DK2311434T3 - Tørpulverformuleringer til inhalator, der omfatter overflademodificerende partikler med antiklæbende additiver - Google Patents

Tørpulverformuleringer til inhalator, der omfatter overflademodificerende partikler med antiklæbende additiver Download PDF

Info

Publication number
DK2311434T3
DK2311434T3 DK10179073.1T DK10179073T DK2311434T3 DK 2311434 T3 DK2311434 T3 DK 2311434T3 DK 10179073 T DK10179073 T DK 10179073T DK 2311434 T3 DK2311434 T3 DK 2311434T3
Authority
DK
Denmark
Prior art keywords
particles
powder
magnesium stearate
lactose
active
Prior art date
Application number
DK10179073.1T
Other languages
English (en)
Inventor
David Morton
Original Assignee
Vectura Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33548732&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2311434(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vectura Ltd filed Critical Vectura Ltd
Application granted granted Critical
Publication of DK2311434T3 publication Critical patent/DK2311434T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Claims (9)

1. Fremgangsmåde til fremstilling af en passiv pulverformulering til anordning, hvor glycopyrrolatpartikler samformales med magnesiumstearat, lactosepartikler samformales separat med magnesiumstearat, og de sam-formalede glycopyrrolat- og lactosepartikler herefter kombineres.
2. Fremgangsmåde ifølge krav 1, hvor samformalingen sker ved mekanofusion, anvendelse af cyclomixer eller slagformaling, såsåom kugleformaling, stråleformaling eller formaling ved anvendelse af en højtrykshomogenisator eller kombinationer deraf.
3. Fremgangsmåde ifølge krav 1 eller krav 2, hvor glycopyrrolatpartiklerne og lactosepartiklerne samformales ved anvendelse af forskellige formalingsprocesser.
4. Fremgangsmåde ifølge et hvilket som helst af ovennævnte krav, hvor glycopyrrolatpartiklerne har en diameter på mindre end 10 ym.
5. Fremgangsmåde ifølge et hvilket som helst af ovennævnte krav, hvor pulverformuleringen inkorporerer magnesiumstearat på overfladen af både glycopyrrolatpartiklerne og lactosepartiklerne.
6. Passiv pulverformulering til anordning, der omfatter glycopyrrolat, magnesiumstearat og lactose, hvor pulverformuleringen inkorporerer magnesiumstearat på overfladen af både glycopyrrolatpartiklerne og lactosepartiklerne, og hvor mængden, der anvendes, når magnesiumstearat tilsættes til glycopyrrolat, er 3 til 8 vægt- o "o ♦
7. Pulverformulering ifølge krav 6, hvilken formulering kan opnås ved samformaling af glycopyrrolatpartikler med magnesiumstearat, separat samformaling af lactosepartikler med magnesiumstearat og kombinering af de samformalede glycopyrrolat- og samformalede lactosepartikler.
8. Pulverformulering ifølge krav 6 eller 7, hvor magnesiumstearat danner en diskontinuert belægning på overfladerne af glycopyrrolat- og lactosepartiklerne.
9. Fremgangsmåde eller formulering ifølge et hvilket som helst af ovennævnte krav, hvor pulverformuleringen har en aftappet densitet på mindst 0,1 g/ml.
DK10179073.1T 2004-11-23 2005-11-23 Tørpulverformuleringer til inhalator, der omfatter overflademodificerende partikler med antiklæbende additiver DK2311434T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0425758.0A GB0425758D0 (en) 2004-11-23 2004-11-23 Preparation of pharmaceutical compositions
EP10151576.5A EP2174653B1 (en) 2004-11-23 2005-11-23 Dry powder inhaler formulations comprising surface-modified particles with anti-adherent additives

Publications (1)

Publication Number Publication Date
DK2311434T3 true DK2311434T3 (da) 2015-10-05

Family

ID=33548732

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10179073.1T DK2311434T3 (da) 2004-11-23 2005-11-23 Tørpulverformuleringer til inhalator, der omfatter overflademodificerende partikler med antiklæbende additiver
DK10151576.5T DK2174653T3 (da) 2004-11-23 2005-11-23 Tørpulverinhalatorformuleringer, der omfatter overflademodificerede partikler med klæbehindrende additiver

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK10151576.5T DK2174653T3 (da) 2004-11-23 2005-11-23 Tørpulverinhalatorformuleringer, der omfatter overflademodificerede partikler med klæbehindrende additiver

Country Status (16)

Country Link
US (4) US20080127972A1 (da)
EP (4) EP2311434B1 (da)
JP (2) JP5339401B2 (da)
CN (2) CN104146960A (da)
AT (1) ATE456363T1 (da)
CA (1) CA2589514C (da)
DE (1) DE602005019192D1 (da)
DK (2) DK2311434T3 (da)
ES (3) ES2548884T3 (da)
GB (1) GB0425758D0 (da)
HU (1) HUE027465T2 (da)
IN (1) IN2014CN04336A (da)
PL (3) PL2311434T3 (da)
PT (3) PT2311434E (da)
SI (2) SI2311434T1 (da)
WO (1) WO2006056812A1 (da)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3269360A1 (en) 2000-11-30 2018-01-17 Vectura Limited Method of making particles for use in a pharmaceutical composition
WO2004073729A1 (ja) 2003-02-21 2004-09-02 Translational Research Ltd. 薬物の経鼻投与用組成物
WO2004087243A1 (ja) 2003-03-27 2004-10-14 Bioactis Limited 鼻腔用粉末薬剤施薬装置
US20120321717A1 (en) * 2003-04-14 2012-12-20 Vectura Ltd. Devices and pharmaceutical compositions for enhancing dosing efficiency
GB0327723D0 (en) 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
GB0321607D0 (en) * 2003-09-15 2003-10-15 Vectura Ltd Manufacture of pharmaceutical compositions
WO2006016530A1 (ja) * 2004-08-10 2006-02-16 Translational Research, Ltd. 速効性でかつ高い吸収性を可能とする経鼻投与用組成物
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
GB0621957D0 (en) * 2006-11-03 2006-12-13 Vectura Group Plc Inhaler devices and bespoke pharmaceutical compositions
WO2008078730A1 (ja) 2006-12-26 2008-07-03 Translational Research, Ltd. 経鼻投与用製剤
US11241420B2 (en) 2007-04-11 2022-02-08 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
US20160331729A9 (en) * 2007-04-11 2016-11-17 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
MX2009010854A (es) * 2007-04-11 2010-01-28 Omeros Corp Composiciones y metodos para profilaxis y tratamiento de adicciones.
GB0712316D0 (en) * 2007-06-26 2007-08-01 Entripneur Ltd A novel powder and its method of manufacture
EP2534957B1 (en) 2007-12-14 2015-05-27 AeroDesigns, Inc Delivering aerosolizable products
US9637840B2 (en) 2008-07-18 2017-05-02 Prosonix Limited Process for improving crystallinity
EP2410981B2 (en) 2009-03-26 2020-02-26 Pulmatrix Operating Company, Inc. Dry powder formulations and methods for treating pulmonary diseases
GB0905840D0 (en) * 2009-04-06 2009-05-20 Sagentia Ltd Apparatus and methods
AU2010238641A1 (en) * 2009-04-24 2011-11-10 Merck Sharp & Dohme Corp. Agglomerate formulations useful in dry powder inhalers
WO2010131486A1 (en) * 2009-05-15 2010-11-18 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
GB2472327B (en) 2009-07-31 2013-03-13 Shin Nippon Biomedical Lab Ltd Intranasal granisetron and nasal applicator
GB0918249D0 (en) 2009-10-19 2009-12-02 Respivert Ltd Compounds
GB0918431D0 (en) 2009-10-21 2009-12-09 Prosonix Ltd Process for improving crystallinity
WO2011131663A1 (en) * 2010-04-21 2011-10-27 Chiesi Farmaceutici S.P.A. "process for providing particles with reduced electrostatic charges"
CN102309456B (zh) * 2010-07-02 2013-05-01 北京化工大学 一种厄贝沙坦纳微复合粉体与片剂及其制备方法
US8758824B2 (en) 2010-08-30 2014-06-24 Pulmatrix, Inc. Respirably dry powder comprising calcium lactate, sodium chloride and leucine
US9061352B2 (en) 2010-08-30 2015-06-23 Pulmatrix, Inc. Dry powder formulations and methods for treating pulmonary diseases
RU2017144619A (ru) * 2010-09-29 2019-02-20 Пулмэтрикс, Инк. Катионы одновалентных металлов сухих порошков для ингаляций
PT3470057T (pt) 2010-09-29 2021-12-03 Pulmatrix Operating Co Inc Pós secos catiónicos compreendendo sais de magnésio
UY33337A (es) 2010-10-18 2011-10-31 Respivert Ltd DERIVADOS SUSTITUIDOS DE 1H-PIRAZOL[ 3,4-d]PIRIMIDINA COMO INHIBIDORES DE LAS FOSFOINOSITIDA 3-QUINASAS
ITMI20120092A1 (it) * 2012-01-26 2013-07-27 Micro Macinazione S A Compositi di inclusione farmaco-carrier preparati con processo di attivazione meccano-chimica mediante mulini a getto di fluido ad alta energia
US20150136130A1 (en) * 2012-02-29 2015-05-21 Pulmatrix, Inc. Inhalable dry powders
LT2834244T (lt) 2012-03-13 2016-11-10 Respivert Limited Kristalinės pi3 kinazės slopikliai
BR112014025518B1 (pt) 2012-04-13 2022-05-24 Glaxosmithkline Intellectual Property Development Limited Partículas agregadas de umeclidinium, vilanterol e fluticasona, composição em pó, inalador, processo para a preparação de partículas agregadas, e, uso de estearato de magnésio em partículas agregadas
CN103570610B (zh) * 2012-07-18 2017-08-11 重庆华邦制药有限公司 一种罗氟司特微粒的制备方法
CN103588846B (zh) * 2012-08-15 2016-08-03 重庆华邦制药有限公司 一种丙酸氟替卡松微粒的制备方法及其用途
WO2014074797A1 (en) * 2012-11-09 2014-05-15 Civitas Therapeutics, Inc. Ultra low density pulmonary powders
JP6116206B2 (ja) * 2012-11-26 2017-04-19 クリニプロ株式会社 吸入用パウダーの製造方法
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757529B2 (en) * 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
GB201305825D0 (en) 2013-03-28 2013-05-15 Vectura Ltd New use
CA2907566C (en) 2013-04-01 2023-08-22 Pulmatrix, Inc. Tiotropium dry powders
ITMI20130572A1 (it) * 2013-04-10 2014-10-11 Eratech Srl Composizione comprendente almeno due polveri secche ottenute per spray dry per aumentare la stabilita' della formulazione
WO2014178891A1 (en) * 2013-04-30 2014-11-06 Otitopic Inc. Dry powder formulations and methods of use
HUE053957T2 (hu) * 2013-07-11 2021-08-30 Chiesi Farm Spa Antikolinerg, kortikoszteroid és béta-adrenerg anyagot tartalmazó száraz porkészítmény inhalálással történõ beadásra
RU2707285C2 (ru) 2013-10-08 2019-11-26 ЭйАй ТЕРАПЬЮТИКС, ИНК. Рапамицин для лечения лимфангиолейомиоматоза
US20160317542A1 (en) 2013-12-09 2016-11-03 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
US10307371B2 (en) 2014-02-11 2019-06-04 AI Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis
WO2015127315A1 (en) * 2014-02-20 2015-08-27 Otitopic Inc. Dry powder formulations for inhalation
MX2016012712A (es) 2014-04-04 2017-03-31 Lam Therapeutics Inc Una formulacion de rapamicina inhalable para tratar afecciones relacionadas con la edad.
TR201818680T4 (tr) 2014-07-09 2019-01-21 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi İnhalasyona yönelik formülasyonların hazırlanması için bir proses.
CA2991760A1 (en) * 2014-07-31 2016-02-04 Otitopic Inc. Dry powder formulations for inhalation
MA40617B1 (fr) 2014-09-09 2020-05-29 Vectura Ltd Formulation comprenant glycopyrrolate, procédé et appareil
EP3209330B1 (en) 2014-10-07 2022-02-23 AI Therapeutics, Inc. An inhalable sirolimus formulation for the treatment of pulmonary hypertension
US20160119692A1 (en) * 2014-10-24 2016-04-28 Sunshine Partners LLC Interactive system and method for viewer selection of objects in context while viewing television
CN107106641B (zh) 2014-10-31 2021-12-21 葛兰素史密斯克莱知识产权发展有限公司 粉末制剂
PE20180690A1 (es) 2015-04-27 2018-04-23 Intercept Pharmaceuticals Inc Composiciones de acido obeticolico y metodos de uso
US10149844B2 (en) 2015-09-16 2018-12-11 Philip Morris Products S.A. Inhalable nicotine formulations, and methods of making and using thereof
US9585835B1 (en) * 2015-09-16 2017-03-07 Sansa Corporation (Barbados) Inc. Inhalable nicotine formulations and methods of making and using the same
US10853435B2 (en) 2016-06-17 2020-12-01 Axon Enterprise, Inc. Systems and methods for aligning event data
AU2017286864A1 (en) * 2016-06-30 2018-11-15 Philip Morris Products S.A. Nicotine particles and compositions
KR102559152B1 (ko) 2016-06-30 2023-07-26 필립모리스 프로덕츠 에스.에이. 니코틴 입자
EP3525759A1 (en) * 2016-10-14 2019-08-21 Pulmatrix Operating Company, Inc. Antifungal dry powders
JP2020510002A (ja) * 2017-03-07 2020-04-02 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム 吸入可能なニコチン製剤、およびその作製および使用方法
EP3630245A1 (en) 2017-06-02 2020-04-08 CSP Technologies, Inc. Inhaler and methods of using and making same
CN109200034A (zh) * 2017-06-30 2019-01-15 正大天晴药业集团股份有限公司 一种可吸入干粉形式的组合物及其制备方法
US10786456B2 (en) 2017-09-22 2020-09-29 Otitopic Inc. Inhaled aspirin and magnesium to treat inflammation
CN111315363B (zh) 2017-09-22 2022-10-11 奥迪托皮克股份有限公司 含有硬脂酸镁的干粉组合物
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
KR20200118034A (ko) 2018-01-05 2020-10-14 임펠 뉴로파마 인코포레이티드 정밀 후각기관 장치에 의한 올란자핀의 비강내 전달
CN112451509B (zh) * 2020-12-19 2023-03-07 沈阳药科大学 一种川丁特罗吸入粉雾剂及其制备方法
WO2023069028A1 (en) * 2021-10-20 2023-04-27 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi A process for the preparation of dry powder compositions for inhalation
US20230191047A1 (en) * 2021-12-17 2023-06-22 Belhaven BioPharma Inc. Medical counter measures including dry powder formulations and associated methods
WO2023128913A1 (en) * 2021-12-31 2023-07-06 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi A process for the preparation of dry powder compositions for inhalation
WO2024009079A1 (en) 2022-07-04 2024-01-11 Hovione Scientia Limited Dry powder inhaler pharmaceutical composition of coated crystalline dry powder for inhalation
CN115060832B (zh) * 2022-08-18 2022-11-29 上海奥科达生物医药科技有限公司 奥卡西平口服混悬液中奥卡西平及防腐剂含量检测方法

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4687773A (en) 1983-03-28 1987-08-18 Mclean Hospital (+)-N-N-propylnorapomorphine and selective limbic activity
EP0705614B1 (en) 1989-04-28 2002-09-25 Riker Laboratories, Inc. Dry powder inhalation device
JPH05963A (ja) 1990-04-13 1993-01-08 Toray Ind Inc ポリペプチド類組成物
US5292520A (en) 1990-09-13 1994-03-08 Akzo N.V. Stabilized solid pharmaceutical composition containing acid addition salts of a basic drug and an alkaline stabilizer
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
TW402506B (en) 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
SA95160463B1 (ar) 1994-12-22 2005-10-04 استرا أكتيبولاج مساحيق للاستنشاق
GB9501841D0 (en) * 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
GB9515182D0 (en) * 1995-07-24 1995-09-20 Co Ordinated Drug Dev Improvements in and relating to powders for use in dry powder inhalers
FR2747311B1 (fr) 1996-04-10 1998-08-14 Pf Medicament Inhalateur a poudre et a air comprime
ES2236832T3 (es) 1997-01-16 2005-07-16 Massachusetts Institute Of Technology Preparacion de particulas para inhalacion.
US6051257A (en) 1997-02-24 2000-04-18 Superior Micropowders, Llc Powder batch of pharmaceutically-active particles and methods for making same
EP0931595A1 (en) 1998-01-26 1999-07-28 Imra Europe S.A. A device for spraying a liquid
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
EP1131059B1 (de) 1998-11-13 2003-03-05 Jago Research Ag Trockenpulver zur inhalation
GB9827145D0 (en) 1998-12-09 1999-02-03 Co Ordinated Drug Dev Improvements in or relating to powders
DK1158958T3 (da) 1999-03-05 2007-10-08 Chiesi Farma Spa Forbedret pulverformulering til inhalering
NZ516083A (en) 1999-05-27 2003-08-29 Acusphere Inc Porous drug matrices and methods of manufacture thereof
US6858199B1 (en) 2000-06-09 2005-02-22 Advanced Inhalation Research, Inc. High efficient delivery of a large therapeutic mass aerosol
GB2353222B (en) 1999-06-23 2001-09-19 Cambridge Consultants Inhalers
US20010036481A1 (en) 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US6586008B1 (en) 1999-08-25 2003-07-01 Advanced Inhalation Research, Inc. Use of simple amino acids to form porous particles during spray drying
JP2001151673A (ja) 1999-09-06 2001-06-05 Nikken Chem Co Ltd 吸入用粉末製剤の製造方法
JP2001072586A (ja) 1999-09-06 2001-03-21 Nikken Chem Co Ltd 吸入用粉末製剤及びその製造方法
PT1219609E (pt) 1999-09-16 2007-06-19 Tanabe Seiyaku Co ''compostos cíclicos aromático azotados de seis membros''
FI20002217A (fi) 1999-12-30 2001-07-01 Orion Yhtymae Oyj Inhalaatiopartikkelit
GB0008411D0 (en) * 2000-04-05 2000-05-24 Vectura Ltd Pharmaceutical preparations and their manufacture
US6506765B2 (en) 2000-04-07 2003-01-14 Tap Pharmaceutical Products, Inc. Apomorphine derivatives and methods for their use
GB0008660D0 (en) 2000-04-07 2000-05-31 Arakis Ltd The treatment of respiratory diseases
GB0009468D0 (en) * 2000-04-17 2000-06-07 Vectura Ltd Improvements in or relating to formulations for use in inhaler devices
PE20011227A1 (es) 2000-04-17 2002-01-07 Chiesi Farma Spa Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros
GB0009469D0 (en) * 2000-04-17 2000-06-07 Vectura Ltd Improvements in or relating to formalities for use in inhaler devices
ATE364381T1 (de) 2000-04-17 2007-07-15 Vectura Ltd Formulierungen zur verwendung in inhalationsvorrichtungen
GB0010709D0 (en) * 2000-05-03 2000-06-28 Vectura Ltd Powders for use a in dry powder inhaler
DK1913939T3 (da) 2000-06-27 2017-09-18 Vectura Ltd Formuleringer til anvendelse i inhalationsanordninger
GB2364919A (en) 2000-07-21 2002-02-13 Cambridge Consultants Inhalers
AU2001277230A1 (en) 2000-08-01 2002-02-13 Inhale Therapeutic Systems, Inc. Apparatus and process to produce particles having a narrow size distribution andparticles made thereby
US6613308B2 (en) 2000-09-19 2003-09-02 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
BR0111982A (pt) 2000-11-15 2003-10-28 Tap Pharmaceuticals Products I Tratamento com apomorfina, de disfunção sexual induzida por droga anti depressão
US20020086876A1 (en) 2000-11-15 2002-07-04 Ruff Dustin D. Treatment of anti-depression drug-induced sexual dysfunction with apomorphine
EP3269360A1 (en) * 2000-11-30 2018-01-17 Vectura Limited Method of making particles for use in a pharmaceutical composition
AU2211502A (en) * 2000-11-30 2002-06-11 Vectura Ltd Method of making particles for use in a pharmaceutical composition
DE60140268D1 (de) * 2000-11-30 2009-12-03 Vectura Ltd Partikel zur verwendung in einer pharmazeutischen zusammensetzung
US20040052733A1 (en) * 2000-11-30 2004-03-18 Staniforth John Nicholas Pharmaceutical compositions for inhalation
IL156596A0 (en) 2000-12-27 2004-01-04 Salus Pharma Inc Inhalable aztreonam for treatment and prevention of pulmonary bacterial infections
GB0109384D0 (en) * 2001-04-12 2001-05-30 Vectura Ltd Pharmaceutical products, preparation and uses thereof
CA2444729A1 (en) 2001-05-10 2002-11-14 Vectura Delivery Devices Limited Inhalers
US6737042B2 (en) 2001-05-24 2004-05-18 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US20040028613A1 (en) 2001-06-25 2004-02-12 Nastech Pharmaceutical Company Inc Dopamine agonist formulations for enhanced central nervous system delivery
JP2005506323A (ja) * 2001-09-05 2005-03-03 ベクトゥラ・リミテッド 経口送達用機能性散剤
EP1490031A1 (en) * 2002-03-07 2004-12-29 Vectura Limited Fast melt multiparticulate formulations for oral delivery
US20040003341A1 (en) 2002-06-20 2004-01-01 Koninklijke Philips Electronics N.V. Method and apparatus for processing electronic forms for use with resource constrained devices
CA2500923A1 (en) * 2002-10-11 2004-04-22 Vectura Limited Pharmaceutical excipients comprising inorganic particles in association with an organic polymeric material and forming a solid reticulated matrix, compositions, manufacturing and use thereof
WO2004093848A2 (en) * 2003-04-14 2004-11-04 Vectura Ltd Dry power inhaler devices and dry power formulations for enhancing dosing efficiency
US20040204439A1 (en) 2003-04-14 2004-10-14 Staniforth John Nicholas Composition, device, and method for treating sexual dysfunction via inhalation
WO2004089374A1 (en) 2003-04-14 2004-10-21 Vectura Ltd Pharmaceutical compositions comprising apomorphine for pulmonary inhalation
US20060147389A1 (en) * 2004-04-14 2006-07-06 Vectura Ltd. Devices and pharmaceutical compositions for enhancing dosing efficiency
GB0321607D0 (en) 2003-09-15 2003-10-15 Vectura Ltd Manufacture of pharmaceutical compositions
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
EP1663164A2 (en) * 2003-09-15 2006-06-07 Vectura Limited Methods for preparing pharmaceutical compositions
GB0330255D0 (en) 2003-12-31 2004-02-04 Vectura Ltd Multiparticulate formulations for oral delivery
GB0408308D0 (en) 2004-04-14 2004-05-19 Vectura Ltd Pharmaceutical compositions
GB0409703D0 (en) 2004-04-30 2004-06-02 Vectura Ltd Pharmaceutical compositions
GB0410399D0 (en) 2004-05-10 2004-06-16 Arakis Ltd The treatment of respiratory disease
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
GB0426301D0 (en) 2004-11-30 2004-12-29 Vectura Ltd Pharmaceutical formulations

Also Published As

Publication number Publication date
US20160000709A1 (en) 2016-01-07
WO2006056812A1 (en) 2006-06-01
EP2949317A1 (en) 2015-12-02
US20080127972A1 (en) 2008-06-05
CA2589514C (en) 2014-07-22
PT1814521E (pt) 2010-04-16
EP2174653A1 (en) 2010-04-14
ES2548884T3 (es) 2015-10-21
GB0425758D0 (en) 2004-12-22
US9585834B2 (en) 2017-03-07
EP2174653B1 (en) 2014-05-14
EP1814521B1 (en) 2010-01-27
ES2340599T3 (es) 2010-06-07
US9642800B2 (en) 2017-05-09
HUE027465T2 (en) 2016-09-28
EP1814521A1 (en) 2007-08-08
EP2949317B1 (en) 2017-01-04
PT2174653E (pt) 2014-08-25
ES2490240T3 (es) 2014-09-03
DE602005019192D1 (de) 2010-03-18
DK2174653T3 (da) 2014-08-11
PT2311434E (pt) 2015-10-23
EP2311434A1 (en) 2011-04-20
IN2014CN04336A (da) 2015-09-04
PL2174653T3 (pl) 2014-11-28
ATE456363T1 (de) 2010-02-15
US20110236492A1 (en) 2011-09-29
JP5579669B2 (ja) 2014-08-27
CN104146960A (zh) 2014-11-19
JP5339401B2 (ja) 2013-11-13
CN101106975A (zh) 2008-01-16
SI2174653T1 (sl) 2014-10-30
JP2011201925A (ja) 2011-10-13
PL2311434T3 (pl) 2015-12-31
CA2589514A1 (en) 2006-06-01
JP2008520307A (ja) 2008-06-19
PL1814521T3 (pl) 2010-07-30
US20170216203A1 (en) 2017-08-03
EP2311434B1 (en) 2015-07-08
SI2311434T1 (sl) 2015-11-30

Similar Documents

Publication Publication Date Title
DK2311434T3 (da) Tørpulverformuleringer til inhalator, der omfatter overflademodificerende partikler med antiklæbende additiver
US10449161B2 (en) Pharmaceutical compositions for inhalation
EP1337239B2 (en) Particles for use in a pharmaceutical composition
DK2283818T3 (da) Fremgangsmåde til fremstilling af partikler til anvendelse i en farmaceutisk sammensætning
EP1617820B1 (en) Dry power inhaler devices and dry power formulations for enhancing dosing efficiency
JP6306145B2 (ja) 吸入可能な製剤におけるステアリン酸塩の使用
RU2666963C2 (ru) Агрегированные частицы
WO2010014827A2 (en) Formulations containing large-size carrier particles for dry powder inhalation aerosols
KR102452773B1 (ko) 흡입용 의약 조성물
Nokhodchi et al. An Investigation into Alternative Sugars as Potential Carriers for a Dry Powder Formulation of Budesonide and Formoterol