DK2298348T3 - Antibody-binding alpha4Beta7 integrin and its use in the treatment of inflammatory bowel disease - Google Patents

Antibody-binding alpha4Beta7 integrin and its use in the treatment of inflammatory bowel disease Download PDF

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Publication number
DK2298348T3
DK2298348T3 DK10010997.4T DK10010997T DK2298348T3 DK 2298348 T3 DK2298348 T3 DK 2298348T3 DK 10010997 T DK10010997 T DK 10010997T DK 2298348 T3 DK2298348 T3 DK 2298348T3
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Prior art keywords
antigen
immunoglobulin
binding fragment
days
integrin
Prior art date
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DK10010997.4T
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Danish (da)
English (en)
Inventor
Lee R Brettman
Judith A Fox
David Edward Allison
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Millennium Pharm Inc
Genentech Inc
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Publication of DK2298348T3 publication Critical patent/DK2298348T3/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
DK10010997.4T 2000-04-14 2001-04-13 Antibody-binding alpha4Beta7 integrin and its use in the treatment of inflammatory bowel disease DK2298348T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55008200A 2000-04-14 2000-04-14
US09/748,960 US20010046496A1 (en) 2000-04-14 2000-12-27 Method of administering an antibody
EP01925028A EP1278543B1 (en) 2000-04-14 2001-04-13 Antibody binding alpha4beta7 integrin and its use to treat inflammatory bowel disease

Publications (1)

Publication Number Publication Date
DK2298348T3 true DK2298348T3 (en) 2017-01-30

Family

ID=27069332

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10010997.4T DK2298348T3 (en) 2000-04-14 2001-04-13 Antibody-binding alpha4Beta7 integrin and its use in the treatment of inflammatory bowel disease
DK01925028.1T DK1278543T3 (da) 2000-04-14 2001-04-13 Antistof der binder alfa4beta7-integrin og dets anvendelse til at behandle inflammatorisk tarmsygdom

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK01925028.1T DK1278543T3 (da) 2000-04-14 2001-04-13 Antistof der binder alfa4beta7-integrin og dets anvendelse til at behandle inflammatorisk tarmsygdom

Country Status (15)

Country Link
US (5) US20010046496A1 (Direct)
EP (3) EP1278543B1 (Direct)
JP (3) JP2003531129A (Direct)
AU (1) AU2001251629A1 (Direct)
BE (1) BE2017C009I2 (Direct)
CA (1) CA2406220C (Direct)
CY (3) CY1113489T1 (Direct)
DK (2) DK2298348T3 (Direct)
ES (2) ES2609689T3 (Direct)
FR (1) FR14C0080I2 (Direct)
LU (1) LUC00014I2 (Direct)
MX (1) MXPA02010059A (Direct)
NL (1) NL300702I1 (Direct)
PT (1) PT2298348T (Direct)
WO (1) WO2001078779A2 (Direct)

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Also Published As

Publication number Publication date
HK1054320A1 (en) 2003-11-28
CY1118429T1 (el) 2017-06-28
DK1278543T3 (da) 2013-01-14
EP2298348A1 (en) 2011-03-23
AU2001251629A1 (en) 2001-10-30
EP3167902A1 (en) 2017-05-17
CY2014046I1 (el) 2016-04-13
FR14C0080I2 (fr) 2015-10-30
LUC00014I2 (Direct) 2017-06-19
ES2398096T3 (es) 2013-03-13
EP1278543B1 (en) 2012-09-19
NL300702I2 (Direct) 2016-01-28
BE2017C009I2 (Direct) 2017-09-22
US20140186345A1 (en) 2014-07-03
MXPA02010059A (es) 2004-08-19
US20120034243A1 (en) 2012-02-09
CA2406220A1 (en) 2001-10-25
EP2298348B1 (en) 2016-10-12
LUC00014I1 (Direct) 2017-04-18
EP2298348B9 (en) 2017-02-15
US20200002423A1 (en) 2020-01-02
CA2406220C (en) 2019-02-12
JP5764524B2 (ja) 2015-08-19
PT2298348T (pt) 2017-01-04
CY1113489T1 (el) 2016-04-13
EP1278543A2 (en) 2003-01-29
JP2003531129A (ja) 2003-10-21
WO2001078779A2 (en) 2001-10-25
CY2014046I2 (el) 2016-04-13
JP2015083603A (ja) 2015-04-30
US20010046496A1 (en) 2001-11-29
EP3167902B1 (en) 2020-07-29
NL300702I1 (Direct) 2016-01-28
WO2001078779A3 (en) 2002-07-04
US20050095238A1 (en) 2005-05-05
JP2012184241A (ja) 2012-09-27
ES2609689T3 (es) 2017-04-21
JP6021959B2 (ja) 2016-11-09
FR14C0080I1 (Direct) 2014-12-19

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