DK2864328T3 - Farmaceutisk aktive forbindelser - Google Patents
Farmaceutisk aktive forbindelser Download PDFInfo
- Publication number
- DK2864328T3 DK2864328T3 DK13731470.4T DK13731470T DK2864328T3 DK 2864328 T3 DK2864328 T3 DK 2864328T3 DK 13731470 T DK13731470 T DK 13731470T DK 2864328 T3 DK2864328 T3 DK 2864328T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- compounds
- pharmaceutically acceptable
- solvate
- acceptable salt
- Prior art date
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- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (10)
1. Forbindelse med formel I vist nedenfor:
i hvor: Ri er Br eller Cl; R2 er valgt fra formel II eller formel III vist nedenfor:
hvor Ra er hydrogen eller methyl; eller et farmaceutisk acceptabelt salt eller solvat deraf.
2. Forbindelse ifølge krav 1, hvor Ri er Cl.
3. Forbindelse ifølge krav 1, hvor Ri er Br.
4. Forbindelse ifølge et hvilket som helst af de foregående krav, hvor R2 er med formel II.
5. Forbindelse ifølge et hvilket som helst af kravene 1 til 3, hvor R2 er med formel III.
6. Forbindelse ifølge et hvilket som helst af de foregående krav, der er valgt fra en hvilken som helst af: 6- chlor-7-(4-(4-chlorbenzyl)piperazin-l-yl)-2-(l,3-dimethyl-lF/-pyrazol-4-yl)-3F/-imidazo[4,5-b]pyridin; 3-((4-(6-chlor-2-(l,3-dimethyl-lF/-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin- 7- yl)piperazin-l-yl)methyl)-l,2,4-oxadiazol; 3-((4-(6-chlor-2-(l,3-dimethyl-lH-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin- 7-yl)piperazin-l-yl)methyl)-5-methyl-l,2,4-oxadiazol; eller et farmaceutisk acceptabelt salt eller solvat deraf.
7. Farmaceutisk sammensætning omfattende en forbindelse ifølge et hvilket som helst af kravene 1 til 6, eller et farmaceutisk acceptabelt salt eller solvat deraf, og én eller flere farmaceutisk acceptable excipienser.
8. Forbindelse ifølge et hvilket som helst af kravene 1 til 6, eller et farmaceutisk acceptabelt salt eller solvat deraf, til anvendelse i terapi.
9. Forbindelse ifølge et hvilket som helst af kravene 1 til 6, eller et farmaceutisk acceptabelt salt eller solvat deraf, til anvendelse i behandlingen af en proliferativ sygdom, såsom cancer.
10. Forbindelse til anvendelse ifølge krav 9, eller et farmaceutisk acceptabelt salt eller solvat deraf, hvor den proliferative sygdom er akut myeloid leukæmi.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1211021.9A GB201211021D0 (en) | 2012-06-21 | 2012-06-21 | Pharmaceutically active compounds |
| PCT/GB2013/051633 WO2013190319A1 (en) | 2012-06-21 | 2013-06-21 | Pharmaceutically active compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2864328T3 true DK2864328T3 (da) | 2018-03-12 |
Family
ID=46641296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13731470.4T DK2864328T3 (da) | 2012-06-21 | 2013-06-21 | Farmaceutisk aktive forbindelser |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9447092B2 (da) |
| EP (1) | EP2864328B8 (da) |
| JP (1) | JP6159397B2 (da) |
| CN (1) | CN104470922B (da) |
| AU (1) | AU2013279040B2 (da) |
| BR (1) | BR112014032142B1 (da) |
| CA (1) | CA2876357C (da) |
| CY (1) | CY1120608T1 (da) |
| DK (1) | DK2864328T3 (da) |
| ES (1) | ES2660159T3 (da) |
| GB (1) | GB201211021D0 (da) |
| HR (1) | HRP20180386T1 (da) |
| HU (1) | HUE036048T2 (da) |
| IN (1) | IN2015MN00045A (da) |
| LT (1) | LT2864328T (da) |
| NO (1) | NO2864328T3 (da) |
| PL (1) | PL2864328T3 (da) |
| PT (1) | PT2864328T (da) |
| RS (1) | RS56996B1 (da) |
| RU (1) | RU2654942C2 (da) |
| SI (1) | SI2864328T1 (da) |
| WO (1) | WO2013190319A1 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201522532D0 (en) * | 2015-12-21 | 2016-02-03 | Cancer Rec Tech Ltd | Novel pyrrolo[3,2-c]pyridine-6-amino derivatives |
| WO2017146253A1 (ja) | 2016-02-26 | 2017-08-31 | 公益財団法人がん研究会 | Ｈｐ１の機能に着目した抗癌剤のスクリーニング方法及び評価系 |
| GB2592622B (en) | 2020-03-04 | 2022-08-03 | Ellipses Pharma Ltd | Formulations of a dual aurora kinase/FLT3 inhibitor |
| GB2596038B (en) * | 2020-03-04 | 2022-12-14 | Ellipses Pharma Ltd | Salts and polymorphic forms of (6-chloro-7-(4-(4-chlorobenzyl)piperazin-1-yl)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-B]pyridine) |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| EP0880508B1 (en) | 1996-02-13 | 2003-04-16 | AstraZeneca AB | Quinazoline derivatives as vegf inhibitors |
| IL125954A (en) | 1996-03-05 | 2003-06-24 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| JP2003535078A (ja) | 2000-05-31 | 2003-11-25 | アストラゼネカ アクチボラグ | 血管損傷活性のあるインドール誘導体 |
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| BR0112224A (pt) | 2000-07-07 | 2003-06-10 | Angiogene Pharm Ltd | Composto, composição farmacêutica, uso de um composto ou de um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo, e, processo para preparar um composto |
| WO2002008213A1 (en) | 2000-07-07 | 2002-01-31 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as angiogenesis inhibitors |
| EP1401831A1 (en) * | 2001-07-03 | 2004-03-31 | Chiron Corporation | Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors |
| TWI372050B (en) * | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| EP2251341A1 (en) * | 2005-07-14 | 2010-11-17 | Astellas Pharma Inc. | Heterocyclic Janus kinase 3 inhibitors |
| ES2526813T3 (es) * | 2005-12-22 | 2015-01-15 | Cancer Research Technology Limited | Inhibidores de enzimas |
| CN101616920A (zh) * | 2007-01-30 | 2009-12-30 | 比奥根艾迪克Ma公司 | 1-H-吡唑并(3,4b)嘧啶衍生物及其作为有丝分裂激酶调节剂的用途 |
| WO2009001021A1 (en) * | 2007-06-26 | 2008-12-31 | Chroma Therapeutics Ltd. | Imidazopyridine derivatives useful as enzyme inhibitors for the treatment of cell proliferative and autoimmune diseases |
| WO2010003133A2 (en) * | 2008-07-03 | 2010-01-07 | Exelixis Inc. | Cdk modulators |
| ES2612503T3 (es) * | 2010-09-14 | 2017-05-17 | Exelixis, Inc. | Compuestos 9H-purina como inhibidores de PI3K-delta y métodos para su preparación |
-
2012
- 2012-06-21 GB GBGB1211021.9A patent/GB201211021D0/en not_active Ceased
-
2013
- 2013-06-21 CN CN201380032901.2A patent/CN104470922B/zh active Active
- 2013-06-21 LT LTEP13731470.4T patent/LT2864328T/lt unknown
- 2013-06-21 WO PCT/GB2013/051633 patent/WO2013190319A1/en active Application Filing
- 2013-06-21 EP EP13731470.4A patent/EP2864328B8/en active Active
- 2013-06-21 US US14/409,042 patent/US9447092B2/en active Active
- 2013-06-21 IN IN45MUN2015 patent/IN2015MN00045A/en unknown
- 2013-06-21 PT PT137314704T patent/PT2864328T/pt unknown
- 2013-06-21 RU RU2015101702A patent/RU2654942C2/ru active
- 2013-06-21 PL PL13731470T patent/PL2864328T3/pl unknown
- 2013-06-21 NO NO13731470A patent/NO2864328T3/no unknown
- 2013-06-21 HU HUE13731470A patent/HUE036048T2/hu unknown
- 2013-06-21 JP JP2015517858A patent/JP6159397B2/ja active Active
- 2013-06-21 AU AU2013279040A patent/AU2013279040B2/en active Active
- 2013-06-21 RS RS20180267A patent/RS56996B1/sr unknown
- 2013-06-21 CA CA2876357A patent/CA2876357C/en active Active
- 2013-06-21 ES ES13731470.4T patent/ES2660159T3/es active Active
- 2013-06-21 SI SI201330965T patent/SI2864328T1/en unknown
- 2013-06-21 BR BR112014032142-6A patent/BR112014032142B1/pt active IP Right Grant
- 2013-06-21 DK DK13731470.4T patent/DK2864328T3/da active
-
2018
- 2018-03-05 HR HRP20180386TT patent/HRP20180386T1/hr unknown
- 2018-03-06 CY CY181100275T patent/CY1120608T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN104470922A (zh) | 2015-03-25 |
| RS56996B1 (sr) | 2018-05-31 |
| JP6159397B2 (ja) | 2017-07-05 |
| GB201211021D0 (en) | 2012-08-01 |
| CY1120608T1 (el) | 2019-12-11 |
| CN104470922B (zh) | 2016-08-24 |
| BR112014032142B1 (pt) | 2022-03-03 |
| NO2864328T3 (da) | 2018-05-05 |
| SI2864328T1 (en) | 2018-04-30 |
| JP2015520222A (ja) | 2015-07-16 |
| AU2013279040B2 (en) | 2017-11-16 |
| RU2654942C2 (ru) | 2018-05-25 |
| IN2015MN00045A (da) | 2015-10-16 |
| PT2864328T (pt) | 2018-03-12 |
| US9447092B2 (en) | 2016-09-20 |
| CA2876357C (en) | 2020-07-14 |
| EP2864328B1 (en) | 2017-12-06 |
| EP2864328B8 (en) | 2018-01-24 |
| LT2864328T (lt) | 2018-04-10 |
| RU2015101702A (ru) | 2016-08-10 |
| CA2876357A1 (en) | 2013-12-27 |
| HRP20180386T1 (hr) | 2018-04-20 |
| HUE036048T2 (hu) | 2018-06-28 |
| ES2660159T3 (es) | 2018-03-21 |
| BR112014032142A2 (pt) | 2017-06-27 |
| US20150266868A1 (en) | 2015-09-24 |
| WO2013190319A1 (en) | 2013-12-27 |
| EP2864328A1 (en) | 2015-04-29 |
| AU2013279040A1 (en) | 2015-01-29 |
| PL2864328T3 (pl) | 2018-06-29 |
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