DK2217329T3 - Anvendelse af navlestrengsblod i behandlingen af komplikationer i forbindelse med præterm fødsel - Google Patents
Anvendelse af navlestrengsblod i behandlingen af komplikationer i forbindelse med præterm fødsel Download PDFInfo
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- DK2217329T3 DK2217329T3 DK08847846.6T DK08847846T DK2217329T3 DK 2217329 T3 DK2217329 T3 DK 2217329T3 DK 08847846 T DK08847846 T DK 08847846T DK 2217329 T3 DK2217329 T3 DK 2217329T3
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
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Claims (27)
- I1. Navlestrengsblod omfattende placentastamceller til anvendelse i en fremgangsmåde til behandling af en lidelse eller tilstand i et præmaturt spædbarn, 5 hvor nævnte lidelse eller tilstand er forårsaget af eller associeret med ufuldstændig udvikling af hjernen, hvor nævnte placentastamceller omfatter celler der er CD34-, CD73+ , CD1 05+ , og CD200+ .
- 2. Navlestrengsblodet til anvendelse ifølge krav 1, yderligere omfattende et 10 blodadditiv, hvor nævnte blodadditiv er erythropoietin, et jernsupplement, et vitamin, eller røde blodlegemer fra en kilde anden end navlestrengsblod.
- 3. Navlestrengsblodet til anvendelse ifølge krav 2, hvor nævnte blodadditiv er erythropoietin. 15
- 4. Navlestrengsblodet til anvendelse ifølge krav 3, hvor nævnte erythropoietin er rekombinant erythropoietin genetisk modificeret til at øge serum-halveringstiden sammenlignet med nativ erythropoietin.
- 5. Navlestrengsblodet til anvendelse ifølge krav 2, hvor nævnte blodadditiv er et vitamin.
- 6. Navlestrengsblodet til anvendelse ifølge krav 5, hvor nævnte vitamin er riboflavin (vitamin B2), pyridoxin (vitamin B6), folinsyre, vitamin B12, eller 25 vitamin E.
- 7. Navlestrengsblodet til anvendelse ifølge krav 2, hvor blodadditivet er et jernsupplement.
- 8. Navlestrengsblodet til anvendelse ifølge krav 7, hvor nævnte jernsupplement er elementært jern.
- 9. Navlestrengsblodet til anvendelse ifølge krav 2, hvor nævnte blodadditiv er røde blodlegemer ikke opnået fra navlestrengsblod. 35 £
- 10. Navlestrengsblodet til anvendelse ifølge krav 9, hvor nævnte røde blodlegemer er blevet bestrålet med mindst 2500 cGy af stråling, eller hvor nævnte røde blodlegemer er blevet leukodepleteret.
- 11. Navlestrengsblodet til anvendelse ifølge krav 1, hvor nævnte præmature spædbarn har gennemlevet fra 23 til 25 uger af svangerskab ved fødslen, fra 26 til 29 uger af svangerskab ved fødslen, fra 30 til 33 uger af svangerskab ved fødslen, eller fra 34 til 37 uger af svangerskab ved fødslen.
- 12. Navlestrengsblodet til anvendelse ifølge krav 1, hvor nævnte præmature spædbarn vejer 800 gram eller mere ved fødslen, 500 gram til 800 gram ved fødslen, eller mindre end 500 gram ved fødslen.
- 13. Navlestrengsblodet til anvendelse ifølge krav 1, hvor nævnte navlestrengsblod 15 er autologt til det præmature spædbarn.4. Navlestrengsblodet til anvendelse ifølge krav 1, hvor placentastamcellerne er autologe til det præmature spædbarn.
- 15. Navlestrengsblodet til anvendelse ifølge krav 1, hvor nævnte navlestrengsblod er opnået fra en efterfødsel-pattedyrsplacenta af en fuldbåren fødsel.
- 16. Navlestrengsblodet til anvendelse ifølge krav 1, hvor nævnte navlestrengsblod er opnået fra en efterfødsel-pattedyrsplacenta af en for tidlig fødsel. 25
- 17. Navlestrengsblodet til anvendelse ifølge krav 16, hvor nævnte placenta er placentaen af nævnte præmature spædbarn, placentaen af et spædbarn født ved 26 til 29 ugers svangerskab, placentaen af et spædbarn født ved 30 til 33 ugers svangerskab, eller placentaen af et spædbarn født ved 34 til 37 ugers 30 svangerskab.
- 18. Navlestrengsblodet til anvendelse ifølge krav 1, hvor nævnte navlestrengsblod er opnået fra en navlestrengsblodbank.
- 19. Navlestrengsblodet til anvendelse ifølge krav 1, hvor nævnte placentastamceller er stamceller isoleret fra placentaperfusat forud for nævnte anvendelse.
- 20. Navlestrengsblodet til anvendelse ifølge krav 1, hvor nævnte placentastamceller er stamceller indeholdt i placentaperfusat.
- 21. Navlestrengsblodet til anvendelse ifølge krav 1, hvor nævnte placentastamceller er opnået fra en efterfødsel-pattedyrsplacenta af en fuldbåren 10 fødsel, fra en efterfødsel-pattedyrsplacenta af en for tidlig fødsel, eller fra en placenta af nævnte præmature spædbarn.
- 22. Navlestrengsblodet til anvendelse ifølge krav 1, hvor nævnte placentastamceller er opnået fra en placenta af et spædbarn født ved 23 til 25 15 ugers svangerskab, fra en placenta af et spædbarn født ved 26 til 29 ugers svangerskab, fra en placenta af et spædbarn født ved 30 til 33 ugers svangerskab, eller fra en placenta af et spædbarn født ved 34 til 37 ugers svangerskab.
- 23. Navlestrengsblodet til anvendelse ifølge krav 1, hvor nævnte navlestrengsblod eller nævnte placentastamceller ikke er immunotypebestemt forud for nævnte anvendelse.
- 24. Navlestrengsblodet til anvendelse ifølge krav 1, hvor nævnte navlestrengsblod 25 er præpareret til at blive administreret én gang efter fødslen af det præmature spædbarn, en flerhed af gange efter fødslen af det præmature spædbarn, inden for én time efter fødslen af det præmature spædbarn, inden for 12 timer efter fødslen af det præmature spædbarn, inden for 24 timer efter fødslen af det præmature spædbarn, eller inden for én uge efter fødslen af det præmature 30 spædbarn.
- 25. Navlestrengsblodet til anvendelse ifølge krav 1, hvor nævnte navlestrengsblod omfatter 1 x 105 til 1 x 106 CD34+ celler per kilogram kropsvægt af nævnte præmature spædbarn. 35 Η-
- 26. Navlestrengsblodet til anvendelse ifølge krav 1, hvor nævnte placentastamceller og nævnte navlestrengsblod sammen omfatter 1 x 105 til 1 x 106 CD34+ celler per kilogram kropsvægt af nævnte præmature spædbarn.
- 27. Navlestrengsblodet til anvendelse ifølge krav 1, hvor nævnte navlestrengsblod er præpareret til at blive administreret ved intravenøs indsprøjtning.
- 28. Navlestrengsblodet til anvendelse ifølge krav 1, hvor nævnte navlestrengsblod er præpareret til at blive administreret inden for 1 time efter fødslen, inden for 12 10 timer efter fødslen, inden for 2 dage efter fødslen, eller inden for 2 uger efter fødslen.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US237507P | 2007-11-07 | 2007-11-07 | |
PCT/US2008/012540 WO2009061447A2 (en) | 2007-11-07 | 2008-11-07 | Treatment of premature birth complications |
Publications (1)
Publication Number | Publication Date |
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DK2217329T3 true DK2217329T3 (da) | 2018-04-23 |
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Application Number | Title | Priority Date | Filing Date |
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DK08847846.6T DK2217329T3 (da) | 2007-11-07 | 2008-11-07 | Anvendelse af navlestrengsblod i behandlingen af komplikationer i forbindelse med præterm fødsel |
Country Status (16)
Country | Link |
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US (4) | US20090136471A1 (da) |
EP (2) | EP2217329B1 (da) |
JP (6) | JP2011503064A (da) |
KR (8) | KR20190004832A (da) |
CN (2) | CN101909694A (da) |
AU (1) | AU2008325142A1 (da) |
CA (1) | CA2704746A1 (da) |
DK (1) | DK2217329T3 (da) |
ES (1) | ES2667210T3 (da) |
HK (2) | HK1232146A1 (da) |
IL (1) | IL205595A0 (da) |
MX (1) | MX2010005018A (da) |
NO (1) | NO2217329T3 (da) |
RU (1) | RU2010123002A (da) |
WO (1) | WO2009061447A2 (da) |
ZA (1) | ZA201003057B (da) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
WO2002046373A1 (en) | 2000-12-06 | 2002-06-13 | Hariri Robert J | Method of collecting placental stem cells |
ES2558626T3 (es) * | 2001-02-14 | 2016-02-05 | Anthrogenesis Corporation | Placenta post-parto de mamíferos, su uso y células madre placentarias de la misma |
US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
WO2004047770A2 (en) * | 2002-11-26 | 2004-06-10 | Anthrogenesis Corporation | Cytotherapeutics, cytotherapeutic units and methods for treatments using them |
CA2560725A1 (en) * | 2004-03-26 | 2005-10-20 | Celgene Corporation | Systems and methods for providing a stem cell bank |
NZ612132A (en) * | 2005-10-13 | 2015-01-30 | Anthrogenesis Corp | Immunomodulation using placental stem cells |
JP5203212B2 (ja) * | 2005-10-13 | 2013-06-05 | アントフロゲネシス コーポレーション | 胎盤由来幹細胞からのオリゴデンドロサイトの産生 |
EP1976978A2 (en) * | 2005-12-29 | 2008-10-08 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
CN108559725A (zh) | 2005-12-29 | 2018-09-21 | 人类起源公司 | 胎盘干细胞群 |
KR20080097190A (ko) * | 2005-12-29 | 2008-11-04 | 안트로제네시스 코포레이션 | 태반 줄기세포의 수집과 보존을 위한 개선된 조성물과 이조성물의 이용 방법 |
US7993918B2 (en) | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
CN104099290A (zh) | 2006-10-23 | 2014-10-15 | 人类起源公司 | 用胎盘细胞群治疗骨缺损的方法和组合物 |
EP3103462A1 (en) | 2007-02-12 | 2016-12-14 | Anthrogenesis Corporation | Treatment of inflammatory diseases using placental stem cells |
JP2010518812A (ja) * | 2007-02-12 | 2010-06-03 | アンスロジェネシス コーポレーション | 接着性胎盤幹細胞由来の肝細胞および軟骨細胞、ならびにcd34+、cd45−胎盤幹細胞の濃縮細胞集団 |
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