DK2099780T3 - 2-alkyl-indazol forbindelser til behandling af visse CNS-relaterede lidelser - Google Patents

2-alkyl-indazol forbindelser til behandling af visse CNS-relaterede lidelser

Info

Publication number
DK2099780T3
DK2099780T3 DK07846673.7T DK07846673T DK2099780T3 DK 2099780 T3 DK2099780 T3 DK 2099780T3 DK 07846673 T DK07846673 T DK 07846673T DK 2099780 T3 DK2099780 T3 DK 2099780T3
Authority
DK
Denmark
Prior art keywords
alkyl
treatment
related disorders
indazole compounds
certain cns
Prior art date
Application number
DK07846673.7T
Other languages
Danish (da)
English (en)
Inventor
Caterina Maugeri
Maria Alessandra Alisi
Nicola Cazzolla
Guido Furlotti
Rosella Ombrato
Lorenzo Polenzani
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Application granted granted Critical
Publication of DK2099780T3 publication Critical patent/DK2099780T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK07846673.7T 2006-11-22 2007-11-19 2-alkyl-indazol forbindelser til behandling af visse CNS-relaterede lidelser DK2099780T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002230A ITMI20062230A1 (it) 2006-11-22 2006-11-22 Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
PCT/EP2007/010000 WO2008061688A1 (en) 2006-11-22 2007-11-19 2 -alkyl- indazole compounds for the treatment of certain cns-related disorders

Publications (1)

Publication Number Publication Date
DK2099780T3 true DK2099780T3 (da) 2013-04-15

Family

ID=38474157

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07846673.7T DK2099780T3 (da) 2006-11-22 2007-11-19 2-alkyl-indazol forbindelser til behandling af visse CNS-relaterede lidelser

Country Status (23)

Country Link
US (1) US8507528B2 (es)
EP (1) EP2099780B1 (es)
JP (1) JP5551443B2 (es)
KR (1) KR101471987B1 (es)
CN (1) CN101558057B (es)
AR (1) AR063881A1 (es)
AU (1) AU2007323368B2 (es)
BR (1) BRPI0718976A2 (es)
CA (1) CA2668205C (es)
DK (1) DK2099780T3 (es)
EA (1) EA019217B1 (es)
ES (1) ES2401199T3 (es)
GE (1) GEP20125414B (es)
HK (1) HK1129112A1 (es)
IL (1) IL198432A (es)
IT (1) ITMI20062230A1 (es)
MX (1) MX2009005250A (es)
PL (1) PL2099780T3 (es)
PT (1) PT2099780E (es)
SG (1) SG176504A1 (es)
SI (1) SI2099780T1 (es)
UA (1) UA98311C2 (es)
WO (1) WO2008061688A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012011231A (es) 2010-04-08 2012-11-12 Acraf Compuesto de indazol triciclico, metodo de preparacion y composicion farmaceutica que lo contiene.
AU2012230503B2 (en) 2011-03-18 2016-07-07 Bayer Intellectual Property Gmbh N-(3-carbamoylphenyl)-1H-pyrazole-5-carboxamide derivatives and the use thereof for controlling animal pests

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57501378A (es) * 1980-09-05 1982-08-05
DE3687080T2 (de) * 1985-04-27 1993-03-25 Beecham Group Plc Azabicyclononyl-indazol-carboxamid mit 5-ht-antagonistischer wirkung.
GB8623142D0 (en) * 1986-09-26 1986-10-29 Beecham Group Plc Compounds
JPH02215779A (ja) * 1989-02-14 1990-08-28 Kuraray Co Ltd カルボン酸アミド誘導体類及びその医薬用途
US5246947A (en) * 1991-09-23 1993-09-21 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1,2-benzisothiazoles and their use for treating depression
AU4949293A (en) 1992-08-28 1994-03-29 Ciba-Geigy Ag Indazole derivatives
JPH08277287A (ja) * 1995-02-09 1996-10-22 Mitsubishi Chem Corp インダゾール類およびその用途
CA2222532A1 (en) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amine
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
US6218390B1 (en) * 1998-12-17 2001-04-17 Synaptic Pharmaceutical Corporation Morpholinone and morpholine derivatives and uses thereof
CN100439341C (zh) 2002-12-02 2008-12-03 弗·哈夫曼-拉罗切有限公司 作为促肾上腺皮质激素释放因子拮抗剂的吲唑衍生物
ITMI20030972A1 (it) 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
ITMI20031468A1 (it) 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
FR2857966A1 (fr) * 2003-07-24 2005-01-28 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
ATE457309T1 (de) * 2003-12-23 2010-02-15 Serodus As Modulatoren von peripheren 5-ht-rezeptoren
BRPI0418351A (pt) * 2004-01-05 2007-05-08 Astrazeneca Ab composto ou um sal farmaceuticamente aceitável do mesmo, métodos de limitar a proliferação celular em um humano ou animal, de tratamento de um humano ou animal sofrendo de cáncer, de tratamento de profilaxia de cáncer, de tratamento de um humano ou animal sofrendo de uma doença neoplásica, de tratamento de um humano ou animal sofrendo de uma doença prolifetativa de tratamento de cáncer, para o tratamento de infecções associadas com cáncer, para o tratamento profilático de infecções associadas com cáncer, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, método de inibir a chk1 quinase, e, processo para a preparação de um composto ou um sal farmaceuticamente aceitável do mesmo
AU2005271737A1 (en) * 2004-08-03 2006-02-16 Wyeth Indazoles useful in treating cardiovascular diseases
TW200621237A (en) * 2004-11-01 2006-07-01 Wyeth Corp [(1-h-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1h-indazol-3-yl)methanones
PE20061130A1 (es) * 2004-11-19 2007-01-05 Arena Pharm Inc Derivados de 3-fenil-pirazol como moduladores del receptor de serotonina 5-ht2a
WO2008054748A2 (en) * 2006-10-31 2008-05-08 Arena Pharmaceuticals, Inc. Indazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto

Also Published As

Publication number Publication date
KR101471987B1 (ko) 2014-12-12
SI2099780T1 (sl) 2013-03-29
KR20090089880A (ko) 2009-08-24
WO2008061688A1 (en) 2008-05-29
CA2668205A1 (en) 2008-05-29
AU2007323368A1 (en) 2008-05-29
HK1129112A1 (en) 2009-11-20
PT2099780E (pt) 2013-03-11
MX2009005250A (es) 2009-05-28
BRPI0718976A2 (pt) 2014-02-04
ES2401199T3 (es) 2013-04-17
ITMI20062230A1 (it) 2008-05-23
JP2010510265A (ja) 2010-04-02
JP5551443B2 (ja) 2014-07-16
EP2099780A1 (en) 2009-09-16
US20100056573A1 (en) 2010-03-04
IL198432A (en) 2013-03-24
GEP20125414B (en) 2012-03-12
US8507528B2 (en) 2013-08-13
PL2099780T3 (pl) 2013-05-31
UA98311C2 (ru) 2012-05-10
CN101558057A (zh) 2009-10-14
SG176504A1 (en) 2011-12-29
EA200970496A1 (ru) 2009-10-30
EA019217B1 (ru) 2014-02-28
AU2007323368B2 (en) 2013-02-07
IL198432A0 (en) 2010-02-17
CN101558057B (zh) 2013-05-01
AR063881A1 (es) 2009-02-25
EP2099780B1 (en) 2013-01-09
CA2668205C (en) 2014-10-21

Similar Documents

Publication Publication Date Title
DK2114886T3 (da) Fremgangsmåde til fremstilling af visse substituerede sulfiliminer
DK2019683T4 (da) Indgivelse af vækstfaktorer til behandling af CNS-lidelser
DK2474321T3 (da) Sammensætninger til behandling af collagenmedierede sygdomme
DK1874781T3 (da) Dihydrothienopyrimidiner til behandling af inflammatoriske sygdomme
DK3456707T3 (da) 4-(p-quinonyl)-2-hydroxybutanamidderivater til behandling af mitokondriesygdomme
BRPI0918527A2 (pt) compostos para o tratamento de disturbios do cns
DK2504005T3 (da) Anvendelse af 1,3-diphenylprop-2-en-1-on-derivater til behandling af lever-sygdomme
DK2044026T3 (da) Fremgangsmde til behandling af cerebral glioma tumor
DK3289876T3 (da) Forbindelser til behandling af cancer
DK2478907T3 (da) Sammensætninger til behandling af kræft
SMAP200900085A (it) 3-imidazolil-indoli per il trattamento di malattieproliferative
DK2431359T3 (da) Fremgangsmåde til fremstilling af diaminophenothiaziniumforbindelser
DK2959894T3 (da) S1p-receptormodulatorer til behandling af multipel sklerose
DK3192520T3 (da) Terapeutiske midler til reducering af niveauerne af parathyreoideahormon
DK3354276T3 (da) Sammensætninger til behandlingen af gastrointestinal inflammation
DK1928438T3 (da) Anvendelse af ibudilast til behandling af stofafhængighed
ZA200806074B (en) Compounds for the treatment of inflammatory disorders
DK2285808T3 (da) Spiroindolderivater til behandling af parasitsygdomme
DK2440230T3 (da) Behandlingsregimener til behandling af neurologisk sygdom
DK2056842T3 (da) Modificeret galactosylceramid til behandling af cancerøse sygdomme
DK2209784T3 (da) Forbindelser til behandling af hepatitis C
DK2117525T3 (da) Anvendelse af 1-phenyl-3-dimethylamino-propanforbindelser til behandling af neuropatismerte
DK2010184T3 (da) Implatanter til behandlingen af dopamin associerede tilstande
DK2117565T3 (da) Anvendelse af chitosaner til behandlingen af negleinflammatoriske sygdomme
DK1841433T3 (da) Præparat til behandling af lidelser i centralnervesystemet