DK2427485T3 - Cd133-epitoper - Google Patents
Cd133-epitoper Download PDFInfo
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- DK2427485T3 DK2427485T3 DK10772898.2T DK10772898T DK2427485T3 DK 2427485 T3 DK2427485 T3 DK 2427485T3 DK 10772898 T DK10772898 T DK 10772898T DK 2427485 T3 DK2427485 T3 DK 2427485T3
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- cells
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- peptide
- immunogen
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A61K9/127—Liposomes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
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- Molecular Biology (AREA)
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- Immunology (AREA)
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- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (15)
1. Immunogen, der omfatter et isoleret peptid på 100 aminosyrerester eller færre, der omfatter aminosyresekvensen ifølge en hvilken som helst af SEQ ID NO: 1. 2, 3, 4, 6, 9, 11, 12, 13, 14, 15, 20 eller 21 med to eller færre aminosyresubstitutioner.
2. Immunogen ifølge krav 1, hvor immunogenet er 80 eller færre, 60 eller færre, 50 eller færre, 40 eller færre, 30 eller færre, 20 eller færre, 15 eller færre, 14 eller færre, 13 eller færre, 12 eller færre, 11 eller færre, 10 eller færre eller 9 aminosyrerester langt.
3. Immunogen ifølge krav 1 eller 2, hvor immunogenet har aminosyresekvensen, der er vist i en hvilken som helst af SEQ ID NO: 1, 2, 3, 4, 6, 9, 11, 12, 13, 14, 15, 20 eller 21.
4. Immunogen ifølge et hvilket som helst af kravene 1 til 3, hvor immunogenet har aminosyresekvensen, der er vist i SEQ ID NO: 11.
5. Sammensætning, der omfatter immunogenet ifølge et hvilket som helst af kravene 1 til 4.
6. Sammensætning ifølge krav 5, der yderligere omfatter en adjuvans eller en cytokin.
7. Sammensætning ifølge krav 6, hvor adjuvansen omfatter Freunds komplette adjuvans, Freunds inkomplette adjuvans, Montanide ISA-51, LAG-3, aluminiumphosphat, aluminiumhydroxid, alun eller saponin.
8. Sammensætning ifølge krav 5, hvor immunogenet er koblet til et immunogent bæremateriale.
9. Sammensætning ifølge krav 5, der yderligere omfatter et farmaceutisk acceptabelt bæremateriale, især hvor det farmaceutisk acceptable bæremateriale er et liposom, et immunstimulerende kompleks (ISCOM) eller en partikel med langsom frigivelse.
10. Sammensætning ifølge krav 5, hvor sammensætningen omfatter antigenpræsenterende celler.
11. Immunogen ifølge et hvilket som helst af kravene 1 til 4 eller sammensætning ifølge et hvilket som helst af kravene 5 til 10 til anvendelse til immunisering af et individ.
12. Sammensætning ifølge et hvilket som helst af kravene 5 til 10 til anvendelse til behandling af en cancer.
13. In vitro-fremgangsmåde til inducering af en cytotoksisk T-lymfocyt (CTL), der er specifik for en celle, der udtrykker CD133, hvilken fremgangsmåde omfatter etablering af kontakt mellem en precursor-CTL og immunogenet ifølge et hvilket som helst af kravene 1 til 4 under betingelser, der fremkalder en CTL-respons mod tumorcellerne.
14. Fremgangsmåde til fremstilling af en cellevaccine til behandling af en cancer, hvilken fremgangsmåde omfatter: dyrkning af knoglemarvsafledte mononukleære celler i en dyrkningsbeholder under betingelser, hvorved de mononukleære celler kan binde til beholderen; selektion af en delmængde af de mononukleære celler, der omfatter celler, der er bundet til beholderen; dyrkning af delmængden af mononukleære celler i nærvær af en eller flere cytokiner under betingelser, hvorved delmængden af mononukleære celler differentierer til antigenpræsenterende celler; og dyrkning af de antigenpræsenterende celler i nærvær af immunogenet ifølge et hvilket som helst af kravene 1 til 4 under betingelser, hvorved cellerne præsenterer peptiderne på MHC-I (major histocompatibility complex class I)-molekyler, til derved fremstilling af en cellevaccine.
15. Nukleinsyremolekyle, der består af en nukleinsyresekvens, der koder for et immunogen ifølge et hvilket som helst af kravene 1 til 4.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17630209P | 2009-05-07 | 2009-05-07 | |
| PCT/US2010/034082 WO2010129895A2 (en) | 2009-05-07 | 2010-05-07 | Cd133 epitopes |
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| DK2427485T3 true DK2427485T3 (da) | 2017-03-13 |
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| EP (1) | EP2427485B1 (da) |
| DK (1) | DK2427485T3 (da) |
| ES (1) | ES2618573T3 (da) |
| PL (1) | PL2427485T3 (da) |
| PT (1) | PT2427485T (da) |
| WO (1) | WO2010129895A2 (da) |
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| JP2007507543A (ja) * | 2003-10-06 | 2007-03-29 | セダーズ−シナイ メディカル センター | 樹状細胞治療によって誘導されるｔ細胞アネルギーを予防するためのｃｏｘ−２インヒビターの使用 |
| WO2008039874A2 (en) | 2006-09-26 | 2008-04-03 | Cedars-Sinai Medical Center | Cancer stem cell antigen vaccines and methods |
| WO2008039969A2 (en) | 2006-09-28 | 2008-04-03 | Cedars-Sinai Medical Center | Cancer vaccines and vaccination methods |
| PL2328923T3 (pl) | 2008-09-02 | 2016-06-30 | Cedars Sinai Medical Center | Epitopy CD133 |
| EP2427485B1 (en) | 2009-05-07 | 2016-12-07 | ImmunoCellular Therapeutics, Ltd. | Cd133 epitopes |
| CN103566377A (zh) * | 2012-07-18 | 2014-02-12 | 上海博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| CA2898457A1 (en) * | 2013-02-14 | 2014-08-21 | Immunocellular Therapeutics, Ltd. | Ovarian cancer vaccines and vaccination methods |
| CA2898474A1 (en) | 2013-02-14 | 2014-08-21 | Immunocellular Therapeutics, Ltd. | Cancer vaccines and vaccination methods |
| JP2017502068A (ja) | 2014-01-10 | 2017-01-19 | シャンハイ バーディー バイオテック インコーポレイテッド | Ｈｅｒ２陽性腫瘍を処置するための化合物及び組成物 |
| JP6760919B2 (ja) | 2014-07-09 | 2020-09-23 | バーディー バイオファーマシューティカルズ インコーポレイテッド | 腫瘍を治療するための抗ｐｄ−ｌ１組み合わせ |
| CN112587672A (zh) | 2014-09-01 | 2021-04-02 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1结合物 |
| KR101726212B1 (ko) * | 2015-05-08 | 2017-04-13 | 한양대학교 산학협력단 | Cd133 검출용 다중 펩타이드 프로브 |
| CN115252792A (zh) | 2016-01-07 | 2022-11-01 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-egfr组合 |
| CN115350279A (zh) | 2016-01-07 | 2022-11-18 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-her2组合 |
| CN106943596A (zh) | 2016-01-07 | 2017-07-14 | 博笛生物科技（北京）有限公司 | 用于治疗肿瘤的抗-cd20组合 |
| CN108794467A (zh) | 2017-04-27 | 2018-11-13 | 博笛生物科技有限公司 | 2-氨基-喹啉衍生物 |
| RU2020102453A (ru) | 2017-06-23 | 2021-07-23 | Бирди Байофармасьютикалз, Инк. | Фармацевтические композиции |
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- 2010-05-07 DK DK10772898.2T patent/DK2427485T3/da active
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Also Published As
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|---|---|
| US8604167B2 (en) | 2013-12-10 |
| EP2427485A4 (en) | 2013-07-10 |
| US20100310643A1 (en) | 2010-12-09 |
| EP2427485B1 (en) | 2016-12-07 |
| US20130115279A1 (en) | 2013-05-09 |
| US8383768B2 (en) | 2013-02-26 |
| PL2427485T3 (pl) | 2017-10-31 |
| PT2427485T (pt) | 2017-03-13 |
| EP2427485A2 (en) | 2012-03-14 |
| WO2010129895A3 (en) | 2011-04-28 |
| WO2010129895A2 (en) | 2010-11-11 |
| ES2618573T3 (es) | 2017-06-21 |
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