DK2117612T3 - Injicerbar calciumphosphat-cement, som frigiver en knogleresorptionshæmmer - Google Patents

Injicerbar calciumphosphat-cement, som frigiver en knogleresorptionshæmmer Download PDF

Info

Publication number
DK2117612T3
DK2117612T3 DK08716830.8T DK08716830T DK2117612T3 DK 2117612 T3 DK2117612 T3 DK 2117612T3 DK 08716830 T DK08716830 T DK 08716830T DK 2117612 T3 DK2117612 T3 DK 2117612T3
Authority
DK
Denmark
Prior art keywords
calcium
solid
cement
salt
phase
Prior art date
Application number
DK08716830.8T
Other languages
English (en)
Inventor
Jean-Michel Bouler
Bruno Bujoli
Pascal Janvier
Ibrahim Khairoun
Jean-Noël Argenson
Original Assignee
Graftys
Univ Nantes
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38218833&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2117612(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Graftys, Univ Nantes, Centre Nat Rech Scient filed Critical Graftys
Application granted granted Critical
Publication of DK2117612T3 publication Critical patent/DK2117612T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
    • A61K6/838—Phosphorus compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0052—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with an inorganic matrix
    • A61L24/0063—Phosphorus containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (16)

1. Fremgangsmåde til fremstilling af en injicerbar calciumphosphat-knogle-cement, der frigiver en geminal bisphosphonforbindelse, hvor fremgangsmåden omfatter tilsætning af en bisphosphonsyre eller et salt deraf eller en fast calcium-prækursor modificeret med en bisphosphonsyre eller et salt deraf til den faste cementfase eller til den flydende cementfase, hvor den faste calci-umprækursor er valgt blandt calcium-ortophosphater og ikke-phosphat-calci-umsalte, såsom CaC03 eller CaSC>4.
2. Fremgangsmåde ifølge krav 1, hvor mængden af bisphosphonsyren eller saltet deraf er op til 2,5 vægt-% i forhold til vægten af faste fase.
3. Fremgangsmåde ifølge krav 1, hvor bisphosphonsyren eller saltet deraf opløses i den flydende cementfase, og mængden af bisphosphonsyren eller saltet deraf er op til 0,3 vægt-% i forhold til vægten af fast fase.
4. Fremgangsmåde ifølge krav 1, hvor bisphosphonsyren eller saltet deraf tilsættes til den faste cementfase, og mængden af bisphosphonsyre eller salt deraf er op til 3,5 vægt-% i forhold til vægten af fast fase.
5. Fremgangsmåde ifølge krav 1, hvor en fast calcium-prækursor modificeret med en bisphosphonsyre eller salt deraf tilsættes til den faste cementfase, og mængden af bisphosphonsyren eller et salt deraf er op til 0,15 vægt-% i forhold til vægten af fast fase.
6. Fremgangsmåde ifølge et af kravene 1 til 5, hvor bisphosphonsyren eller saltet deraf er udvalgt fra gruppen bestående af etidronat, clodronat, pa-midronat, alendronat, risedronat, tiludronat, ibandronat, zoledronat, incadro-nat, olpadronat og neridronat.
7. Fremgangsmåde ifølge et af kravene 1,2, 5 og 6, hvor den faste calcium-prækursor er valgt fra gruppen bestående af: calcium-deficitær apatit (CDA), α-TCP, DCPD og CaCC>3.
8. Fremgangsmåde ifølge et af kravene 1 til 7, hvor den faste fase omfatter en eller flere calcium- og/eller phosphatforbindelser udvalgt fra gruppen bestående af HA, a-TCP, β-TCP, ACP, MCPH, DCPA, CDA, CaC03 og blandinger deraf.
9. Fremgangsmåde ifølge et af kravene 1 til 8, hvor den faste fase også omfatter mindst en syntetisk polymer eller biopolymer.
10. Fremgangsmåde ifølge et af kravene 1 til 9, hvor den flydende fase består i en vandig Na2HPC>4-opløsning, en vandig NaH2P04-opløsning eller en vandig citronsyreopløsning.
11. Fremgangsmåde ifølge et af kravene 1 til 10, hvor pH-værdien af den flydende fase er mellem 5 og 10, fortrinsvis mellem 5 og 9, mest foretrukket mellem 5 og 7.
12. Fremgangsmåde ifølge et af kravene 1 til 11, hvor forholdet mellem den flydende fase/den faste fase (L/S) ligger mellem 0,20 og 0,9 ml/g, mere foretrukket mellem 0,25 og 0,8 ml/g, stadig foretrukket mellem 0,25 og 0,45 ml/g, mest foretrukket 0,30 til 0,45 ml/g.
13. Injicerbar apatitisk calciumphosphat-cement, der kan opnås ifølge fremgangsmåden ifølge et af kravene 1 til 12.
14. Injicerbar apatitisk calciumphosphat-cement ifølge krav 13, yderligere omfattende et kontrastmiddel, fortrinsvis bariumsulfat.
15. Anvendelse af en injicerbar apatitisk CPC ifølge et af kravene 13 eller 14, til fremstilling af et medikament til fyldning af en knogledefekt, en tanddefekt eller en fraktur.
16. Kit til fremstilling af en injicerbar calciumphosphat-knoglecement, der frigiver en bisphosphonsyre eller et salt deraf ifølge et af kravene 13 eller 14 omfattende en bisphosphonsyre eller et salt deraf eller en fast calcium-prækursor modificeret med en bisphosphonsyre eller et salt deraf, en fast fase og en flydende fase, hvor den faste calciumprækursor er valgt blandt calcium-ortophosphater og ikke-phosphat-calciumsalte, såsom CaC03 eller CaSC>4.
DK08716830.8T 2007-02-14 2008-02-13 Injicerbar calciumphosphat-cement, som frigiver en knogleresorptionshæmmer DK2117612T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90109007P 2007-02-14 2007-02-14
EP07290185A EP1958649A1 (en) 2007-02-14 2007-02-14 Injectable calcium-phosphate cement releasing a bone resorption inhibitor
PCT/EP2008/051735 WO2008098959A1 (en) 2007-02-14 2008-02-13 Injectable calcium-phosphate cement releasing a bone resorption inhibitor

Publications (1)

Publication Number Publication Date
DK2117612T3 true DK2117612T3 (da) 2015-10-26

Family

ID=38218833

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08716830.8T DK2117612T3 (da) 2007-02-14 2008-02-13 Injicerbar calciumphosphat-cement, som frigiver en knogleresorptionshæmmer

Country Status (15)

Country Link
US (3) US20100197636A1 (da)
EP (2) EP1958649A1 (da)
JP (1) JP5570224B2 (da)
KR (2) KR101565591B1 (da)
CN (1) CN101687059B (da)
BR (1) BRPI0807267A2 (da)
CA (1) CA2678063C (da)
DK (1) DK2117612T3 (da)
ES (1) ES2550935T3 (da)
HU (1) HUE025972T2 (da)
IL (1) IL200392A (da)
PL (1) PL2117612T3 (da)
RU (1) RU2465922C2 (da)
WO (1) WO2008098959A1 (da)
ZA (1) ZA200905617B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2228080A1 (en) * 2009-03-03 2010-09-15 Graftys Galliated calcium phosphate biomaterials
DK2427485T3 (da) 2009-05-07 2017-03-13 Immunocellular Therapeutics Ltd Cd133-epitoper
CN102574879B (zh) * 2009-06-05 2016-11-02 新加坡南洋理工大学 递送至骨的靶向药物
US8529933B2 (en) * 2009-07-27 2013-09-10 Warsaw Orthopedic, Inc. Biphasic calcium phosphate cement for drug delivery
US8882740B2 (en) * 2009-12-23 2014-11-11 Stryker Trauma Gmbh Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone
US8614190B2 (en) 2010-06-30 2013-12-24 Industrial Technology Research Institute Thermal responsive composition for treating bone diseases
EP2608778B1 (en) 2010-08-26 2017-11-01 University of Louisville Research Foundation, Inc. Compositions and methods for treating bone defects
MA33231B1 (fr) 2010-09-20 2012-05-02 Univ Hassan Ii Mohammedia Ciments macroporeux a base de bioverre, bioactif, bioresorbable a usage biomedical
GB201200868D0 (en) * 2012-01-19 2012-02-29 Depuy Int Ltd Bone filler composition
RU2494694C1 (ru) * 2012-01-23 2013-10-10 Государственное Бюджетное Учреждение "Санкт-Петербургский Научно-Исследовательский Институт Скорой Помощи Им. И.И.Джанелидзе" Способ лечения переломов трубчатых костей при выраженном остеопорозе
US9675640B2 (en) 2012-08-07 2017-06-13 Southwest Research Institute Magnetic calcium phosphate nanoparticles, applications and methods of preparation thereof
CN103463678B (zh) * 2013-08-30 2015-05-13 中国人民解放军第四军医大学 一种多功能医用生物骨水泥
US10046090B2 (en) 2013-10-08 2018-08-14 Vivorte, Inc. Processed bone particle compositions and related methods
US9566216B2 (en) * 2013-11-18 2017-02-14 Southwest Research Institute Bone cements containing magnetic calcium phosphate nanoparticles
ES2553302B1 (es) * 2014-05-05 2016-09-14 Universitat Politècnica De Catalunya Cemento inorgánico, inyectable y termosensible para reconstrucción ósea: preparación y uso.
JO3394B1 (ar) 2014-07-04 2019-10-20 Osteo Pharma B V تركيبات ومنتجات للاستعمال في علاج كسور وعيوب العظام
WO2016088915A1 (ko) * 2014-12-03 2016-06-09 한국기계연구원 골다공증 치료용 유효성분을 함유하는 경조직 재생용 지지체 및 이의 제조방법
AU2017254618B2 (en) 2016-04-19 2021-04-01 Warsaw Orthopedic, Inc. An implantable composite containing carbonated hydroxyapatite
KR102286084B1 (ko) * 2018-11-13 2021-08-06 한국재료연구원 인산칼슘 지지체의 경화속도 제어방법
CN109930209B (zh) * 2019-03-07 2022-02-15 华南理工大学 一种具高结晶度及长径比双膦酸盐晶体及其制备方法
CN110063740B (zh) * 2019-04-25 2020-07-07 泰山医学院 适用于ct标准值检测的体模材料、制备方法及应用
CN111544655B (zh) * 2020-05-21 2022-06-24 中鼎凯瑞科技成都有限公司 双膦酸盐型自凝固复合骨移植物及其制备方法
CN113116858A (zh) * 2021-03-26 2021-07-16 张皓轩 一种载伊班膦酸钠plga微球及采用该微球的复合组织工程骨的制备方法
KR102660274B1 (ko) * 2022-08-30 2024-04-24 이노시스 주식회사 마그네슘 이온을 함유하는 골 이식재 및 이를 위한 경화액
CN118141982A (zh) * 2024-03-08 2024-06-07 华东理工大学 一种用于骨质疏松症的可生物降解、可注射粘结性骨水泥及其制备方法和应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880610A (en) * 1988-04-20 1989-11-14 Norian Corporation In situ calcium phosphate minerals--method and composition
US5129905A (en) 1988-04-20 1992-07-14 Norian Corporation Methods for in situ prepared calcium phosphate minerals
US5053212A (en) * 1988-04-20 1991-10-01 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
US5605713A (en) * 1991-11-22 1997-02-25 Boltong; Maria G. Process for the preparation of calcium phosphate cements and its application as bio-materials
ES2040626B1 (es) 1991-11-22 1994-05-16 Boltong Maria G Procedimiento para la obtencion de cementos de fosfatos de calcio y su empleo como biomteriales.
FI92465C (fi) * 1993-04-14 1994-11-25 Risto Tapani Lehtinen Menetelmä endo-osteaalisten materiaalien käsittelemiseksi
RU2077329C1 (ru) 1993-07-21 1997-04-20 Акционерное общество закрытого типа "ОСТИМ" Средство для стимуляции роста костной ткани
FR2715853B1 (fr) * 1994-02-08 1996-04-26 Centre Nat Rech Scient Composition pour bio-matériau; procédé de préparation.
GB9408775D0 (en) * 1994-05-04 1994-06-22 Ciba Geigy Ag Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration
US5676976A (en) * 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
AU5973496A (en) * 1995-06-06 1996-12-24 Merck & Co., Inc. Bisphosphonate cement composition to prevent aseptic loosening of orthopedic implant devices
WO1998028068A1 (en) * 1996-12-13 1998-07-02 Norian Corporation Preparation, storage and administration of cements
US6063289A (en) * 1998-10-01 2000-05-16 Albright & Wilson Americas Inc. Method for controlling scale using synergistic phosphonate blends
CA2360319A1 (en) * 1999-02-09 2000-08-17 Memorial Sloan-Kettering Cancer Center Anti-resorptive bone cements and allogeneic, autografic, and xenografic bone grafts
CN1221293C (zh) * 2000-03-14 2005-10-05 瑞安大药厂股份有限公司 α－三钙磷酸盐/氢氧基磷灰石两相骨水泥及其制造方法
SE517168C2 (sv) * 2000-07-17 2002-04-23 Bone Support Ab En komposition för ett injicerbart ersättningsmaterial för benmineral
US7294187B2 (en) * 2001-01-24 2007-11-13 Ada Foundation Rapid-hardening calcium phosphate cement compositions
ES2341296T3 (es) † 2001-12-20 2010-06-17 Bone Support Ab Un nuevo sustituto mineral de hueso.
FR2836681B1 (fr) † 2002-03-04 2004-06-18 Centre Nat Rech Scient Compose phosphocalcique modifie, composition injectable le contenant
AU2003227524A1 (en) * 2002-05-31 2003-12-19 Kobenhavns Universitet Use of bisphosphonic acid derivatives for the treatment of calcium phrophosphated deposition disease and dental treatment
CN1319603C (zh) * 2002-06-19 2007-06-06 H·C·罗伯特·马泰斯·斯蒂夫腾 外科用磷酸钙基水硬性胶凝材料
CN1230181C (zh) * 2002-07-24 2005-12-07 清华大学 一种骨修复材料
SE0300620D0 (sv) † 2003-03-05 2003-03-05 Bone Support Ab A new bone substitute composition
PL1675608T3 (pl) † 2003-09-12 2007-11-30 Wyeth Corp Stałe fosforanowo wapniowe pałeczki do wstrzyknięć dla dostarczania białek osteogennych
CN1244379C (zh) * 2004-01-19 2006-03-08 肖应庆 磷酸钙活性骨活化剂与制备方法及其用途
US7351280B2 (en) * 2004-02-10 2008-04-01 New York University Macroporous, resorbable and injectible calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment
AU2004316731B2 (en) * 2004-03-08 2010-12-02 Dr.H.C. Robert Mathys Stiftung Hydraulic cement based on calcium phosphate for surgical use
JP2006130122A (ja) * 2004-11-08 2006-05-25 Ngk Spark Plug Co Ltd 粉剤、リン酸カルシウム系ペースト、およびリン酸カルシウム系ペーストキット

Also Published As

Publication number Publication date
ZA200905617B (en) 2011-10-26
US20150140118A1 (en) 2015-05-21
US8889165B2 (en) 2014-11-18
EP2117612B1 (en) 2015-07-29
HUE025972T2 (en) 2016-05-30
US20080206296A1 (en) 2008-08-28
WO2008098959A1 (en) 2008-08-21
JP2010517716A (ja) 2010-05-27
PL2117612T3 (pl) 2016-03-31
AU2008214596A1 (en) 2008-08-21
EP2117612A1 (en) 2009-11-18
CA2678063C (en) 2016-06-14
EP2117612B2 (en) 2018-11-21
US20100197636A1 (en) 2010-08-05
CA2678063A1 (en) 2008-08-21
CN101687059B (zh) 2013-03-27
JP5570224B2 (ja) 2014-08-13
IL200392A0 (en) 2010-04-29
KR20090118037A (ko) 2009-11-17
RU2009134119A (ru) 2011-03-20
EP1958649A1 (en) 2008-08-20
ES2550935T3 (es) 2015-11-13
BRPI0807267A2 (pt) 2014-05-06
RU2465922C2 (ru) 2012-11-10
US9913928B2 (en) 2018-03-13
KR20140129374A (ko) 2014-11-06
CN101687059A (zh) 2010-03-31
KR101565591B1 (ko) 2015-11-04
IL200392A (en) 2015-07-30

Similar Documents

Publication Publication Date Title
DK2117612T3 (da) Injicerbar calciumphosphat-cement, som frigiver en knogleresorptionshæmmer
JP6130098B2 (ja) ガリウム化リン酸カルシウム生体材料
Bohner Design of ceramic-based cements and putties for bone graft substitution
AU2007287334B2 (en) Macroporous and highly resorbable apatitic calcium-phosphate cement
JP5307547B2 (ja) 骨修復のための２相セメント前駆体系
JP2005526538A (ja) 新規骨無機代替物
US8894958B2 (en) Galliated calcium phosphate biomaterials
AU2008214596B2 (en) Injectable calcium-phosphate cement releasing a bone resorption inhibitor
RU2824989C1 (ru) Остеопластический материал для замещения дефектов костной ткани