DK2340809T3 - Lægemiddel indeholdende fluorquinoloner - Google Patents
Lægemiddel indeholdende fluorquinoloner Download PDFInfo
- Publication number
- DK2340809T3 DK2340809T3 DK11151745.4T DK11151745T DK2340809T3 DK 2340809 T3 DK2340809 T3 DK 2340809T3 DK 11151745 T DK11151745 T DK 11151745T DK 2340809 T3 DK2340809 T3 DK 2340809T3
- Authority
- DK
- Denmark
- Prior art keywords
- chloride
- alkyl
- dimethyl
- acid
- ammonium chloride
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (6)
1. Lægemiddel indeholdende i opløst form: (a) 1 til 15 % (m/v) pradofloxacin og (b) 0,001 til 10 % af en kvaternær ammoniumforbindelse.
2. Lægemiddel ifølge krav 1 indeholdende di- eller trivalente metalkationer.
3. Lægemiddel ifølge krav 2 indeholdende Mg2+.
4. Lægemiddel ifølge et af kravene 1 til 3 indeholdende som kvaternær ammoniumforbindelse en forbindelse med formel (III) [R1R2R3R4N]+ X” (III) hvor R1 til R4 er ens eller forskellige og står for Ch-is-alkyl, som i givet fald kan være afbrudt en eller flere gange med oxygen og kan være substitueret med hydroxyl eller med en i givet fald med et eller flere halogenatomer eller Ch-s-alkylgrupper substitueret arylgruppe, eller R1 til R4 ved hjælp af ringlukning af tre grupper danner 5-eller 6-leddede heterocykliske grupper såsom f.eks. pyridin eller thiazolin, som for deres vedkommende i givet fald er substitueret en eller flere gange med Ci-4-alkyl eller C1-4-alkenyl, som i givet fald bærer en arylgruppe, som for sit vedkommende kan være substitueret med halogen, navnlig chlor, amino eller dimethylamino, og X står for sulfat, halogenid, navnlig chlorid, bromid eller iodid, eller en lignende modion.
5. Lægemiddel ifølge et af kravene 1 til 4 indeholdende som kvaternær ammoniumforbindelse en forbindelse udvalgt af: alkyl-dimethyl-benzylammoniumchlorider, navnlig benzalkoniumchlorid [ (Cs-is) -alkyl-dimethyl-benzyl- ammoniumchlorid] eller n- (C12-C18) -alkyl- benzyldimethylammoniumchlorid med gennemsnitlige molekylvægte på ca. 380, benzethoniumchlorid (diisobutylphenoxyethoxyethyl-dimethylbenzyl-ammoniumchlorid) , dichlorbenzyl-dimethyl-alkyl- ammoniumchlorid, benzoxoniumchlorid (benzyl-dodecyl-bis- (2-hydroxyethyl)-ammoniumchlorid), cetrimoniumbromid (N- hexadecyl-N,N-trimethyl-ammoniumbromid, di-(Cs-Cis) -alkyl- dimethyl-ammoniumchlorid som f.eks. dioctyl-dimethyl-ammoniumchlorid eller di-n-decyl-dimethyl-ammoniumchlorid, cetylpyridiniumchlorid (1-hexadecyl-pyridiniumchlorid) samt thiazoliniodid (3-heptyl-2-(3-heptyl-4-methyl-4-thiazolin-2-yliden-methyl)-4-methyl-thiazoliniumjodid).
6. Lægemiddel ifølge et af kravene 1 til 5 endvidere indeholdende et analgetikum, navnlig et NSAID.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006010643A DE102006010643A1 (de) | 2006-03-08 | 2006-03-08 | Arzneimittel enthaltend Fluorchinolone |
| EP07846476A EP1993510A1 (de) | 2006-03-08 | 2007-02-23 | Arzneimittel enthaltend fluorchinolone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2340809T3 true DK2340809T3 (da) | 2015-07-20 |
Family
ID=38171208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11151745.4T DK2340809T3 (da) | 2006-03-08 | 2007-02-23 | Lægemiddel indeholdende fluorquinoloner |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US10231925B2 (da) |
| EP (2) | EP2340809B1 (da) |
| JP (1) | JP5584418B2 (da) |
| KR (2) | KR20080106253A (da) |
| CN (2) | CN104208064A (da) |
| AR (1) | AR059696A1 (da) |
| AU (1) | AU2007291622B2 (da) |
| BR (1) | BRPI0708613B1 (da) |
| CA (1) | CA2645037C (da) |
| CR (1) | CR10270A (da) |
| DE (1) | DE102006010643A1 (da) |
| DK (1) | DK2340809T3 (da) |
| EC (1) | ECSP088716A (da) |
| ES (1) | ES2542206T3 (da) |
| GT (1) | GT200800173A (da) |
| HU (1) | HUE025044T2 (da) |
| IL (1) | IL193429A0 (da) |
| MX (1) | MX2008011344A (da) |
| MY (1) | MY152885A (da) |
| NZ (1) | NZ571046A (da) |
| PE (1) | PE20071021A1 (da) |
| PL (1) | PL2340809T3 (da) |
| PT (1) | PT2340809E (da) |
| RU (1) | RU2527327C2 (da) |
| SI (1) | SI2340809T1 (da) |
| SV (1) | SV2008003014A (da) |
| TW (1) | TWI494105B (da) |
| UA (1) | UA96753C2 (da) |
| UY (1) | UY30191A1 (da) |
| WO (1) | WO2008025380A1 (da) |
| ZA (1) | ZA200807484B (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5027983B2 (ja) | 2001-05-15 | 2012-09-19 | ユーロケラ エスエヌシー | サーモクロミック材料 |
| DE102006010642A1 (de) * | 2006-03-08 | 2007-09-27 | Bayer Healthcare Aktiengesellschaft | Arzneimittelformulierungen, enthaltend Fluorchinolone |
| WO2010069493A1 (de) * | 2008-12-18 | 2010-06-24 | Bayer Animal Health Gmbh | Verbesserte wirkstoffkombination enthaltend ein antibiotikum und einen nichtsteroidalen entzündungshemmer (nsaid) |
| EP2332916A3 (en) | 2009-11-19 | 2011-08-03 | Krka Tovarna Zdravil, D.D., Novo Mesto | A process for a preparation of marbofloxacin and intermediate thereof |
| CN101716141B (zh) * | 2010-01-20 | 2011-11-30 | 白求恩医科大学制药厂 | 一种氟罗沙星注射液及其制备方法 |
| GB2480276A (en) * | 2010-05-11 | 2011-11-16 | Michael Hilary Burke | Process for the preparation of an aqueous injectable enrofloxacin antimicrobial formulation |
| RU2682171C2 (ru) * | 2016-10-11 | 2019-03-15 | Закрытое Акционерное Общество "Биологические Исследования И Системы" (Зао "Бис") | Фармацевтическая комбинированная композиция для лечения гнойных ран на основе фторхинолонов (варианты) |
| CN110113942A (zh) * | 2016-11-07 | 2019-08-09 | 朱比兰特生命科学有限公司 | 协同抗微生物组合物 |
| KR102504435B1 (ko) * | 2017-02-13 | 2023-02-27 | 바이엘 애니멀 헬스 게엠베하 | 프라도플록사신을 함유하는 액체 조성물 |
| WO2019023842A1 (en) | 2017-07-31 | 2019-02-07 | Dow Silicones Corporation | MOISTURE CURING COMPOSITIONS |
| KR102682503B1 (ko) | 2017-07-31 | 2024-07-09 | 다우 실리콘즈 코포레이션 | 수분 경화성 조성물 |
| CN111620901B (zh) * | 2020-06-08 | 2023-03-21 | 蚌埠医学院第二附属医院 | 一种含硅氧烷基的氟喹诺酮化合物、其制备方法及用途 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS5746986A (en) | 1980-09-02 | 1982-03-17 | Dai Ichi Seiyaku Co Ltd | Pyrido(1,2,3-de)(1,4)benzoxazine derivative |
| US4670444B1 (en) | 1980-09-03 | 1999-02-09 | Bayer Ag | and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds |
| US4472405A (en) | 1982-11-12 | 1984-09-18 | Riker Laboratories, Inc. | Antimicrobial 6,7-dihydro-5,8-dimethyl-9 fluoro-1-oxo-1H, 5H-benzo (ij) quinolizine-2-carboxylic acid and derivatives |
| US4730000A (en) | 1984-04-09 | 1988-03-08 | Abbott Laboratories | Quinoline antibacterial compounds |
| US4551456A (en) * | 1983-11-14 | 1985-11-05 | Merck & Co., Inc. | Ophthalmic use of norfloxacin and related antibiotics |
| AT392789B (de) | 1985-01-23 | 1991-06-10 | Toyama Chemical Co Ltd | Verfahren zur herstellung von 1-substituierten aryl-1,4-dihydro-4-oxonaphthyridinderivaten |
| IN166416B (da) | 1985-09-18 | 1990-05-05 | Pfizer | |
| DE3713672A1 (de) | 1987-04-24 | 1988-11-17 | Bayer Ag | Verfahren zur herstellung von parenteral verabreichbaren chinoloncarbonsaeuren |
| DE3831514A1 (de) | 1988-09-16 | 1990-03-22 | Bayer Ag | Ph-neutrale waessrige loesungen von chinoloncarbonsaeuren |
| US5225413A (en) | 1988-09-16 | 1993-07-06 | Bayer-Aktiengesellschaft | pH-neutral aqueous solutions of quinolone-carboxylic acids |
| JP2832535B2 (ja) | 1989-04-04 | 1998-12-09 | 富山化学工業株式会社 | キノロンカルボン酸またはその塩の可溶化法 |
| WO1991009616A1 (en) * | 1989-12-22 | 1991-07-11 | Yale University | Quinolone antibiotics encapsulated in lipid vesicles |
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| FR2665635A1 (fr) | 1990-08-10 | 1992-02-14 | Merck Sharp & Dohme | Composition pharmaceutique fluide a base d'un complexe metallique et son procede de preparation. |
| DK0604570T3 (da) | 1991-09-17 | 1998-09-14 | Alcon Lab Inc | Præparater, der indeholder quinolon-antibiotika og sulfonat af polystyren |
| WO1997023217A1 (en) | 1995-12-21 | 1997-07-03 | Pfizer Inc. | Injectable quinolone formulations |
| ATE228130T1 (de) * | 1996-02-23 | 2002-12-15 | Bayer Ag | Gegebenenfalls substituierte 8-cyan-1-cyclopropyl-7-(2,8-diazabicyclo- 4.3.0)-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3- hinolincarbonsäuren und ihre derivate |
| EP0974364A4 (en) | 1996-10-25 | 2000-12-20 | Yoshitomi Pharmaceutical | METHOD FOR PREVENTING THE PREPARATION OF MEDICINAL PRODUCTS |
| GB9714218D0 (en) | 1997-07-04 | 1997-09-10 | Allied Therapeutics Ltd | Peritoneal dialysis fluid |
| DE19729879C2 (de) * | 1997-07-11 | 1999-07-08 | Mann Gerhard Chem Pharm Fab | Lagerstabile ophthalmische Zusammensetzungen, umfassend Diclofenac und Ofloxacin |
| HUP0100051A3 (en) * | 1997-09-15 | 2002-08-28 | Procter & Gamble | Antimicrobial quinolones, their compositions and uses |
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| DE19918324A1 (de) * | 1999-04-22 | 2000-10-26 | Mann Gerhard Chem Pharm Fab | Pharmazeutische Zusammensetzung wirksam gegen durch Bakterien, Viren, Pilze, Hefen und Protozoen verursachte Krankheitszustände |
| US6482799B1 (en) | 1999-05-25 | 2002-11-19 | The Regents Of The University Of California | Self-preserving multipurpose ophthalmic solutions incorporating a polypeptide antimicrobial |
| DE19937115A1 (de) | 1999-08-06 | 2001-02-08 | Bayer Ag | Wäßrige Arzneimittelformulierung von Moxifloxacin oder Salzen davon |
| BR0014203A (pt) | 1999-09-24 | 2002-05-21 | Alcon Inc | Formulações de suspensão tópicas contendo ciprofloxacina e dexametasona |
| US20070148192A1 (en) * | 2003-02-21 | 2007-06-28 | Laddha Ritu N | Stable ophthalmic composition |
| DE10312346A1 (de) * | 2003-03-20 | 2004-09-30 | Bayer Healthcare Ag | Kontrolliertes Freisetzungssystem |
| RU2248199C1 (ru) * | 2003-06-02 | 2005-03-20 | Открытое Акционерное Общество "Акционерное Курганское общество медицинских препаратов и изделий "Синтез" (ОАО "Синтез") | Глазные капли и способ их получения |
| DE10337191A1 (de) * | 2003-08-13 | 2005-03-17 | Bayer Healthcare Ag | Neue Verwendung von Chinolon-Antibiotika |
| DE102004001558A1 (de) * | 2004-01-10 | 2005-08-18 | Bayer Healthcare Ag | Arzneimittel zur topischen Applikation bei Tieren |
| DE102004015981A1 (de) | 2004-04-01 | 2005-10-20 | Bayer Healthcare Ag | Neue kirstalline Form von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure |
| PT1776109E (pt) * | 2004-08-13 | 2009-03-25 | Schering Plough Ltd | Formulação farmacêutica que compreende um antibiótico, um triazol e um corticosteróide |
-
2006
- 2006-03-08 DE DE102006010643A patent/DE102006010643A1/de not_active Withdrawn
-
2007
- 2007-02-23 HU HUE11151745A patent/HUE025044T2/en unknown
- 2007-02-23 PL PL11151745T patent/PL2340809T3/pl unknown
- 2007-02-23 MY MYPI20083457 patent/MY152885A/en unknown
- 2007-02-23 SI SI200731666T patent/SI2340809T1/sl unknown
- 2007-02-23 KR KR1020087022334A patent/KR20080106253A/ko active Application Filing
- 2007-02-23 BR BRPI0708613-0A patent/BRPI0708613B1/pt active IP Right Grant
- 2007-02-23 ES ES11151745.4T patent/ES2542206T3/es active Active
- 2007-02-23 UA UAA200811959A patent/UA96753C2/ru unknown
- 2007-02-23 US US12/280,448 patent/US10231925B2/en active Active
- 2007-02-23 AU AU2007291622A patent/AU2007291622B2/en active Active
- 2007-02-23 CN CN201410443858.5A patent/CN104208064A/zh active Pending
- 2007-02-23 PT PT111517454T patent/PT2340809E/pt unknown
- 2007-02-23 NZ NZ571046A patent/NZ571046A/en unknown
- 2007-02-23 EP EP11151745.4A patent/EP2340809B1/de active Active
- 2007-02-23 CN CN200780008116.8A patent/CN101394836B/zh active Active
- 2007-02-23 DK DK11151745.4T patent/DK2340809T3/da active
- 2007-02-23 CA CA2645037A patent/CA2645037C/en active Active
- 2007-02-23 KR KR20157009314A patent/KR20150046367A/ko not_active Application Discontinuation
- 2007-02-23 WO PCT/EP2007/001569 patent/WO2008025380A1/de active Application Filing
- 2007-02-23 MX MX2008011344A patent/MX2008011344A/es not_active Application Discontinuation
- 2007-02-23 RU RU2008139635/15A patent/RU2527327C2/ru not_active IP Right Cessation
- 2007-02-23 JP JP2008557622A patent/JP5584418B2/ja active Active
- 2007-02-23 EP EP07846476A patent/EP1993510A1/de not_active Withdrawn
- 2007-03-01 AR ARP070100842A patent/AR059696A1/es unknown
- 2007-03-07 UY UY30191A patent/UY30191A1/es not_active Application Discontinuation
- 2007-03-07 TW TW096107754A patent/TWI494105B/zh not_active IP Right Cessation
- 2007-03-07 PE PE2007000249A patent/PE20071021A1/es not_active Application Discontinuation
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2008
- 2008-08-13 IL IL193429A patent/IL193429A0/en unknown
- 2008-08-28 SV SV2008003014A patent/SV2008003014A/es unknown
- 2008-09-01 ZA ZA200807484A patent/ZA200807484B/xx unknown
- 2008-09-03 GT GT200800173A patent/GT200800173A/es unknown
- 2008-09-03 CR CR10270A patent/CR10270A/es not_active Application Discontinuation
- 2008-09-04 EC EC2008008716A patent/ECSP088716A/es unknown
Also Published As
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