DK3326622T3 - Modificerede peptider og deres anvendelse ved hæmning af AXL-signalering inden for anti-metastaseterapi - Google Patents
Modificerede peptider og deres anvendelse ved hæmning af AXL-signalering inden for anti-metastaseterapi Download PDFInfo
- Publication number
- DK3326622T3 DK3326622T3 DK17196662.5T DK17196662T DK3326622T3 DK 3326622 T3 DK3326622 T3 DK 3326622T3 DK 17196662 T DK17196662 T DK 17196662T DK 3326622 T3 DK3326622 T3 DK 3326622T3
- Authority
- DK
- Denmark
- Prior art keywords
- modified peptides
- axl signaling
- inhibiting axl
- metastasis therapy
- metastasis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261737276P | 2012-12-14 | 2012-12-14 | |
| EP13862780.7A EP2931265B3 (en) | 2012-12-14 | 2013-12-12 | Modified axl peptides and their use in inhibition of axl signaling in anti-metastatic therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3326622T3 true DK3326622T3 (da) | 2021-04-06 |
Family
ID=50934967
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17196662.5T DK3326622T3 (da) | 2012-12-14 | 2013-12-12 | Modificerede peptider og deres anvendelse ved hæmning af AXL-signalering inden for anti-metastaseterapi |
| DK13862780.7T DK2931265T6 (da) | 2012-12-14 | 2013-12-12 | Modificerede AXL-petider og deres anvendelse til inhibering af AXL-signalering i en antimetastatisk terapi |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13862780.7T DK2931265T6 (da) | 2012-12-14 | 2013-12-12 | Modificerede AXL-petider og deres anvendelse til inhibering af AXL-signalering i en antimetastatisk terapi |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US9822347B2 (da) |
| EP (2) | EP2931265B3 (da) |
| JP (2) | JP6345690B2 (da) |
| AU (3) | AU2013359179B2 (da) |
| CA (1) | CA2894539C (da) |
| DK (2) | DK3326622T3 (da) |
| ES (2) | ES2665323T7 (da) |
| FI (1) | FI2931265T6 (da) |
| HK (1) | HK1256071A1 (da) |
| NO (1) | NO3049208T3 (da) |
| PT (2) | PT2931265T (da) |
| WO (1) | WO2014093690A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3241840B1 (en) * | 2010-01-22 | 2022-07-27 | The Board of Trustees of the Leland Stanford Junior University | Inhibition of axl signaling in anti-metastatic therapy |
| US9074192B2 (en) * | 2010-01-22 | 2015-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL signaling in anti-metastatic therapy |
| WO2013090776A1 (en) | 2011-12-15 | 2013-06-20 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl/gas6 signaling in the treatment of disease |
| WO2014093690A1 (en) | 2012-12-14 | 2014-06-19 | The Board Of Trustees Of The Leland Stanford Junior University | Modified axl peptides and their use in inhibition of axl signaling in anti-metastatic therapy |
| CA2909669C (en) | 2014-10-20 | 2023-12-12 | Ruga Corporation | Antiviral activity of gas6 inhibitor |
| US10876176B2 (en) * | 2014-12-18 | 2020-12-29 | Aravive Biologics, Inc. | Antifibrotic activity of GAS6 inhibitor |
| KR20200085307A (ko) * | 2017-11-04 | 2020-07-14 | 아라바이브 바이올로직스, 인크. | Axl 유인 수용체를 이용한 전이성 암의 치료 방법 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| EP0394827A1 (en) | 1989-04-26 | 1990-10-31 | F. Hoffmann-La Roche Ag | Chimaeric CD4-immunoglobulin polypeptides |
| US5538861A (en) | 1994-07-29 | 1996-07-23 | Amgen Inc. | DNA encoding a stimulating factor for the axl receptor |
| US20030166109A1 (en) | 1997-09-18 | 2003-09-04 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| EP1382969A1 (en) | 2002-07-17 | 2004-01-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Diagnosis and prevention of cancer cell invasion |
| AU2003304180A1 (en) | 2002-09-24 | 2005-01-04 | Dow, Kenneth, Centocor, Inc. | Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses |
| JP2006524496A (ja) | 2003-04-18 | 2006-11-02 | ノバルティス アクチエンゲゼルシャフト | 骨関節炎の診断および処置のためのチロシンキナーゼを標的化する方法および組成物 |
| JP2005278631A (ja) | 2004-03-04 | 2005-10-13 | National Institute Of Advanced Industrial & Technology | Ａｘｌリガンド結合領域蛋白質、その製造方法及びそれを用いたスクリーニング方法 |
| JP2008522162A (ja) | 2004-11-24 | 2008-06-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド | Ｍｅｒの診断用および治療用の作用薬 |
| JP5219029B2 (ja) | 2005-05-02 | 2013-06-26 | 東レ株式会社 | 食道ガン及び食道ガン転移診断のための組成物及び方法 |
| WO2008098139A2 (en) | 2007-02-07 | 2008-08-14 | The Regents Of The University Of Colorado | Axl tyrosine kinase inhibitors and methods of making and using the same |
| US7998966B2 (en) | 2007-04-13 | 2011-08-16 | Supergen, Inc. | Axl kinase inhibitors |
| WO2009005813A1 (en) | 2007-07-02 | 2009-01-08 | Wyeth | Modulators of axl for use in treating bone disorders |
| WO2010014755A1 (en) * | 2008-07-29 | 2010-02-04 | The Regents Of The University Of Colorado | Methods and compounds for enhancing anti-cancer therapy |
| JP2012512640A (ja) * | 2008-12-19 | 2012-06-07 | ノバルティス アーゲー | 自己免疫および炎症性障害の処置に使用するための可溶性ポリペプチド |
| US8841424B2 (en) * | 2009-05-11 | 2014-09-23 | U3 Pharma Gmbh | Humanized AXL antibodies |
| US9074192B2 (en) | 2010-01-22 | 2015-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL signaling in anti-metastatic therapy |
| EP3241840B1 (en) * | 2010-01-22 | 2022-07-27 | The Board of Trustees of the Leland Stanford Junior University | Inhibition of axl signaling in anti-metastatic therapy |
| JP6170435B2 (ja) | 2010-11-08 | 2017-07-26 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 改変ノッチンペプチドを含む融合タンパク質及びその使用 |
| WO2013090776A1 (en) * | 2011-12-15 | 2013-06-20 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl/gas6 signaling in the treatment of disease |
| US20150315552A1 (en) | 2012-12-14 | 2015-11-05 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL Signaling in Primary Tumor Therapy |
| WO2014093690A1 (en) | 2012-12-14 | 2014-06-19 | The Board Of Trustees Of The Leland Stanford Junior University | Modified axl peptides and their use in inhibition of axl signaling in anti-metastatic therapy |
| WO2015030849A1 (en) * | 2013-08-30 | 2015-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | High-affinity binding to gas6 |
| CA2909669C (en) * | 2014-10-20 | 2023-12-12 | Ruga Corporation | Antiviral activity of gas6 inhibitor |
| US10876176B2 (en) * | 2014-12-18 | 2020-12-29 | Aravive Biologics, Inc. | Antifibrotic activity of GAS6 inhibitor |
-
2013
- 2013-12-12 WO PCT/US2013/074786 patent/WO2014093690A1/en active Application Filing
- 2013-12-12 DK DK17196662.5T patent/DK3326622T3/da active
- 2013-12-12 CA CA2894539A patent/CA2894539C/en active Active
- 2013-12-12 JP JP2015547567A patent/JP6345690B2/ja active Active
- 2013-12-12 FI FIEP13862780.7T patent/FI2931265T6/fi active
- 2013-12-12 ES ES13862780T patent/ES2665323T7/es active Active
- 2013-12-12 EP EP13862780.7A patent/EP2931265B3/en active Active
- 2013-12-12 DK DK13862780.7T patent/DK2931265T6/da active
- 2013-12-12 PT PT138627807T patent/PT2931265T/pt unknown
- 2013-12-12 AU AU2013359179A patent/AU2013359179B2/en active Active
- 2013-12-12 PT PT171966625T patent/PT3326622T/pt unknown
- 2013-12-12 EP EP17196662.5A patent/EP3326622B1/en active Active
- 2013-12-12 US US14/650,854 patent/US9822347B2/en active Active
- 2013-12-12 ES ES17196662T patent/ES2862335T3/es active Active
-
2014
- 2014-06-30 NO NO14741534A patent/NO3049208T3/no unknown
-
2017
- 2017-10-13 US US15/783,850 patent/US11136563B2/en active Active
- 2017-12-06 AU AU2017272193A patent/AU2017272193A1/en not_active Abandoned
-
2018
- 2018-05-23 JP JP2018098435A patent/JP6832887B2/ja active Active
- 2018-11-27 HK HK18115132.7A patent/HK1256071A1/zh unknown
-
2019
- 2019-08-02 AU AU2019210662A patent/AU2019210662B2/en active Active
-
2021
- 2021-09-02 US US17/465,203 patent/US20220220458A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US9822347B2 (en) | 2017-11-21 |
| US11136563B2 (en) | 2021-10-05 |
| PT3326622T (pt) | 2021-04-07 |
| US20220220458A1 (en) | 2022-07-14 |
| DK2931265T3 (da) | 2018-04-16 |
| HK1256071A1 (zh) | 2019-09-13 |
| FI2931265T6 (fi) | 2023-05-23 |
| EP2931265B1 (en) | 2018-01-31 |
| JP6832887B2 (ja) | 2021-02-24 |
| PT2931265T (pt) | 2018-04-16 |
| AU2017272193A1 (en) | 2017-12-21 |
| ES2862335T3 (es) | 2021-10-07 |
| JP2018154641A (ja) | 2018-10-04 |
| CA2894539C (en) | 2021-09-28 |
| AU2013359179A1 (en) | 2015-07-02 |
| EP2931265A4 (en) | 2016-08-31 |
| CA2894539A1 (en) | 2014-06-19 |
| US20150315553A1 (en) | 2015-11-05 |
| ES2665323T7 (es) | 2023-06-15 |
| EP3326622B1 (en) | 2021-01-20 |
| US20180030422A1 (en) | 2018-02-01 |
| EP2931265A1 (en) | 2015-10-21 |
| EP2931265B3 (en) | 2023-04-05 |
| WO2014093690A1 (en) | 2014-06-19 |
| NO3049208T3 (da) | 2018-04-14 |
| JP6345690B2 (ja) | 2018-06-20 |
| AU2019210662B2 (en) | 2021-07-01 |
| ES2665323T3 (es) | 2018-04-25 |
| JP2016510309A (ja) | 2016-04-07 |
| DK2931265T6 (da) | 2023-05-01 |
| AU2019210662A1 (en) | 2019-08-22 |
| AU2013359179B2 (en) | 2017-10-05 |
| EP3326622A1 (en) | 2018-05-30 |
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