DK2177528T3 - Fremgangsmåde til fremstilling af blandinger af trifluoracetylglatirameracetat ved anvendelse af oprenset hydrogenbromid - Google Patents
Fremgangsmåde til fremstilling af blandinger af trifluoracetylglatirameracetat ved anvendelse af oprenset hydrogenbromidInfo
- Publication number
- DK2177528T3 DK2177528T3 DK10150124.5T DK10150124T DK2177528T3 DK 2177528 T3 DK2177528 T3 DK 2177528T3 DK 10150124 T DK10150124 T DK 10150124T DK 2177528 T3 DK2177528 T3 DK 2177528T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydrogen bromide
- glatiramer acetate
- purified hydrogen
- preparing mixtures
- trifluoroacetyl glatiramer
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 title 2
- 108010072051 Glatiramer Acetate Proteins 0.000 title 1
- -1 Trifluoroacetyl Glatiramer Acetate Chemical compound 0.000 title 1
- 229960003776 glatiramer acetate Drugs 0.000 title 1
- 229910000042 hydrogen bromide Inorganic materials 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 235000018977 lysine Nutrition 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 235000002374 tyrosine Nutrition 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
- 150000003668 tyrosines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Rehabilitation Therapy (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60884304P | 2004-09-09 | 2004-09-09 | |
| EP05791236A EP1799703B1 (en) | 2004-09-09 | 2005-09-09 | Process for preparation of mixtures of polypeptides using purified hydrobromic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2177528T3 true DK2177528T3 (da) | 2012-03-26 |
Family
ID=36037047
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05791236.2T DK1799703T3 (da) | 2004-09-09 | 2005-09-09 | Fremgangsmåde til fremstilling af blandinger af polypeptider ved hjælp af oprenset hydrogenbromid |
| DK10150124.5T DK2177528T3 (da) | 2004-09-09 | 2005-09-09 | Fremgangsmåde til fremstilling af blandinger af trifluoracetylglatirameracetat ved anvendelse af oprenset hydrogenbromid |
| DK10194363.7T DK2361924T3 (en) | 2004-09-09 | 2005-09-09 | A process for the preparation of mixtures of trifluoroacetyl glatiramer acetate using purified hydrobromic acid |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05791236.2T DK1799703T3 (da) | 2004-09-09 | 2005-09-09 | Fremgangsmåde til fremstilling af blandinger af polypeptider ved hjælp af oprenset hydrogenbromid |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10194363.7T DK2361924T3 (en) | 2004-09-09 | 2005-09-09 | A process for the preparation of mixtures of trifluoroacetyl glatiramer acetate using purified hydrobromic acid |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7495072B2 (OSRAM) |
| EP (3) | EP1799703B1 (OSRAM) |
| JP (1) | JP5149008B2 (OSRAM) |
| KR (1) | KR101317131B1 (OSRAM) |
| CN (1) | CN101166754B (OSRAM) |
| AT (2) | ATE536363T1 (OSRAM) |
| AU (1) | AU2005282249B2 (OSRAM) |
| BR (1) | BRPI0515033B1 (OSRAM) |
| CA (1) | CA2579656C (OSRAM) |
| CY (1) | CY1110280T1 (OSRAM) |
| DE (1) | DE602005018800D1 (OSRAM) |
| DK (3) | DK1799703T3 (OSRAM) |
| ES (3) | ES2451006T3 (OSRAM) |
| HR (3) | HRP20100164T1 (OSRAM) |
| IL (2) | IL181596A (OSRAM) |
| IS (1) | IS8622A (OSRAM) |
| MX (1) | MX2007002760A (OSRAM) |
| NO (1) | NO20071632L (OSRAM) |
| NZ (1) | NZ554018A (OSRAM) |
| PL (3) | PL2361924T3 (OSRAM) |
| PT (3) | PT1799703E (OSRAM) |
| RS (3) | RS53248B (OSRAM) |
| RU (1) | RU2388764C2 (OSRAM) |
| SI (3) | SI2361924T1 (OSRAM) |
| UA (1) | UA91029C2 (OSRAM) |
| WO (1) | WO2006029393A2 (OSRAM) |
| ZA (1) | ZA200702591B (OSRAM) |
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| WO2002076503A1 (en) * | 2000-06-20 | 2002-10-03 | Mayo Foundation For Medical Education And Research | Treatment of central nervous system diseases by antibodies against glatiramer acetate |
| DE60237170D1 (de) * | 2001-12-04 | 2010-09-09 | Teva Pharma | Verfahren zur messung der wirkstärke von glatirameracetat |
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| WO2006029411A2 (en) * | 2004-09-09 | 2006-03-16 | Yeda Research And Development Co. Ltd. | Mixtures of polypeptides, compositions containing and processes for preparing same, and uses thereof |
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| NZ556156A (en) * | 2005-02-02 | 2010-03-26 | Teva Pharma | Process for producing acetate salts of polypeptides using hydrogenolysis |
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| AU2008330093A1 (en) * | 2007-11-28 | 2009-06-04 | Yeda Research And Development Co., Ltd. | Method of delaying the onset of clinically definite multiple sclerosis |
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| US8759302B2 (en) | 2010-03-16 | 2014-06-24 | Teva Pharmaceutical Industries, Ltd. | Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis |
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| EA025780B1 (ru) | 2010-10-11 | 2017-01-30 | Тева Фармасьютикал Индастриз Лтд. | Цитокиновые биомаркеры в качестве биомаркеров, прогнозирующих клинический ответ на глатирамер ацетат |
| US8788046B2 (en) | 2010-11-11 | 2014-07-22 | Spr Therapeutics, Llc | Systems and methods for the treatment of pain through neural fiber stimulation |
| CA2827275A1 (en) * | 2011-02-14 | 2012-09-20 | Usv Limited | Copolymer-1, process for preparation and analytical methods thereof |
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| CN102717992A (zh) * | 2012-05-30 | 2012-10-10 | 苏州市旭洋工业搪瓷厂 | 一种搪玻璃溴素贮罐 |
| CN102718963B (zh) * | 2012-06-19 | 2014-10-15 | 深圳翰宇药业股份有限公司 | 聚合物多肽的制备方法 |
| TW201420111A (zh) | 2012-10-10 | 2014-06-01 | Teva Pharma | 對格拉默醋酸鹽（ｇｌａｔｉｒａｍｅｒ ａｃｅｔａｔｅ）之臨床反應具預測性之生物標記 |
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| DE10353960B4 (de) | 2003-10-16 | 2006-03-23 | Vertilas Gmbh | Oberflächenemittierender Halbleiterlaser mit strukturiertem Wellenleiter |
| WO2006029411A2 (en) * | 2004-09-09 | 2006-03-16 | Yeda Research And Development Co. Ltd. | Mixtures of polypeptides, compositions containing and processes for preparing same, and uses thereof |
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