AU2012326682B2 - Method for inhibition of deubiquitinating activity - Google Patents
Method for inhibition of deubiquitinating activity Download PDFInfo
- Publication number
- AU2012326682B2 AU2012326682B2 AU2012326682A AU2012326682A AU2012326682B2 AU 2012326682 B2 AU2012326682 B2 AU 2012326682B2 AU 2012326682 A AU2012326682 A AU 2012326682A AU 2012326682 A AU2012326682 A AU 2012326682A AU 2012326682 B2 AU2012326682 B2 AU 2012326682B2
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- compound
- phenyl
- cancer
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1100776 | 2011-10-19 | ||
| SE1100776-2 | 2011-10-19 | ||
| SE1200303-4 | 2012-05-16 | ||
| SE1200303 | 2012-05-16 | ||
| PCT/SE2012/000158 WO2013058691A1 (en) | 2011-10-19 | 2012-10-15 | Method for inhibition of deubiquitinating activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2012326682A1 AU2012326682A1 (en) | 2014-05-01 |
| AU2012326682B2 true AU2012326682B2 (en) | 2016-02-18 |
Family
ID=48141165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012326682A Ceased AU2012326682B2 (en) | 2011-10-19 | 2012-10-15 | Method for inhibition of deubiquitinating activity |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9221761B2 (enExample) |
| EP (1) | EP2780326B1 (enExample) |
| JP (1) | JP6165748B2 (enExample) |
| KR (1) | KR102022575B1 (enExample) |
| CN (1) | CN104271557B (enExample) |
| AU (1) | AU2012326682B2 (enExample) |
| BR (1) | BR112014009365B1 (enExample) |
| CA (1) | CA2852518C (enExample) |
| CL (1) | CL2014000998A1 (enExample) |
| DK (1) | DK2780326T3 (enExample) |
| EA (1) | EA026409B1 (enExample) |
| ES (1) | ES2713484T3 (enExample) |
| HU (1) | HUE041816T2 (enExample) |
| IL (1) | IL232118A (enExample) |
| MX (1) | MX345467B (enExample) |
| MY (1) | MY169330A (enExample) |
| PL (1) | PL2780326T3 (enExample) |
| PT (1) | PT2780326T (enExample) |
| SG (1) | SG11201401608PA (enExample) |
| WO (1) | WO2013058691A1 (enExample) |
| ZA (1) | ZA201403302B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2780326T (pt) * | 2011-10-19 | 2019-03-04 | Vivolux Ab | Método para inibição da atividade da desubiquitinação |
| EP2938610A2 (en) | 2012-12-28 | 2015-11-04 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Inhibitors of the usp1/uaf1 deubiquitinase complex and uses thereof |
| EP3164506A4 (en) * | 2014-07-01 | 2018-02-28 | Mayo Foundation for Medical Education and Research | Methods and materials for identifying and treating mammals resistant to proteasome inhibitor treatments |
| GB201416754D0 (en) * | 2014-09-23 | 2014-11-05 | Mission Therapeutics Ltd | Novel compounds |
| MY188957A (en) * | 2015-03-30 | 2022-01-14 | Mission Therapeutics Ltd | 1-cyano-pyrrolidine compounds as usp30 inhibitors |
| CN106146542A (zh) * | 2015-04-23 | 2016-11-23 | 北京大学 | 姜黄素硼酸衍生物,其制备方法和应用 |
| GB201522768D0 (en) * | 2015-12-23 | 2016-02-03 | Mission Therapeutics Ltd | Novel compounds |
| US10416163B2 (en) * | 2016-02-26 | 2019-09-17 | Regents Of The University Of Minnesota | Method and treatment of recurring endometrial cancer with an inhibitor of USP14 |
| WO2018140907A1 (en) * | 2017-01-30 | 2018-08-02 | Up Therapeutics Inc. | Novel spiro and cyclic bis-benzylidine proteasome inhibitor for the treatment of cancer, diabetes and neurological disorders |
| US12539292B2 (en) | 2018-04-01 | 2026-02-03 | Arvinas Operations, Inc. | BRM targeting compounds and associated methods of use |
| CN111956804B (zh) * | 2020-07-21 | 2022-01-07 | 广州医科大学 | Otub1的抑制剂的新应用 |
| CN114959036A (zh) * | 2022-06-07 | 2022-08-30 | 北京大学 | Rpn11标记物在检测骨髓瘤及其患病风险、预后分析及治疗药物中的应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007007207A2 (en) * | 2005-04-13 | 2007-01-18 | Khairia Youssef | Pharmaceutical compositions of 3, 5 -bis (arylidene) -4 -piperidones and analogues there of for modulating cell proliferation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1242379A1 (en) * | 1999-12-03 | 2002-09-25 | Emory University | Curcumin analogues for treating cancer |
| EP1572078A4 (en) * | 2002-03-08 | 2006-08-09 | Univ Emory | NEW CURCUMINOID FACTOR VIIa CONSTRUCTS AS MEANS OF SUPPRESSING TUMOR GROWTH AND ANGIOGENESIS |
| ATE411300T1 (de) * | 2005-08-05 | 2008-10-15 | Hybrigenics Sa | Neue cysteine protease hemmers und ihre therapeutische anwendungen |
| WO2007059613A1 (en) * | 2005-11-22 | 2007-05-31 | University Of Saskatchewan | Antineoplastic compounds |
| CA2767808A1 (en) * | 2009-07-06 | 2011-01-13 | The Ohio State University Research Foundation | Compositions and methods for inhibition of cancers |
| PT2780326T (pt) * | 2011-10-19 | 2019-03-04 | Vivolux Ab | Método para inibição da atividade da desubiquitinação |
-
2012
- 2012-10-15 PT PT12841677T patent/PT2780326T/pt unknown
- 2012-10-15 CN CN201280062713.XA patent/CN104271557B/zh not_active Expired - Fee Related
- 2012-10-15 EP EP12841677.3A patent/EP2780326B1/en active Active
- 2012-10-15 CA CA2852518A patent/CA2852518C/en active Active
- 2012-10-15 PL PL12841677T patent/PL2780326T3/pl unknown
- 2012-10-15 SG SG11201401608PA patent/SG11201401608PA/en unknown
- 2012-10-15 AU AU2012326682A patent/AU2012326682B2/en not_active Ceased
- 2012-10-15 MY MYPI2014001125A patent/MY169330A/en unknown
- 2012-10-15 HU HUE12841677A patent/HUE041816T2/hu unknown
- 2012-10-15 DK DK12841677.3T patent/DK2780326T3/en active
- 2012-10-15 ES ES12841677T patent/ES2713484T3/es active Active
- 2012-10-15 MX MX2014004646A patent/MX345467B/es active IP Right Grant
- 2012-10-15 WO PCT/SE2012/000158 patent/WO2013058691A1/en not_active Ceased
- 2012-10-15 EA EA201490800A patent/EA026409B1/ru not_active IP Right Cessation
- 2012-10-15 JP JP2014537023A patent/JP6165748B2/ja not_active Expired - Fee Related
- 2012-10-15 KR KR1020147012947A patent/KR102022575B1/ko not_active Expired - Fee Related
- 2012-10-15 BR BR112014009365-2A patent/BR112014009365B1/pt not_active IP Right Cessation
-
2014
- 2014-04-13 IL IL232118A patent/IL232118A/en active IP Right Grant
- 2014-04-17 CL CL2014000998A patent/CL2014000998A1/es unknown
- 2014-04-18 US US14/256,280 patent/US9221761B2/en not_active Expired - Fee Related
- 2014-05-08 ZA ZA2014/03302A patent/ZA201403302B/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007007207A2 (en) * | 2005-04-13 | 2007-01-18 | Khairia Youssef | Pharmaceutical compositions of 3, 5 -bis (arylidene) -4 -piperidones and analogues there of for modulating cell proliferation |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2852518C (en) | Azepanone compounds and their use for the inhibition of deubiquitinating activity and the treatment of cancer | |
| Blackburn et al. | Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform | |
| Zhang et al. | Targeting p53-MDM2-MDMX loop for cancer therapy | |
| Sosič et al. | Cathepsin B inhibitors: Further exploration of the nitroxoline core | |
| MX2008011837A (es) | Compuestos de union al dominio de repeticion de inhibidores de proteinas de apoptosis de baculovirus. | |
| US20050203063A1 (en) | Proteasome pathway inhibitors and related methods | |
| US20140073668A1 (en) | N-quinolin-benzensulfonamides and related compounds for the treatment of cancer, autoimmune disorders and inflammation | |
| WO2008118626A9 (en) | Inhibitors of jnk and methods for identifying inhibitors of jnk | |
| JP2018508563A (ja) | Ｕｓｐ７阻害剤化合物及び使用方法 | |
| Blaquiere et al. | Medicinal chemistry of inhibiting RING-type E3 ubiquitin ligases | |
| Xiong et al. | Development of potent NEDD8-activating enzyme inhibitors bearing a pyrimidotriazole scaffold | |
| Tasneem et al. | Heterocyclic moieties as HDAC inhibitors: role in cancer therapeutics | |
| US9261497B2 (en) | Method of treating cancer with modulators of SCFSkp2 | |
| Xu et al. | Recent advances in the development of Rho kinase inhibitors (2015–2021) | |
| US20130079370A1 (en) | Method for the Inhibition of Deubiquitinating Activity | |
| Momose et al. | Antitumor effects of tyropeptin‐boronic acid derivatives: New proteasome inhibitors | |
| WO2023131305A1 (zh) | Prmt5抑制剂和抗癌治疗剂的组合 | |
| SE1200735A1 (sv) | Sätt att inhibera deubiqutineringsaktivitet | |
| Li et al. | Development of novel PRMT7 inhibitors for the treatment of prostate cancer | |
| NZ624019B2 (en) | Method for inhibition of deubiquitinating activity | |
| HK1203194B (en) | Method for inhibition of deubiquitinating activity | |
| Mao et al. | The ubiquitin-proteasomal system and blood cancer therapy | |
| Bonache de Marcos et al. | Highly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity | |
| Mendes | Internship and Monograph Reports Entitled” Ubiquitin Specific Protease 7 (USP7) Inhibitors as new Agents in Cancer Treatment | |
| Song et al. | A Novel Aromatic Amide Derivative SY-65 co-Targeting Tubulin and Histone Deacetylase 1 with Potent Anticancer Activity in Vitro and in Vivo |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |