DK2125025T3 - Multifunktionelle medikamentbærere - Google Patents
Multifunktionelle medikamentbærereInfo
- Publication number
- DK2125025T3 DK2125025T3 DK08728317.2T DK08728317T DK2125025T3 DK 2125025 T3 DK2125025 T3 DK 2125025T3 DK 08728317 T DK08728317 T DK 08728317T DK 2125025 T3 DK2125025 T3 DK 2125025T3
- Authority
- DK
- Denmark
- Prior art keywords
- drug carriers
- multifunctional drug
- multifunctional
- carriers
- drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/48—Polymers modified by chemical after-treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
- C08G65/46—Post-polymerisation treatment, e.g. recovery, purification, drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyamides (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88701107P | 2007-01-29 | 2007-01-29 | |
US91536407P | 2007-05-01 | 2007-05-01 | |
PCT/US2008/052094 WO2008094834A2 (en) | 2007-01-29 | 2008-01-25 | Multi-functional drug carriers |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2125025T3 true DK2125025T3 (da) | 2013-02-25 |
Family
ID=39537096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08728317.2T DK2125025T3 (da) | 2007-01-29 | 2008-01-25 | Multifunktionelle medikamentbærere |
Country Status (9)
Country | Link |
---|---|
US (2) | US20080181852A1 (da) |
EP (1) | EP2125025B1 (da) |
JP (1) | JP2010516783A (da) |
KR (1) | KR20090119863A (da) |
CN (1) | CN101631567B (da) |
CA (1) | CA2676912A1 (da) |
DK (1) | DK2125025T3 (da) |
TW (1) | TW200838562A (da) |
WO (1) | WO2008094834A2 (da) |
Families Citing this family (26)
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WO2007067417A1 (en) * | 2005-12-05 | 2007-06-14 | Nitto Denko Corporation | Polyglutamate-amino acid conjugates and methods |
EP2144631A2 (en) * | 2007-04-10 | 2010-01-20 | Nitto Denko Corporation | Multi-functional polyglutamate drug carriers |
WO2008141110A2 (en) * | 2007-05-09 | 2008-11-20 | Nitto Denko Corporation | Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs |
WO2008141107A2 (en) | 2007-05-09 | 2008-11-20 | Nitto Denko Corporation | Compositions that include a hydrophobic compound and a polyamino acid conjugate |
EP2262537A1 (en) * | 2008-03-06 | 2010-12-22 | Nitto Denko Corporation | Polymer paclitaxel conjugates and methods for treating cancer |
EP2303288A4 (en) | 2008-05-22 | 2015-04-22 | Univ Ramot | CONJUGATES OF A POLYMER, BISPHOSPHONATE AND ANTI-ANGIOGENESIS AGENT AND USES THEREOF IN THE TREATMENT AND MONITORING OF DISEASES RELATING TO BONES |
WO2009141826A2 (en) | 2008-05-22 | 2009-11-26 | Ramot At Tel Aviv University Ltd. | Novel conjugates of polymers having a therapeutically active agent and an angiogenesis targeting moiety attached thereto and uses thereof in the treatment of angiogenesis related diseases |
US20130011336A1 (en) * | 2008-09-12 | 2013-01-10 | Nitto Denko Corporation | Imaging agents of fibrotic diseases |
US20100093935A1 (en) * | 2008-10-15 | 2010-04-15 | Nitto Denko Corporation | Method of preparing polyglutamate conjugates |
KR101059285B1 (ko) | 2009-05-07 | 2011-08-24 | 가톨릭대학교 산학협력단 | 가돌리늄 착물, 그 제조방법, 및 그것을 포함하는 mri 조영제 |
CN102421827B (zh) * | 2009-05-15 | 2014-07-30 | 日本化药株式会社 | 具有羟基的生理活性物质的高分子结合体 |
WO2011075483A1 (en) * | 2009-12-16 | 2011-06-23 | Nitto Denko Corporation | Controlled synthesis of polyglutamic acid |
CN101991867B (zh) * | 2010-10-22 | 2013-01-23 | 复旦大学附属中山医院 | 用于早期肝纤维化诊断的多模式靶向探针及其制备方法 |
WO2013124867A1 (en) | 2012-02-21 | 2013-08-29 | Amrita Vishwa Vidyapeetham University | Polymer - polymer or polymer - protein core - shell nano medicine loaded with multiple drug molecules |
WO2013132485A1 (en) | 2012-03-05 | 2013-09-12 | Ramot At Tel-Aviv University Ltd. | Polymers having therapeutically active agents conjugated thereto, processes of preparing same and uses thereof |
WO2013154707A1 (en) | 2012-04-12 | 2013-10-17 | Nitto Denko Corporation | Co-polymer conjugates |
CN102617852B (zh) * | 2012-04-24 | 2013-07-17 | 华东师范大学 | 马来酰亚胺-聚谷氨酸-天冬氨酸聚合物和其复合物、及其制备方法和用途 |
ES2633765T3 (es) | 2012-05-07 | 2017-09-25 | Nitto Denko Corporation | Conjugados poliméricos con un ligador |
CN103923310B (zh) * | 2013-01-11 | 2018-03-02 | 张雅珍 | 一种接枝蒽环类抗生素的树枝状聚合物的制备和用途 |
WO2014141289A1 (en) | 2013-03-12 | 2014-09-18 | Amrita Vishwa Vidyapeetham University | Photo - chemo composition on the basis of microcapsules with a core -shell structure |
CN105143242A (zh) * | 2013-04-26 | 2015-12-09 | 日东电工株式会社 | 大规模制备聚(谷氨酰基-谷氨酸盐)偶联物的方法 |
CA2911344C (en) * | 2013-05-14 | 2022-08-30 | California Institute Of Technology | Method of delivering therapeutics and imaging agents by nanoparticles that cross the blood brain barrier |
CN104055787B (zh) * | 2013-07-25 | 2017-04-26 | 北京蓝贝望生物医药科技股份有限公司 | 药用水溶性抗真菌大分子化合物 |
CN104448300B (zh) * | 2014-12-09 | 2017-01-11 | 西安医学院 | 低分子量l-聚谷氨酸-丝裂霉素c及其合成方法和应用 |
CN111617250B (zh) | 2015-08-11 | 2022-07-01 | 同宜医药(苏州)有限公司 | 多配体药物偶联体及其用途 |
TWI602577B (zh) * | 2015-08-27 | 2017-10-21 | 國立陽明大學 | 雙重標靶融合蛋白 |
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-
2008
- 2008-01-24 US US12/019,612 patent/US20080181852A1/en not_active Abandoned
- 2008-01-25 EP EP08728317A patent/EP2125025B1/en not_active Not-in-force
- 2008-01-25 WO PCT/US2008/052094 patent/WO2008094834A2/en active Application Filing
- 2008-01-25 KR KR1020097017675A patent/KR20090119863A/ko not_active Application Discontinuation
- 2008-01-25 CN CN200880007747.2A patent/CN101631567B/zh active Active
- 2008-01-25 DK DK08728317.2T patent/DK2125025T3/da active
- 2008-01-25 CA CA002676912A patent/CA2676912A1/en not_active Abandoned
- 2008-01-25 JP JP2009547443A patent/JP2010516783A/ja active Pending
- 2008-01-29 TW TW097103288A patent/TW200838562A/zh unknown
-
2012
- 2012-04-02 US US13/437,557 patent/US20120189554A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2125025B1 (en) | 2012-11-14 |
TW200838562A (en) | 2008-10-01 |
CN101631567A (zh) | 2010-01-20 |
CN101631567B (zh) | 2015-04-29 |
EP2125025A2 (en) | 2009-12-02 |
JP2010516783A (ja) | 2010-05-20 |
US20120189554A1 (en) | 2012-07-26 |
CA2676912A1 (en) | 2008-08-07 |
WO2008094834A3 (en) | 2009-04-30 |
KR20090119863A (ko) | 2009-11-20 |
WO2008094834A2 (en) | 2008-08-07 |
US20080181852A1 (en) | 2008-07-31 |
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