DK2160398T3 - Industriel fremgangsmåde til syntese af 17-acetoxy-11ss-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dion og fremgangsmådens væsentligste mellemprodukter - Google Patents

Industriel fremgangsmåde til syntese af 17-acetoxy-11ss-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dion og fremgangsmådens væsentligste mellemprodukter

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Publication number
DK2160398T3
DK2160398T3 DK08762676.8T DK08762676T DK2160398T3 DK 2160398 T3 DK2160398 T3 DK 2160398T3 DK 08762676 T DK08762676 T DK 08762676T DK 2160398 T3 DK2160398 T3 DK 2160398T3
Authority
DK
Denmark
Prior art keywords
norpregna
acetoxy
dione
diene
dimethylamino
Prior art date
Application number
DK08762676.8T
Other languages
English (en)
Inventor
Jozsef Bodi
Gyoergy Visky
Janos Szeles
Sandor Maho
Csaba Santa
Janos Csoergei
Zoltan Tuba
Laszlo Terdy
Csaba Molnar
Antal Aranyi
Zoltan Horvath
Gabor Balogh
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Application granted granted Critical
Publication of DK2160398T3 publication Critical patent/DK2160398T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK08762676.8T 2007-06-27 2008-06-19 Industriel fremgangsmåde til syntese af 17-acetoxy-11ss-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dion og fremgangsmådens væsentligste mellemprodukter DK2160398T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0700439A HU228636B1 (en) 2007-06-27 2007-06-27 Industrial method for the synthesis of 17-acetoxy-11betha-4[-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process
PCT/HU2008/000073 WO2009001148A2 (en) 2007-06-27 2008-06-19 INDUSTRIAL METHOD FOR THE SYNTHESIS OF 17-ACETOXY-11β-[4-(DIMETHYLAMINO)-PHENYL]-21-METHOXY-19-NORPREGNA-4,9-DIEN-3,20-DIONE AND THE KEY INTERMEDIATES OF THE PROCESS

Publications (1)

Publication Number Publication Date
DK2160398T3 true DK2160398T3 (da) 2012-01-23

Family

ID=89987607

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08762676.8T DK2160398T3 (da) 2007-06-27 2008-06-19 Industriel fremgangsmåde til syntese af 17-acetoxy-11ss-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dion og fremgangsmådens væsentligste mellemprodukter

Country Status (27)

Country Link
US (1) US8183402B2 (da)
EP (1) EP2160398B1 (da)
JP (1) JP5261481B2 (da)
KR (1) KR101535686B1 (da)
CN (1) CN101622268B (da)
AR (1) AR067189A1 (da)
AT (1) ATE528313T1 (da)
AU (1) AU2008269531B2 (da)
BR (1) BRPI0813654B8 (da)
CA (1) CA2677195C (da)
CY (1) CY1112529T1 (da)
DK (1) DK2160398T3 (da)
EA (1) EA015478B1 (da)
ES (1) ES2375320T3 (da)
HR (1) HRP20120008T1 (da)
HU (1) HU228636B1 (da)
IL (1) IL200124A (da)
MX (1) MX2009011861A (da)
MY (1) MY149296A (da)
NZ (1) NZ579029A (da)
PL (1) PL2160398T3 (da)
PT (1) PT2160398E (da)
SI (1) SI2160398T1 (da)
TW (1) TWI411616B (da)
UA (1) UA100241C2 (da)
WO (1) WO2009001148A2 (da)
ZA (1) ZA200907030B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0900171A2 (hu) 2009-03-20 2010-12-28 Richter Gedeon Nyrt 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos módosulata és eljárás elõállítására
HUP0900487A2 (hu) 2009-08-05 2011-03-28 Richter Gedeon Nyrt 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos polimorf módosulata és eljárás elõállítására
CN102516345B (zh) * 2011-11-01 2014-11-26 上海优拓医药科技有限公司 醋酸乌利司他及其关键中间体的制备方法
CN102942612A (zh) * 2012-10-30 2013-02-27 四川大学 一种合成醋酸乌利司他的新方法
KR20160058722A (ko) * 2013-03-15 2016-05-25 더 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 ent-프로게스테론 및 그의 중간생성물의 합성
HU230319B1 (hu) * 2013-10-01 2016-01-28 Richter Gedeon Nyrt. Ipari eljárás szteroid hatóanyagok előállítására
HU230397B1 (hu) 2013-11-25 2016-04-28 Richter Gedeon Nyrt. Eljárás (11b,17a)-17-acetoxi-11-metil-19-norpregn-4-én-3,20-dion előállítására
CN103601785A (zh) * 2013-11-25 2014-02-26 四川大学 一种醋酸优力斯特新的合成方法
HU230381B1 (hu) 2014-02-17 2016-03-29 Richter Gedeon Nyrt Ipari eljárás szteroid intermedier előállítására
CN107200770B (zh) * 2016-03-18 2019-11-01 华东师范大学 特拉司酮合成中环氧异构体的高效分离和循环利用方法
CN109575098B (zh) * 2019-01-18 2021-01-01 湖南成大生物科技有限公司 诺孕美特的合成方法
CN115536529B (zh) * 2022-09-26 2024-06-25 浦拉司科技（上海）有限责任公司 一种3,5-二（2-氰基-异丙基）-甲苯的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3722486A1 (de) * 1987-07-03 1989-01-12 Schering Ag Neues epoxidierungs-reagenz und seine verwendung
US4954490A (en) * 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
US6900193B1 (en) * 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
CA2253673C (en) * 1996-05-01 2009-09-08 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
DE60021422T2 (de) 1999-12-29 2006-05-24 The Government of the United States of America, as represented by the Secretary National Institute of Health, Office of Technology Transfer Verfahren zur Herstellung von 17α-acetoxy-11β-[4-n,n-(dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dion, für das Verfahren nützliche Zwischenprodukte und Verfahren zur Herstellung derartiger Zwischenprodukte
ES2546291T3 (es) * 2000-03-17 2015-09-22 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services 17-Alfa-sustituida, 11-beta-sustituida-4-arilo y 21-sustituida 19-norpregnadienodionas como agentes antiprogestacionales

Also Published As

Publication number Publication date
UA100241C2 (uk) 2012-12-10
JP5261481B2 (ja) 2013-08-14
CN101622268A (zh) 2010-01-06
TW200918549A (en) 2009-05-01
IL200124A0 (en) 2010-04-15
EP2160398A2 (en) 2010-03-10
MX2009011861A (es) 2009-11-18
SI2160398T1 (sl) 2012-01-31
NZ579029A (en) 2011-09-30
EP2160398B1 (en) 2011-10-12
HUP0700439A2 (en) 2009-11-30
BRPI0813654B8 (pt) 2021-05-25
EA201070061A1 (ru) 2010-04-30
AU2008269531A1 (en) 2008-12-31
BRPI0813654A2 (pt) 2014-12-30
HRP20120008T1 (hr) 2012-01-31
ZA200907030B (en) 2010-07-28
US8183402B2 (en) 2012-05-22
WO2009001148A2 (en) 2008-12-31
AR067189A1 (es) 2009-09-30
JP2010531346A (ja) 2010-09-24
KR20100036218A (ko) 2010-04-07
EA015478B1 (ru) 2011-08-30
HU228636B1 (en) 2013-04-29
CA2677195C (en) 2014-08-05
AU2008269531B2 (en) 2013-07-04
US20100137622A1 (en) 2010-06-03
IL200124A (en) 2011-10-31
TWI411616B (zh) 2013-10-11
WO2009001148A3 (en) 2009-03-19
ES2375320T3 (es) 2012-02-28
ATE528313T1 (de) 2011-10-15
BRPI0813654B1 (pt) 2021-05-04
PT2160398E (pt) 2012-01-06
KR101535686B1 (ko) 2015-07-24
PL2160398T3 (pl) 2012-03-30
CA2677195A1 (en) 2008-12-31
CN101622268B (zh) 2012-09-05
CY1112529T1 (el) 2015-12-09
HU0700439D0 (en) 2007-08-28
MY149296A (en) 2013-08-30

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