DK2838883T3 - New phenyl-tetrahydroisoquinoline derivatives - Google Patents

New phenyl-tetrahydroisoquinoline derivatives Download PDF

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Publication number
DK2838883T3
DK2838883T3 DK13716291.3T DK13716291T DK2838883T3 DK 2838883 T3 DK2838883 T3 DK 2838883T3 DK 13716291 T DK13716291 T DK 13716291T DK 2838883 T3 DK2838883 T3 DK 2838883T3
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DK
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Prior art keywords
trifluoromethyl
phenyl
propionamide
tetrahydroisoquinolin
rac
Prior art date
Application number
DK13716291.3T
Other languages
Danish (da)
English (en)
Inventor
Rainer E Martin
Alexander V Mayweg
Peter Mohr
Xuefei Tan
Johannes Aebi
Kurt Amrein
Bernd Kuhn
Yonfu Liu
Hans P Maerki
Benoît Hornsperger
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
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Publication of DK2838883T3 publication Critical patent/DK2838883T3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DK13716291.3T 2012-04-17 2013-04-15 New phenyl-tetrahydroisoquinoline derivatives DK2838883T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNPCT/CN2012/074170 2012-04-17
PCT/EP2013/057761 WO2013156423A1 (en) 2012-04-17 2013-04-15 New phenyl-tetrahydroisoquinoline derivatives

Publications (1)

Publication Number Publication Date
DK2838883T3 true DK2838883T3 (en) 2018-01-15

Family

ID=48095859

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13716291.3T DK2838883T3 (en) 2012-04-17 2013-04-15 New phenyl-tetrahydroisoquinoline derivatives

Country Status (22)

Country Link
US (1) US9187429B2 (ja)
EP (1) EP2838883B1 (ja)
JP (1) JP6144755B2 (ja)
KR (1) KR20150001828A (ja)
CN (1) CN104245674B (ja)
AR (1) AR090678A1 (ja)
CA (1) CA2861060A1 (ja)
DK (1) DK2838883T3 (ja)
ES (1) ES2655066T3 (ja)
HK (1) HK1200817A1 (ja)
HR (1) HRP20171996T1 (ja)
HU (1) HUE035274T2 (ja)
LT (1) LT2838883T (ja)
MX (1) MX2014009712A (ja)
NO (1) NO2838883T3 (ja)
PL (1) PL2838883T3 (ja)
PT (1) PT2838883T (ja)
RS (1) RS56703B1 (ja)
RU (1) RU2014144883A (ja)
SI (1) SI2838883T1 (ja)
TW (1) TW201345895A (ja)
WO (1) WO2013156423A1 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2016116435A (ru) * 2013-10-17 2017-11-22 Ф. Хоффманн-Ля Рош Аг Производные фенил-дигидропиридина в качестве ингибиторов альдостеронсинтазы
RU2016116433A (ru) * 2013-10-17 2017-11-22 Ф. Хоффманн-Ля Рош Аг Новые производные фенил-дигидропиридина в качестве ингибиторов альдостерон синтазы
EP3227300B1 (en) 2014-12-02 2019-06-19 Boehringer Ingelheim International GmbH Aldosterone synthase inhibitors
KR20180094923A (ko) 2015-12-24 2018-08-24 교와 핫꼬 기린 가부시키가이샤 α, β 불포화 아미드 화합물
JP7221202B2 (ja) 2017-06-23 2023-02-13 協和キリン株式会社 α、β不飽和アミド化合物
JP7037711B2 (ja) 2018-03-29 2022-03-17 第一工業製薬株式会社 セラミックスの湿式成形用組成物および湿式成形体の製造方法
EP3962903A1 (en) 2019-05-01 2022-03-09 Boehringer Ingelheim International GmbH (r)-(2-methyloxiran-2-yl)methyl 4-bromobenzenesulfonate
CN113325096B (zh) * 2021-05-08 2022-12-13 石家庄四药有限公司 一种1-(2,3-二甲基苯基)乙醇有关物质的检测方法
WO2024061371A1 (zh) * 2022-09-23 2024-03-28 广州威诺森医药科技有限公司 一种骈环吡啶类甾体合成酶抑制剂及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US20060111394A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
WO2006092430A1 (de) * 2005-03-03 2006-09-08 Universität des Saarlandes Selektive hemmstoffe humaner corticoidsynthasen
CN101440096A (zh) * 2005-07-11 2009-05-27 浙江大学 1-(3＇,4＇,5＇-三取代苯基)-四氢异喹啉类化合物及其用途
US20100240641A1 (en) * 2006-05-26 2010-09-23 Julien Papillon Aldosterone Synthase and/or 11B-hydroxylase Inhibitors
WO2008076336A2 (en) * 2006-12-18 2008-06-26 Novartis Ag Imidazoles as aldosterone synthase inhibitors
DE102008022221A1 (de) * 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
WO2010112799A1 (en) * 2009-02-26 2010-10-07 University Of York Luminophores comprising platinum-ligand complexes
EA201101619A1 (ru) * 2009-05-15 2012-05-30 Новартис Аг Производные 5-пиридин-3-ил-1,3-дигидроиндол-2-она и их применение в качестве модуляторов альдостеронсинтазы и/или cyp11b1
US9353081B2 (en) * 2011-09-23 2016-05-31 Hoffmann-La Roche Inc. Bicyclic dihydroquinoline-2-one derivatives

Also Published As

Publication number Publication date
SI2838883T1 (en) 2018-02-28
HRP20171996T1 (hr) 2018-02-09
TW201345895A (zh) 2013-11-16
HK1200817A1 (en) 2015-08-14
US20130274287A1 (en) 2013-10-17
NO2838883T3 (ja) 2018-04-07
PL2838883T3 (pl) 2018-05-30
AR090678A1 (es) 2014-11-26
RS56703B1 (sr) 2018-03-30
PT2838883T (pt) 2018-01-04
JP2015514732A (ja) 2015-05-21
LT2838883T (lt) 2018-01-25
CN104245674B (zh) 2017-07-11
EP2838883B1 (en) 2017-11-08
MX2014009712A (es) 2014-09-12
ES2655066T3 (es) 2018-02-16
US9187429B2 (en) 2015-11-17
HUE035274T2 (en) 2018-05-02
KR20150001828A (ko) 2015-01-06
JP6144755B2 (ja) 2017-06-07
WO2013156423A1 (en) 2013-10-24
CA2861060A1 (en) 2013-10-24
EP2838883A1 (en) 2015-02-25
CN104245674A (zh) 2014-12-24
RU2014144883A (ru) 2016-06-10

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