DK2909198T3 - Bicykliske heterocykliske forbindelser og anvendelser deraf ved terapi - Google Patents
Bicykliske heterocykliske forbindelser og anvendelser deraf ved terapi Download PDFInfo
- Publication number
- DK2909198T3 DK2909198T3 DK13780389.6T DK13780389T DK2909198T3 DK 2909198 T3 DK2909198 T3 DK 2909198T3 DK 13780389 T DK13780389 T DK 13780389T DK 2909198 T3 DK2909198 T3 DK 2909198T3
- Authority
- DK
- Denmark
- Prior art keywords
- therapy
- heterocyclic compounds
- bicyclic heterocyclic
- bicyclic
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261716084P | 2012-10-19 | 2012-10-19 | |
| GBGB1218850.4A GB201218850D0 (en) | 2012-10-19 | 2012-10-19 | Bicyclic heterocycle compounds and their uses in therapy |
| PCT/GB2013/052723 WO2014060770A1 (en) | 2012-10-19 | 2013-10-18 | Bicyclic heterocycle compounds and their uses in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2909198T3 true DK2909198T3 (da) | 2020-12-21 |
Family
ID=47359182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13780389.6T DK2909198T3 (da) | 2012-10-19 | 2013-10-18 | Bicykliske heterocykliske forbindelser og anvendelser deraf ved terapi |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9617248B2 (da) |
| EP (1) | EP2909198B1 (da) |
| KR (1) | KR102298474B1 (da) |
| CN (1) | CN104870442B (da) |
| CA (1) | CA2887912C (da) |
| DK (1) | DK2909198T3 (da) |
| ES (1) | ES2834462T3 (da) |
| GB (1) | GB201218850D0 (da) |
| WO (1) | WO2014060770A1 (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201106814D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compounds |
| GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| US9980973B2 (en) | 2012-10-19 | 2018-05-29 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| SG11201604795RA (en) | 2013-12-20 | 2016-07-28 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
| WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
| CA3020792A1 (en) | 2016-04-20 | 2017-10-26 | Glaxosmithkline Intellectual Property Development Limited | Conjugates comprising ripk2 inhibitors |
| WO2017194390A1 (en) * | 2016-05-09 | 2017-11-16 | F. Hoffmann-La Roche Ag | Dimeric compounds |
| CN106265764B (zh) | 2016-08-18 | 2018-03-16 | 广州威溶特医药科技有限公司 | Iap抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用 |
| CN107099576A (zh) * | 2017-06-15 | 2017-08-29 | 大连理工大学 | 一种细胞周期阻滞剂kr在人乳腺癌细胞中的应用 |
| US10800745B2 (en) * | 2017-08-18 | 2020-10-13 | Purdue Research Foundation | Methods for 1,4-diazo n-heterocycle synthesis |
| JP7515175B2 (ja) | 2018-07-31 | 2024-07-12 | ファイメクス株式会社 | 複素環化合物 |
| GB201815018D0 (en) * | 2018-09-14 | 2018-10-31 | Univ Oxford Innovation Ltd | Enantiomeric compounds |
| JPWO2021020585A1 (da) | 2019-07-31 | 2021-02-04 | ||
| US20230183234A1 (en) | 2020-05-04 | 2023-06-15 | Otsuka Pharmaceutical Co., Ltd. | Iap antagonist compounds and intermediates and methods for synthesizing the same |
| KR20230020942A (ko) * | 2020-06-04 | 2023-02-13 | 베이진 엘티디 | Iap 길항제로서 피리도[2,3-b][1,4]옥사진 또는 테트라하이드로피리도[2,3-b][1,4]옥사제핀 |
| CN116731016A (zh) * | 2022-03-11 | 2023-09-12 | 苏州亚盛药业有限公司 | 作为iap拮抗剂的三环杂环化合物 |
| AR129423A1 (es) * | 2022-05-27 | 2024-08-21 | Viiv Healthcare Co | Compuestos útiles en la terapia contra el hiv |
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| NZ321575A (en) | 1995-10-30 | 1999-05-28 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives |
| DK0778277T3 (da) | 1995-12-08 | 2003-10-27 | Pfizer | Substituerede heterocycliske derivater som CRF antagonister |
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| TR199902590T2 (xx) | 1997-04-18 | 2000-06-21 | Smithkline Beecham P.L.C. | Birle�ik 5HT1A 5HT1B ve 5HT1D resept�r antagonist aktivitesi olan indol t�revleri. |
| US6084098A (en) | 1999-02-26 | 2000-07-04 | Neurogen Corporation | Benzylpiperazinyl and piperidinyl ethanone derivatives: dopamine receptor subtype specific ligands |
| KR100672186B1 (ko) | 1998-03-31 | 2007-01-19 | 아카디아 파마슈티칼스 인코포레이티드 | 무스카린 수용체에 대해 활성을 갖는 화합물 |
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| HUP0104766A3 (en) | 1998-08-26 | 2002-08-28 | Aventis Pharma Ltd West Mallin | Aza-bicycles which modulate the inhibition of cell adhesion and medicaments containing them |
| GB9905010D0 (en) | 1999-03-04 | 1999-04-28 | Merck Sharp & Dohme | Therapeutic agents |
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| GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| SG11201604795RA (en) | 2013-12-20 | 2016-07-28 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| JP6510539B2 (ja) | 2014-01-09 | 2019-05-08 | ザ ジェイ． デヴィッド グラッドストーン インスティテューツ， ア テスタメンタリー トラスト エスタブリッシュド アンダー ザ ウィル オブ ジェイ． デヴィッド グラッドストーン | 置換ベンゾオキサジン及び関連化合物 |
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2012
- 2012-10-19 GB GBGB1218850.4A patent/GB201218850D0/en not_active Ceased
-
2013
- 2013-10-18 CN CN201380066497.0A patent/CN104870442B/zh active Active
- 2013-10-18 KR KR1020157012695A patent/KR102298474B1/ko active IP Right Grant
- 2013-10-18 EP EP13780389.6A patent/EP2909198B1/en active Active
- 2013-10-18 WO PCT/GB2013/052723 patent/WO2014060770A1/en active Application Filing
- 2013-10-18 CA CA2887912A patent/CA2887912C/en active Active
- 2013-10-18 DK DK13780389.6T patent/DK2909198T3/da active
- 2013-10-18 US US14/436,319 patent/US9617248B2/en active Active
- 2013-10-18 ES ES13780389T patent/ES2834462T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2887912C (en) | 2021-06-22 |
| US9617248B2 (en) | 2017-04-11 |
| WO2014060770A1 (en) | 2014-04-24 |
| US20150353537A1 (en) | 2015-12-10 |
| KR102298474B1 (ko) | 2021-09-03 |
| CN104870442B (zh) | 2018-10-19 |
| KR20150072434A (ko) | 2015-06-29 |
| CA2887912A1 (en) | 2014-04-24 |
| CN104870442A (zh) | 2015-08-26 |
| EP2909198A1 (en) | 2015-08-26 |
| EP2909198B1 (en) | 2020-10-14 |
| ES2834462T3 (es) | 2021-06-17 |
| GB201218850D0 (en) | 2012-12-05 |
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