DK2838506T3 - Magnesiumsammensætninger til modulering af farmakokinetikken og farmakodynamikken af insulin og smerter på injektionsstedet - Google Patents
Magnesiumsammensætninger til modulering af farmakokinetikken og farmakodynamikken af insulin og smerter på injektionsstedet Download PDFInfo
- Publication number
- DK2838506T3 DK2838506T3 DK13721441.7T DK13721441T DK2838506T3 DK 2838506 T3 DK2838506 T3 DK 2838506T3 DK 13721441 T DK13721441 T DK 13721441T DK 2838506 T3 DK2838506 T3 DK 2838506T3
- Authority
- DK
- Denmark
- Prior art keywords
- pharmacodynamics
- pharmacokinetics
- insulin
- modulating
- pain
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title 1
- 238000002347 injection Methods 0.000 title 1
- 239000007924 injection Substances 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 229910052749 magnesium Inorganic materials 0.000 title 1
- 239000011777 magnesium Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000003285 pharmacodynamic effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261624844P | 2012-04-16 | 2012-04-16 | |
| US201261704066P | 2012-09-21 | 2012-09-21 | |
| US13/826,806 US9381247B2 (en) | 2012-04-16 | 2013-03-14 | Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain |
| PCT/US2013/036742 WO2013158618A1 (en) | 2012-04-16 | 2013-04-16 | Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2838506T3 true DK2838506T3 (da) | 2021-01-18 |
Family
ID=48326401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13721441.7T DK2838506T3 (da) | 2012-04-16 | 2013-04-16 | Magnesiumsammensætninger til modulering af farmakokinetikken og farmakodynamikken af insulin og smerter på injektionsstedet |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9381247B2 (enExample) |
| EP (2) | EP3827813A1 (enExample) |
| JP (2) | JP6422855B2 (enExample) |
| KR (1) | KR101966484B1 (enExample) |
| CN (1) | CN104394847A (enExample) |
| AU (1) | AU2013249495B2 (enExample) |
| CA (1) | CA2869883A1 (enExample) |
| CY (1) | CY1123825T1 (enExample) |
| DK (1) | DK2838506T3 (enExample) |
| ES (1) | ES2854874T3 (enExample) |
| HK (2) | HK1203371A1 (enExample) |
| HR (1) | HRP20210417T1 (enExample) |
| HU (1) | HUE053303T2 (enExample) |
| IL (1) | IL234987A0 (enExample) |
| IN (1) | IN2014DN08417A (enExample) |
| LT (1) | LT2838506T (enExample) |
| MX (1) | MX2014012245A (enExample) |
| PL (1) | PL2838506T3 (enExample) |
| PT (1) | PT2838506T (enExample) |
| RS (1) | RS61533B1 (enExample) |
| RU (1) | RU2014145846A (enExample) |
| SG (1) | SG11201406491PA (enExample) |
| SI (1) | SI2838506T1 (enExample) |
| WO (1) | WO2013158618A1 (enExample) |
| ZA (1) | ZA201407410B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2919804B1 (fr) | 2012-11-13 | 2018-01-31 | Adocia | Formulation à action rapide d'insuline comprenant un composé anionique substitué |
| CA2936563A1 (en) * | 2014-01-13 | 2015-07-16 | Thermalin Diabetes, Llc | Rapid action insulin formulations and pharmaceutical delivery systems |
| WO2015120457A1 (en) * | 2014-02-10 | 2015-08-13 | Biodel Inc. | Stabilized ultra-rapid-acting insulin formulations |
| TWI685348B (zh) * | 2014-05-08 | 2020-02-21 | 美國禮來大藥廠 | 速效胰島素組合物 |
| US9672328B2 (en) | 2014-07-10 | 2017-06-06 | Companion Medical, Inc. | Medicine administering system including injection pen and companion device |
| AR102869A1 (es) | 2014-12-16 | 2017-03-29 | Lilly Co Eli | Composiciones de insulina de rápida acción |
| JP2018505874A (ja) * | 2015-01-20 | 2018-03-01 | ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎ Ｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ | 選択的シグナリング特性及びより低い分裂促進性を有するインスリンアナログ |
| JO3749B1 (ar) * | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
| EP3407940A4 (en) | 2016-01-29 | 2019-09-04 | Companion Medical, Inc. | PURPOSES OF AUTOMATIC DRUG DISPOSAL |
| GB201607918D0 (en) | 2016-05-06 | 2016-06-22 | Arecor Ltd | Novel formulations |
| EP4265296A3 (en) | 2016-09-29 | 2023-12-20 | Arecor Limited | Pharmaceutical formulation comprising an insulin compound |
| GB201707189D0 (en) * | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
| CA3065308C (en) | 2017-06-01 | 2022-05-17 | Eli Lilly And Company | Rapid-acting insulin compositions |
| US11484657B2 (en) | 2017-06-09 | 2022-11-01 | Medtronic Minimed, Inc. | Intelligent medication delivery systems and methods |
| EP3694583B1 (en) * | 2017-10-12 | 2026-05-06 | Medtronic MiniMed, Inc. | Intelligent medication delivery systems and methods for dose recommendation and management |
| US11077243B2 (en) | 2017-12-12 | 2021-08-03 | Bigfoot Biomedical, Inc. | Devices, systems, and methods for estimating active medication from injections |
| US11464459B2 (en) | 2017-12-12 | 2022-10-11 | Bigfoot Biomedical, Inc. | User interface for diabetes management systems including flash glucose monitor |
| US11197964B2 (en) | 2017-12-12 | 2021-12-14 | Bigfoot Biomedical, Inc. | Pen cap for medication injection pen having temperature sensor |
| US11083852B2 (en) | 2017-12-12 | 2021-08-10 | Bigfoot Biomedical, Inc. | Insulin injection assistance systems, methods, and devices |
| US10987464B2 (en) | 2017-12-12 | 2021-04-27 | Bigfoot Biomedical, Inc. | Pen cap for insulin injection pens and associated methods and systems |
| AU2018383731B2 (en) | 2017-12-12 | 2024-11-07 | Bigfoot Biomedical, Inc. | Therapy management systems, methods, and devices |
| US11116899B2 (en) | 2017-12-12 | 2021-09-14 | Bigfoot Biomedical, Inc. | User interface for diabetes management systems and devices |
| EP3773474B1 (en) | 2018-04-04 | 2026-01-07 | Arecor Limited | Medical infusion pump system for the delivery of an insulin compound |
| US10898653B2 (en) | 2018-05-08 | 2021-01-26 | Companion Medical, Inc. | Intelligent medication delivery systems and methods for dose setting and dispensing monitoring |
| US11664107B2 (en) | 2018-05-08 | 2023-05-30 | Medtronic Minimed, Inc. | Intelligent medication delivery systems and methods using a prescription-regulated software application |
| USD893020S1 (en) | 2018-05-11 | 2020-08-11 | Companion Medical, Inc. | Injection pen |
| USD892819S1 (en) | 2018-06-20 | 2020-08-11 | Companion Medical, Inc. | Display screen with graphical user interface |
| US11587663B2 (en) | 2018-06-20 | 2023-02-21 | Medtronic Minimed, Inc. | Intelligent medication delivery systems and methods for medicine dose calculation and reporting |
| FR3083985A1 (fr) | 2018-07-23 | 2020-01-24 | Adocia | Dispositif pour injecter une solution d'insuline(s) |
| FR3083984A1 (fr) | 2018-07-23 | 2020-01-24 | Adocia | Dispositif pour injecter une solution d'insuline(s) |
| WO2019243627A1 (fr) | 2018-06-23 | 2019-12-26 | Adocia | Dispositif pour injecter une solution d'insuline(s) |
| US12205699B1 (en) | 2018-10-30 | 2025-01-21 | Bigfoot Biomedical, Inc. | Method of pairing therapy devices using shared secrets, and related systems, methods and devices |
| US11948671B2 (en) | 2019-04-11 | 2024-04-02 | Medtronic Minimed, Inc. | Intelligent accessories for medicine dispensing device |
| US12667674B2 (en) | 2020-10-02 | 2026-06-30 | Bigfoot Biomedical, Inc. | Injection site determination systems and methods for injection site tracking and recommending injection sites |
| JP2023544832A (ja) * | 2020-10-08 | 2023-10-25 | ドクター メアリー モリス アンド アソシエイツ リミテッド ライアビリティ カンパニー | １型糖尿病の治療および予防のための方法および組成物 |
| US11701473B2 (en) | 2021-06-23 | 2023-07-18 | Medtronic Minimed, Inc. | Reusable injection pens |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4196196A (en) | 1978-06-19 | 1980-04-01 | Tiholiz Ivan C | Divalen/monovalent bipolar cation therapy for enhancement of tissue perfusion and reperfusion in disease states |
| PH23446A (en) * | 1986-10-20 | 1989-08-07 | Novo Industri As | Peptide preparations |
| DK503386D0 (da) * | 1986-10-20 | 1986-10-20 | Novo Industri As | Peptidpraeparater |
| EP2221361A3 (en) | 1996-08-30 | 2011-02-09 | Life Technologies Corporation | Method for producing a polypeptide in vitro in mammalian cells in a protein-free and serum-free culture medium |
| DE69924232D1 (de) * | 1998-01-09 | 2005-04-21 | Novo Nordisk As | Stabilisierte insulin-zubereitungen |
| US20080090753A1 (en) * | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
| US20080096800A1 (en) | 2004-03-12 | 2008-04-24 | Biodel, Inc. | Rapid mucosal gel or film insulin compositions |
| US20080085298A1 (en) | 2004-03-12 | 2008-04-10 | Biodel, Inc. | Rapid Mucosal Gel or Film Insulin Compositions |
| EP2106790B1 (en) | 2004-03-12 | 2012-10-24 | Biodel, Inc. | Rapid acting drug delivery compositions |
| EP2543249B1 (en) | 2007-02-17 | 2018-05-23 | President and Fellows of Harvard College | Compositions and method for tissue preservation |
| TWI394580B (zh) | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
| US9060927B2 (en) * | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
| FR2943538B1 (fr) * | 2009-03-27 | 2011-05-20 | Adocia | Formulation a action rapide d'insuline recombinante humaine |
| CA2805031A1 (en) | 2010-07-07 | 2012-01-12 | Biodel, Inc. | Compositions and methods for modulating the pharmacokinetics and pharmacodynamics of insulin |
-
2013
- 2013-03-14 US US13/826,806 patent/US9381247B2/en active Active
- 2013-04-16 DK DK13721441.7T patent/DK2838506T3/da active
- 2013-04-16 KR KR1020147032221A patent/KR101966484B1/ko active Active
- 2013-04-16 ES ES13721441T patent/ES2854874T3/es active Active
- 2013-04-16 SG SG11201406491PA patent/SG11201406491PA/en unknown
- 2013-04-16 HR HRP20210417TT patent/HRP20210417T1/hr unknown
- 2013-04-16 PT PT137214417T patent/PT2838506T/pt unknown
- 2013-04-16 LT LTEP13721441.7T patent/LT2838506T/lt unknown
- 2013-04-16 HK HK15103911.3A patent/HK1203371A1/xx unknown
- 2013-04-16 EP EP20215156.9A patent/EP3827813A1/en not_active Withdrawn
- 2013-04-16 JP JP2015505989A patent/JP6422855B2/ja active Active
- 2013-04-16 IN IN8417DEN2014 patent/IN2014DN08417A/en unknown
- 2013-04-16 HK HK15108257.4A patent/HK1207577A1/xx unknown
- 2013-04-16 WO PCT/US2013/036742 patent/WO2013158618A1/en not_active Ceased
- 2013-04-16 RU RU2014145846A patent/RU2014145846A/ru not_active Application Discontinuation
- 2013-04-16 PL PL13721441T patent/PL2838506T3/pl unknown
- 2013-04-16 SI SI201331836T patent/SI2838506T1/sl unknown
- 2013-04-16 CA CA2869883A patent/CA2869883A1/en not_active Abandoned
- 2013-04-16 HU HUE13721441A patent/HUE053303T2/hu unknown
- 2013-04-16 AU AU2013249495A patent/AU2013249495B2/en active Active
- 2013-04-16 RS RS20210209A patent/RS61533B1/sr unknown
- 2013-04-16 EP EP13721441.7A patent/EP2838506B1/en active Active
- 2013-04-16 MX MX2014012245A patent/MX2014012245A/es unknown
- 2013-04-16 CN CN201380029323.7A patent/CN104394847A/zh active Pending
-
2014
- 2014-10-05 IL IL234987A patent/IL234987A0/en unknown
- 2014-10-13 ZA ZA2014/07410A patent/ZA201407410B/en unknown
-
2018
- 2018-10-16 JP JP2018194834A patent/JP2019023223A/ja active Pending
-
2021
- 2021-02-10 CY CY20211100113T patent/CY1123825T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2838506T (pt) | 2021-02-23 |
| JP6422855B2 (ja) | 2018-11-14 |
| HK1207577A1 (en) | 2016-02-05 |
| HUE053303T2 (hu) | 2021-06-28 |
| JP2015512952A (ja) | 2015-04-30 |
| MX2014012245A (es) | 2015-06-05 |
| AU2013249495B2 (en) | 2016-05-12 |
| JP2019023223A (ja) | 2019-02-14 |
| US9381247B2 (en) | 2016-07-05 |
| CY1123825T1 (el) | 2022-05-27 |
| EP2838506B1 (en) | 2021-01-06 |
| US20140113856A1 (en) | 2014-04-24 |
| SI2838506T1 (sl) | 2021-02-26 |
| PL2838506T3 (pl) | 2021-06-28 |
| EP2838506A1 (en) | 2015-02-25 |
| LT2838506T (lt) | 2021-03-25 |
| RU2014145846A (ru) | 2016-06-10 |
| WO2013158618A1 (en) | 2013-10-24 |
| KR101966484B1 (ko) | 2019-04-05 |
| IL234987A0 (en) | 2014-12-31 |
| ZA201407410B (en) | 2015-06-24 |
| EP3827813A1 (en) | 2021-06-02 |
| CN104394847A (zh) | 2015-03-04 |
| IN2014DN08417A (enExample) | 2015-05-08 |
| HK1203371A1 (en) | 2015-10-30 |
| RS61533B1 (sr) | 2021-04-29 |
| CA2869883A1 (en) | 2013-10-24 |
| ES2854874T3 (es) | 2021-09-23 |
| HRP20210417T1 (hr) | 2021-04-30 |
| KR20140146209A (ko) | 2014-12-24 |
| SG11201406491PA (en) | 2014-11-27 |
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