DK2364185T3 - Disubstituerede phthalazin-hedgehog-pathway-antagonister - Google Patents

Disubstituerede phthalazin-hedgehog-pathway-antagonister

Info

Publication number
DK2364185T3
DK2364185T3 DK09740613.6T DK09740613T DK2364185T3 DK 2364185 T3 DK2364185 T3 DK 2364185T3 DK 09740613 T DK09740613 T DK 09740613T DK 2364185 T3 DK2364185 T3 DK 2364185T3
Authority
DK
Denmark
Prior art keywords
hedgehog pathway
pathway antagonists
disubstituted phthalazine
phthalazine
disubstituted
Prior art date
Application number
DK09740613.6T
Other languages
Danish (da)
English (en)
Inventor
Jolie Anne Bastian
Philip Arthur Hipskind
Daniel Jon Sall
Takako Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41566219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2364185(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK2364185T3 publication Critical patent/DK2364185T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK09740613.6T 2008-11-03 2009-10-22 Disubstituerede phthalazin-hedgehog-pathway-antagonister DK2364185T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11070308P 2008-11-03 2008-11-03
PCT/US2009/061573 WO2010062507A1 (en) 2008-11-03 2009-10-22 Disubstituted phthalazine hedgehog pathway antagonists

Publications (1)

Publication Number Publication Date
DK2364185T3 true DK2364185T3 (da) 2013-06-03

Family

ID=41566219

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09740613.6T DK2364185T3 (da) 2008-11-03 2009-10-22 Disubstituerede phthalazin-hedgehog-pathway-antagonister

Country Status (29)

Country Link
US (1) US8404687B2 (cg-RX-API-DMAC10.html)
EP (1) EP2364185B1 (cg-RX-API-DMAC10.html)
JP (1) JP2012507535A (cg-RX-API-DMAC10.html)
KR (1) KR101335746B1 (cg-RX-API-DMAC10.html)
CN (1) CN102202737B (cg-RX-API-DMAC10.html)
AU (1) AU2009320251C1 (cg-RX-API-DMAC10.html)
BR (1) BRPI0921437A2 (cg-RX-API-DMAC10.html)
CA (1) CA2742539C (cg-RX-API-DMAC10.html)
CL (1) CL2011000979A1 (cg-RX-API-DMAC10.html)
CO (1) CO6382123A2 (cg-RX-API-DMAC10.html)
CR (1) CR20110202A (cg-RX-API-DMAC10.html)
CY (1) CY1114023T1 (cg-RX-API-DMAC10.html)
DK (1) DK2364185T3 (cg-RX-API-DMAC10.html)
EA (1) EA018931B1 (cg-RX-API-DMAC10.html)
EC (1) ECSP11011021A (cg-RX-API-DMAC10.html)
ES (1) ES2418479T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20130527T1 (cg-RX-API-DMAC10.html)
IL (1) IL211841A0 (cg-RX-API-DMAC10.html)
MA (1) MA32726B1 (cg-RX-API-DMAC10.html)
MX (1) MX2011004683A (cg-RX-API-DMAC10.html)
NZ (1) NZ591945A (cg-RX-API-DMAC10.html)
PE (1) PE20110433A1 (cg-RX-API-DMAC10.html)
PL (1) PL2364185T3 (cg-RX-API-DMAC10.html)
PT (1) PT2364185E (cg-RX-API-DMAC10.html)
SI (1) SI2364185T1 (cg-RX-API-DMAC10.html)
TN (1) TN2011000166A1 (cg-RX-API-DMAC10.html)
UA (1) UA102115C2 (cg-RX-API-DMAC10.html)
WO (1) WO2010062507A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201102448B (cg-RX-API-DMAC10.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA100684C2 (uk) * 2007-03-15 2013-01-25 Новартіс Аг Похідні бензилу та піридинілу як модулятори сигнального шляху hedgehog
US7981892B2 (en) 2008-04-29 2011-07-19 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
US8507490B2 (en) 2008-11-17 2013-08-13 Eli Lilly And Company Tetrasubstituted pyridazine hedgehog pathway antagonists
WO2010056620A1 (en) 2008-11-17 2010-05-20 Eli Lilly And Company Tetrasubstituted pyridazines hedgehog pathway antagonists
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
WO2015073691A1 (en) 2013-11-14 2015-05-21 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of bmp signaling
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
EP4229828A4 (en) 2020-10-13 2024-08-28 Endeavor Biomedicines, Inc. METHODS OF TREATMENT OF FIBROSIS
KR20250069659A (ko) * 2022-09-23 2025-05-19 머크 샤프 앤드 돔 엘엘씨 Nod-유사 수용체 단백질 3의 억제제로서 유용한 프탈라진 유도체
US12447148B2 (en) 2024-03-05 2025-10-21 Endeavor Biomedicines, Inc. Methods of improving lung function

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
NZ326354A (en) 1996-01-15 1999-05-28 Janssen Pharmaceutica Nv 3-(substituted-1-piperazinyl)-6-(substituted-1,2,4-thiadiazol-5 -yl)-pyridazine derivatives and medicaments
EP0882717B1 (en) * 1996-10-01 2010-09-08 Kyowa Hakko Kirin Co., Ltd. Nitrogenous heterocyclic compounds
IL138645A0 (en) 1998-04-09 2001-10-31 Univ Johns Hopkins Med Use of steroidal alkaloid derivatives as inhibitors of hedghog signalling pathways
US6432970B2 (en) * 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
EP1183040B1 (en) 1999-06-08 2004-12-01 Lorantis Limited Therapeutic use of an inhibitor of a hedgehog signalling pathway
US7655674B2 (en) 2002-04-22 2010-02-02 The Johns Hopkins University Modulators of hedgehog signaling pathways, compositions and uses related thereto
WO2004020599A2 (en) 2002-08-29 2004-03-11 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
WO2005080378A1 (ja) 2004-02-24 2005-09-01 Mitsubishi Pharma Corporation 縮合ピリダジン誘導体
JP5221952B2 (ja) 2004-05-08 2013-06-26 ノバルティス・インターナショナル・ファーマシューティカル・リミテッド ３−アリール−５，６−ジ置換ピリダジン類
CA2579002C (en) * 2004-09-02 2012-11-27 Genentech, Inc. Pyridyl inhibitors of hedgehog signalling
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
UA100684C2 (uk) * 2007-03-15 2013-01-25 Новартіс Аг Похідні бензилу та піридинілу як модулятори сигнального шляху hedgehog
US8153633B2 (en) * 2007-06-25 2012-04-10 Amgen Inc. Phthalazine compounds, compositions and methods of use
CA2697682A1 (en) 2007-09-07 2009-03-19 Amgen Inc. Annelated pyridazines for the treatment of tumors driven by inapropriate hedgehog signalling
US7981892B2 (en) 2008-04-29 2011-07-19 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
US8507490B2 (en) 2008-11-17 2013-08-13 Eli Lilly And Company Tetrasubstituted pyridazine hedgehog pathway antagonists
WO2010056620A1 (en) 2008-11-17 2010-05-20 Eli Lilly And Company Tetrasubstituted pyridazines hedgehog pathway antagonists
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
US20110190304A1 (en) 2011-08-04
MX2011004683A (es) 2011-06-20
CN102202737A (zh) 2011-09-28
CA2742539A1 (en) 2010-06-03
CO6382123A2 (es) 2012-02-15
AU2009320251A1 (en) 2010-06-03
CL2011000979A1 (es) 2011-10-07
IL211841A0 (en) 2011-06-30
EA018931B1 (ru) 2013-11-29
PE20110433A1 (es) 2011-07-09
ZA201102448B (en) 2012-09-26
CY1114023T1 (el) 2016-07-27
US8404687B2 (en) 2013-03-26
AU2009320251B2 (en) 2013-01-24
ES2418479T3 (es) 2013-08-14
HK1159010A1 (en) 2012-07-27
WO2010062507A1 (en) 2010-06-03
NZ591945A (en) 2012-10-26
CA2742539C (en) 2014-05-06
BRPI0921437A2 (pt) 2018-10-30
EP2364185A1 (en) 2011-09-14
EA201170640A1 (ru) 2011-12-30
PT2364185E (pt) 2013-07-24
MA32726B1 (fr) 2011-10-02
JP2012507535A (ja) 2012-03-29
KR20110066212A (ko) 2011-06-16
UA102115C2 (ru) 2013-06-10
CR20110202A (es) 2011-06-09
HRP20130527T1 (en) 2013-07-31
KR101335746B1 (ko) 2013-12-12
SI2364185T1 (sl) 2013-07-31
TN2011000166A1 (en) 2012-12-17
ECSP11011021A (es) 2011-06-30
CN102202737B (zh) 2014-03-26
PL2364185T3 (pl) 2013-10-31
AU2009320251C1 (en) 2013-08-15
EP2364185B1 (en) 2013-05-22

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