DK2318028T3 - Antagonister af opløselig activin-aktriia og anvendelser til øgning af røde blodcelleniveauer - Google Patents
Antagonister af opløselig activin-aktriia og anvendelser til øgning af røde blodcelleniveauer Download PDFInfo
- Publication number
- DK2318028T3 DK2318028T3 DK09770571.9T DK09770571T DK2318028T3 DK 2318028 T3 DK2318028 T3 DK 2318028T3 DK 09770571 T DK09770571 T DK 09770571T DK 2318028 T3 DK2318028 T3 DK 2318028T3
- Authority
- DK
- Denmark
- Prior art keywords
- activia
- activin
- solvable
- antagonists
- applications
- Prior art date
Links
- 102000005606 Activins Human genes 0.000 title 1
- 108010059616 Activins Proteins 0.000 title 1
- 239000000488 activin Substances 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 210000003743 erythrocyte Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Marine Sciences & Fisheries (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13336808P | 2008-06-26 | 2008-06-26 | |
| PCT/US2009/003838 WO2009158033A2 (en) | 2008-06-26 | 2009-06-26 | Antagonists of activin-actriia and uses for increasing red blood cell levels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2318028T3 true DK2318028T3 (da) | 2020-05-04 |
Family
ID=41445146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09770571.9T DK2318028T3 (da) | 2008-06-26 | 2009-06-26 | Antagonister af opløselig activin-aktriia og anvendelser til øgning af røde blodcelleniveauer |
Country Status (10)
| Country | Link |
|---|---|
| EP (4) | EP2318028B1 (OSRAM) |
| JP (8) | JP5773868B2 (OSRAM) |
| KR (4) | KR20210047374A (OSRAM) |
| CN (2) | CN107252486B (OSRAM) |
| AU (4) | AU2009262968A1 (OSRAM) |
| CA (3) | CA2729054C (OSRAM) |
| DK (1) | DK2318028T3 (OSRAM) |
| ES (2) | ES2852699T3 (OSRAM) |
| NZ (2) | NZ590326A (OSRAM) |
| WO (2) | WO2009158033A2 (OSRAM) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2314617B1 (en) | 2004-07-23 | 2015-06-24 | Acceleron Pharma Inc. | ActRII receptor polypeptides |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| EA201692543A1 (ru) | 2005-11-23 | 2017-08-31 | Акселерон Фарма Инк. | Антагонисты активина-actriia и их применение для стимулирования роста кости |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| MX354099B (es) | 2007-02-01 | 2018-02-13 | Acceleron Pharma Inc | Antagonistas de activina-actriia y usos para tratar o prevenir cancer de mama. |
| TWI432449B (zh) | 2007-02-02 | 2014-04-01 | Acceleron Pharma Inc | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
| KR20160129095A (ko) | 2007-02-09 | 2016-11-08 | 악셀레론 파마 인코포레이티드 | 액티빈-ＡｃｔＲⅡＡ 길항제 및 암 환자에서 골 생장을 촉진시키기 위한 이의 용도 |
| CA2699936A1 (en) | 2007-09-18 | 2009-03-26 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| PT2340031T (pt) | 2008-08-14 | 2019-07-25 | Acceleron Pharma Inc | Armadilhas de gdf para uso no tratamento de anemia |
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| CN102482339B (zh) | 2009-06-08 | 2015-06-17 | 阿塞勒隆制药公司 | 用于增加产热脂肪细胞的方法 |
| EP2440577A4 (en) | 2009-06-12 | 2013-01-23 | Acceleron Pharma Inc | SHORTEN ACTRIIB FC FUSION PROTEINS |
| RU2642302C1 (ru) * | 2009-08-13 | 2018-01-24 | Акселерон Фарма Инк. | Комбинированное применение ловушек gdf и активаторов рецепторов эритропоэтина для повышения содержания эритроцитов |
| AU2015203400A1 (en) * | 2009-08-13 | 2015-07-16 | Acceleron Pharma Inc. | Combined use of GDF traps and erythropoietin receptor activators to increase red blood cell levels |
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| US20120121576A1 (en) | 2010-11-08 | 2012-05-17 | Jasbir Seehra | Actriia binding agents and uses thereof |
| GR1007832B (el) * | 2011-11-21 | 2013-02-14 | Ιδρυμα Ιατροβιολογικων Ερευνων Ακαδημιας Αθηνων, | Αδρανοποιητες της ακτιβινης και χρηση τους για την θεραπεια ασθενειων που σχετιζονται με παρεκκλινουσα ενεργοποιηση της "αμυντικης αποκρισης του ξενιστη" |
| US9809636B2 (en) * | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
| CN112957462A (zh) * | 2012-10-24 | 2021-06-15 | 细胞基因公司 | 用于治疗贫血的方法 |
| MX366336B (es) | 2012-11-02 | 2019-07-05 | Celgene Corp | Antagonistas de activina - actrii y usos para el tratar trastornos oseos y otros. |
| AU2014209178B2 (en) | 2013-01-25 | 2018-11-08 | Takeda Pharmaceutical Company Limited | Follistatin in treating Duchenne muscular dystrophy |
| AP2016009549A0 (en) * | 2014-04-18 | 2016-11-30 | Acceleron Pharma Inc | Methods for increasing red blood cell levels and treating sickle-cell disease |
| KR102305109B1 (ko) * | 2014-06-04 | 2021-09-27 | 악셀레론 파마 인코포레이티드 | 폴리스타틴 폴리펩티드를 이용한 장애의 치료방법 및 치료를 위한 조성물 |
| BR112016029226A2 (pt) | 2014-06-13 | 2017-10-17 | Acceleron Pharma Inc | métodos e composições para o tratamento de úlceras |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| FI3227675T3 (fi) | 2014-12-03 | 2023-05-25 | Celgene Corp | Aktiviini-actrii-antagonisteja ja niiden käyttöjä myelodysplastisen oireyhtymän hoitamiseksi |
| AU2016246602B2 (en) * | 2015-04-06 | 2020-11-19 | Acceleron Pharma Inc. | Single-arm type I and type II receptor fusion proteins and uses thereof |
| RS61881B1 (sr) | 2015-04-22 | 2021-06-30 | Biogen Ma Inc | Novi hibridni actriib proteini zamke za ligand za lečenje bolesti gubljenja mišića |
| JP7072507B2 (ja) | 2015-11-23 | 2022-05-20 | アクセルロン ファーマ インコーポレイテッド | 眼の障害を処置するための方法 |
| US20170306027A1 (en) | 2016-04-06 | 2017-10-26 | Acceleron Pharma Inc. | Alk7 antagonists and uses thereof |
| MX2019001043A (es) | 2016-07-27 | 2019-09-26 | Acceleron Pharma Inc | Metodos y composiciones para el tratamiento de la mielofibrosis. |
| JP7280182B2 (ja) | 2016-10-05 | 2023-05-23 | アクセルロン ファーマ インコーポレイテッド | バリアントＡｃｔＲＩＩＢタンパク質およびその使用 |
| JOP20190085A1 (ar) | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| JP7051846B2 (ja) * | 2016-11-10 | 2022-04-11 | ケロス セラピューティクス インコーポレイテッド | アクチビンＩＩａ型受容体変異体および同変異体を含む医薬組成物 |
| JP7258021B2 (ja) | 2017-11-09 | 2023-04-14 | ケロス セラピューティクス インコーポレイテッド | アクチビンＩＩａ型受容体変異体を含む医薬組成物 |
| KR20200109330A (ko) | 2018-01-12 | 2020-09-22 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iib 변이체 및 그의 사용 방법 |
| CA3098679A1 (en) * | 2018-05-09 | 2019-11-14 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
| CN113015743B (zh) * | 2018-11-15 | 2025-06-24 | 三菱化学株式会社 | 改变型激活素a |
| KR20220049568A (ko) * | 2019-08-22 | 2022-04-21 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 엔젤만 증후군의 치료를 위한 ube3a |
| WO2021189010A1 (en) | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
| CA3228901A1 (en) * | 2021-09-03 | 2023-03-09 | Chris Xiangyang Lu | Anti-acvr2a antibodies and uses thereof |
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| KR20160129095A (ko) | 2007-02-09 | 2016-11-08 | 악셀레론 파마 인코포레이티드 | 액티빈-ＡｃｔＲⅡＡ 길항제 및 암 환자에서 골 생장을 촉진시키기 위한 이의 용도 |
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| DE102008016742B4 (de) * | 2008-03-31 | 2010-01-14 | Thyssenkrupp Presta Ag | Lenksäule für ein Kraftfahrzeug |
-
2009
- 2009-06-26 EP EP09770571.9A patent/EP2318028B1/en active Active
- 2009-06-26 JP JP2011516323A patent/JP5773868B2/ja active Active
- 2009-06-26 NZ NZ590326A patent/NZ590326A/xx unknown
- 2009-06-26 CA CA2729054A patent/CA2729054C/en active Active
- 2009-06-26 DK DK09770571.9T patent/DK2318028T3/da active
- 2009-06-26 EP EP09770553.7A patent/EP2303917B1/en active Active
- 2009-06-26 CN CN201710403739.0A patent/CN107252486B/zh active Active
- 2009-06-26 NZ NZ602471A patent/NZ602471A/en unknown
- 2009-06-26 CN CN200980133280.0A patent/CN102131515B/zh active Active
- 2009-06-26 WO PCT/US2009/003838 patent/WO2009158033A2/en not_active Ceased
- 2009-06-26 KR KR1020217011646A patent/KR20210047374A/ko not_active Ceased
- 2009-06-26 AU AU2009262968A patent/AU2009262968A1/en not_active Abandoned
- 2009-06-26 CA CA3049354A patent/CA3049354A1/en not_active Abandoned
- 2009-06-26 ES ES09770553T patent/ES2852699T3/es active Active
- 2009-06-26 KR KR1020117001139A patent/KR20110031951A/ko not_active Withdrawn
- 2009-06-26 WO PCT/US2009/003808 patent/WO2009158015A2/en not_active Ceased
- 2009-06-26 KR KR1020177008278A patent/KR102024444B1/ko active Active
- 2009-06-26 EP EP20195139.9A patent/EP3804746A1/en not_active Withdrawn
- 2009-06-26 ES ES09770571T patent/ES2791699T3/es active Active
- 2009-06-26 EP EP19191414.2A patent/EP3620795A1/en not_active Withdrawn
- 2009-06-26 CA CA2729098A patent/CA2729098C/en active Active
- 2009-06-26 KR KR1020197012336A patent/KR20190049912A/ko not_active Ceased
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2014
- 2014-02-07 JP JP2014022289A patent/JP2014088438A/ja not_active Withdrawn
-
2015
- 2015-07-23 JP JP2015145499A patent/JP2015187180A/ja not_active Withdrawn
-
2016
- 2016-05-12 AU AU2016203098A patent/AU2016203098B2/en active Active
- 2016-11-11 JP JP2016220297A patent/JP2017036331A/ja not_active Withdrawn
-
2018
- 2018-06-08 AU AU2018204105A patent/AU2018204105A1/en not_active Abandoned
- 2018-09-03 JP JP2018164196A patent/JP2018184484A/ja not_active Withdrawn
- 2018-09-03 JP JP2018164195A patent/JP6643432B2/ja active Active
-
2019
- 2019-12-23 JP JP2019231523A patent/JP2020041002A/ja not_active Withdrawn
-
2020
- 2020-08-17 AU AU2020220046A patent/AU2020220046A1/en not_active Abandoned
-
2021
- 2021-10-28 JP JP2021176418A patent/JP2022023184A/ja not_active Withdrawn
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