DK2911700T5 - The drug-protein conjugates - Google Patents

Info

Publication number

DK2911700T5

DK2911700T5 DK13786530.9T DK13786530T DK2911700T5 DK 2911700 T5 DK2911700 T5 DK 2911700T5 DK 13786530 T DK13786530 T DK 13786530T DK 2911700 T5 DK2911700 T5 DK 2911700T5

Authority

DK

Denmark

Prior art keywords

group

conjugate

val

auristatin

antibody

Prior art date

2012-10-24

Links

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• 229940009098 aspartate Drugs 0.000 claims description 20
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• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
• IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical group CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims description 13
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