DK2909197T3 - Bicykliske heterocykliske forbindelser og anvendelser deraf ved terapi - Google Patents
Bicykliske heterocykliske forbindelser og anvendelser deraf ved terapi Download PDFInfo
- Publication number
- DK2909197T3 DK2909197T3 DK13780388.8T DK13780388T DK2909197T3 DK 2909197 T3 DK2909197 T3 DK 2909197T3 DK 13780388 T DK13780388 T DK 13780388T DK 2909197 T3 DK2909197 T3 DK 2909197T3
- Authority
- DK
- Denmark
- Prior art keywords
- therapy
- applications
- heterocyclic compounds
- bicyclic heterocyclic
- bicyclic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261716089P | 2012-10-19 | 2012-10-19 | |
| GBGB1218864.5A GB201218864D0 (en) | 2012-10-19 | 2012-10-19 | Bicyclic heterocycle compounds and their uses in therapy |
| PCT/GB2013/052721 WO2014060768A1 (en) | 2012-10-19 | 2013-10-18 | Bicyclic heterocycle compounds and their uses in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2909197T3 true DK2909197T3 (da) | 2020-05-25 |
Family
ID=47359191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13780388.8T DK2909197T3 (da) | 2012-10-19 | 2013-10-18 | Bicykliske heterocykliske forbindelser og anvendelser deraf ved terapi |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9663512B2 (enExample) |
| EP (1) | EP2909197B1 (enExample) |
| JP (1) | JP6324976B2 (enExample) |
| KR (1) | KR102299832B1 (enExample) |
| CN (1) | CN104870440B (enExample) |
| CA (1) | CA2888112C (enExample) |
| DK (1) | DK2909197T3 (enExample) |
| ES (1) | ES2794009T3 (enExample) |
| GB (1) | GB201218864D0 (enExample) |
| WO (1) | WO2014060768A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201106814D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compounds |
| GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| US9980973B2 (en) | 2012-10-19 | 2018-05-29 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| WO2015092420A1 (en) | 2013-12-20 | 2015-06-25 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
| WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
| WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
| GB201506871D0 (en) | 2015-04-22 | 2015-06-03 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| CA3020792A1 (en) | 2016-04-20 | 2017-10-26 | Glaxosmithkline Intellectual Property Development Limited | Conjugates comprising ripk2 inhibitors |
| GB201610147D0 (en) | 2016-06-10 | 2016-07-27 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| CN106265764B (zh) | 2016-08-18 | 2018-03-16 | 广州威溶特医药科技有限公司 | Iap抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用 |
| EP4310496A3 (en) | 2017-07-12 | 2024-12-04 | Dana-Farber Cancer Institute, Inc. | Compounds for tau protein degradation |
| EP3866801A4 (en) | 2018-10-16 | 2022-11-09 | Dana-Farber Cancer Institute, Inc. | DEGRADER OF WILD-TYPE AND MUTANT FORMS OF LRRK2 |
| EP3947368B1 (en) | 2019-04-04 | 2025-09-03 | Dana-Farber Cancer Institute, Inc. | Bifunctional compounds comprising a cdk2/5 ligand, a linker and a e3 ubiquitin ligase binding degron for the treatment of cancer |
| WO2021011913A1 (en) | 2019-07-17 | 2021-01-21 | Arvinas Operations, Inc. | Tau-protein targeting compounds and associated methods of use |
| US20230183234A1 (en) | 2020-05-04 | 2023-06-15 | Otsuka Pharmaceutical Co., Ltd. | Iap antagonist compounds and intermediates and methods for synthesizing the same |
| TWI864633B (zh) * | 2022-03-11 | 2024-12-01 | 大陸商蘇州亞盛藥業有限公司 | 作為iap拮抗劑的三環雜環化合物 |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
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| TW218875B (enExample) | 1992-03-09 | 1994-01-11 | Takeda Pharm Industry Co Ltd | |
| NZ321575A (en) | 1995-10-30 | 1999-05-28 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives |
| EP0778277B1 (en) | 1995-12-08 | 2003-06-25 | Pfizer Inc. | Substituted heterocyclic derivatives as CRF antagonists |
| DE69717268T2 (de) | 1996-02-22 | 2003-09-04 | Bristol-Myers Squibb Pharma Co., Wilmington | M-amidinophenyl-analoga als faktor-xa-inhibitoren |
| CA2249601A1 (en) | 1996-04-03 | 1997-10-23 | Thorsten E. Fisher | Inhibitors of farnesyl-protein transferase |
| EP0912513A1 (en) | 1996-06-28 | 1999-05-06 | Merck & Co., Inc. | Fibrinogen receptor antagonist prodrugs |
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| WO1998050346A2 (en) | 1997-04-18 | 1998-11-12 | Smithkline Beecham Plc | Acetamide and urea derivatives, process for their preparation and their use in the treatment of cns disorders |
| IL132409A0 (en) | 1997-04-18 | 2001-03-19 | Smithkline Beecham Plc | Indole derivatives having combined 5ht1a 5ht1b and 5ht1d receptor antagonist activity |
| US6084098A (en) | 1999-02-26 | 2000-07-04 | Neurogen Corporation | Benzylpiperazinyl and piperidinyl ethanone derivatives: dopamine receptor subtype specific ligands |
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| GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| WO2015092420A1 (en) | 2013-12-20 | 2015-06-25 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
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-
2012
- 2012-10-19 GB GBGB1218864.5A patent/GB201218864D0/en not_active Ceased
-
2013
- 2013-10-18 CA CA2888112A patent/CA2888112C/en active Active
- 2013-10-18 US US14/436,364 patent/US9663512B2/en active Active
- 2013-10-18 KR KR1020157012697A patent/KR102299832B1/ko active Active
- 2013-10-18 JP JP2015537355A patent/JP6324976B2/ja active Active
- 2013-10-18 DK DK13780388.8T patent/DK2909197T3/da active
- 2013-10-18 WO PCT/GB2013/052721 patent/WO2014060768A1/en not_active Ceased
- 2013-10-18 EP EP13780388.8A patent/EP2909197B1/en active Active
- 2013-10-18 ES ES13780388T patent/ES2794009T3/es active Active
- 2013-10-18 CN CN201380066425.6A patent/CN104870440B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015534975A (ja) | 2015-12-07 |
| CN104870440A (zh) | 2015-08-26 |
| EP2909197B1 (en) | 2020-03-04 |
| ES2794009T3 (es) | 2020-11-17 |
| KR20150072436A (ko) | 2015-06-29 |
| US9663512B2 (en) | 2017-05-30 |
| CA2888112C (en) | 2021-03-30 |
| EP2909197A1 (en) | 2015-08-26 |
| CN104870440B (zh) | 2018-10-19 |
| CA2888112A1 (en) | 2014-04-24 |
| KR102299832B1 (ko) | 2021-09-07 |
| US20150266873A1 (en) | 2015-09-24 |
| JP6324976B2 (ja) | 2018-05-16 |
| GB201218864D0 (en) | 2012-12-05 |
| WO2014060768A1 (en) | 2014-04-24 |
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