JP6324976B2 - 二環式複素環化合物およびそれらの治療での使用 - Google Patents

二環式複素環化合物およびそれらの治療での使用 Download PDF

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Publication number
JP6324976B2
JP6324976B2 JP2015537355A JP2015537355A JP6324976B2 JP 6324976 B2 JP6324976 B2 JP 6324976B2 JP 2015537355 A JP2015537355 A JP 2015537355A JP 2015537355 A JP2015537355 A JP 2015537355A JP 6324976 B2 JP6324976 B2 JP 6324976B2
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methyl
alkyl
dimethyl
compound
pyrrolo
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Japanese (ja)
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JP2015534975A (ja
JP2015534975A5 (enExample
Inventor
ジャンニ、チェサーリ
クリストファー、ノルベルト、ジョンソン
リー、ウィリアム、ページ
アレッシア、ミルマッジ
スティーブン、ハワード
ゴードン、サクスティ
トーマス、ダニエル、ハイトマン
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Astex Therapeutics Ltd
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Astex Therapeutics Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2015537355A 2012-10-19 2013-10-18 二環式複素環化合物およびそれらの治療での使用 Active JP6324976B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261716089P 2012-10-19 2012-10-19
US61/716,089 2012-10-19
GBGB1218864.5A GB201218864D0 (en) 2012-10-19 2012-10-19 Bicyclic heterocycle compounds and their uses in therapy
GB1218864.5 2012-10-19
PCT/GB2013/052721 WO2014060768A1 (en) 2012-10-19 2013-10-18 Bicyclic heterocycle compounds and their uses in therapy

Publications (3)

Publication Number Publication Date
JP2015534975A JP2015534975A (ja) 2015-12-07
JP2015534975A5 JP2015534975A5 (enExample) 2016-12-08
JP6324976B2 true JP6324976B2 (ja) 2018-05-16

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JP2015537355A Active JP6324976B2 (ja) 2012-10-19 2013-10-18 二環式複素環化合物およびそれらの治療での使用

Country Status (10)

Country Link
US (1) US9663512B2 (enExample)
EP (1) EP2909197B1 (enExample)
JP (1) JP6324976B2 (enExample)
KR (1) KR102299832B1 (enExample)
CN (1) CN104870440B (enExample)
CA (1) CA2888112C (enExample)
DK (1) DK2909197T3 (enExample)
ES (1) ES2794009T3 (enExample)
GB (1) GB201218864D0 (enExample)
WO (1) WO2014060768A1 (enExample)

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Publication number Publication date
JP2015534975A (ja) 2015-12-07
ES2794009T3 (es) 2020-11-17
KR102299832B1 (ko) 2021-09-07
DK2909197T3 (da) 2020-05-25
US9663512B2 (en) 2017-05-30
EP2909197B1 (en) 2020-03-04
CN104870440B (zh) 2018-10-19
CA2888112C (en) 2021-03-30
US20150266873A1 (en) 2015-09-24
EP2909197A1 (en) 2015-08-26
CA2888112A1 (en) 2014-04-24
CN104870440A (zh) 2015-08-26
WO2014060768A1 (en) 2014-04-24
GB201218864D0 (en) 2012-12-05
KR20150072436A (ko) 2015-06-29

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