MX2009005250A - Compuestos 2-alquil-indazol para el tratamiento de ciertas enfermedades relacionadas con el sistema nervioso central (cns). - Google Patents

Compuestos 2-alquil-indazol para el tratamiento de ciertas enfermedades relacionadas con el sistema nervioso central (cns).

Info

Publication number
MX2009005250A
MX2009005250A MX2009005250A MX2009005250A MX2009005250A MX 2009005250 A MX2009005250 A MX 2009005250A MX 2009005250 A MX2009005250 A MX 2009005250A MX 2009005250 A MX2009005250 A MX 2009005250A MX 2009005250 A MX2009005250 A MX 2009005250A
Authority
MX
Mexico
Prior art keywords
alkyl
treatment
related disorders
indazole compounds
certain cns
Prior art date
Application number
MX2009005250A
Other languages
English (en)
Inventor
Maria Alessandra Alisi
Nicola Cazzolla
Guido Furlotti
Lorenzo Polenzani
Caterina Maugeri
Rosella Ombrato
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of MX2009005250A publication Critical patent/MX2009005250A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Un compuesto 2-alquil-indazol y sus sales de adición ácida farmacéuticamente aceptables, métodos e intermediarios para prepararlo y una composición farmacéutica que comprende el uso de los mismos. El compuesto 2-alquil-indazol tiene la siguiente fórmula general (I) en la cual R1, R2, R3, R4, R6, R7, X Y, W, n, p, y m tiene los significados mencionados en la descripción.
MX2009005250A 2006-11-22 2007-11-19 Compuestos 2-alquil-indazol para el tratamiento de ciertas enfermedades relacionadas con el sistema nervioso central (cns). MX2009005250A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002230A ITMI20062230A1 (it) 2006-11-22 2006-11-22 Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
PCT/EP2007/010000 WO2008061688A1 (en) 2006-11-22 2007-11-19 2 -alkyl- indazole compounds for the treatment of certain cns-related disorders

Publications (1)

Publication Number Publication Date
MX2009005250A true MX2009005250A (es) 2009-05-28

Family

ID=38474157

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005250A MX2009005250A (es) 2006-11-22 2007-11-19 Compuestos 2-alquil-indazol para el tratamiento de ciertas enfermedades relacionadas con el sistema nervioso central (cns).

Country Status (23)

Country Link
US (1) US8507528B2 (es)
EP (1) EP2099780B1 (es)
JP (1) JP5551443B2 (es)
KR (1) KR101471987B1 (es)
CN (1) CN101558057B (es)
AR (1) AR063881A1 (es)
AU (1) AU2007323368B2 (es)
BR (1) BRPI0718976A2 (es)
CA (1) CA2668205C (es)
DK (1) DK2099780T3 (es)
EA (1) EA019217B1 (es)
ES (1) ES2401199T3 (es)
GE (1) GEP20125414B (es)
HK (1) HK1129112A1 (es)
IL (1) IL198432A (es)
IT (1) ITMI20062230A1 (es)
MX (1) MX2009005250A (es)
PL (1) PL2099780T3 (es)
PT (1) PT2099780E (es)
SG (1) SG176504A1 (es)
SI (1) SI2099780T1 (es)
UA (1) UA98311C2 (es)
WO (1) WO2008061688A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2788762C (en) * 2010-04-08 2018-04-10 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F.S.P.A. Tricyclic indazole compound, method of preparation and pharmaceutical composition containing it
MX350121B (es) 2011-03-18 2017-08-28 Bayer Ip Gmbh Derivados de n-(3-carbamoilfenil)-1h-pirazol-5-carboxamida y el uso de los mismos para el control de plagas de animales.

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982000824A1 (en) * 1980-09-05 1982-03-18 Geissmann F 1h and 2h indazol derivatives and medicaments containing them
GB8623142D0 (en) 1986-09-26 1986-10-29 Beecham Group Plc Compounds
DE3650772T2 (de) * 1985-04-27 2003-04-03 Hoffmann La Roche Derivate von Indazole-3-carboxamide und -3-carboxylsäure
JPH02215779A (ja) * 1989-02-14 1990-08-28 Kuraray Co Ltd カルボン酸アミド誘導体類及びその医薬用途
US5246947A (en) * 1991-09-23 1993-09-21 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1,2-benzisothiazoles and their use for treating depression
WO1994005642A1 (en) 1992-08-28 1994-03-17 Ciba-Geigy Ag Indazole derivatives
JPH08277287A (ja) * 1995-02-09 1996-10-22 Mitsubishi Chem Corp インダゾール類およびその用途
CA2222532A1 (en) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amine
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
US6218390B1 (en) * 1998-12-17 2001-04-17 Synaptic Pharmaceutical Corporation Morpholinone and morpholine derivatives and uses thereof
CA2507074A1 (en) 2002-12-02 2004-06-17 F. Hoffmann-La Roche Ag Indazole derivatives as crf antagonists
ITMI20030972A1 (it) 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
ITMI20031468A1 (it) 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
FR2857966A1 (fr) * 2003-07-24 2005-01-28 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
EP1701951B1 (en) * 2003-12-23 2010-02-10 Serodus AS Modulators of peripheral 5-ht receptors
RU2397168C2 (ru) * 2004-01-05 2010-08-20 Астразенека Аб Производные тиофена в качестве ингибиторов снк 1
AR050279A1 (es) * 2004-08-03 2006-10-11 Wyeth Corp Indazoles como moduladores de lxr utiles en la preparacion de medicamentos pata el tratamiento de enfermedades cardiovasculares y mediadas por th1 y composiciones farmaceuticas que los contienen como principio activo.
TW200621237A (en) * 2004-11-01 2006-07-01 Wyeth Corp [(1-h-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1h-indazol-3-yl)methanones
SA05260357B1 (ar) * 2004-11-19 2008-09-08 ارينا فارماسيتو تيكالز ، أنك مشتقات 3_فينيل_بيرازول كمعدلات لمستقبل سيروتينين 5_ht2a مفيدة في علاج الاضطرابات المتعلقه به
WO2008054748A2 (en) * 2006-10-31 2008-05-08 Arena Pharmaceuticals, Inc. Indazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto

Also Published As

Publication number Publication date
BRPI0718976A2 (pt) 2014-02-04
CN101558057A (zh) 2009-10-14
PL2099780T3 (pl) 2013-05-31
CA2668205A1 (en) 2008-05-29
EP2099780A1 (en) 2009-09-16
US8507528B2 (en) 2013-08-13
WO2008061688A1 (en) 2008-05-29
HK1129112A1 (en) 2009-11-20
JP2010510265A (ja) 2010-04-02
CN101558057B (zh) 2013-05-01
EA200970496A1 (ru) 2009-10-30
EP2099780B1 (en) 2013-01-09
GEP20125414B (en) 2012-03-12
KR101471987B1 (ko) 2014-12-12
SI2099780T1 (sl) 2013-03-29
PT2099780E (pt) 2013-03-11
ES2401199T3 (es) 2013-04-17
US20100056573A1 (en) 2010-03-04
CA2668205C (en) 2014-10-21
DK2099780T3 (da) 2013-04-15
ITMI20062230A1 (it) 2008-05-23
SG176504A1 (en) 2011-12-29
AU2007323368A1 (en) 2008-05-29
IL198432A (en) 2013-03-24
JP5551443B2 (ja) 2014-07-16
IL198432A0 (en) 2010-02-17
UA98311C2 (ru) 2012-05-10
EA019217B1 (ru) 2014-02-28
AR063881A1 (es) 2009-02-25
KR20090089880A (ko) 2009-08-24
AU2007323368B2 (en) 2013-02-07

Similar Documents

Publication Publication Date Title
MX2013003019A (es) Compuestos de azabenzotiazol, composiciones y metodos de uso.
GEP20125456B (en) Azetidines as mek inhibitors for the treatment of proliferative diseases
TN2012000125A1 (en) Substituted carbamoylmethylamino acetic acid derivatives as novel nep inhibitors
MX2011012627A (es) Derivados aminobutiricos sustituidos como inhibidores de nepralisina.
MY140638A (en) New heterocyclic compounds, which are active as inhibitors of beta-lactamases
MX2009011997A (es) Derivados de pirrolopirimidin-7-ona y su uso como farmaceuticos.
MX2009004900A (es) Arilamidas sustituidas por tiazol u oxazol.
MX2009009238A (es) Nuevos inhibidores de fosfodiesterasa.
DE602006021539D1 (en) Morpholine als 5ht2c-agonisten
NO20083708L (no) 4-Fenyl-tiazol-5-karboksylsyre og 4-fenyl-tiazol-5-karboksylmider som PLK1-inhibitorer
MX2012004311A (es) Derivados de ciclohexano spiro condensados como inhibidores de lipasa sensible a hormonas (hsl) utiles en el tratamiento de diabetes.
GEP20125389B (en) Substituted pyrazole and triazole compounds as ksp inhibitors
GB0722077D0 (en) Compounds
GEP20125415B (en) Imidazole derivatives as kinesin spindle protein inhibitors (eg-5)
MX2010009022A (es) Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso.
UA99787C2 (en) Lactams as beta secretase inhibitors
TW200639156A (en) New compounds
MX2009013501A (es) Compuestos piperidinicos y sus usos.
IN2012DN01232A (es)
MX2010009756A (es) Agonistas de receptores muscarinicos, composiciones, metodos de tratamiento de los mismos, y proceso para preparacion de los mismos.
MY161749A (en) Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use
MX2011011080A (es) Antagonistas de ccr3 de arilsulfonamida 2, 5-disustituida.
TW200640465A (en) New pharmaceutically active compounds for the treatment of respiratory diseases
TW200637552A (en) Macrocyclic analogs for the treatment of immunoregulatory disorders and respiratory diseases
MX2010006108A (es) Inhibidores de estearoil-coa-desaturasa.

Legal Events

Date Code Title Description
FG Grant or registration