DK2201115T3 - Mutanter med evne til at producere 1,4-butandiol og fremgangsmåde til at fremstille 1,4-butandiol ved anvendelse heraf - Google Patents

Mutanter med evne til at producere 1,4-butandiol og fremgangsmåde til at fremstille 1,4-butandiol ved anvendelse heraf

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Publication number
DK2201115T3
DK2201115T3 DK08793214.1T DK08793214T DK2201115T3 DK 2201115 T3 DK2201115 T3 DK 2201115T3 DK 08793214 T DK08793214 T DK 08793214T DK 2201115 T3 DK2201115 T3 DK 2201115T3
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DK
Denmark
Prior art keywords
butanediol
producing
mutants capable
mutants
Prior art date
Application number
DK08793214.1T
Other languages
English (en)
Other versions
DK2201115T4 (da
Inventor
Si Jae Park
Sang Hyun Lee
Sang Yup Lee
Eun Jeong Lee
Original Assignee
Lg Chemical Ltd
Korea Advanced Inst Sci & Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40429511&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2201115(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lg Chemical Ltd, Korea Advanced Inst Sci & Tech filed Critical Lg Chemical Ltd
Publication of DK2201115T3 publication Critical patent/DK2201115T3/da
Application granted granted Critical
Publication of DK2201115T4 publication Critical patent/DK2201115T4/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/02—Preparation of hybrid cells by fusion of two or more cells, e.g. protoplast fusion
    • C12N15/03—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01061—4-Hydroxybutyrate dehydrogenase (1.1.1.61)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01024—Succinate-semialdehyde dehydrogenase (NAD+) (1.2.1.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/99—Oxidoreductases acting on the CH-CH group of donors (1.3) with other acceptors (1.3.99)
    • C12Y103/99002—Butyryl-CoA dehydrogenase (1.3.99.2), i.e. short chain acyl-CoA dehydrogenase

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK08793214.1T 2007-09-07 2008-08-13 Mutanter med evne til at producere 1,4-butandiol og fremgangsmåde til at fremstille 1,4-butandiol ved anvendelse heraf DK2201115T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020070091081A KR101042242B1 (ko) 2007-09-07 2007-09-07 1,4-부탄디올 생성능을 가지는 변이체 및 이를 이용한1,4-부탄디올의 제조방법
PCT/KR2008/004700 WO2009031766A2 (en) 2007-09-07 2008-08-13 Mutants having capability to produce 1,4-butanediol and method for preparing 1,4-butanediol using the same

Publications (2)

Publication Number Publication Date
DK2201115T3 true DK2201115T3 (da) 2013-02-11
DK2201115T4 DK2201115T4 (da) 2016-11-07

Family

ID=40429511

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08793214.1T DK2201115T4 (da) 2007-09-07 2008-08-13 Mutanter med evne til at producere 1,4-butandiol og fremgangsmåde til at fremstille 1,4-butandiol ved anvendelse heraf

Country Status (8)

Country Link
US (2) US9096860B2 (da)
EP (1) EP2201115B2 (da)
KR (1) KR101042242B1 (da)
CN (1) CN101883853B (da)
AU (1) AU2008295788B2 (da)
DK (1) DK2201115T4 (da)
ES (1) ES2396179T5 (da)
WO (1) WO2009031766A2 (da)

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WO2009094485A1 (en) 2008-01-22 2009-07-30 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
CA2717586C (en) 2008-03-05 2020-08-11 Genomatica, Inc. Primary alcohol producing organisms
AU2009291825B2 (en) 2008-09-10 2016-05-05 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
EP3318626B1 (en) 2009-04-30 2020-01-15 Genomatica, Inc. Organisms for the production of 1,3-butanediol
WO2010127303A1 (en) 2009-04-30 2010-11-04 Genomatica, Inc. Organisms for the production of isopropanol, n-butanol, and isobutanol
ES2625623T3 (es) 2009-06-04 2017-07-20 Genomatica, Inc. Procedimiento de separación de componentes de un caldo de fermentación
EP4056706A1 (en) 2009-06-04 2022-09-14 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol and related methods
EP2462221B1 (en) 2009-08-05 2017-02-22 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
EP2933338A3 (en) * 2009-09-09 2016-01-06 Genomatica, Inc. Microorganisms and methods for the co-production of isopropanol with primary alcohols, diols and acids
WO2011050326A1 (en) 2009-10-23 2011-04-28 Genomatica, Inc. Microorganisms for the production of aniline
US8530210B2 (en) 2009-11-25 2013-09-10 Genomatica, Inc. Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
EP2510102A4 (en) * 2009-12-10 2014-01-22 Genomatica Inc METHODS AND ORGANIZATIONS FOR THE CONVERSION OF SYNTHESIS GAS OR OTHER CARBONACEOUS GAS SOURCES AND METHANOL TO 1,3-BUTANEDIOL
SG182686A1 (en) 2010-01-29 2012-08-30 Genomatica Inc Microorganisms and methods for the biosynthesis of p-toluate and terephthalate
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US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
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AU2012272856A1 (en) 2011-06-22 2013-05-02 Genomatica, Inc. Microorganisms for producing 1,4-butanediol and methods related thereto
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WO2013085361A2 (ko) * 2011-12-07 2013-06-13 한국과학기술원 4-하이드록시부티릭산 고생성능을 가지는 변이 미생물 및 이를 이용한 4-하이드록시부티릭산의 제조방법
KR20130094115A (ko) * 2012-02-15 2013-08-23 삼성전자주식회사 1,4-부탄디올의 생산을 위한 변형 미생물
US11932845B2 (en) 2012-06-04 2024-03-19 Genomatica, Inc. Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
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KR102023618B1 (ko) 2012-07-27 2019-09-20 삼성전자주식회사 1,4-ｂｄｏ 생성능이 개선된 변이 미생물 및 이를 이용한 1,4-ｂｄｏ의 제조방법
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KR101748930B1 (ko) * 2015-02-09 2017-06-20 지에스칼텍스 주식회사 다이올 생산용 재조합 미생물
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JP6905518B2 (ja) * 2015-10-13 2021-07-21 ランザテク・ニュージーランド・リミテッド エネルギー発生発酵経路を含む遺伝子操作細菌
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Also Published As

Publication number Publication date
US9096860B2 (en) 2015-08-04
CN101883853B (zh) 2013-12-25
EP2201115A2 (en) 2010-06-30
AU2008295788B2 (en) 2013-01-17
WO2009031766A3 (en) 2009-04-30
EP2201115B2 (en) 2016-07-20
ES2396179T3 (es) 2013-02-19
WO2009031766A2 (en) 2009-03-12
KR101042242B1 (ko) 2011-06-17
EP2201115A4 (en) 2010-09-22
US20150353964A1 (en) 2015-12-10
CN101883853A (zh) 2010-11-10
EP2201115B1 (en) 2012-10-24
US9920325B2 (en) 2018-03-20
AU2008295788A1 (en) 2009-03-12
ES2396179T5 (es) 2017-02-01
DK2201115T4 (da) 2016-11-07
US20100330634A1 (en) 2010-12-30
KR20090025902A (ko) 2009-03-11

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