DK2705146T3 - Sammensætninger og fremgangsmåder, der omfatter serinproteasevarianter - Google Patents

Sammensætninger og fremgangsmåder, der omfatter serinproteasevarianter Download PDF

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Publication number
DK2705146T3
DK2705146T3 DK12722991.2T DK12722991T DK2705146T3 DK 2705146 T3 DK2705146 T3 DK 2705146T3 DK 12722991 T DK12722991 T DK 12722991T DK 2705146 T3 DK2705146 T3 DK 2705146T3
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Prior art keywords
protease
variant
cleaning
composition
amino acid
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DK12722991.2T
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English (en)
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Neelam S Amin
Katherine Augustyn
Joshua R Basler
Luis G Cascao-Pereira
Katherine D Collier
Edward M Concar
David A Estell
Jr James T Kellis
Euan John Magennis
Alexander Pisarchik
Ayrookaran J Poulose
Philip Frank Souter
Glenn Steven Ward
Jian Yao
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Danisco Us Inc
Procter & Gamble
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Publication of DK2705146T3 publication Critical patent/DK2705146T3/da

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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cleaning By Liquid Or Steam (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (7)

  1. SAMMENSÆTNINGER OG FREMGANGSMÅDER, DER OMFATTER SERINPROTE ASE VARIANTER
    1. Isoleret subtilisinvariant, hvor subtilisinvarianten er en moden form med proteolytisk aktivitet, hvor subtilisinvarianten: (i) omfatter en aminosyresekvens, der omfatter en kombination af aminosyresubstitutioner ved positioner valgt fra: T022R-S024F-S101G-S103A-V104I-A232V-Q245R-E271H, T022R-S101G-S103A-V104I-A232V-Q245R-E271H, T022R-S024F-S101G-S103A-V104I-A232V-Q245R-T260M, T022R-S024F-S101G-S103A-V104I-A232V-Q245R, T022R-S101G-S103A-V104I-A232V-P239G-Q245R, T022R-S101G-S103A-V104I-A232V-Q245R-T260K-L267N, T022R-S101G-S103 A-V104I-S128 A-A232V-Q245R, T022R-S024F-S101G-S103A-V104I-V121F-A232V-Q245R, T022R-S078N-S101G-S103A-V104I-N116L-A232V-Q245R, T022R-S101G-S103A-V104I-A232V-P239G-Q245R-E271I, T022R-S024G-G097S-S101G-S103A-V104I-Q109G-N116L-S128A-A232V-Q245R, T022R-S024G-S078N-S101G-S103A-V104I-N116L-S128A-A232V-Q245R, T022R-G097S-S101G-S103A-V104I-S128A-A232V-Q245R, T022R-S024G-S078N-G097A-S101G-S103A-V104I-N116L-L217Q-A232V-Q245R, T022R-S024G-S078N-G097S-S101G-S103A-V104I-Q109N-N116L-L217Q-A232V-Q245R, T022R-S024G-S101G-S103A-V104I-N116L-L217Q-A232V-Q245R, T022R-S024G-G097A-S101G-S103A-V104I-Q109G-N116L-L217Q-A232V-Q245R, T022R-G097A-S101G-S103 A- V104I-Q109G-N116L-L217Q-A232V-Q245R, T022R-S024G-S078N-G097A-S101G-S103A-V104I-N116L-S128A-L217Q-A232V-Q245R, T022R-S024G-G097A-S101G-S103A-V104I-N116L-S128A-L217Q-A232V-Q245R, T022R-G097S-S101G-S103A-V104I-L217Q-A232V-Q245R, T022R-S078N-G097S-S101G-S103A-V104I-N116L-S128A-L217Q-A232V-Q245R, T022R-S101 G-S 103 A-V104I-Q109N-S128 A-A23 2V-Q245R, T022R-S024G-G097S-S101G-S103A-V104I-S128A-L217Q-A232V-Q245R, T022R-S101G-S103A-V104I-A232V-Q245R-E271A, R010A-T022R-S024F-S101G-S103A-V104I-A232V-Q245R-L267N-E271H, T022R-S101G-S103A-V104I-A232V-Q245R-E271F, T022R-S101G-S103A-V104I-A232V-Q245R-E271H, T022R-S078N-G097S-S101G-S103A-V104I-Q109G-S128A-A232V-Q245R og T022R-S101G-S103 A-V104I-M222S-A232V-Q245R-E271 Η, hvor aminosyrepositioner af subtilisinvarianten er nummereret ifølge nummereringen af tilsvarende aminosyrepositioner i aminosyresekvensen af Bacillus amyloliquefaciens subtilisin BPN' vist i SEQ ID NO: 1, og hvor subtilisinvarianten har mindst 80 % aminosyresekvensidentitet med SEQ ID NO: 2, og hvor subtilisinvarianten har forbedret vaskeevne sammenlignet med subtilisinet ifølge SEQ ID NO: 2; eller (ii) er subtilisinvarianten, der kun adskiller sig fra aminosyresekvensen ifølge SEQ ID NO: 2 med følgende kombination af substitutioner: T022R-S101G-S103A-V104I-A232V-Q245R.
  2. 2. Isoleret subtilisinvariant ifølge krav 1, hvor subtilisinvarianten har mindst 90 % aminosyreidentitet med Bacillus lentus subtilisin GG36 proteasen, der omfatter aminosyresekvensen vist i SEQ ID NO: 2.
  3. 3. Isoleret nukleinsyre, der omfatter en polynukleotidsekvens, der koder for subtilisinvarianten tilvejebragt i krav 1 eller krav 2.
  4. 4. Fremgangsmåde til fremstilling af mindst én subtilisinvariant af et Bacillus-subtilisin, hvilken fremgangsmåde omfatter: a) transformering af en værtscelle med en ekspressionsvektor, der omfatter mindst én nukleinsyre, der koder for mindst én subtilisinvariant ifølge krav 1 eller krav 2, for at frembringe en transformeret værtscelle; og b) dyrkning af den transformerede værtscelle under betingelser, der er egnede til frembringelse af mindst én subtilisinvariant, for at frembringe mindst én subtilisinvariant.
  5. 5. Sammensætning, der omfatter mindst én subtilisinvariant ifølge et hvilket som helst krav 1 eller krav 2, hvor sammensætningen ikke er et stof eller hjemmeplejeprodukt.
  6. 6. Sammensætning ifølge krav 5, hvor sammensætningen endvidere omfatter mindst ét supplerende enzym valgt fra hemicellulaser, cellulaser, peroxidaser, proteaser, metalloproteaser, xylanaser, lipaser, phospholipaser, esteraser, perhydrolaser, cutinaser, pectinaser, pectatlyaser, mannanaser, keratinaser, reduktaser, oxidaser, phenoloxidaser, lipoxygenaser, ligninaser, pullulanaser, tannaser, pentosanaser, malanaser, β-glucanaser, arabinosidaser, hyaluronidaser, chondroitinaser, laccaser og amylaser eller en hvilken som helst kombination deraf.
  7. 7. Fremgangsmåde til rengøring, der omfatter at etablere kontakt mellem en overflade eller en genstand med en rengøringssammensætning, der omfatter mindst én subtilisinvariant ifølge krav 1 eller krav 2.
DK12722991.2T 2011-05-05 2012-05-04 Sammensætninger og fremgangsmåder, der omfatter serinproteasevarianter DK2705146T3 (da)

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US201161482938P 2011-05-05 2011-05-05
PCT/US2012/036608 WO2012151534A1 (en) 2011-05-05 2012-05-04 Compositions and methods comprising serine protease variants

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US (1) US9856466B2 (da)
EP (3) EP2705146B1 (da)
JP (2) JP6105560B2 (da)
CN (1) CN103764823B (da)
AR (1) AR086281A1 (da)
BR (1) BR112013027963A2 (da)
CA (3) CA3111256C (da)
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ES (1) ES2707869T3 (da)
MX (1) MX338925B (da)
RU (1) RU2718648C2 (da)
TR (1) TR201901382T4 (da)
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CA2834865A1 (en) 2012-11-08
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CA2834865C (en) 2021-03-09
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