DK2585064T3 - C5ar-antagonister - Google Patents

C5ar-antagonister Download PDF

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Publication number
DK2585064T3
DK2585064T3 DK11799027.5T DK11799027T DK2585064T3 DK 2585064 T3 DK2585064 T3 DK 2585064T3 DK 11799027 T DK11799027 T DK 11799027T DK 2585064 T3 DK2585064 T3 DK 2585064T3
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disease
compound
compounds
group
vol
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DK11799027.5T
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Pingchen Fan
Kevin Lloyd Greenman
Manmohan Reddy Leleti
Yandong Li
Jay Powers
Hiroko Tanaka
Ju Yang
Yibin Zeng
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Chemocentryx Inc
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Priority claimed from US12/823,039 external-priority patent/US20100311753A1/en
Priority claimed from US13/072,616 external-priority patent/US20110275639A1/en
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
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Publication of DK2585064T3 publication Critical patent/DK2585064T3/da

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    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Claims (14)

1
1. Forbindelse udvalgt fra gruppen bestående af:
eller et farmaceutisk acceptabelt salt, hydrat eller rotomer deraf.
2. Forbindelse udvalgt fra gruppen bestående af:
eller et farmaceutisk acceptabelt salt, hydrat eller rotomer deraf.
3. Forbindelse udvalgt fra gruppen bestående af:
eller et farmaceutisk acceptabelt salt, hydrat eller rotomer deraf.
4. Forbindelse ifølge krav 1, der er udvalgt ffa gruppen bestående af:
5 eller et farmaceutisk acceptabelt salt, hydrat eller rotomer deraf.
5. Forbindelse, der er 1.543
6. Farmaceutisk acceptable sammensætning, der omfatter en farmaceutisk acceptable bærer eller forbindelse ifølge et hvilket som helst af kravene 1 til 5.
7. Forbindelse ifølge et hvilket som helst af kravene 1 til 5 til anvendelse ved en fremgangsmåde til behandling af et pattedyr, som har eller er modtagelig for en sygdom eller lidelse, der involverer patologisk aktivering af C5a-receptorer, hvor sygdommen eller lidelsen er en inflammatorisk sygdom eller lidelse; en kardiovaskulær eller cerebrovaskulær sygdom; en autoimmun sygdom; eller en patologisk følgetilstand knyttet til gruppen bestående af insulinkrævende diabetes mellitus, lupus nefropati, Heymanns neffitis, membranøs nefritis, glomerulonefritis, kontaktfølsomhedsreaktioner og inflammation som følge af kontakt mellem blod og kunstige overflader.
8. Forbindelse til anvendelse ifølge krav 7, hvor sygdommen eller lidelsen er en inflammatorisk sygdom eller lidelse.
9. Forbindelse til anvendelse ifølge krav 8, hvor sygdommen eller lidelsen er valgt fra gruppen bestående af neutropeni, sepsis, septisk shock, Alzheimers sygdom, multipel sklerose, apopleksi, inflammatorisk tarmsygdom, kronisk obstruktiv lungesygdom (KOL), inflammation i forbindelse med forbrændinger, lungeskade, osteoarthritis, atopisk dermatitis, kronisk urticaria, iskæmi-reperfusionsskade, akut respiratory distress-syndrom, systemisk inflammatorisk responssyndrom, multiorgandysfunktion, vævstransplantatafstødning og hyperakut afstødning af transplanterede organer.
10. Forbindelse til anvendelse ifølge krav 7, hvor sygdommen eller lidelsen er en kardiovaskulær eller cerebrovaskulær sygdom.
11. Forbindelse til anvendelse ifølge krav 10, hvor den kardiovaskulære eller cerebrovaskulære sygdom er valgt fra gruppen bestående af myokardieinfarkt, koronartrombose, vaskulær okklusion, postoperativ vaskulær reokklusion, aterosklerose, traumatisk skade på centralnervesystemet og iskæmisk hjertesygdom.
12. Forbindelse til anvendelse ifølge krav 7, hvor sygdommen eller lidelsen er en autoimmun sygdom.
13. Forbindelse til anvendelse ifølge krav 12, hvor den autoimmune sygdom er valgt fra gruppen bestående af reumatoid arthritis, systemisk lupus erythematosus, Guillain-Barrés syndrom, pancreatitis, lupus nefritis, lupus glomerulonefritis, psoriasis, Crohns sygdom, vaskulitis, colon irritabile, dermatomyositis, multipel sklerose, bronkial astma, pemphigus, pemfxgoid, sklerodermi, myasthenia gravis, autoimmune hæmolytiske og trombocytopeniske tilstande, Goodpastures syndrom, immunvaskulitis, vævstransplantatafstødning og hyperakut afstødning af transplanterede organer.
14. Forbindelse til anvendelse ifølge krav 7, hvor sygdommen eller lidelsen er en patologisk følgetilstand knyttet til gruppen bestående af insulinkrævende diabetes mellitus, lupus nefropati, Heymanns nefritis, membranøs nefritis, glomerulonefritis, kontaktfølsomhedsreaktioner og inflammation som følge af kontakt mellem blod og kunstige overflader.
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US9126939B2 (en) 2015-09-08
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