DK2760475T3 - Fusionsproteiner til behandling af metaboliske lidelser - Google Patents

Fusionsproteiner til behandling af metaboliske lidelser Download PDF

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Publication number
DK2760475T3
DK2760475T3 DK12768999.0T DK12768999T DK2760475T3 DK 2760475 T3 DK2760475 T3 DK 2760475T3 DK 12768999 T DK12768999 T DK 12768999T DK 2760475 T3 DK2760475 T3 DK 2760475T3
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pro
leu
fgf21
ser
gly
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DK12768999.0T
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Brian R Boettcher
Shari L Caplan
Douglas S Daniels
Norio Hamamatsu
Stuart Licht
Stephen Craig Weldon
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Novartis Ag
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Claims (7)

1. Fusionprotein omfattende en FGF21 variant og en Fc region, hvor sekvensen for det nævnte protein er valgt fra en i det følgende angivet sekvens
2. Fusionsprotein ifølge krav 1 til anvendelse ved behandlingen af FGF21-associerede lidelser valgt fra gruppen bestående af obesitas, type 1 og type 2 diabetes mellitus, pancreatitis, dyslipidemi, ikke-alkoholisk fedtleverlidelse (NAFLD), ikke-alkoholisk steatohepatitis (NASH), insulinresistens, hyperinsulinemi, glucoseintolerance, hyperglykæmi, metabolisk syndrom, akut myocardial infarkt, hypertension, cardio-vaskulær lidelse, atherosclerose, perifer arteriel lidelse, slagtilfælde, hjertesvigt, koronær hjertelidelse, nyrelidelse, diabetiske komplikationer, neuropati, gastroparese og lidelser associerede med alvorlige inaktiveringsmutationer i insulinreceptoren.
3. Farmaceutisk sammensætning omfattende fusionsproteinet ifølge krav 1 og et farmaceutisk acceptabelt formuleringsmiddel.
4. Farmaceutisk sammensætning ifølge krav 3 til anvendelse ved behandlingen af en metabolisk lidelse.
5. Polynucleotid, som koder for fusionsproteinet ifølge krav 1.
6. Vektor indeholdende polynicleotidet ifølge krav 5.
7. Værtscelle, som bærer vektoren ifølge krav 6.
DK12768999.0T 2011-09-26 2012-09-26 Fusionsproteiner til behandling af metaboliske lidelser DK2760475T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161539280P 2011-09-26 2011-09-26
PCT/US2012/057384 WO2013049247A1 (en) 2011-09-26 2012-09-26 Fusion proteins for treating metabolic disorders

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DK2760475T3 true DK2760475T3 (da) 2018-10-15

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DK17201957.2T DK3321276T3 (da) 2011-09-26 2012-09-26 Fusionsproteiner til behandling af metaboliske lidelser
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EP (2) EP3321276B1 (da)
JP (4) JP6186361B2 (da)
KR (1) KR102085605B1 (da)
CN (2) CN103945871B (da)
AP (1) AP2014007543A0 (da)
AR (2) AR088044A1 (da)
AU (1) AU2012316052A1 (da)
BR (1) BR112014007069B1 (da)
CA (1) CA2849464C (da)
CL (2) CL2014000736A1 (da)
CO (1) CO6920257A2 (da)
CR (1) CR20140140A (da)
CU (2) CU24314B1 (da)
CY (2) CY1120928T1 (da)
DK (2) DK3321276T3 (da)
EA (1) EA039633B1 (da)
ES (2) ES2895080T3 (da)
GT (1) GT201400055A (da)
HK (1) HK1251238A1 (da)
HR (2) HRP20211575T1 (da)
HU (2) HUE055584T2 (da)
IL (1) IL231533B (da)
IN (1) IN2014DN02043A (da)
JO (1) JO3476B1 (da)
LT (2) LT2760475T (da)
MA (1) MA35437B1 (da)
MX (1) MX350273B (da)
MY (1) MY166059A (da)
PE (2) PE20141551A1 (da)
PL (2) PL3321276T3 (da)
PT (2) PT2760475T (da)
RS (2) RS62341B1 (da)
SG (2) SG10201602339XA (da)
SI (2) SI2760475T1 (da)
TN (1) TN2014000109A1 (da)
TW (1) TWI593708B (da)
UA (1) UA113856C2 (da)
UY (2) UY34346A (da)
WO (1) WO2013049247A1 (da)
ZA (1) ZA201401700B (da)

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