DK2082226T3 - Sekventiel analyse af biologiske prøver - Google Patents
Sekventiel analyse af biologiske prøverInfo
- Publication number
- DK2082226T3 DK2082226T3 DK07871481.3T DK07871481T DK2082226T3 DK 2082226 T3 DK2082226 T3 DK 2082226T3 DK 07871481 T DK07871481 T DK 07871481T DK 2082226 T3 DK2082226 T3 DK 2082226T3
- Authority
- DK
- Denmark
- Prior art keywords
- sample
- fluorescent probe
- binding
- detecting
- probe
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/560,599 US7629125B2 (en) | 2006-11-16 | 2006-11-16 | Sequential analysis of biological samples |
| US11/864,085 US7741045B2 (en) | 2006-11-16 | 2007-09-28 | Sequential analysis of biological samples |
| PCT/US2007/084800 WO2008064067A2 (en) | 2006-11-16 | 2007-11-15 | Method for the sequential analysis of different components in a single biological sample and reagents therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2082226T3 true DK2082226T3 (da) | 2011-11-14 |
Family
ID=39313177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07871481.3T DK2082226T3 (da) | 2006-11-16 | 2007-11-15 | Sekventiel analyse af biologiske prøver |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7741045B2 (https=) |
| EP (2) | EP2381257B1 (https=) |
| JP (1) | JP5149303B2 (https=) |
| AT (1) | ATE520026T1 (https=) |
| AU (1) | AU2007323794B2 (https=) |
| CA (1) | CA2669092C (https=) |
| DK (1) | DK2082226T3 (https=) |
| ES (1) | ES2459725T3 (https=) |
| PL (1) | PL2082226T3 (https=) |
| PT (1) | PT2082226E (https=) |
| WO (1) | WO2008064067A2 (https=) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080032321A1 (en) * | 2006-08-07 | 2008-02-07 | General Electric Company | System and methods for analyzing images of tissue samples |
| US8131476B2 (en) * | 2006-08-07 | 2012-03-06 | General Electric Company | System and method for co-registering multi-channel images of a tissue micro array |
| US8060348B2 (en) * | 2006-08-07 | 2011-11-15 | General Electric Company | Systems for analyzing tissue samples |
| US7629125B2 (en) * | 2006-11-16 | 2009-12-08 | General Electric Company | Sequential analysis of biological samples |
| US20100279272A1 (en) * | 2008-02-13 | 2010-11-04 | Michael Craig Burrell | Multiplexed analysis methods using sers-active nanoparticles |
| EP2110076A1 (en) * | 2008-02-19 | 2009-10-21 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Method and device for near-field dual-wave modality imaging |
| JP5749164B2 (ja) | 2008-07-25 | 2015-07-15 | ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト(ゲーエムベーハー)Helmholtz Zentrum MuenchenDeutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH) | 組織バイオマーカーの定量的多重スペクトル光音響トモグラフィ |
| US9271654B2 (en) | 2009-06-29 | 2016-03-01 | Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) | Thermoacoustic imaging with quantitative extraction of absorption map |
| EP2459987A1 (en) | 2009-07-27 | 2012-06-06 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Imaging device and method for optoacoustic imaging of small animals |
| US8269827B2 (en) * | 2009-09-29 | 2012-09-18 | General Electric Company | System and methods for mapping fluorescent images into a bright field color space |
| US9677125B2 (en) * | 2009-10-21 | 2017-06-13 | General Electric Company | Detection of plurality of targets in biological samples |
| EP2633080B1 (en) | 2010-10-29 | 2018-12-05 | President and Fellows of Harvard College | Method of detecting targets using fluorescently labelled nucleic acid nanotube probes |
| US20120269419A1 (en) * | 2011-04-22 | 2012-10-25 | Ge Global Research | Analyzing the expression of biomarkers in cells with moments |
| US8639013B2 (en) | 2011-08-17 | 2014-01-28 | General Electric Company | System and methods for generating a brightfield image using fluorescent images |
| US8568991B2 (en) | 2011-12-23 | 2013-10-29 | General Electric Company | Photoactivated chemical bleaching of dyes |
| US9176032B2 (en) | 2011-12-23 | 2015-11-03 | General Electric Company | Methods of analyzing an H and E stained biological sample |
| WO2013137715A1 (en) * | 2012-03-16 | 2013-09-19 | Umc Utrecht Holding B.V. | Biomarkers for adverse cardiac remodeling |
| EP2831587B1 (en) | 2012-03-27 | 2018-05-16 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
| CN104520689A (zh) | 2012-03-30 | 2015-04-15 | 克拉里安特诊断服务公司 | 产生生物样品的图像的方法 |
| US20140024024A1 (en) * | 2012-07-17 | 2014-01-23 | General Electric Company | Methods of detecting dna, rna and protein in biological samples |
| EP2742854B1 (en) | 2012-12-11 | 2021-03-10 | iThera Medical GmbH | Handheld device and method for tomographic optoacoustic imaging of an object |
| EP2754388B1 (en) | 2013-01-15 | 2020-09-09 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | System and method for quality-enhanced high-rate optoacoustic imaging of an object |
| US9915592B2 (en) | 2013-03-06 | 2018-03-13 | General Electric Company | Methods of analyzing an H and E stained biological sample |
| HK1213296A1 (zh) * | 2013-06-04 | 2016-06-30 | 豪夫迈‧罗氏有限公司 | 用於fret的新化合物及与其相关的方法 |
| AU2014296253A1 (en) | 2013-07-30 | 2016-02-04 | President And Fellows Of Harvard College | Quantitative DNA-based imaging and super-resolution imaging |
| US9778263B2 (en) | 2013-11-13 | 2017-10-03 | General Electric Company | Quantitative in situ characterization of biological samples |
| CN112094347A (zh) * | 2014-03-05 | 2020-12-18 | 奥托路斯有限公司 | 具有针对T细胞受体beta恒定区的抗原结合域的嵌合抗原受体(CAR) |
| US20230027993A1 (en) | 2014-03-05 | 2023-01-26 | Autolus Limited | Methods |
| EP4245859A3 (en) | 2014-03-11 | 2023-11-08 | President and Fellows of Harvard College | High-throughput and highly multiplexed imaging with programmable nucleic acid probes |
| CN112029826B (zh) | 2014-07-30 | 2025-03-14 | 哈佛学院院长及董事 | 用于测定核酸的系统和方法 |
| US9933431B2 (en) | 2014-08-22 | 2018-04-03 | Arizona Board Of Regents On Behalf Of Arizona State University | System and method for iterative detection of biological molecules |
| EP3037820A1 (en) | 2014-12-27 | 2016-06-29 | Miltenyi Biotec GmbH | Cell detection methods and reagents having a releasable labelling moiety |
| JP6841609B2 (ja) | 2015-07-10 | 2021-03-10 | 3スキャン インコーポレイテッド | 組織学的染色の空間的多重化 |
| EP3325649B1 (en) | 2015-07-17 | 2024-01-03 | Nanostring Technologies, Inc. | Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue |
| WO2017015099A1 (en) | 2015-07-17 | 2017-01-26 | Nanostring Technologies, Inc. | Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue |
| US20170241911A1 (en) | 2016-02-22 | 2017-08-24 | Miltenyi Biotec Gmbh | Automated analysis tool for biological specimens |
| US10871490B2 (en) | 2016-02-29 | 2020-12-22 | Multenyi Biotec, gmbH | Assay for detection of chimeric antigen receptor T cells |
| EP3463452A1 (en) | 2016-05-24 | 2019-04-10 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd) |
| US11161111B2 (en) | 2016-06-29 | 2021-11-02 | Miltenyi Biotec B. V. & Co. KG | Multilevel disposable cartridge for biological specimens |
| CN106290878A (zh) * | 2016-09-10 | 2017-01-04 | 天津大学 | 基于量子点的胰腺癌肿瘤标志物ca242免疫层析试纸条的制备方法 |
| JP2020504600A (ja) | 2016-12-09 | 2020-02-13 | アルティヴュー, インク. | 標識化核酸イメージング剤を使用した多重イメージングのための改善された方法 |
| WO2018122245A1 (en) | 2016-12-28 | 2018-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting the survival time of patients suffering from cms3 colorectal cancer |
| WO2018122249A1 (en) | 2016-12-28 | 2018-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer |
| US20200150109A1 (en) | 2017-05-05 | 2020-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Microtubule-targeting drugs as immune checkpoint inhibitors and methods of screening novel immune checkpoint inhibitors for the treatment of cancers and infectious diseases |
| WO2018218150A1 (en) | 2017-05-26 | 2018-11-29 | President And Fellows Of Harvard College | Systems and methods for high-throughput image-based screening |
| EP3489684B1 (en) | 2017-11-27 | 2024-06-26 | Miltenyi Biotec B.V. & Co. KG | Method for photobleaching stained cells |
| KR20250161650A (ko) | 2018-02-12 | 2025-11-17 | 브루커 스페이셜 바이올로지, 인크. | 유전자 및 단백질 발현을 검출하는 생체 분자 프로브 및 방법 |
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| CA3122569A1 (en) | 2018-12-13 | 2020-06-18 | President And Fellows Of Harvard College | Amplification methods and systems for merfish and other applications |
| EP3906415B1 (en) | 2019-01-03 | 2026-04-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for enhancing cd8+ t cell-dependent immune responses in subjects suffering from cancer |
| CN109770853B (zh) * | 2019-01-30 | 2022-01-14 | 上海师范大学 | 一种斑马鱼伤口检测方法 |
| US11633741B2 (en) | 2019-03-19 | 2023-04-25 | Miltenyi Biotec B.V. & Co. KG | Slide chamber |
| JP2022527972A (ja) | 2019-04-02 | 2022-06-07 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 前悪性病変を有する患者において癌を予測及び予防する方法 |
| US20220160692A1 (en) | 2019-04-09 | 2022-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of sk2 inhibitors in combination with immune checkpoint blockade therapy for the treatment of cancer |
| JP7354285B2 (ja) | 2019-04-23 | 2023-10-02 | ミルテニー バイオテック ベー.フェー. ウント コー. カー・ゲー | 蛍光輝度を増加させるためのリンカー及び酵素により遊離可能な蛍光部分を有する接合体での可逆的な細胞検出 |
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| US20240301497A1 (en) | 2019-10-17 | 2024-09-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing nasal intestinal type adenocarcinomas |
| WO2021076919A1 (en) * | 2019-10-17 | 2021-04-22 | C2Sense, Inc. | Luminescence imaging for sensing and/or authentication |
| US20210116377A1 (en) | 2019-10-17 | 2021-04-22 | C2Sense, Inc. | White light emissive species and related methods |
| US20230113705A1 (en) | 2020-02-28 | 2023-04-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing, prognosing and managing treatment of breast cancer |
| EP3916393B1 (en) * | 2020-05-27 | 2023-01-25 | Miltenyi Biotec B.V. & Co. KG | Method for detection of cells by repetitive staining and destaining |
| EP3916388A1 (en) | 2020-05-27 | 2021-12-01 | Miltenyi Biotec B.V. & Co. KG | Reagents for detection of chimeric antigen receptor cells |
| JP7741831B2 (ja) | 2020-06-30 | 2025-09-18 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 術前補助療法及び根治手術後の固形がんを患っている患者の再発及び/又は死亡のリスクを予測するための方法 |
| CN115997123A (zh) | 2020-06-30 | 2023-04-21 | 国家医疗保健研究所 | 用于预测实体癌患者在术前辅助治疗后复发和/或死亡风险的方法 |
| KR20240012352A (ko) | 2021-03-23 | 2024-01-29 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | T 세포 림프종의 진단 및 치료 방법 |
| WO2022217084A1 (en) | 2021-04-09 | 2022-10-13 | Neogenomics Laboratories, Inc. | Perivascular accumulation of immune cells in the diagnosis and treatment of cancer |
| CN113684256B (zh) * | 2021-08-30 | 2024-05-14 | 中国药科大学 | 基于绿色溶剂及可编程寡核苷酸探针的多重定位检测多种靶标的方法 |
| WO2023143179A1 (zh) * | 2022-01-28 | 2023-08-03 | 南京大学 | 一种对抗原样本的处理方法和应用 |
| US20250067745A1 (en) | 2022-01-31 | 2025-02-27 | Institut National de la Santé et de la Recherche Médicale | Cd38 as a biomarker and biotarget in t-cell lymphomas |
| US20250035635A1 (en) | 2022-03-17 | 2025-01-30 | Institut National De La Sante Et De La Recherche Medicale | Methods for predicting response to an immunotherapeutic treatment in a patient with a cancer |
| JP2025514669A (ja) | 2022-04-11 | 2025-05-09 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | T細胞悪性腫瘍の診断及び処置のための方法 |
| WO2023198874A1 (en) | 2022-04-15 | 2023-10-19 | Institut National de la Santé et de la Recherche Médicale | Methods for the diagnosis and treatment of t cell-lymphomas |
| WO2024003310A1 (en) | 2022-06-30 | 2024-01-04 | Institut National de la Santé et de la Recherche Médicale | Methods for the diagnosis and treatment of acute lymphoblastic leukemia |
| JP2025526336A (ja) | 2022-07-22 | 2025-08-13 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | T細胞悪性腫瘍におけるバイオマーカー及びバイオターゲットとしてのgarp |
| WO2024023283A1 (en) | 2022-07-29 | 2024-02-01 | Institut National de la Santé et de la Recherche Médicale | Lrrc33 as a biomarker and biotarget in cutaneous t-cell lymphomas |
| EP4602372A1 (en) | 2022-10-12 | 2025-08-20 | Institut National de la Santé et de la Recherche Médicale | Cd81 as a biomarker and biotarget in t-cell malignancies |
| WO2025068451A1 (en) | 2023-09-28 | 2025-04-03 | Miltenyi Biotec B.V. & Co. KG | Flow cell for sequencing |
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2007
- 2007-09-28 US US11/864,085 patent/US7741045B2/en active Active
- 2007-11-15 EP EP11175116.0A patent/EP2381257B1/en active Active
- 2007-11-15 AT AT07871481T patent/ATE520026T1/de active
- 2007-11-15 WO PCT/US2007/084800 patent/WO2008064067A2/en not_active Ceased
- 2007-11-15 AU AU2007323794A patent/AU2007323794B2/en not_active Ceased
- 2007-11-15 PL PL07871481T patent/PL2082226T3/pl unknown
- 2007-11-15 JP JP2009537360A patent/JP5149303B2/ja not_active Expired - Fee Related
- 2007-11-15 ES ES11175116.0T patent/ES2459725T3/es active Active
- 2007-11-15 PT PT07871481T patent/PT2082226E/pt unknown
- 2007-11-15 EP EP07871481A patent/EP2082226B1/en active Active
- 2007-11-15 CA CA2669092A patent/CA2669092C/en active Active
- 2007-11-15 DK DK07871481.3T patent/DK2082226T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2381257B1 (en) | 2014-03-26 |
| EP2381257A1 (en) | 2011-10-26 |
| EP2082226B1 (en) | 2011-08-10 |
| PT2082226E (pt) | 2011-10-31 |
| ES2459725T3 (es) | 2014-05-12 |
| WO2008064067A3 (en) | 2008-07-10 |
| US20080118934A1 (en) | 2008-05-22 |
| JP2010510493A (ja) | 2010-04-02 |
| CA2669092A1 (en) | 2008-05-29 |
| CA2669092C (en) | 2016-07-26 |
| PL2082226T3 (pl) | 2012-01-31 |
| AU2007323794A1 (en) | 2008-05-29 |
| WO2008064067A2 (en) | 2008-05-29 |
| EP2082226A2 (en) | 2009-07-29 |
| ATE520026T1 (de) | 2011-08-15 |
| JP5149303B2 (ja) | 2013-02-20 |
| AU2007323794B2 (en) | 2013-08-22 |
| US7741045B2 (en) | 2010-06-22 |
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