DK2736920T3 - Forbindelse til inhibering af notch-signalvejen - Google Patents
Forbindelse til inhibering af notch-signalvejen Download PDFInfo
- Publication number
- DK2736920T3 DK2736920T3 DK12741192.4T DK12741192T DK2736920T3 DK 2736920 T3 DK2736920 T3 DK 2736920T3 DK 12741192 T DK12741192 T DK 12741192T DK 2736920 T3 DK2736920 T3 DK 2736920T3
- Authority
- DK
- Denmark
- Prior art keywords
- cancer
- mmol
- compound
- add
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (7)
1. Forbindelse med strukturen:
Forbindelse 1 eller et farmaceutisk acceptabelt salt eller hydrat deraf.
2. Forbindelse med strukturen:
Forbindelse 1 eller et farmaceutisk acceptabelt salt deraf.
3. Farmaceutisk sammensætning omfattende en forbindelse ifølge krav 1 eller et farmaceutisk acceptabelt salt eller hydrat deraf sammen med en farmaceutisk acceptabel bærer.
4. Forbindelse ifølge krav 1 eller et farmaceutisk acceptabelt salt eller hydrat deraf til anvendelse inden for terapi.
5. Forbindelse ifølge krav 1 eller et farmaceutisk acceptabelt salt eller hydrat deraf til anvendelse ved behandling af en kræft, som er en T-celle akut lym-foblastisk leukæmi, akut lymfoblastisk leukæmi, akut myeloid leukæmi, kronisk myelogen leukæmi, erythroleukæmi, brystkræft, æggestokkræft, mela-nom, lungekræft, bugspytkirtelkræft, glioblastom, kolorektal kræft, hoved- og halskræft, livmoderhalskræft, prostatakræft, leverkræft, pladecellekarcinom (oralt), hudkræft eller medulloblastom.
6. Forbindelse ifølge krav 1 eller et farmaceutisk acceptabelt salt eller hydrat deraf til anvendelse ved behandling af en kræft, som er en T-celle akut lym-foblastisk leukæmi, kronisk myelogen leukæmi, erythroleukæmi, brystkræft, æggestokkræft, melanom, bugspytkirtelkræft, glioblastom eller kolorektal kræft.
7. Forbindelse ifølge krav 1, som er et krystallinsk hydrat, kendetegnet ved et røntgenpulverdiffraktionsmønster ved anvendelse af CuKa-stråling med et peak ved 22,97 ±0,2 grader 2-theta i kombination med et eller flere peaks ved 11,96 ±0,2, 18,81 ±0,2, 20,78 ±0,2 eller 21,07 ±0,2 grader 2-theta ved en omgivelsestemperatur og relativ fugtighed.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161512016P | 2011-07-27 | 2011-07-27 | |
US201161560486P | 2011-11-16 | 2011-11-16 | |
PCT/US2012/047100 WO2013016081A1 (en) | 2011-07-27 | 2012-07-18 | Notch pathway signaling inhibitor compound |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2736920T3 true DK2736920T3 (da) | 2015-07-20 |
Family
ID=46598983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12741192.4T DK2736920T3 (da) | 2011-07-27 | 2012-07-18 | Forbindelse til inhibering af notch-signalvejen |
Country Status (36)
Country | Link |
---|---|
US (1) | US8569286B2 (da) |
EP (1) | EP2736920B1 (da) |
JP (1) | JP6027110B2 (da) |
KR (1) | KR101578309B1 (da) |
CN (1) | CN103732612B (da) |
AP (1) | AP4080A (da) |
AR (1) | AR087107A1 (da) |
AU (1) | AU2012287251B2 (da) |
BR (1) | BR112014001600B1 (da) |
CA (1) | CA2841178C (da) |
CL (1) | CL2014000175A1 (da) |
CO (1) | CO6862159A2 (da) |
CR (1) | CR20140036A (da) |
CY (1) | CY1116645T1 (da) |
DK (1) | DK2736920T3 (da) |
DO (1) | DOP2014000011A (da) |
EA (1) | EA023044B1 (da) |
EC (1) | ECSP14013179A (da) |
ES (1) | ES2544937T3 (da) |
GT (1) | GT201400012A (da) |
HK (1) | HK1194086A1 (da) |
HR (1) | HRP20150771T1 (da) |
HU (1) | HUE027534T2 (da) |
IL (1) | IL229988A (da) |
JO (1) | JO3148B1 (da) |
MA (1) | MA35611B1 (da) |
ME (1) | ME02171B (da) |
MX (1) | MX356536B (da) |
MY (1) | MY184303A (da) |
PE (1) | PE20141061A1 (da) |
PL (1) | PL2736920T3 (da) |
PT (1) | PT2736920E (da) |
RS (1) | RS54135B1 (da) |
SI (1) | SI2736920T1 (da) |
TW (1) | TWI568730B (da) |
WO (1) | WO2013016081A1 (da) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10350216B2 (en) | 2013-01-14 | 2019-07-16 | The Trustees Of Columbia University In The City Of New York | Methods of treating, preventing and diagnosing leukemia and other blood diseases and disorders |
KR20160099081A (ko) | 2013-07-26 | 2016-08-19 | 업데이트 파마 인코포레이트 | 비산트렌의 치료 효과 개선용 조합 방법 |
TWI704151B (zh) | 2014-12-22 | 2020-09-11 | 美商美國禮來大藥廠 | Erk抑制劑 |
TWI609687B (zh) * | 2015-04-14 | 2018-01-01 | 美國禮來大藥廠 | 平滑肌肉瘤之標靶性治療 |
JO3491B1 (ar) * | 2015-07-07 | 2020-07-05 | Audion Therapeutics | مركبات مثبطة لإشارات مسار notch |
CR20180413A (es) | 2016-02-05 | 2018-12-04 | Denali Therapeutics Inc | Inhibidores de la proteína quinasa 1 que interactua con el receptor |
AU2017233898B2 (en) | 2016-03-15 | 2022-12-15 | Oryzon Genomics, S.A. | Combinations of LSD1 inhibitors for use in the treatment of solid tumors |
US11564929B2 (en) | 2016-04-12 | 2023-01-31 | Eli Lilly And Company | Combination therapy with Notch and PI3K/mTOR inhibitors for use in treating cancer |
JP6911047B2 (ja) * | 2016-04-12 | 2021-07-28 | イーライ リリー アンド カンパニー | がんの処置のための、Notch阻害剤およびCDK4/6阻害剤の併用療法 |
MX2018013941A (es) * | 2016-05-20 | 2019-03-21 | Lilly Co Eli | Terapia de combinacion con inhibidores de notch y pd-1 o pd-l1. |
CN109562114A (zh) * | 2016-08-31 | 2019-04-02 | 伊莱利利公司 | 用于治疗实体瘤的给药方案 |
EP3525796A1 (en) | 2016-10-12 | 2019-08-21 | Eli Lilly and Company | Targeted treatment of mature t-cell lymphoma |
EP3552017B1 (en) | 2016-12-09 | 2022-02-23 | Denali Therapeutics Inc. | Compounds useful as ripk1 inhibitors |
EP4269594A3 (en) | 2017-02-17 | 2023-12-20 | Fred Hutchinson Cancer Center | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
WO2019090003A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for b-cell maturation antigen (bcma) |
EP3706754A1 (en) * | 2017-11-06 | 2020-09-16 | Juno Therapeutics, Inc. | Combination of a cell therapy and a gamma secretase inhibitor |
JP2021523169A (ja) * | 2018-05-06 | 2021-09-02 | アヤラ ファーマシューティカルズ インコーポレイテッド | ビスフルオロアルキル−1,4−ベンゾジアゼピノン化合物を含む組み合わせ組成物およびその使用方法 |
EP3860562A1 (en) | 2018-10-02 | 2021-08-11 | Frequency Therapeutics, Inc. | Pharmaceutical compositions comprising otic therapeutic agents and related methods |
AU2020271067A1 (en) | 2019-04-08 | 2021-11-25 | Frequency Therapeutics, Inc. | Combination of CHIR99021 and valproic acid for treating hearing loss |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA002100B1 (ru) * | 1996-12-23 | 2001-12-24 | Элан Фармасьютикалз, Инк. | ЦИКЛОАЛКИЛЬНЫЕ СОЕДИНЕНИЯ, ЛАКТАМЫ, ЛАКТОНЫ И РОДСТВЕННЫЕ СОЕДИНЕНИЯ, СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И СПОСОБЫ ИНГИБИРОВАНИЯ ВЫСВОБОЖДЕНИЯ И/ИЛИ СИНТЕЗА β-АМИЛОИДНОГО ПЕПТИДА С ПОМОЩЬЮ УКАЗАННЫХ СОЕДИНЕНИЙ |
JP2002518483A (ja) * | 1998-06-22 | 2002-06-25 | エラン ファーマシューティカルズ,インコーポレイテッド | β−アミロイドペプチド放出を阻害するための化合物および/またはその合成 |
JP2002518481A (ja) | 1998-06-22 | 2002-06-25 | エラン ファーマシューティカルズ,インコーポレイテッド | β−アミロイドペプチドの放出および/またはその合成を阻害するための化合物 |
WO2004069826A1 (en) | 2003-02-04 | 2004-08-19 | F. Hoffmann-La Roche Ag | Malonamide derivatives as gamma-secretase inhibitors |
DK1711470T3 (da) | 2003-09-09 | 2009-06-08 | Hoffmann La Roche | Malonamidderivater der blokerer aktiviteten af gamma-sekretase |
AU2004283803B2 (en) | 2003-10-06 | 2010-06-24 | F. Hoffmann-La Roche Ag | Substituted dibenzo-azepine and benzo-diazepine derivatives useful as gamma-secretase inhibitors |
ES2398531T3 (es) | 2006-03-27 | 2013-03-20 | F. Hoffmann-La Roche Ag | Derivados de malonamida como inhibidores de gamma secretasa |
MX2009007864A (es) * | 2007-02-02 | 2009-07-31 | Hoffmann La Roche | Derivados de 6-oxo-6,7-dihidro-5h-dibenzo[b,d]azepin-7-ilo. |
MA33076B1 (fr) | 2008-01-11 | 2012-03-01 | Hoffmann La Roche | Utilisation d'un inhibiteur de la gamma-secretase pour le traitement du cancer |
US8637493B2 (en) * | 2009-11-12 | 2014-01-28 | University Of Massachusetts | Methods for treating glioblastoma |
-
2012
- 2012-07-10 JO JOP/2012/0190A patent/JO3148B1/ar active
- 2012-07-10 AR ARP120102486A patent/AR087107A1/es not_active Application Discontinuation
- 2012-07-13 TW TW101125459A patent/TWI568730B/zh active
- 2012-07-18 MY MYPI2014700183A patent/MY184303A/en unknown
- 2012-07-18 EP EP12741192.4A patent/EP2736920B1/en active Active
- 2012-07-18 BR BR112014001600-3A patent/BR112014001600B1/pt active IP Right Grant
- 2012-07-18 PL PL12741192T patent/PL2736920T3/pl unknown
- 2012-07-18 US US13/551,681 patent/US8569286B2/en active Active
- 2012-07-18 AU AU2012287251A patent/AU2012287251B2/en active Active
- 2012-07-18 KR KR1020147001731A patent/KR101578309B1/ko active IP Right Grant
- 2012-07-18 HU HUE12741192A patent/HUE027534T2/en unknown
- 2012-07-18 RS RS20150496A patent/RS54135B1/en unknown
- 2012-07-18 SI SI201230246T patent/SI2736920T1/sl unknown
- 2012-07-18 EA EA201490161A patent/EA023044B1/ru not_active IP Right Cessation
- 2012-07-18 MX MX2014001084A patent/MX356536B/es active IP Right Grant
- 2012-07-18 CN CN201280037471.9A patent/CN103732612B/zh active Active
- 2012-07-18 ME MEP-2015-105A patent/ME02171B/me unknown
- 2012-07-18 PT PT127411924T patent/PT2736920E/pt unknown
- 2012-07-18 ES ES12741192.4T patent/ES2544937T3/es active Active
- 2012-07-18 DK DK12741192.4T patent/DK2736920T3/da active
- 2012-07-18 PE PE2014000129A patent/PE20141061A1/es active IP Right Grant
- 2012-07-18 CA CA2841178A patent/CA2841178C/en active Active
- 2012-07-18 JP JP2014522877A patent/JP6027110B2/ja active Active
- 2012-07-18 WO PCT/US2012/047100 patent/WO2013016081A1/en active Application Filing
- 2012-07-18 AP AP2014007362A patent/AP4080A/en active
-
2013
- 2013-12-17 IL IL229988A patent/IL229988A/en active IP Right Grant
-
2014
- 2014-01-22 MA MA36712A patent/MA35611B1/fr unknown
- 2014-01-22 DO DO2014000011A patent/DOP2014000011A/es unknown
- 2014-01-23 CL CL2014000175A patent/CL2014000175A1/es unknown
- 2014-01-24 GT GT201400012A patent/GT201400012A/es unknown
- 2014-01-24 CR CR20140036A patent/CR20140036A/es unknown
- 2014-01-24 CO CO14014585A patent/CO6862159A2/es active IP Right Grant
- 2014-01-27 EC ECSP14013179 patent/ECSP14013179A/es unknown
- 2014-07-22 HK HK14107480.6A patent/HK1194086A1/xx unknown
-
2015
- 2015-07-14 HR HRP20150771TT patent/HRP20150771T1/hr unknown
- 2015-08-25 CY CY20151100742T patent/CY1116645T1/el unknown
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