DK2838506T3 - Magnesiumsammensætninger til modulering af farmakokinetikken og farmakodynamikken af insulin og smerter på injektionsstedet - Google Patents
Magnesiumsammensætninger til modulering af farmakokinetikken og farmakodynamikken af insulin og smerter på injektionsstedet Download PDFInfo
- Publication number
- DK2838506T3 DK2838506T3 DK13721441.7T DK13721441T DK2838506T3 DK 2838506 T3 DK2838506 T3 DK 2838506T3 DK 13721441 T DK13721441 T DK 13721441T DK 2838506 T3 DK2838506 T3 DK 2838506T3
- Authority
- DK
- Denmark
- Prior art keywords
- pharmacodynamics
- pharmacokinetics
- insulin
- modulating
- pain
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title 1
- 238000002347 injection Methods 0.000 title 1
- 239000007924 injection Substances 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 229910052749 magnesium Inorganic materials 0.000 title 1
- 239000011777 magnesium Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000003285 pharmacodynamic effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261624844P | 2012-04-16 | 2012-04-16 | |
| US201261704066P | 2012-09-21 | 2012-09-21 | |
| US13/826,806 US9381247B2 (en) | 2012-04-16 | 2013-03-14 | Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain |
| PCT/US2013/036742 WO2013158618A1 (en) | 2012-04-16 | 2013-04-16 | Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2838506T3 true DK2838506T3 (da) | 2021-01-18 |
Family
ID=48326401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13721441.7T DK2838506T3 (da) | 2012-04-16 | 2013-04-16 | Magnesiumsammensætninger til modulering af farmakokinetikken og farmakodynamikken af insulin og smerter på injektionsstedet |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9381247B2 (enExample) |
| EP (2) | EP3827813A1 (enExample) |
| JP (2) | JP6422855B2 (enExample) |
| KR (1) | KR101966484B1 (enExample) |
| CN (1) | CN104394847A (enExample) |
| AU (1) | AU2013249495B2 (enExample) |
| CA (1) | CA2869883A1 (enExample) |
| CY (1) | CY1123825T1 (enExample) |
| DK (1) | DK2838506T3 (enExample) |
| ES (1) | ES2854874T3 (enExample) |
| HK (2) | HK1203371A1 (enExample) |
| HR (1) | HRP20210417T1 (enExample) |
| HU (1) | HUE053303T2 (enExample) |
| IL (1) | IL234987A0 (enExample) |
| IN (1) | IN2014DN08417A (enExample) |
| LT (1) | LT2838506T (enExample) |
| MX (1) | MX2014012245A (enExample) |
| PL (1) | PL2838506T3 (enExample) |
| PT (1) | PT2838506T (enExample) |
| RS (1) | RS61533B1 (enExample) |
| RU (1) | RU2014145846A (enExample) |
| SG (1) | SG11201406491PA (enExample) |
| SI (1) | SI2838506T1 (enExample) |
| WO (1) | WO2013158618A1 (enExample) |
| ZA (1) | ZA201407410B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2670969T3 (es) | 2012-11-13 | 2018-06-04 | Adocia | Formulación de acción rápida de insulina que comprende un compuesto aniónico sustituido |
| KR102351111B1 (ko) * | 2014-01-13 | 2022-01-14 | 써멀린 다이어비티즈, 엘엘씨 | 초속효성 인슐린 제형 및 약제학적 전달 시스템 |
| US20150273022A1 (en) * | 2014-02-10 | 2015-10-01 | Biodel Inc. | Stabilized ultra-rapid-acting insulin formulations |
| JO3624B1 (ar) * | 2014-05-08 | 2020-08-27 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
| WO2016007935A2 (en) | 2014-07-10 | 2016-01-14 | Companion Medical, Inc. | Medicine administering system including injection pen and companion device |
| TW201630622A (zh) | 2014-12-16 | 2016-09-01 | 美國禮來大藥廠 | 速效胰島素組合物 |
| CN107428814A (zh) * | 2015-01-20 | 2017-12-01 | 卡斯西部储备大学 | 具有选择性信号传导特性和降低的促有丝分裂性的胰岛素类似物 |
| JO3749B1 (ar) * | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
| WO2017132577A1 (en) | 2016-01-29 | 2017-08-03 | Companion Medical, Inc. | Automatic medication delivery tracking |
| GB201607918D0 (en) | 2016-05-06 | 2016-06-22 | Arecor Ltd | Novel formulations |
| EP3518893A1 (en) | 2016-09-29 | 2019-08-07 | Arecor Limited | Novel formulations |
| GB201707189D0 (en) * | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
| KR20190140048A (ko) | 2017-06-01 | 2019-12-18 | 일라이 릴리 앤드 캄파니 | 신속-작용 인슐린 조성물 |
| WO2018227163A1 (en) | 2017-06-09 | 2018-12-13 | Companion Medical, Inc. | Intelligent medication delivery systems and methods |
| EP3694583B1 (en) | 2017-10-12 | 2026-05-06 | Medtronic MiniMed, Inc. | Intelligent medication delivery systems and methods for dose recommendation and management |
| AU2018383743A1 (en) | 2017-12-12 | 2020-07-23 | Bigfoot Biomedical, Inc. | Therapy assist information and/or tracking device and related methods and systems |
| US11116899B2 (en) | 2017-12-12 | 2021-09-14 | Bigfoot Biomedical, Inc. | User interface for diabetes management systems and devices |
| US11083852B2 (en) | 2017-12-12 | 2021-08-10 | Bigfoot Biomedical, Inc. | Insulin injection assistance systems, methods, and devices |
| US11464459B2 (en) | 2017-12-12 | 2022-10-11 | Bigfoot Biomedical, Inc. | User interface for diabetes management systems including flash glucose monitor |
| US10987464B2 (en) | 2017-12-12 | 2021-04-27 | Bigfoot Biomedical, Inc. | Pen cap for insulin injection pens and associated methods and systems |
| US11197964B2 (en) | 2017-12-12 | 2021-12-14 | Bigfoot Biomedical, Inc. | Pen cap for medication injection pen having temperature sensor |
| US11077243B2 (en) | 2017-12-12 | 2021-08-03 | Bigfoot Biomedical, Inc. | Devices, systems, and methods for estimating active medication from injections |
| CA3094237A1 (en) | 2018-04-04 | 2019-10-10 | Arecor Limited | Medical infusion pump system for the delivery of an insulin compound |
| US11664107B2 (en) | 2018-05-08 | 2023-05-30 | Medtronic Minimed, Inc. | Intelligent medication delivery systems and methods using a prescription-regulated software application |
| US10898653B2 (en) | 2018-05-08 | 2021-01-26 | Companion Medical, Inc. | Intelligent medication delivery systems and methods for dose setting and dispensing monitoring |
| USD893020S1 (en) | 2018-05-11 | 2020-08-11 | Companion Medical, Inc. | Injection pen |
| US11587663B2 (en) | 2018-06-20 | 2023-02-21 | Medtronic Minimed, Inc. | Intelligent medication delivery systems and methods for medicine dose calculation and reporting |
| USD892819S1 (en) | 2018-06-20 | 2020-08-11 | Companion Medical, Inc. | Display screen with graphical user interface |
| WO2019243627A1 (fr) | 2018-06-23 | 2019-12-26 | Adocia | Dispositif pour injecter une solution d'insuline(s) |
| FR3083985A1 (fr) | 2018-07-23 | 2020-01-24 | Adocia | Dispositif pour injecter une solution d'insuline(s) |
| FR3083984A1 (fr) | 2018-07-23 | 2020-01-24 | Adocia | Dispositif pour injecter une solution d'insuline(s) |
| US12205699B1 (en) | 2018-10-30 | 2025-01-21 | Bigfoot Biomedical, Inc. | Method of pairing therapy devices using shared secrets, and related systems, methods and devices |
| US11948671B2 (en) | 2019-04-11 | 2024-04-02 | Medtronic Minimed, Inc. | Intelligent accessories for medicine dispensing device |
| EP4225352A4 (en) * | 2020-10-08 | 2024-01-10 | Dr. Mary Morris & Associates, LLC | Methods and compositions for the treatment and prevention of type 1 diabetes |
| US11701473B2 (en) | 2021-06-23 | 2023-07-18 | Medtronic Minimed, Inc. | Reusable injection pens |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4196196A (en) | 1978-06-19 | 1980-04-01 | Tiholiz Ivan C | Divalen/monovalent bipolar cation therapy for enhancement of tissue perfusion and reperfusion in disease states |
| PH23446A (en) * | 1986-10-20 | 1989-08-07 | Novo Industri As | Peptide preparations |
| DK503386D0 (da) * | 1986-10-20 | 1986-10-20 | Novo Industri As | Peptidpraeparater |
| EP2243827B2 (en) | 1996-08-30 | 2017-11-22 | Life Technologies Corporation | Serum-free mammalian cell culture medium, and uses thereof |
| DE69924232D1 (de) | 1998-01-09 | 2005-04-21 | Novo Nordisk As | Stabilisierte insulin-zubereitungen |
| US20080085298A1 (en) | 2004-03-12 | 2008-04-10 | Biodel, Inc. | Rapid Mucosal Gel or Film Insulin Compositions |
| PL2319500T3 (pl) | 2004-03-12 | 2013-05-31 | Biodel Inc | Szybko działające kompozycje do dostarczania leku |
| US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
| US20080096800A1 (en) | 2004-03-12 | 2008-04-24 | Biodel, Inc. | Rapid mucosal gel or film insulin compositions |
| CN105123670B (zh) | 2007-02-17 | 2018-12-14 | 哈佛学院董事会 | 用于进行组织保存的组合物以及方法 |
| TWI394580B (zh) | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
| US9060927B2 (en) * | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
| FR2943538B1 (fr) * | 2009-03-27 | 2011-05-20 | Adocia | Formulation a action rapide d'insuline recombinante humaine |
| US20120178675A1 (en) | 2010-07-07 | 2012-07-12 | Biodel Inc. | Compositions And Methods For Modulating The Pharmacokinetics and Pharmacodynamics of Insulin |
-
2013
- 2013-03-14 US US13/826,806 patent/US9381247B2/en active Active
- 2013-04-16 WO PCT/US2013/036742 patent/WO2013158618A1/en not_active Ceased
- 2013-04-16 HK HK15103911.3A patent/HK1203371A1/xx unknown
- 2013-04-16 CN CN201380029323.7A patent/CN104394847A/zh active Pending
- 2013-04-16 HK HK15108257.4A patent/HK1207577A1/xx unknown
- 2013-04-16 PT PT137214417T patent/PT2838506T/pt unknown
- 2013-04-16 IN IN8417DEN2014 patent/IN2014DN08417A/en unknown
- 2013-04-16 MX MX2014012245A patent/MX2014012245A/es unknown
- 2013-04-16 RS RS20210209A patent/RS61533B1/sr unknown
- 2013-04-16 ES ES13721441T patent/ES2854874T3/es active Active
- 2013-04-16 SG SG11201406491PA patent/SG11201406491PA/en unknown
- 2013-04-16 KR KR1020147032221A patent/KR101966484B1/ko active Active
- 2013-04-16 PL PL13721441T patent/PL2838506T3/pl unknown
- 2013-04-16 RU RU2014145846A patent/RU2014145846A/ru not_active Application Discontinuation
- 2013-04-16 HU HUE13721441A patent/HUE053303T2/hu unknown
- 2013-04-16 EP EP20215156.9A patent/EP3827813A1/en not_active Withdrawn
- 2013-04-16 HR HRP20210417TT patent/HRP20210417T1/hr unknown
- 2013-04-16 SI SI201331836T patent/SI2838506T1/sl unknown
- 2013-04-16 JP JP2015505989A patent/JP6422855B2/ja active Active
- 2013-04-16 EP EP13721441.7A patent/EP2838506B1/en active Active
- 2013-04-16 DK DK13721441.7T patent/DK2838506T3/da active
- 2013-04-16 AU AU2013249495A patent/AU2013249495B2/en active Active
- 2013-04-16 LT LTEP13721441.7T patent/LT2838506T/lt unknown
- 2013-04-16 CA CA2869883A patent/CA2869883A1/en not_active Abandoned
-
2014
- 2014-10-05 IL IL234987A patent/IL234987A0/en unknown
- 2014-10-13 ZA ZA2014/07410A patent/ZA201407410B/en unknown
-
2018
- 2018-10-16 JP JP2018194834A patent/JP2019023223A/ja active Pending
-
2021
- 2021-02-10 CY CY20211100113T patent/CY1123825T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015512952A (ja) | 2015-04-30 |
| IN2014DN08417A (enExample) | 2015-05-08 |
| RU2014145846A (ru) | 2016-06-10 |
| MX2014012245A (es) | 2015-06-05 |
| HUE053303T2 (hu) | 2021-06-28 |
| ES2854874T3 (es) | 2021-09-23 |
| EP2838506A1 (en) | 2015-02-25 |
| PT2838506T (pt) | 2021-02-23 |
| WO2013158618A1 (en) | 2013-10-24 |
| ZA201407410B (en) | 2015-06-24 |
| AU2013249495B2 (en) | 2016-05-12 |
| CA2869883A1 (en) | 2013-10-24 |
| LT2838506T (lt) | 2021-03-25 |
| CY1123825T1 (el) | 2022-05-27 |
| EP3827813A1 (en) | 2021-06-02 |
| SI2838506T1 (sl) | 2021-02-26 |
| RS61533B1 (sr) | 2021-04-29 |
| HK1207577A1 (en) | 2016-02-05 |
| CN104394847A (zh) | 2015-03-04 |
| IL234987A0 (en) | 2014-12-31 |
| PL2838506T3 (pl) | 2021-06-28 |
| KR101966484B1 (ko) | 2019-04-05 |
| JP2019023223A (ja) | 2019-02-14 |
| HRP20210417T1 (hr) | 2021-04-30 |
| SG11201406491PA (en) | 2014-11-27 |
| EP2838506B1 (en) | 2021-01-06 |
| US20140113856A1 (en) | 2014-04-24 |
| US9381247B2 (en) | 2016-07-05 |
| HK1203371A1 (en) | 2015-10-30 |
| JP6422855B2 (ja) | 2018-11-14 |
| KR20140146209A (ko) | 2014-12-24 |
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