DK2780326T3 - PROCEDURE FOR INHIBITING DEUBIQUITINATION ACTIVITY - Google Patents
PROCEDURE FOR INHIBITING DEUBIQUITINATION ACTIVITY Download PDFInfo
- Publication number
- DK2780326T3 DK2780326T3 DK12841677.3T DK12841677T DK2780326T3 DK 2780326 T3 DK2780326 T3 DK 2780326T3 DK 12841677 T DK12841677 T DK 12841677T DK 2780326 T3 DK2780326 T3 DK 2780326T3
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- DK
- Denmark
- Prior art keywords
- alkyl
- compound
- alkoxy
- cancer
- alkenyl
- Prior art date
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- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 230000000803 paradoxical effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000003053 piperidines Chemical class 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000008389 polyethoxylated castor oil Substances 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000000861 pro-apoptotic effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 230000004844 protein turnover Effects 0.000 description 1
- 230000004063 proteosomal degradation Effects 0.000 description 1
- 230000005588 protonation Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 description 1
- 230000008844 regulatory mechanism Effects 0.000 description 1
- 210000000844 retinal pigment epithelial cell Anatomy 0.000 description 1
- 239000013037 reversible inhibitor Substances 0.000 description 1
- 125000006413 ring segment Chemical group 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000012192 staining solution Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- GJZYNYJIBDCRFC-UHFFFAOYSA-N tert-butyl 2-oxoazepane-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCCCC1=O GJZYNYJIBDCRFC-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 230000001810 trypsinlike Effects 0.000 description 1
- 230000004565 tumor cell growth Effects 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 238000002525 ultrasonication Methods 0.000 description 1
- 230000004906 unfolded protein response Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- YCGBUPXEBUFYFV-UHFFFAOYSA-N withaferin A Natural products CC(C1CC(=C(CO)C(=O)O1)C)C2CCC3C4CC5OC56C(O)C=CC(O)C6(C)C4CCC23C YCGBUPXEBUFYFV-UHFFFAOYSA-N 0.000 description 1
- DBRXOUCRJQVYJQ-CKNDUULBSA-N withaferin A Chemical compound C([C@@H]1[C@H]([C@@H]2[C@]3(CC[C@@H]4[C@@]5(C)C(=O)C=C[C@H](O)[C@@]65O[C@@H]6C[C@H]4[C@@H]3CC2)C)C)C(C)=C(CO)C(=O)O1 DBRXOUCRJQVYJQ-CKNDUULBSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1100776 | 2011-10-19 | ||
| SE1200303 | 2012-05-16 | ||
| PCT/SE2012/000158 WO2013058691A1 (en) | 2011-10-19 | 2012-10-15 | Method for inhibition of deubiquitinating activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2780326T3 true DK2780326T3 (en) | 2019-03-04 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12841677.3T DK2780326T3 (en) | 2011-10-19 | 2012-10-15 | PROCEDURE FOR INHIBITING DEUBIQUITINATION ACTIVITY |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9221761B2 (enExample) |
| EP (1) | EP2780326B1 (enExample) |
| JP (1) | JP6165748B2 (enExample) |
| KR (1) | KR102022575B1 (enExample) |
| CN (1) | CN104271557B (enExample) |
| AU (1) | AU2012326682B2 (enExample) |
| BR (1) | BR112014009365B1 (enExample) |
| CA (1) | CA2852518C (enExample) |
| CL (1) | CL2014000998A1 (enExample) |
| DK (1) | DK2780326T3 (enExample) |
| EA (1) | EA026409B1 (enExample) |
| ES (1) | ES2713484T3 (enExample) |
| HU (1) | HUE041816T2 (enExample) |
| IL (1) | IL232118A (enExample) |
| MX (1) | MX345467B (enExample) |
| MY (1) | MY169330A (enExample) |
| PL (1) | PL2780326T3 (enExample) |
| PT (1) | PT2780326T (enExample) |
| SG (1) | SG11201401608PA (enExample) |
| WO (1) | WO2013058691A1 (enExample) |
| ZA (1) | ZA201403302B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA026409B1 (ru) * | 2011-10-19 | 2017-04-28 | Виволюкс Аб | Соединение, ингибирующее деубиквитинирующую активность, и использование его в композиции и в способе лечения рака |
| EP2938610A2 (en) | 2012-12-28 | 2015-11-04 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Inhibitors of the usp1/uaf1 deubiquitinase complex and uses thereof |
| US20170128518A1 (en) * | 2014-07-01 | 2017-05-11 | Mayo Foundation For Medical Education And Research | Methods and materials for identifying and treating mammals resistant to proteasome inhibitor treatments |
| GB201416754D0 (en) * | 2014-09-23 | 2014-11-05 | Mission Therapeutics Ltd | Novel compounds |
| US10343992B2 (en) * | 2015-03-30 | 2019-07-09 | Missions Therapeutics Limited | 1-cyano-pyrrolidine compounds as USP30 inhibitors |
| CN106146542A (zh) * | 2015-04-23 | 2016-11-23 | 北京大学 | 姜黄素硼酸衍生物,其制备方法和应用 |
| GB201522768D0 (en) * | 2015-12-23 | 2016-02-03 | Mission Therapeutics Ltd | Novel compounds |
| US10416163B2 (en) * | 2016-02-26 | 2019-09-17 | Regents Of The University Of Minnesota | Method and treatment of recurring endometrial cancer with an inhibitor of USP14 |
| JP2020506230A (ja) * | 2017-01-30 | 2020-02-27 | アップ セラピューティクス インコーポレイテッド | がん、糖尿病および神経障害の処置のための新規スピロおよび環式ビス−ベンジリジンプロテアソーム阻害剤 |
| CN111956804B (zh) * | 2020-07-21 | 2022-01-07 | 广州医科大学 | Otub1的抑制剂的新应用 |
| CN114959036A (zh) * | 2022-06-07 | 2022-08-30 | 北京大学 | Rpn11标记物在检测骨髓瘤及其患病风险、预后分析及治疗药物中的应用 |
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| JP2003515590A (ja) * | 1999-12-03 | 2003-05-07 | エモリー ユニバーシティ | 癌を処置するためのクルクミンアナログ |
| WO2003075847A2 (en) * | 2002-03-08 | 2003-09-18 | Emory University | NOVEL CURCUMINOID-FACTOR VIIa CONSTRUCTS AS SUPPRESSORS OF TUMOR GROWTH AND ANGIOGENESIS |
| WO2007007207A2 (en) * | 2005-04-13 | 2007-01-18 | Khairia Youssef | Pharmaceutical compositions of 3, 5 -bis (arylidene) -4 -piperidones and analogues there of for modulating cell proliferation |
| DE602005010421D1 (de) * | 2005-08-05 | 2008-11-27 | Hybrigenics Sa | Neue Cysteine Protease Hemmers und ihre therapeutische Anwendungen |
| WO2007059613A1 (en) * | 2005-11-22 | 2007-05-31 | University Of Saskatchewan | Antineoplastic compounds |
| CA2767808A1 (en) * | 2009-07-06 | 2011-01-13 | The Ohio State University Research Foundation | Compositions and methods for inhibition of cancers |
| EA026409B1 (ru) * | 2011-10-19 | 2017-04-28 | Виволюкс Аб | Соединение, ингибирующее деубиквитинирующую активность, и использование его в композиции и в способе лечения рака |
-
2012
- 2012-10-15 EA EA201490800A patent/EA026409B1/ru not_active IP Right Cessation
- 2012-10-15 JP JP2014537023A patent/JP6165748B2/ja not_active Expired - Fee Related
- 2012-10-15 DK DK12841677.3T patent/DK2780326T3/en active
- 2012-10-15 KR KR1020147012947A patent/KR102022575B1/ko not_active Expired - Fee Related
- 2012-10-15 WO PCT/SE2012/000158 patent/WO2013058691A1/en not_active Ceased
- 2012-10-15 EP EP12841677.3A patent/EP2780326B1/en active Active
- 2012-10-15 AU AU2012326682A patent/AU2012326682B2/en not_active Ceased
- 2012-10-15 CA CA2852518A patent/CA2852518C/en active Active
- 2012-10-15 HU HUE12841677A patent/HUE041816T2/hu unknown
- 2012-10-15 CN CN201280062713.XA patent/CN104271557B/zh not_active Expired - Fee Related
- 2012-10-15 ES ES12841677T patent/ES2713484T3/es active Active
- 2012-10-15 MY MYPI2014001125A patent/MY169330A/en unknown
- 2012-10-15 BR BR112014009365-2A patent/BR112014009365B1/pt not_active IP Right Cessation
- 2012-10-15 SG SG11201401608PA patent/SG11201401608PA/en unknown
- 2012-10-15 PT PT12841677T patent/PT2780326T/pt unknown
- 2012-10-15 MX MX2014004646A patent/MX345467B/es active IP Right Grant
- 2012-10-15 PL PL12841677T patent/PL2780326T3/pl unknown
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2014
- 2014-04-13 IL IL232118A patent/IL232118A/en active IP Right Grant
- 2014-04-17 CL CL2014000998A patent/CL2014000998A1/es unknown
- 2014-04-18 US US14/256,280 patent/US9221761B2/en not_active Expired - Fee Related
- 2014-05-08 ZA ZA2014/03302A patent/ZA201403302B/en unknown
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