DK2220070T3 - 2-benzylpyridazinonderivater som Met-kinaseinhibitorer - Google Patents
2-benzylpyridazinonderivater som Met-kinaseinhibitorerInfo
- Publication number
- DK2220070T3 DK2220070T3 DK08865961.0T DK08865961T DK2220070T3 DK 2220070 T3 DK2220070 T3 DK 2220070T3 DK 08865961 T DK08865961 T DK 08865961T DK 2220070 T3 DK2220070 T3 DK 2220070T3
- Authority
- DK
- Denmark
- Prior art keywords
- benzylpyridazine
- derivatives
- kinase inhibitors
- met kinase
- met
- Prior art date
Links
- FPYJSJDOHRDAMT-KQWNVCNZSA-N 1h-indole-5-sulfonamide, n-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1h-pyrrol-2-yl]methylene]-2,3-dihydro-n-methyl-2-oxo-, (3z)- Chemical compound C=1C=C2NC(=O)\C(=C/C3=C(C(C(=O)N4CCN(C)CC4)=C(C)N3)C)C2=CC=1S(=O)(=O)N(C)C1=CC=CC(Cl)=C1 FPYJSJDOHRDAMT-KQWNVCNZSA-N 0.000 title 1
- ZQQANBBIPSYLIG-UHFFFAOYSA-N 2-benzyl-1h-pyridazine Chemical class C=1C=CC=CC=1CN1NC=CC=C1 ZQQANBBIPSYLIG-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007061963A DE102007061963A1 (de) | 2007-12-21 | 2007-12-21 | Pyridazinonderivate |
| PCT/EP2008/009970 WO2009083076A1 (de) | 2007-12-21 | 2008-11-25 | 2-benzylpyridazinonderivate als met-kinasehemmer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2220070T3 true DK2220070T3 (da) | 2011-07-04 |
Family
ID=40262707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08865961.0T DK2220070T3 (da) | 2007-12-21 | 2008-11-25 | 2-benzylpyridazinonderivater som Met-kinaseinhibitorer |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US8557813B2 (enExample) |
| EP (1) | EP2220070B1 (enExample) |
| JP (1) | JP5443381B2 (enExample) |
| KR (1) | KR101606945B1 (enExample) |
| CN (1) | CN101903374B (enExample) |
| AR (1) | AR069843A1 (enExample) |
| AT (1) | ATE506358T1 (enExample) |
| AU (1) | AU2008342339B2 (enExample) |
| BR (1) | BRPI0821743B8 (enExample) |
| CA (1) | CA2710092C (enExample) |
| CL (1) | CL2008003854A1 (enExample) |
| CO (1) | CO6220964A2 (enExample) |
| CY (1) | CY1111556T1 (enExample) |
| DE (2) | DE102007061963A1 (enExample) |
| DK (1) | DK2220070T3 (enExample) |
| EA (1) | EA021362B1 (enExample) |
| EC (1) | ECSP10010361A (enExample) |
| ES (1) | ES2362472T3 (enExample) |
| HR (1) | HRP20110441T1 (enExample) |
| IL (1) | IL206394A (enExample) |
| MY (1) | MY155719A (enExample) |
| NZ (1) | NZ586894A (enExample) |
| PE (1) | PE20091527A1 (enExample) |
| PL (1) | PL2220070T3 (enExample) |
| PT (1) | PT2220070E (enExample) |
| SI (1) | SI2220070T1 (enExample) |
| TW (1) | TWI433845B (enExample) |
| UA (1) | UA100540C2 (enExample) |
| WO (1) | WO2009083076A1 (enExample) |
| ZA (1) | ZA201005166B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102007038957A1 (de) * | 2007-08-17 | 2009-02-19 | Merck Patent Gmbh | 6-Thioxo-pyridazinderivate |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
| HRP20130993T1 (hr) | 2008-12-22 | 2013-11-22 | Merck Patent Gmbh | Novi polimorfni oblici 6-(1-metil-1h-pirazol-4-il)-2-{3-[5-(2-morfolin-4-il-etoksi)-pirimidin-2-il]-benzil}-2h-piridazin-3-on dihidrogenfosfata i postupak njihove proizvodnje |
| DE102008062826A1 (de) * | 2008-12-23 | 2010-07-01 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102009003954A1 (de) * | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102009004061A1 (de) | 2009-01-08 | 2010-07-15 | Merck Patent Gmbh | Pyridazinonderivate |
| WO2012003338A1 (en) | 2010-07-01 | 2012-01-05 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| CN102731409A (zh) * | 2011-04-08 | 2012-10-17 | 中国科学院上海药物研究所 | 一类哒嗪酮类化合物，其药物组合物、制备方法及用途 |
| US9212227B2 (en) | 2012-04-30 | 2015-12-15 | Janssen Biotech, Inc. | ST2L antibody antagonists for the treatment of ST2L-mediated inflammatory pulmonary conditions |
| JP6864953B2 (ja) | 2014-12-09 | 2021-04-28 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Ａｘｌに対するヒトモノクローナル抗体 |
| WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
| GB201514015D0 (en) | 2015-08-07 | 2015-09-23 | Arnér Elias S J And Dept Of Health And Human Services | Novel pyridazinones and their use in the treatment of cancer |
| TWI797176B (zh) | 2017-10-17 | 2023-04-01 | 西班牙商帕羅製藥有限公司 | ４-胺基嘧啶化合物之合成 |
| EP3941475A4 (en) * | 2019-03-20 | 2023-01-25 | Goldfinch Bio, Inc. | PYRIDAZINONES AND METHODS OF USE THEREOF |
| EP4472624A2 (en) * | 2022-02-03 | 2024-12-11 | D.E. Shaw Research, LLC | Pyridazinone compounds as trpa1 inhibitors |
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-
2007
- 2007-12-21 DE DE102007061963A patent/DE102007061963A1/de not_active Withdrawn
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2008
- 2008-11-25 AU AU2008342339A patent/AU2008342339B2/en not_active Ceased
- 2008-11-25 PT PT08865961T patent/PT2220070E/pt unknown
- 2008-11-25 SI SI200830314T patent/SI2220070T1/sl unknown
- 2008-11-25 DE DE502008003317T patent/DE502008003317D1/de active Active
- 2008-11-25 EA EA201001005A patent/EA021362B1/ru not_active IP Right Cessation
- 2008-11-25 CA CA2710092A patent/CA2710092C/en active Active
- 2008-11-25 US US12/808,928 patent/US8557813B2/en not_active Expired - Fee Related
- 2008-11-25 NZ NZ586894A patent/NZ586894A/en not_active IP Right Cessation
- 2008-11-25 ES ES08865961T patent/ES2362472T3/es active Active
- 2008-11-25 BR BRPI0821743A patent/BRPI0821743B8/pt not_active IP Right Cessation
- 2008-11-25 CN CN2008801212236A patent/CN101903374B/zh not_active Expired - Fee Related
- 2008-11-25 KR KR1020107016204A patent/KR101606945B1/ko not_active Expired - Fee Related
- 2008-11-25 DK DK08865961.0T patent/DK2220070T3/da active
- 2008-11-25 MY MYPI2010002840A patent/MY155719A/en unknown
- 2008-11-25 WO PCT/EP2008/009970 patent/WO2009083076A1/de not_active Ceased
- 2008-11-25 EP EP08865961A patent/EP2220070B1/de active Active
- 2008-11-25 AT AT08865961T patent/ATE506358T1/de active
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- 2008-11-25 HR HR20110441T patent/HRP20110441T1/hr unknown
- 2008-11-25 UA UAA201008995A patent/UA100540C2/ru unknown
- 2008-12-19 TW TW097149958A patent/TWI433845B/zh not_active IP Right Cessation
- 2008-12-19 PE PE2008002158A patent/PE20091527A1/es not_active Application Discontinuation
- 2008-12-19 CL CL2008003854A patent/CL2008003854A1/es unknown
- 2008-12-19 AR ARP080105562A patent/AR069843A1/es not_active Application Discontinuation
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- 2010-06-15 IL IL206394A patent/IL206394A/en active IP Right Grant
- 2010-06-18 CO CO10073802A patent/CO6220964A2/es active IP Right Grant
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