC ADENOCARCINOMA USING AXL DECOY RECEPTORS AS FIRST-LINE THERAPY

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US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
EP0394827A1 (en) 1989-04-26 1990-10-31 F. Hoffmann-La Roche Ag Chimaeric CD4-immunoglobulin polypeptides
US5538861A (en) 1994-07-29 1996-07-23 Amgen Inc. DNA encoding a stimulating factor for the axl receptor
US20030032103A1 (en) 1997-09-18 2003-02-13 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6737056B1 (en) * 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
EP1382969A1 (en) 2002-07-17 2004-01-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Diagnosis and prevention of cancer cell invasion
WO2004108748A2 (en) 2002-09-24 2004-12-16 Dow, Kenneth, Centocor, Inc. Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses
WO2004092735A2 (en) 2003-04-18 2004-10-28 Novartis Ag Methods and compositions targeting tyrosine kinases for the diagnosis and treatment of osteoarthritis
JP2005278631A (ja) 2004-03-04 2005-10-13 National Institute Of Advanced Industrial & Technology Ａｘｌリガンド結合領域蛋白質、その製造方法及びそれを用いたスクリーニング方法
CA2630475A1 (en) 2004-11-24 2006-06-01 The Regents Of The University Of Colorado Mer diagnostic and therapeutic agents
CA2607133A1 (en) 2005-05-02 2006-11-09 Toray Industries, Inc. Composition and method for diagnosing esophageal cancer and metastasis of esophageal cancer
US8168415B2 (en) * 2007-02-07 2012-05-01 The Regents Of The University Of Colorado Axl fusion proteins as Axl tyrosine kinase inhibitors
AU2008240188A1 (en) 2007-04-13 2008-10-23 Supergen, Inc. Axl kinase inhibitors useful for the treatment of cancer or hyperproliferative disorders
EP2170395A1 (en) 2007-07-02 2010-04-07 Wyeth LLC Modulators of axl for use in treating bone disorders
WO2010014755A1 (en) * 2008-07-29 2010-02-04 The Regents Of The University Of Colorado Methods and compounds for enhancing anti-cancer therapy
CN102257001A (zh) * 2008-12-19 2011-11-23 诺瓦提斯公司 治疗自体免疫和炎性病症的可溶性多肽
US8841424B2 (en) * 2009-05-11 2014-09-23 U3 Pharma Gmbh Humanized AXL antibodies
US9074192B2 (en) * 2010-01-22 2015-07-07 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of AXL signaling in anti-metastatic therapy
AU2011207381B2 (en) * 2010-01-22 2016-06-09 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of AXL signaling in anti-metastatic therapy
AU2011326164B2 (en) 2010-11-08 2016-05-05 The Board Of Trustees Of The Leland Stanford Junior University Fusion proteins comprising an engineered knottin peptide and uses thereof
WO2013090776A1 (en) * 2011-12-15 2013-06-20 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of axl/gas6 signaling in the treatment of disease
PT3326622T (pt) * 2012-12-14 2021-04-07 Univ Leland Stanford Junior Péptidos axl modificados e sua utilização na inibição da sinalização de axl em terapêutica anti-metastática
WO2014093707A1 (en) 2012-12-14 2014-06-19 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of axl signaling in primary tumor therapy
US20160266136A1 (en) * 2013-08-30 2016-09-15 The Board Of Trustees Of The Leland Stanford Junior University High-affinity binding to gas6
CA2909669C (en) * 2014-10-20 2023-12-12 Ruga Corporation Antiviral activity of gas6 inhibitor
ES2834618T3 (es) * 2014-12-18 2021-06-18 Aravive Biologics Inc Actividad antifibrótica del inhibidor de GAS6

Also Published As

Publication number Publication date
US11136563B2 (en) 2021-10-05
JP6832887B2 (ja) 2021-02-24
US20150315553A1 (en) 2015-11-05
AU2013359179A1 (en) 2015-07-02
PT2931265T (pt) 2018-04-16
WO2014093690A1 (en) 2014-06-19
JP2016510309A (ja) 2016-04-07
AU2019210662A1 (en) 2019-08-22
AU2013359179B2 (en) 2017-10-05
DK3326622T3 (da) 2021-04-06
EP2931265B1 (en) 2018-01-31
DK2931265T3 (en) 2018-04-16
PT3326622T (pt) 2021-04-07
ES2665323T3 (es) 2018-04-25
NO3049208T3 (cg-RX-API-DMAC7.html) 2018-04-14
EP3326622B1 (en) 2021-01-20
FI2931265T6 (fi) 2023-05-23
HK1256071A1 (en) 2019-09-13
AU2017272193A1 (en) 2017-12-21
JP6345690B2 (ja) 2018-06-20
JP2018154641A (ja) 2018-10-04
AU2019210662B2 (en) 2021-07-01
US9822347B2 (en) 2017-11-21
CA2894539C (en) 2021-09-28
US20220220458A1 (en) 2022-07-14
EP2931265B3 (en) 2023-04-05
ES2665323T7 (es) 2023-06-15
EP2931265A4 (en) 2016-08-31
EP3326622A1 (en) 2018-05-30
EP2931265A1 (en) 2015-10-21
US20180030422A1 (en) 2018-02-01
CA2894539A1 (en) 2014-06-19
ES2862335T3 (es) 2021-10-07

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