MX2020007130A - Métodos para el tratamiento de cánceres metastásicos utilizando receptores señuelo axl. - Google Patents
Métodos para el tratamiento de cánceres metastásicos utilizando receptores señuelo axl.Info
- Publication number
- MX2020007130A MX2020007130A MX2020007130A MX2020007130A MX2020007130A MX 2020007130 A MX2020007130 A MX 2020007130A MX 2020007130 A MX2020007130 A MX 2020007130A MX 2020007130 A MX2020007130 A MX 2020007130A MX 2020007130 A MX2020007130 A MX 2020007130A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- metastatic cancers
- axl
- treating metastatic
- decoy receptors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6815—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Marine Sciences & Fisheries (AREA)
Abstract
Se proporcionan composiciones y métodos para tratar un cáncer metastásico humano en un mamífero mediante la administración de una dosis terapéutica de una composición farmacéutica que inhibe la actividad de la proteína AXL, por ejemplo mediante la inhibición de la interacción de unión entre AXL y su ligando GAS6.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762581671P | 2017-11-04 | 2017-11-04 | |
US201862618916P | 2018-01-18 | 2018-01-18 | |
US201862681944P | 2018-06-07 | 2018-06-07 | |
PCT/US2018/059218 WO2019090227A1 (en) | 2017-11-04 | 2018-11-05 | Methods of treating metastatic cancers using axl decoy receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020007130A true MX2020007130A (es) | 2021-02-15 |
Family
ID=66333375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020007130A MX2020007130A (es) | 2017-11-04 | 2018-11-05 | Métodos para el tratamiento de cánceres metastásicos utilizando receptores señuelo axl. |
Country Status (9)
Country | Link |
---|---|
US (2) | US20200289613A1 (es) |
EP (1) | EP3703731A4 (es) |
JP (1) | JP7286179B2 (es) |
KR (1) | KR20200085307A (es) |
CN (1) | CN111565742B (es) |
AU (1) | AU2018359863A1 (es) |
CA (1) | CA3080732A1 (es) |
MX (1) | MX2020007130A (es) |
WO (1) | WO2019090227A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230084893A1 (en) * | 2020-01-06 | 2023-03-16 | Aravive Inc | METHODS OF TREATING CLEAR CELL RENAL CELL CARCINOMA (ccRCC) USING AXL DECOY RECEPTORS |
GB202004189D0 (en) * | 2020-03-23 | 2020-05-06 | Bergenbio As | Combination therapy |
AU2021312139A1 (en) * | 2020-07-19 | 2023-03-02 | Aravive Inc. | Diagnostic methods for cancer using AXL decoy receptors |
TW202313044A (zh) * | 2021-08-16 | 2023-04-01 | 大陸商應世生物科技(南京)有限公司 | In10018與pld的聯用 |
CA3231358A1 (en) * | 2021-09-11 | 2023-03-16 | Gail Mcintyre | Methods of treating locally advanced or metastatic pancreatic adenocarcinoma using axl decoy receptors as first-line therapy |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020151508A1 (en) * | 2001-02-09 | 2002-10-17 | Schering Corporation | Methods for treating proliferative diseases |
CN102281875B (zh) * | 2009-01-16 | 2017-09-22 | 里格尔药品股份有限公司 | 预防、治疗或应对转移癌的使用axl抑制剂的组合疗法 |
ES2928111T3 (es) * | 2010-01-22 | 2022-11-15 | Univ Leland Stanford Junior | Inhibición de la señalización AXL en terapia antimetastásica |
US9074192B2 (en) * | 2010-01-22 | 2015-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL signaling in anti-metastatic therapy |
ES2862335T3 (es) * | 2012-12-14 | 2021-10-07 | Univ Leland Stanford Junior | Péptidos de AXL modificados y su uso en la inhibición de la señalización de AXL en terapia anti-metastásica |
CA2971406A1 (en) * | 2014-12-18 | 2016-06-23 | Aravive Biologics, Inc. | Antifibrotic activity of gas6 inhibitor |
ES2848118T3 (es) * | 2015-08-20 | 2021-08-05 | Ipsen Biopharm Ltd | Terapia de combinación que usa irinotecán liposomal y un inhibidor de PARP para el tratamiento del cáncer |
US20180140679A1 (en) * | 2016-11-23 | 2018-05-24 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of axl receptor activity in combination with cytoreductive therapy |
-
2018
- 2018-11-05 CA CA3080732A patent/CA3080732A1/en active Pending
- 2018-11-05 WO PCT/US2018/059218 patent/WO2019090227A1/en unknown
- 2018-11-05 JP JP2020523776A patent/JP7286179B2/ja active Active
- 2018-11-05 KR KR1020207016082A patent/KR20200085307A/ko not_active Application Discontinuation
- 2018-11-05 MX MX2020007130A patent/MX2020007130A/es unknown
- 2018-11-05 AU AU2018359863A patent/AU2018359863A1/en active Pending
- 2018-11-05 CN CN201880084046.2A patent/CN111565742B/zh active Active
- 2018-11-05 US US16/761,246 patent/US20200289613A1/en not_active Abandoned
- 2018-11-05 EP EP18872866.1A patent/EP3703731A4/en active Pending
-
2023
- 2023-08-01 US US18/228,879 patent/US20240009271A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3703731A4 (en) | 2021-07-21 |
JP7286179B2 (ja) | 2023-06-05 |
AU2018359863A1 (en) | 2020-07-02 |
RU2020116224A (ru) | 2021-12-06 |
CN111565742A (zh) | 2020-08-21 |
RU2020116224A3 (es) | 2022-05-06 |
US20240009271A1 (en) | 2024-01-11 |
CN111565742B (zh) | 2024-03-01 |
WO2019090227A1 (en) | 2019-05-09 |
CA3080732A1 (en) | 2019-05-09 |
EP3703731A1 (en) | 2020-09-09 |
US20200289613A1 (en) | 2020-09-17 |
KR20200085307A (ko) | 2020-07-14 |
JP2021502334A (ja) | 2021-01-28 |
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