DK2822558T3 - Procaspase 3 aktivering ved hjælp af kombinations terapi - Google Patents

Procaspase 3 aktivering ved hjælp af kombinations terapi Download PDF

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Publication number
DK2822558T3
DK2822558T3 DK13757357.2T DK13757357T DK2822558T3 DK 2822558 T3 DK2822558 T3 DK 2822558T3 DK 13757357 T DK13757357 T DK 13757357T DK 2822558 T3 DK2822558 T3 DK 2822558T3
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Prior art keywords
procaspase
activation
combination therapy
therapy
combination
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DK13757357.2T
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Danish (da)
English (en)
Inventor
Paul J Hergenrother
Rachel C Botham
Timothy M Fan
Mark J Gilbert
Michael K Handley
Howard S Roth
Theodore M Tarasow
Original Assignee
The Board Of Trustees Of The Univ Of Illionis
Vanquish Oncology Inc
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Application filed by The Board Of Trustees Of The Univ Of Illionis, Vanquish Oncology Inc filed Critical The Board Of Trustees Of The Univ Of Illionis
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Publication of DK2822558T3 publication Critical patent/DK2822558T3/da

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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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DK13757357.2T 2012-03-06 2013-03-06 Procaspase 3 aktivering ved hjælp af kombinations terapi DK2822558T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261607098P 2012-03-06 2012-03-06
PCT/US2013/029405 WO2013134407A2 (en) 2012-03-06 2013-03-06 Procaspase 3 activation by combination therapy

Publications (1)

Publication Number Publication Date
DK2822558T3 true DK2822558T3 (da) 2020-03-23

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DK13757357.2T DK2822558T3 (da) 2012-03-06 2013-03-06 Procaspase 3 aktivering ved hjælp af kombinations terapi

Country Status (14)

Country Link
US (4) US9399035B2 (OSRAM)
EP (2) EP2822558B1 (OSRAM)
JP (1) JP6172865B2 (OSRAM)
KR (1) KR102074530B1 (OSRAM)
CN (1) CN104507479B (OSRAM)
AU (1) AU2016213862B2 (OSRAM)
BR (1) BR112014022103B1 (OSRAM)
CA (1) CA2866021C (OSRAM)
DK (1) DK2822558T3 (OSRAM)
ES (1) ES2774930T3 (OSRAM)
IN (1) IN2014MN01945A (OSRAM)
MX (2) MX365392B (OSRAM)
RU (1) RU2659936C2 (OSRAM)
WO (2) WO2013134407A2 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008134474A2 (en) 2007-04-27 2008-11-06 The Board Of Trustees Of The University Of Illinois Compositions and methods including cell death inducers and procaspase activation
KR102074530B1 (ko) 2012-03-06 2020-02-06 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 조합 요법에 의한 프로카스파제 3 활성화
CA2922575C (en) * 2013-11-01 2022-10-11 Newsouth Innovations Pty Limited Pharmaceutical combinations for the treatment of cancer
AU2015341700A1 (en) * 2014-11-07 2017-06-08 Lipoxen Technologies Limited Method for treatment of primary hormone resistant endometrial and breast cancers
WO2016090371A2 (en) 2014-12-05 2016-06-09 An2H Discovery Limited Parkin ligase activation methods and compositions
WO2016197129A1 (en) 2015-06-05 2016-12-08 The Board Of Trustees Of The University Of Illinois Pac-1 combination therapy
KR101712638B1 (ko) * 2015-08-19 2017-03-07 한국과학기술연구원 Pac-1을 이용한 단백질 발현 조절 시스템과 방법 및 pac-1을 유효성분 포함하는 독시사이클린 길항제
US10308617B2 (en) 2016-06-03 2019-06-04 An2H Discovery Limited Triazole benzamide derivatives and the compositions and methods of treatment regarding the same
IL274663B2 (en) * 2017-11-17 2024-01-01 Univ Illinois Cancer therapy by degrading dual mek signaling
US10889553B2 (en) 2017-12-01 2021-01-12 Nysnobio Ireland Dac Asymmetric triazole benzamide derivatives and the compositions and methods of treatment regarding the same
CA3114385A1 (en) * 2018-10-05 2020-04-09 The Board Of Trustees Of The University Of Illinois Combination therapy for the treatment of uveal melanoma
JP7648155B2 (ja) * 2019-05-30 2025-03-18 ザ ボード オブ トラスティーズ オブ ザ ユニバーシテイ オブ イリノイ プロカスパーゼ‐3の活性化及びがんの治療のための免疫療法

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US597287A (en) 1898-01-11 Bicycle attachment
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US5723459A (en) * 1991-05-09 1998-03-03 Vertex Pharmaceuticals Incorporated Biologically active acylated amino acid derivatives
US5844001A (en) * 1993-02-26 1998-12-01 Research Development Foundation Combination platinum chemotherapeutic/antiestrogen therapy for human cancers
US6403765B1 (en) 1998-06-16 2002-06-11 Thomas Jefferson University Truncated Apaf-1 and methods of use thereof
EP1100932A2 (en) 1998-07-27 2001-05-23 PHARMACIA & UPJOHN COMPANY Method for autoactivation of procaspase 8
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6110691A (en) 2000-01-06 2000-08-29 Board Of Regents, The University Of Texas System Activators of caspases
US6608026B1 (en) * 2000-08-23 2003-08-19 Board Of Regents, The University Of Texas System Apoptotic compounds
WO2002030399A2 (en) 2000-10-11 2002-04-18 Johns Hopkins University Polymer controlled delivery of a therapeutic agent
AU2002241508A1 (en) 2000-11-20 2002-06-24 Lawrence C. Fritz Membrane derived caspase-3, compositions comprising the same and methods of use therefor
DE10128840A1 (de) * 2001-06-15 2003-01-09 Otis Elevator Co Verfahren und Vorrichtung zur Steuerung des Antriebs einer Fördereinrichtung
US6878743B2 (en) 2001-09-18 2005-04-12 Sunesis Pharmaceuticals, Inc. Small molecule inhibitors of caspases
US6702122B2 (en) * 2002-07-11 2004-03-09 Frank G. Hopkins Rack for fork lift extensions
US20040180828A1 (en) 2003-01-30 2004-09-16 Yigong Shi Caspase-9 : BIR domain of XIAP complexes and methods of use
US7632972B2 (en) 2003-10-30 2009-12-15 The Board Of Trustees Of The University Of Illionis Compounds and methods for treatment of cancer and modulation of programmed cell death for melanoma and other cancer cells
TR200808208T1 (tr) * 2003-12-09 2008-12-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bir immün tepkinin bastırılması veya proliferatif bir hastalığın tedavisi
KR20070119745A (ko) * 2005-05-12 2007-12-20 화이자 인코포레이티드 수니티닙 말레이트를 사용하는 항암 병행 요법
US20070049602A1 (en) 2005-05-26 2007-03-01 The Board Of Trustees Of The University Of Illinois Selective Apoptotic Induction in Cancer Cells Including Activation of Procaspase-3
WO2008134474A2 (en) 2007-04-27 2008-11-06 The Board Of Trustees Of The University Of Illinois Compositions and methods including cell death inducers and procaspase activation
CN101184491A (zh) * 2005-05-26 2008-05-21 伊利诺伊大学评议会 包括活化半胱天冬酶-3酶原的癌细胞内选择性细胞凋亡诱导
US7550478B2 (en) 2005-06-23 2009-06-23 Merck & Co. Inc. Tyrosine kinase inhibitors
TWI373473B (en) 2005-09-02 2012-10-01 Otsuka Pharma Co Ltd Anticancer agent
US8039462B2 (en) * 2005-09-19 2011-10-18 Neuronascent, Inc. Methods and compositons for stimulating neurogenesis and inhibiting neuronal degeneration
PE20071042A1 (es) * 2005-11-04 2007-10-12 Wyeth Corp Producto farmaceutico que comprende temsirolimus y malato de sunitinib
US20070111936A1 (en) 2005-11-15 2007-05-17 Vladimir Pak Complex of alpha-fetoprotein and inducers of apoptosis for the treatment of cancer
US7886969B2 (en) 2005-12-06 2011-02-15 Visa U.S.A. Inc. Method and system for loading and reloading portable consumer devices
US8778845B2 (en) * 2005-12-15 2014-07-15 Genral Electric Company Composition, device and associated method
JP2009537636A (ja) * 2006-05-19 2009-10-29 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ 黒色腫及び他の癌を治療するためのトリフェニルメチルホスホン酸エステルを含めたリン含有化合物
TWI433674B (zh) * 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明(cyclopamine)類似物類
CN101896177A (zh) * 2007-12-13 2010-11-24 诺瓦提斯公司 用于治疗癌症的治疗剂的组合
RU2360692C1 (ru) * 2007-12-21 2009-07-10 Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран) Средство, стимулирующее апоптоз клеток лейкемии человека
WO2009089508A1 (en) 2008-01-11 2009-07-16 The Regents Of The University Of California Activators of executioner procaspases 3, 6 and 7
US8349353B2 (en) * 2008-06-27 2013-01-08 Otonomy, Inc. Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders
CN102159960B (zh) * 2008-09-17 2013-03-27 爱德万测试株式会社 测试装置及块间同步方法
US20100291214A1 (en) 2008-12-23 2010-11-18 Armark Authentication Technologies, Llc Three-dimensional microfiber extrudate structure and process for forming three-dimensional microfiber extrudate structure
AU2010210403B2 (en) * 2009-02-09 2016-07-28 The Board Of Trustees Of The University Of Illinois Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs
EA023913B1 (ru) * 2009-05-11 2016-07-29 БЕРГ ФАРМА ЭлЭлСи Способы лечения метаболических нарушений, использующие эпиметаболические переключатели, многоаспектные внутриклеточные молекулы или факторы влияния
CA2763471A1 (en) * 2009-05-27 2010-12-02 Cephalon, Inc. Combination therapy for the treatment of multiple myeloma
WO2010151746A2 (en) * 2009-06-26 2010-12-29 Armark Authentication Technologies, Llc Three-dimensional microfiber extrudate structure and process for forming three-dimensional microfiber extrudate structure
JP5094797B2 (ja) 2009-08-07 2012-12-12 日立オートモティブシステムズ株式会社 直流電源平滑用コンデンサーの放電回路
CN102085214A (zh) * 2011-01-27 2011-06-08 范晓青 低分子柑橘果胶联和临床常用化疗药用于控制癌症和癌症转移扩散
KR102074530B1 (ko) 2012-03-06 2020-02-06 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 조합 요법에 의한 프로카스파제 3 활성화
WO2016197129A1 (en) * 2015-06-05 2016-12-08 The Board Of Trustees Of The University Of Illinois Pac-1 combination therapy

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