DK2298802T3 - T1R3-smagsreceptordomæner og gener, der koder derfor - Google Patents

T1R3-smagsreceptordomæner og gener, der koder derfor

Info

Publication number
DK2298802T3
DK2298802T3 DK10180329.4T DK10180329T DK2298802T3 DK 2298802 T3 DK2298802 T3 DK 2298802T3 DK 10180329 T DK10180329 T DK 10180329T DK 2298802 T3 DK2298802 T3 DK 2298802T3
Authority
DK
Denmark
Prior art keywords
methods
taste
genes
mammal
receptors
Prior art date
Application number
DK10180329.4T
Other languages
Danish (da)
English (en)
Inventor
Jon Elliot Alder
Sergey Zozulya
Shawn M O'connell
Xiaodong Li
Lena Staszewski
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Application granted granted Critical
Publication of DK2298802T3 publication Critical patent/DK2298802T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Confectionery (AREA)
  • General Preparation And Processing Of Foods (AREA)
DK10180329.4T 2000-03-07 2001-03-07 T1R3-smagsreceptordomæner og gener, der koder derfor DK2298802T3 (da)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US18754600P 2000-03-07 2000-03-07
US19553600P 2000-04-07 2000-04-07
US20984000P 2000-06-06 2000-06-06
US21421300P 2000-06-23 2000-06-23
US22644800P 2000-08-17 2000-08-17
US25922701P 2001-01-03 2001-01-03
EP09174166A EP2143732B1 (en) 2000-03-07 2001-03-07 T1R1 Taste receptor domains and genes encoding same

Publications (1)

Publication Number Publication Date
DK2298802T3 true DK2298802T3 (da) 2013-01-02

Family

ID=27558784

Family Applications (3)

Application Number Title Priority Date Filing Date
DK01914732T DK1309606T3 (da) 2000-03-07 2001-03-07 T1R-smagsreceptorer og gener, der koder for samme
DK10180329.4T DK2298802T3 (da) 2000-03-07 2001-03-07 T1R3-smagsreceptordomæner og gener, der koder derfor
DK08152887.9T DK1944319T3 (da) 2000-03-07 2001-03-07 T1R -smagsreceptorer og gener, der koder for samme

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK01914732T DK1309606T3 (da) 2000-03-07 2001-03-07 T1R-smagsreceptorer og gener, der koder for samme

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK08152887.9T DK1944319T3 (da) 2000-03-07 2001-03-07 T1R -smagsreceptorer og gener, der koder for samme

Country Status (15)

Country Link
US (25) US7244835B2 (enExample)
EP (4) EP2298802B1 (enExample)
JP (2) JP5403842B2 (enExample)
CN (3) CN1766108A (enExample)
AT (2) ATE456577T1 (enExample)
AU (2) AU2001240086B2 (enExample)
CA (1) CA2402214C (enExample)
DE (3) DE60135229D1 (enExample)
DK (3) DK1309606T3 (enExample)
ES (3) ES2396681T3 (enExample)
IL (1) IL151578A0 (enExample)
MX (1) MXPA02008724A (enExample)
NO (1) NO20024276L (enExample)
TW (1) TW201006846A (enExample)
WO (1) WO2001066563A2 (enExample)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU764180B2 (en) * 1998-07-28 2003-08-14 Regents Of The University Of California, The Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
TW201006846A (en) * 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
JP2003531614A (ja) * 2000-04-28 2003-10-28 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 炭水化物化合物および他の甘味物質の感知に関連する遺伝子および配列変異
GB2364058A (en) * 2000-05-05 2002-01-16 Smithkline Beecham Corp AXOR79, a G-protein coupled receptor
EP1301595A2 (en) * 2000-05-22 2003-04-16 Incyte Genomics, Inc. G-protein coupled receptors
ATE432350T1 (de) * 2000-06-16 2009-06-15 Incyte Corp G-protein gekoppelte rezeptoren
WO2002024885A2 (en) * 2000-09-25 2002-03-28 Bayer Aktiengesellschaft Regulation of human g protein-coupled receptor
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US7309577B2 (en) 2001-03-07 2007-12-18 Senomyx, Inc. Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste
US7763431B1 (en) 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
US6955887B2 (en) 2001-03-30 2005-10-18 Senomyx, Inc. Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling
US7301009B2 (en) * 2001-06-26 2007-11-27 Senomyx, Inc. Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli
US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US20080244761A1 (en) 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
JP2005501519A (ja) * 2001-04-20 2005-01-20 マウント シナイ スクール オブ メディスン 新規な味覚受容体t1r3
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
EP2327985B2 (en) * 2001-06-26 2019-08-21 Senomyx, Inc. T1R Hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
AU2002320294B2 (en) * 2001-07-03 2009-01-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Mammalian sweet and amino acid heterodimeric taste receptors
US20040029789A1 (en) * 2001-07-05 2004-02-12 Anderson David W. Novel proteins and nucleic acids encoding same
AU2002326429B2 (en) 2001-07-20 2007-09-20 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Phenylthiocarbamide (PTC) taste receptor
US7335487B2 (en) * 2001-09-18 2008-02-26 Irm Llc Sweet taste receptors
AU2003230176A1 (en) * 2002-05-20 2003-12-19 Tvd Taste Virtual Dimensions, Inc. Antibodies and their use for the modulation of taste sensation___
EP1644528A2 (en) 2003-06-19 2006-04-12 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services, Variants of human taste receptor genes
CA2535036C (en) 2003-08-06 2015-11-24 Senomyx, Inc. Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
US20050244810A1 (en) * 2003-09-29 2005-11-03 Egan Josephine M Taste signaling in gastrointestinal cells
US20050106571A1 (en) 2003-10-02 2005-05-19 The Regents Of The University Of California Mammalian T1R3 sweet taste receptors
US20060045953A1 (en) * 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
WO2006068745A1 (en) 2004-12-22 2006-06-29 Cargill, Incorporated Methods for determining cellular response to stimuli
AR052477A1 (es) * 2005-02-04 2007-03-21 Senomyx Inc Moleculas que comprenden restos organicos conectados como modificadores del sabor para composiciones comestibles
BRPI0607006B1 (pt) 2005-02-04 2017-05-16 Senomyx Inc compostos que compreendem funções orgânicas de hetero arilas ligadas e seus usos como novos modificadores, flavorizantes e promotores do sabor umami para composições comestíveis
US8796441B2 (en) 2005-04-13 2014-08-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human sweet and umami taste receptor variants
US7851006B2 (en) 2005-05-23 2010-12-14 Cadbury Adams Usa Llc Taste potentiator compositions and beverages containing same
CN101179943B (zh) 2005-05-23 2013-06-26 卡夫食品环球品牌有限责任公司 填充液体的咀嚼型胶基糖组合物
US7851005B2 (en) 2005-05-23 2010-12-14 Cadbury Adams Usa Llc Taste potentiator compositions and beverages containing same
CA2604760C (en) 2005-05-23 2012-06-26 Cadbury Adams Usa Llc Taste potentiator compositions and beverages containing same
TW200715993A (en) * 2005-06-15 2007-05-01 Senomyx Inc Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers
US20110097741A1 (en) * 2006-04-20 2011-04-28 Jay Patrick Slack Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays
KR101387563B1 (ko) 2006-04-21 2014-04-25 세노믹스, 인코포레이티드 고효능의 조미용 향료를 포함하는 식품 조성물 및 이의 제조 방법
US20070259875A1 (en) * 2006-04-28 2007-11-08 Atwal Karnail S Triaryl substituted imidazole derivatives and taste-inhibiting uses thereof
WO2008008224A2 (en) 2006-07-10 2008-01-17 Duke University Sour taste receptor compositions and methods
EP2087358A2 (en) * 2006-11-15 2009-08-12 Redpoint Bio Corporation Spicematrix technology for taste compound identification
US8633186B2 (en) 2007-06-08 2014-01-21 Senomyx Inc. Modulation of chemosensory receptors and ligands associated therewith
US9603848B2 (en) * 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US7928111B2 (en) * 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
GB0713297D0 (en) 2007-07-10 2007-08-15 Cadbury Schweppes Plc Chocolate compositions having improved flavour characteristics
US9714941B2 (en) * 2007-07-31 2017-07-25 Massachusetts Institute Of Technology Bio-sensing nanodevice
RU2511315C2 (ru) 2008-07-31 2014-04-10 Синомикс, Инк. Композиции, содержащие усилители сладкого вкуса, и способы их получения
WO2010014903A1 (en) 2008-07-31 2010-02-04 Massachusetts Institute Of Technology Multiplexed olfactory receptor-based microsurface plasmon polariton detector
UA113831C2 (xx) 2008-07-31 2017-03-27 Способи і проміжні сполуки для одержання підсилювачів солодкого смаку
US20120184465A1 (en) * 2009-07-20 2012-07-19 Verdezyne, Inc. Combinatorial methods for optimizing engineered microorganism function
WO2011067202A1 (en) 2009-12-02 2011-06-09 Unilever Nv Improved method for screening a potential modulator compound of a taste receptor
EP2603098B1 (en) 2010-08-12 2025-08-06 Firmenich Incorporated Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
ES2656944T3 (es) 2011-04-29 2018-03-01 Intercontinental Great Brands Llc Ácido encapsulado, método de preparación del mismo, y goma de mascar que lo comprende
US9128079B2 (en) 2011-08-08 2015-09-08 The Coca-Cola Company Methods of using lung or bronchial epithelial cells to identify bitter taste modulators
US9442100B2 (en) 2013-12-18 2016-09-13 Medibotics Llc Caloric intake measuring system using spectroscopic and 3D imaging analysis
US10314492B2 (en) 2013-05-23 2019-06-11 Medibotics Llc Wearable spectroscopic sensor to measure food consumption based on interaction between light and the human body
US9456916B2 (en) 2013-03-12 2016-10-04 Medibotics Llc Device for selectively reducing absorption of unhealthy food
US9254099B2 (en) 2013-05-23 2016-02-09 Medibotics Llc Smart watch and food-imaging member for monitoring food consumption
US9042596B2 (en) 2012-06-14 2015-05-26 Medibotics Llc Willpower watch (TM)—a wearable food consumption monitor
US9536449B2 (en) 2013-05-23 2017-01-03 Medibotics Llc Smart watch and food utensil for monitoring food consumption
KR20200028050A (ko) 2012-08-06 2020-03-13 피르메니히 인코포레이티드 단맛 향미 개질제
JO3155B1 (ar) 2013-02-19 2017-09-20 Senomyx Inc معدِّل نكهة حلوة
US9011365B2 (en) 2013-03-12 2015-04-21 Medibotics Llc Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food
US9067070B2 (en) 2013-03-12 2015-06-30 Medibotics Llc Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type
US9804157B1 (en) 2013-03-15 2017-10-31 Senomyx, Inc. Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives
US9529385B2 (en) 2013-05-23 2016-12-27 Medibotics Llc Smart watch and human-to-computer interface for monitoring food consumption
US9826662B2 (en) 2013-12-12 2017-11-21 General Electric Company Reusable phase-change thermal interface structures
US10660571B2 (en) * 2013-12-19 2020-05-26 Kent State University Thermochromic fabrics utilizing cholesteric liquid crystal material
WO2015123282A1 (en) 2014-02-12 2015-08-20 Fotsing Joseph R Improved process for the synthesis of substituted 1-benzyl-3-(1-(isoxazol-4-ylmethyl)-1h-pyrazol-4-yl)imidazolidine-2,4-diones
WO2015163905A1 (en) 2014-04-25 2015-10-29 General Mills, Inc. Food products having sweetness enhancer
JP6383704B2 (ja) * 2015-07-02 2018-08-29 日立オートモティブシステムズ株式会社 電池制御装置
EP3814344B1 (en) 2018-08-07 2024-07-24 Firmenich Incorporated 5-substituted 4-amino-1h-benzo[c][1,2,6]thiadiazine 2,2-dioxides and formulations and uses thereof
EP3693975A1 (en) 2019-02-06 2020-08-12 Tata Consultancy Services Limited System and method for evaluation of at least one potential tastant from a plurality of tastants
WO2021150686A1 (en) 2020-01-22 2021-07-29 Firmenich Incorporated High-sensitivity detection of gpcr activity and uses thereof
BR112022025416A2 (pt) * 2020-06-25 2023-01-24 Mycotechnology Inc Proteína doce de trufa
US20240345068A1 (en) 2023-03-01 2024-10-17 Alcheme Bio Inc. Systems, methods, and compositions for production of cellular agriculture products
CN116554350B (zh) * 2023-04-26 2024-01-09 之江实验室 基于人类甜味受体蛋白的生物传感器及其应用

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US788470A (en) * 1903-06-16 1905-04-25 Edouard Jehn Changing mechanism for picture-exhibitors.
US1733847A (en) * 1927-03-11 1929-10-29 Variety Fire Door Company Door-latch retainer
JPS5825980B2 (ja) 1976-02-12 1983-05-31 ヤマサ醤油株式会社 サイクリックヌクレオチドの定量法
US4391904A (en) 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4517288A (en) 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
US4661768A (en) * 1983-09-14 1987-04-28 Johnson Service Company Capacitance transducing method and apparatus
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
EP1484412A3 (en) 1989-12-22 2007-10-17 Laboratoires Serono SA Eukaryotic host cell line in which an endogenous gene has been activated, and uses thereof
EP0466874A1 (fr) 1990-02-09 1992-01-22 Asulab S.A. Micromoteur electrostatique a champ radial realise par microfabrication photolithographique et procede de realisation d'un tel micromoteur
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
CA2106847A1 (en) 1991-04-05 1992-10-06 Linda B. Buck Odorant receptors and uses thereof
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
NZ245015A (en) 1991-11-05 1995-12-21 Transkaryotic Therapies Inc Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production
US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US6664107B1 (en) 1993-05-26 2003-12-16 Ontario Cancer Institute, University Health Network CD45 disrupted nucleic acid
US5426039A (en) 1993-09-08 1995-06-20 Bio-Rad Laboratories, Inc. Direct molecular cloning of primer extended DNA containing an alkane diol
NZ273015A (en) * 1993-09-20 1997-09-22 Ciba Geigy Ag Human metabotropic glutamate receptor proteins, production, dna code, fusion proteins, antibodies and method of detecting glutamate agonist
IL108205A0 (en) 1993-12-28 1994-04-12 Yeda Res & Dev Olfactory genes and receptors
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5691188A (en) 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
JPH10510433A (ja) 1995-06-06 1998-10-13 アイシス・ファーマシューティカルス・インコーポレーテッド 高いキラル純度のホスホロチオエート結合を有するオリゴヌクレオチド
US5985662A (en) 1995-07-13 1999-11-16 Isis Pharmaceuticals Inc. Antisense inhibition of hepatitis B virus replication
AU1118197A (en) 1995-11-09 1997-05-29 Johns Hopkins University School Of Medicine, The Novel sperm receptors
US5874243A (en) 1997-03-28 1999-02-23 Smithkline Beecham Corporation OLRCC15 receptor
US5993778A (en) 1997-05-07 1999-11-30 Firestein; Stuart J. Functional expression of, and assay for, functional cellular receptors in vivo
US5940153A (en) * 1998-04-03 1999-08-17 Motorola, Inc. Display assembly having LCD and seal captured between interlocking lens cover and lightpipe
FR2780405B1 (fr) 1998-06-25 2001-12-28 Centre Nat Rech Scient Nouveaux recepteurs olfactifs et leurs utilisations
BR9912545A (pt) 1998-07-28 2001-10-30 Univ California ácidos nucleicos codificando um receptorcopulado a proteìna g envolvido em transduçãosensorial
AU5022399A (en) 1998-07-28 2000-02-21 Canadian Inovatech, Inc. Methods and compositions for inhibiting microbial growth in wine
AU764180B2 (en) 1998-07-28 2003-08-14 Regents Of The University Of California, The Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
JP2002522030A (ja) 1998-07-28 2002-07-23 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 感覚伝達に関与するタンパク質をコードする核酸
WO2000006693A1 (en) 1998-07-28 2000-02-10 Victoria Ann Heslop A digester
US6106555A (en) 1998-12-15 2000-08-22 Av Healing Llc Method for tissue fixation
ES2337322T3 (es) 1998-12-23 2010-04-22 Mount Sinai School Of Medicine Of New York University Inhibidores de la respuesta al sabor amargo.
WO2001018050A2 (en) 1999-09-10 2001-03-15 The Regents Of The University Of California T2r taste receptor family
US6558910B2 (en) 1999-09-10 2003-05-06 The Regents Of The University Of California SF, a novel family of taste receptors
US20030036089A1 (en) 1999-12-20 2003-02-20 Applera Corporation Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof
AU2001243345A1 (en) * 2000-02-29 2001-09-12 Millennium Pharmaceuticals, Inc. 1983, 52881, 2398, 45449, 50289, and 52872, g protein-coupled receptors and uses therefor
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
US6608176B2 (en) 2000-03-31 2003-08-19 University Of Miami Taste receptor for umami (monosodium glutamate) taste
AU5125801A (en) 2000-04-07 2001-10-23 Senomyx Inc T2r taste receptors and genes encoding same
JP2003531614A (ja) * 2000-04-28 2003-10-28 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 炭水化物化合物および他の甘味物質の感知に関連する遺伝子および配列変異
ATE432350T1 (de) 2000-06-16 2009-06-15 Incyte Corp G-protein gekoppelte rezeptoren
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US6955887B2 (en) 2001-03-30 2005-10-18 Senomyx, Inc. Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling
US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US7301009B2 (en) 2001-06-26 2007-11-27 Senomyx, Inc. Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli
US20080244761A1 (en) 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US7763431B1 (en) 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
US7309577B2 (en) 2001-03-07 2007-12-18 Senomyx, Inc. Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste
EP2327985B2 (en) 2001-06-26 2019-08-21 Senomyx, Inc. T1R Hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
AU2002320294B2 (en) 2001-07-03 2009-01-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Mammalian sweet and amino acid heterodimeric taste receptors
US7335487B2 (en) 2001-09-18 2008-02-26 Irm Llc Sweet taste receptors
CN1296374C (zh) * 2001-11-08 2007-01-24 北兴化学工业株式会社 生产三有机基-单烷氧基硅烷的方法以及生产三有机基-单氯硅烷的方法
US7208290B2 (en) 2001-12-14 2007-04-24 Senomyx, Inc. Methods of co-expressing umami taste receptors and chimeric Gα15 variants
US7107837B2 (en) * 2002-01-22 2006-09-19 Baxter International Inc. Capacitance fluid volume measurement
US7441104B2 (en) 2002-03-30 2008-10-21 Hewlett-Packard Development Company, L.P. Parallel subword instructions with distributed results
US9314194B2 (en) * 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US20070142748A1 (en) * 2002-04-19 2007-06-21 Ajay Deshmukh Tissue penetration device
CA2488863A1 (en) 2002-07-29 2004-02-05 Senomyx, Inc. Identification of a novel bitter taste receptor, t2r76
WO2004069191A2 (en) * 2003-02-03 2004-08-19 Senomyx Inc. Identification of t1r and t2r modulators
US7906627B2 (en) 2003-08-06 2011-03-15 Senomyx, Inc. Chimeric human sweet-umami and umami-sweet taste receptors
CA2535036C (en) 2003-08-06 2015-11-24 Senomyx, Inc. Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
US20050106571A1 (en) 2003-10-02 2005-05-19 The Regents Of The University Of California Mammalian T1R3 sweet taste receptors
US9351680B2 (en) * 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
EP1737345A1 (en) * 2004-04-15 2007-01-03 Roche Diagnostics GmbH Integrated spot monitoring device with fluid sensor
US20060045953A1 (en) 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
TWI399228B (zh) * 2006-07-21 2013-06-21 Alcon Inc 低黏性的眼科與耳鼻喉科裝置材料(二)
US20080047764A1 (en) * 2006-08-28 2008-02-28 Cypress Semiconductor Corporation Temperature compensation method for capacitive sensors
US20090061456A1 (en) 2007-08-30 2009-03-05 Allard William J Method for predicting progression free and overall survival at each follow-up time point during therapy of metastatic breast cancer patients using circulating tumor cells
US7936111B2 (en) 2008-08-07 2011-05-03 Samsung Electronics Co., Ltd. Apparatus for generating electrical energy and method for manufacturing the same
JO3421B1 (ar) 2011-06-20 2019-10-20 H Lundbeck As طريقة لإعطاء 1-((1ار.3س)-6-كلورو-3-فينيل-اندان-1-ايل)-1.2.2-ترايميثيل- بيبيرازين واملاجها لمعالجة انفصام الشخصية

Also Published As

Publication number Publication date
DK1309606T3 (da) 2008-11-24
WO2001066563A8 (en) 2004-06-24
US20090053730A1 (en) 2009-02-26
ATE403669T1 (de) 2008-08-15
ES2311508T3 (es) 2009-02-16
US20090004676A1 (en) 2009-01-01
US20110207212A1 (en) 2011-08-25
MXPA02008724A (es) 2004-09-06
US10093718B2 (en) 2018-10-09
JP2013247957A (ja) 2013-12-12
US8314224B2 (en) 2012-11-20
US20040132075A1 (en) 2004-07-08
HK1139965A1 (en) 2010-09-30
US20110207133A1 (en) 2011-08-25
AU2001240086B2 (en) 2008-01-03
US8816057B2 (en) 2014-08-26
US20130065235A1 (en) 2013-03-14
US20090093051A1 (en) 2009-04-09
US7524637B2 (en) 2009-04-28
US7244835B2 (en) 2007-07-17
US20190085051A1 (en) 2019-03-21
DK1944319T3 (da) 2010-05-10
EP1309606A1 (en) 2003-05-14
US20170313761A1 (en) 2017-11-02
US7772385B2 (en) 2010-08-10
US7452685B2 (en) 2008-11-18
EP1309606A4 (en) 2004-06-09
US20150299293A1 (en) 2015-10-22
EP2143732A1 (en) 2010-01-13
TW201006846A (en) 2010-02-16
US20080233596A1 (en) 2008-09-25
DE60135229D1 (de) 2008-09-18
AU4008601A (en) 2001-09-17
JP5403842B2 (ja) 2014-01-29
US9040247B2 (en) 2015-05-26
US7737254B2 (en) 2010-06-15
US7927823B2 (en) 2011-04-19
JP5903078B2 (ja) 2016-04-13
NO20024276D0 (no) 2002-09-06
IL151578A0 (en) 2003-04-10
US20040191805A1 (en) 2004-09-30
US7507544B2 (en) 2009-03-24
DE01914732T1 (de) 2004-04-15
US20080038741A1 (en) 2008-02-14
US20090176657A1 (en) 2009-07-09
CA2402214A1 (en) 2001-09-13
US20100330590A1 (en) 2010-12-30
EP2298802A1 (en) 2011-03-23
DE60141237D1 (de) 2010-03-18
ES2396681T3 (es) 2013-02-25
US20090233807A1 (en) 2009-09-17
JP2004513608A (ja) 2004-05-13
US7705121B2 (en) 2010-04-27
US7799905B2 (en) 2010-09-21
EP1944319A1 (en) 2008-07-16
ATE456577T1 (de) 2010-02-15
US9637536B2 (en) 2017-05-02
US8263341B2 (en) 2012-09-11
AU2001240086B9 (en) 2001-09-17
WO2001066563A2 (en) 2001-09-13
CN1766108A (zh) 2006-05-03
CA2402214C (en) 2013-10-15
EP1309606B1 (en) 2008-08-06
ES2338497T3 (es) 2010-05-07
EP2143732B1 (en) 2012-10-03
EP2298802B1 (en) 2012-10-24
WO2001066563A3 (en) 2004-05-27
US20110081658A1 (en) 2011-04-07
US7790848B2 (en) 2010-09-07
US20040229239A1 (en) 2004-11-18
US7842785B2 (en) 2010-11-30
EP1944319B1 (en) 2010-01-27
NO20024276L (no) 2002-11-06
US20110244563A1 (en) 2011-10-06
CN101445800A (zh) 2009-06-03
US20080213880A1 (en) 2008-09-04
US7223551B2 (en) 2007-05-29
US7847080B2 (en) 2010-12-07
CN1543474A (zh) 2004-11-03
US8802379B2 (en) 2014-08-12
US10544204B2 (en) 2020-01-28
US20090029455A1 (en) 2009-01-29
US7834165B2 (en) 2010-11-16
US20080026404A1 (en) 2008-01-31
US20040171042A1 (en) 2004-09-02
US8815525B2 (en) 2014-08-26
US20030008344A1 (en) 2003-01-09
US8247542B2 (en) 2012-08-21
US20130171727A1 (en) 2013-07-04

Similar Documents

Publication Publication Date Title
DK2298802T3 (da) T1R3-smagsreceptordomæner og gener, der koder derfor
DK1985630T3 (da) T1R2-hybridsmagsreceptor
WO2001068805A3 (en) Human olfactory receptors and genes encoding same
DK1934353T3 (da) IL-15R alpha sushi domæner som en selektiv og effektiv forstærker af IL-15-virkningen gennem IL-15Rbeta/gamma, i hyperagonist IL-15 Ralpha sushi -IL 15 fusionsproteiner
ATE369144T1 (de) Verfahren zur steigerung des haarwuchses durch wnt polypeptid
WO2005044996A3 (en) Chimeric receptors with 4-1bb stimulatory signaling domain
DE60322426D1 (enExample)
DK0517895T3 (da) Kimæriske kæder til receptorforbundne signaltransduktionsveje
WO2006036445A3 (en) Chimeric nk receptor and methods for treating cancer
DE69811710D1 (de) Verfahren zur herstellung von igf-i formulierungen mit verzögerter freisetzung
ATE471722T1 (de) Verfahren zur regulierung von angiogenese mit apelin-zusammensetzungen
Vignal et al. Significance of temporal and spectral acoustic cues for sexual recognition in Xenopus laevis
ATE277178T1 (de) C-typ lektine
ATE417112T1 (de) Steigerung der immunantwort unter verwendung von zielgerichteten molekülen
Gonzalez et al. Mammoths, volcanism and early humans in the basin of Mexico during the Late Pleistocene/Early Holocene
DK1446733T3 (da) Glycosylphosphatidylinositol indeholdende polypeptider
ATE520303T1 (de) Mausmodell für perimenopause und menopause und verfahren zur herstellung
EP4209586A4 (en) EXTRACELLULAR VESICLE EXPRESSING CYTOKINE AND ANTIBODY, ITS PRODUCTION METHOD AND ITS USE
Glade-Wright Body coral