DK206987A - Hidtil ukendte diphosphonsyreforbindelser, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende disse forbindelser - Google Patents

Hidtil ukendte diphosphonsyreforbindelser, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende disse forbindelser

Info

Publication number
DK206987A
DK206987A DK206987A DK206987A DK206987A DK 206987 A DK206987 A DK 206987A DK 206987 A DK206987 A DK 206987A DK 206987 A DK206987 A DK 206987A DK 206987 A DK206987 A DK 206987A
Authority
DK
Denmark
Prior art keywords
compounds
unknown
procedures
preparing
pharmaceutical preparation
Prior art date
Application number
DK206987A
Other languages
English (en)
Other versions
DK206987D0 (da
Inventor
Teruo Oku
Eishiro Todo
Chiyoshi Kasahara
Katsuya Nakamura
Hiroshi Kayakiri
Masashi Hashimoto
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868610019A external-priority patent/GB8610019D0/en
Priority claimed from GB868619074A external-priority patent/GB8619074D0/en
Priority claimed from GB878705347A external-priority patent/GB8705347D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of DK206987D0 publication Critical patent/DK206987D0/da
Publication of DK206987A publication Critical patent/DK206987A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/60—Quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
    • C07F9/655354—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK206987A 1986-04-24 1987-04-23 Hidtil ukendte diphosphonsyreforbindelser, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende disse forbindelser DK206987A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB868610019A GB8610019D0 (en) 1986-04-24 1986-04-24 Diphosphonic acid compounds
GB868619074A GB8619074D0 (en) 1986-08-05 1986-08-05 Diphosphonic acid compounds
GB878705347A GB8705347D0 (en) 1987-03-06 1987-03-06 Diphosphonic acid compounds

Publications (2)

Publication Number Publication Date
DK206987D0 DK206987D0 (da) 1987-04-23
DK206987A true DK206987A (da) 1987-10-25

Family

ID=27263007

Family Applications (1)

Application Number Title Priority Date Filing Date
DK206987A DK206987A (da) 1986-04-24 1987-04-23 Hidtil ukendte diphosphonsyreforbindelser, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende disse forbindelser

Country Status (7)

Country Link
US (2) US4857513A (da)
EP (1) EP0243173B1 (da)
KR (1) KR870010067A (da)
DE (1) DE3770982D1 (da)
DK (1) DK206987A (da)
ES (1) ES2039237T3 (da)
GR (1) GR3002193T3 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071840A (en) * 1986-12-19 1991-12-10 Norwich Eaton Pharmaceuticals, Inc. Certain heterocyclic substituted diphosphonate compounds pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism
PH26923A (en) * 1989-03-08 1992-12-03 Ciba Geigy N-substituted amino alkanediphosphonic acids
IE912115A1 (en) * 1990-06-25 1992-01-01 Takeda Chemical Industries Ltd Bisphosphonic acid derivatives, their production and use
IE914417A1 (en) * 1990-12-19 1992-07-01 Takeda Chemical Industries Ltd Bisphosphonic acid derivatives, their production and use
IT1244698B (it) * 1991-02-01 1994-08-08 Gentili Ist Spa Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale
JPH0826048B2 (ja) * 1991-09-05 1996-03-13 東レ株式会社 メタンジホスホン酸誘導体、その製造方法およびその医薬用途
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
FR2683528A1 (fr) * 1991-11-12 1993-05-14 Bretagne Occidentale Universit Prodrogues et analogues gem-bisphosphoniques d'antiinflammatoires non-sterouidiens de type arylacetique ou arylpropionique.
TW222637B (da) * 1991-12-12 1994-04-21 Hoechst Ag
CZ295994A3 (en) * 1992-05-29 1995-10-18 Procter & Gamble Pharma Thiosubstituted heterocyclic phosphonate compounds containing nitrogen for treating abnormal metabolism of calcium and phosphate
AU670337B2 (en) 1992-11-30 1996-07-11 Novartis Ag Use of certain methanebisphosphonic acid derivatives in fracture healing
EP0600834A1 (en) * 1992-11-30 1994-06-08 Ciba-Geigy Ag Use of methanebisphosphonic acid derivatives for the manufacture of a medicament for fracture healing
JPH11513383A (ja) * 1995-09-29 1999-11-16 ノバルティス アクチェンゲゼルシャフト ウマの舟状骨病を治療する方法
BR9810456A (pt) * 1997-06-27 2001-09-25 Fujisawa Pharmaceutical Co Composto de sulfonamida, método para sua obtenção e seu uso farmacêutico
DE59903329D1 (en) * 1998-07-16 2002-12-12 Aventis Pharma Gmbh Phosphin- und phosphonsäurederivate als arzneimittel
DE69910045T2 (de) 1998-09-09 2004-04-22 Metabasis Therapeutics Inc., San Diego Neue heteroaromatische fructose 1,6-bisphosphatase inhibitoren
ATE350385T1 (de) * 2000-03-08 2007-01-15 Metabasis Therapeutics Inc Neue aryl fructose-1,6-bisphosphatase inhibitoren
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
US6548042B2 (en) 2000-08-07 2003-04-15 Arstad Erik Bis-phosphonate compounds
US20100144679A1 (en) * 2007-03-21 2010-06-10 Duke University Medication kits and formulations for preventing, treating or reducing secondary fractures after previous fracture
HUE025737T2 (en) 2009-09-01 2016-05-30 Univ Duke Bisphosphonate compositions and methods for treating heart failure
CN104010647A (zh) 2011-11-16 2014-08-27 杜克大学 用于治疗和/或减轻心功能障碍的双膦酸盐组合物及方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3965254A (en) * 1973-05-23 1976-06-22 The Procter & Gamble Company Compositions for the treatment of calcific tumors
US4134969A (en) * 1974-02-04 1979-01-16 Henkel Kommanditgesellschaft Auf Aktien (Henkel Kgaa) Method of treatment of calcium disorders using aminoalkane-diphosphonic acids
US3906062A (en) * 1974-08-09 1975-09-16 Monsanto Co Alpha,alpha-diphosphonato acetanilides
DE2530139C3 (de) * 1975-04-30 1979-06-21 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen N-Acyl-1 -aminoalkan-1,1 -diphosphonsäuren, deren Herstellung und Verwendung
US4447256A (en) * 1977-07-20 1984-05-08 Nissan Chemical Industries, Ltd. N-(Unsubstituted or substituted pyridyl)aminomethylene-diphosphonic acids, herbicidal compositions containing same, their use for herbicides, and process for preparing same
DE2741513A1 (de) * 1977-09-15 1979-03-22 Benckiser Gmbh Joh A Verfahren zum stabilisieren von calciumhydrogenphosphat-dihydrat gegen hydrolyse
DE3203308A1 (de) * 1982-01-27 1983-07-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
DE3428524A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3512536A1 (de) * 1985-04-06 1986-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4761406A (en) * 1985-06-06 1988-08-02 The Procter & Gamble Company Regimen for treating osteoporosis
DE3540150A1 (de) * 1985-11-13 1987-05-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
EP0243173A3 (en) 1988-07-06
GR3002193T3 (en) 1992-12-30
DE3770982D1 (de) 1991-08-01
ES2039237T3 (es) 1993-09-16
DK206987D0 (da) 1987-04-23
EP0243173B1 (en) 1991-06-26
KR870010067A (ko) 1987-11-30
US4963536A (en) 1990-10-16
US4857513A (en) 1989-08-15
EP0243173A2 (en) 1987-10-28

Similar Documents

Publication Publication Date Title
DK206987D0 (da) Hidtil ukendte diphosphonsyreforbindelser, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende disse forbindelser
DK362787D0 (da) Benzensulfonamido-indanylforbindelser, laegemidler indeholdende disse forbindelser og fremgangsmaade til deres fremstilling
DK170785A (da) 4-substituerede-piperazin-2-carboxylsyre-derivater og farmaceutisk acceptable salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og farmaceutiske praeparater indeholdende disse
DK167187A (da) Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
DK164594C (da) 1,4-dihydro-pyridin-3,5-yl-dicarboxylsyrederivater, farmaceutiske praeparater indeholdende disse derivater samt fremgangsmaade til fremstilling deraf
DK241585A (da) 8-chlor-quinolincarboxylsyre-derivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende saadanne forbindelser
DK538885D0 (da) Imidazolylalkylguanidinderivater, fremgangsmaade til fremstilling herafsamt laegemidler indeholdende disse forbindelser
DK162600C (da) Oe4-(2-hydroxycyklohexylmethyl)phenylaaalkansyrederivater og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende disse
DK183986A (da) Cyklopentylaetere, fremgangsmaade til fremstilling deraf og laegemiddelpraeparat indeholdende saadanne forbindelser
DK457787D0 (da) Sulfonamidoethylforbindelser, laegemidler indeholdende disse forbindelser og fremgangsmaade til deres fremstilling
DK396385A (da) 2,3-dihydro-lh-indenderivater, fremgangsmaade til fremstilling heraf og farmaceutiske praeparater indeholdende disse forbindelser
DK494088A (da) 4-oxo-3-quinolincarboxylsyrer, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse
DK634788D0 (da) 22-deklorteicoplaniner, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende saadanne forbindelser
DK493988D0 (da) 4-oxo-3-quinolincarboxylsyrer, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse forbindelser
DK607388D0 (da) Polynukleotider, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende saadanne forbindelser
DK251386D0 (da) 11-betasubstituerede steroider, fremgangsmaade til fremstilling heraf og farmaceutiske og veterinaere praeparater indeholdende disse forbindelser
DK605186A (da) 16,17-acetalsubstituerede pregnan-21-ionsyrederivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende saadanne forbindelser
DK369088D0 (da) Fremgangsmaade til fremstilling af nukleinsyrederivater og fremgangsmaade til fremstilling af farmaceutiske praeparater indeholdende disse
DK106287D0 (da) Glycero-3(2)-phospho-l-serin-derivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og farmaceutiske praeparater indeholdende disse
DK164453C (da) Dibenzooeb,daathiopyran-6-carboxylsyreforbindelser, fremgangsmaade til fremstilling heraf og farmaceutiske praeparater indeholdende disse forbindelser
DK245787A (da) Nicotinsyrederivater, fremgangsmaade til fremstilling deraf og praeparater med fungicid virkning indeholdende disse derivater
DK575387A (da) Hydrofluorenderivater, fremgangsmaade til fremstilling deraf og praeparater indeholdende saadanne forbindelser
DK159779C (da) Substituerede phenoxypropylthiopyrazolo(1,5-a)-pyridin- eller -benzimidazolderivater, fremgangsmaade til fremstilling deraf og laegemiddel indeholdende disse forbindelser
DK365087D0 (da) 1,3,5-trithianderivater, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
DK21588A (da) 4-arylcarbonyl-1-((4-morpholinyl)-alkyl)-1h-indoler, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse forbindelser

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment